Pub Date : 2025-12-01Epub Date: 2025-09-02DOI: 10.1016/j.jebdp.2025.102203
IMAN ABD-ELWAHAB RADI (Reviewers), HOSSAM ELMALAHI
Article Title and Bibliographic Information
Application of Emerging Teaching Models in Dental Education: A Systematic Review and Meta-Analysis. Pang X, Li L, Liu X, Wang Y, Yang B. Int Dent J 2024;74:1185–1196. https://doi.org/10.1016/j.identj.2024.05.016
Source of Funding
This review was funded by the Teaching Reform Project of Guangdong New Medical Science and Education Committee (grant no. 20230724) and the Undergraduate Teaching Quality Engineering Project, SunYat-sen University (grant no. 3942023).
Type of Study/Design
Systematic review with meta-analysis of data (SRMA)
{"title":"COMBINED USE OF FLIPPED, PROBLEM-, OR CASE-BASED LEARNING WITH TRADITIONAL TEACHING MAY IMPROVE CLINICAL AND THEORETICAL PERFORMANCE IN DENTAL EDUCATION","authors":"IMAN ABD-ELWAHAB RADI (Reviewers), HOSSAM ELMALAHI","doi":"10.1016/j.jebdp.2025.102203","DOIUrl":"10.1016/j.jebdp.2025.102203","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Application of Emerging Teaching Models in Dental Education: A Systematic Review and Meta-Analysis. Pang X, Li L, Liu X, Wang Y, Yang B. Int Dent J 2024;74:1185–1196. <span><span>https://doi.org/10.1016/j.identj.2024.05.016</span><svg><path></path></svg></span></div></div><div><h3>Source of Funding</h3><div>This review was funded by the Teaching Reform Project of <span>Guangdong New Medical Science and Education Committee</span> (grant no. <span><span>20230724</span></span>) and the Undergraduate Teaching Quality Engineering Project, <span>SunYat-sen University</span> (grant no. <span><span>3942023</span></span>).</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with meta-analysis of data (SRMA)</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102203"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PREMOLAR EXTRACTION MAY REDUCE ARCH WIDTH COMPARED TO NONEXTRACTION IN ORTHODONTIC TREATMENT, THOUGH EVIDENCE REMAINS INCONSISTENT","authors":"IVAN ARSIC (Reviewers), ALEKSANDAR JAKOVLJEVIC, MILOS BELOICA","doi":"10.1016/j.jebdp.2025.102198","DOIUrl":"10.1016/j.jebdp.2025.102198","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Extraction vs nonextraction orthodontic treatment: A systematic review and meta-analysis. Elias, KG, Sivamurthy, G, Bearn, DR. Angle Orthod 2024; 94(1):83-106. <span><span>doi:10.2319/021123-98.1</span><svg><path></path></svg></span>.</div></div><div><h3>Source of Funding</h3><div>Not reported.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with meta-analysis of data</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102198"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-23DOI: 10.1016/S1532-3382(25)00128-9
{"title":"Statement of Purpose/Levels of Evidence","authors":"","doi":"10.1016/S1532-3382(25)00128-9","DOIUrl":"10.1016/S1532-3382(25)00128-9","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102213"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-08-05DOI: 10.1016/j.jebdp.2025.102190
VOJISLAV KOMLENIC (Reviewers), KATARINA PUZOVIC, KATARINA BELJIC-IVANOVIC, ALEKSANDAR JAKOVLJEVIC
Article Title and Bibliographic Information
Effects of disinfectants on physical properties of denture base resins: A systematic review and meta-analysis. Zhang K, Zhang S, Shi Y, Zhang L, Fu B. J Prosthet Dent. 2024;131(5):841-858.
{"title":"Glutaraldehyde, Chlorhexidine, and Peracetic Acid are Preferred Disinfectants for Repeated or Prolonged Disinfection of Denture Base Resins","authors":"VOJISLAV KOMLENIC (Reviewers), KATARINA PUZOVIC, KATARINA BELJIC-IVANOVIC, ALEKSANDAR JAKOVLJEVIC","doi":"10.1016/j.jebdp.2025.102190","DOIUrl":"10.1016/j.jebdp.2025.102190","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Effects of disinfectants on physical properties of denture base resins: A systematic review and meta-analysis. Zhang K, Zhang S, Shi Y, Zhang L, Fu B. J Prosthet Dent. 2024;131(5):841-858.</div></div><div><h3>Source of Funding</h3><div>Not reported.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with meta-analysis of data</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102190"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-08-22DOI: 10.1016/j.jebdp.2025.102201
ZHAN WANG (Reviewers), NUO HU, XINYU LI
Article Title and Bibliographic Information
Gerber S, Woliansky M, Neiva-Sousa M, Visholm T, Limacher A, Sidebottom A. Complications of temporomandibular joint replacement surgery in adult patients: A systematic review and meta-analysis. J Craniomaxillofac Surg. 2025 Apr 21:S1010-5182(25)00112-X. doi:10.1016/j.jcms.2025.03.016. Epub ahead of print. PMID: 40263055.
Source of Funding
None reported.
Type of Study/Design
Systematic review with meta-analysis of data.
erber S, Woliansky M, neva - sousa M, Visholm T, Limacher A, Sidebottom A.成年患者颞下颌关节置换术并发症的系统回顾和meta分析。[J]颅颌面外科杂志,2015年4月21日:1010-5182(25)00112-X。doi: 10.1016 / j.jcms.2025.03.016。打印前Epub。PMID: 40263055。资金来源无报告。研究类型/设计系统评价,数据荟萃分析。
{"title":"ALLOPLASTIC TMJ REPLACEMENT MAY BE GENERALLY SAFE BUT ASSOCIATED WITH MODERATE NEUROGENIC AND PAIN-RELATED COMPLICATIONS","authors":"ZHAN WANG (Reviewers), NUO HU, XINYU LI","doi":"10.1016/j.jebdp.2025.102201","DOIUrl":"10.1016/j.jebdp.2025.102201","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Gerber S, Woliansky M, Neiva-Sousa M, Visholm T, Limacher A, Sidebottom A. Complications of temporomandibular joint replacement surgery in adult patients: A systematic review and meta-analysis. J Craniomaxillofac Surg. 2025 Apr 21:S1010-5182(25)00112-X. <span><span>doi:10.1016/j.jcms.2025.03.016</span><svg><path></path></svg></span>. Epub ahead of print. PMID: 40263055.</div></div><div><h3>Source of Funding</h3><div>None reported.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with meta-analysis of data.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102201"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-06-18DOI: 10.1016/j.jebdp.2025.102172
YUQING ZHANG , CE BIAN , CHAORAN YU , MENGYAO ZHU , MICHAEL D. WEIR , HOCKIN H.K. XU , YUXING BAI , NING ZHANG
Objective
The prevention of stroke is of paramount importance, and periodontal disease may play an important role in this process. This study aims to evaluate the association between periodontal disease and stroke risk.
Methods
The study was conducted in accordance with the PRISMA 2020 guidelines. We comprehensively searched PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library from inception to December 2024 to identify relevant studies. Quality assessment was conducted using both the original and modified versions of the Newcastle-Ottawa Scale as appropriate. Data such as sample size, region, age, and gender of participants were extracted. Odds ratios (OR) were pooled using a random-effects model, and 95% confidence intervals (CI) were calculated. Sensitivity analysis, cumulative meta-analysis, multiple subgroup analyses, and publication bias assessments were also performed to assess the stability of the results.
Results
A total of 36 studies, including 7,665,431 participants, were included in the meta-analysis, consisting of 20 cohort studies, 9 case-control studies, and 7 cross-sectional studies. The findings indicate that individuals with periodontal disease have a significantly higher risk of stroke compared to the healthy population (OR: 1.724, 95% CI: 1.481-2.008). This conclusion holds across different regions, genders, and age groups. Periodontitis patients exhibited a higher risk of stroke compared to those with gingivitis (OR: 2.008 vs 1.673), and the risk of ischemic stroke was higher in individuals with periodontal disease than the risk of hemorrhagic stroke (OR: 1.846 vs 1.476). Sensitivity analysis, cumulative meta-analysis, and publication bias detection further confirm that the conclusion remains stable (Egger’s tests, P = .280 and Begg’s tests P = .703), even after imputing missing studies using the trim-and-fill method. Meta-regression analysis suggested that age may contribute to the heterogeneity observed in the studies.
Conclusions
Periodontal disease has been identified as an independent risk factor for stroke. Regular and effective dental biofilm control may help reduce the risk of stroke in patients with periodontal disease. The underlying mechanisms by which periodontal disease increases stroke risk warrant further investigation.
目的预防脑卒中至关重要,牙周病可能在卒中预防中起重要作用。本研究旨在评估牙周病与中风风险之间的关系。方法本研究按照PRISMA 2020指南进行。我们全面检索了PubMed、EMBASE、Scopus、Web of Science和Cochrane Library从成立到2024年12月的相关研究。根据情况,使用纽卡斯尔-渥太华量表的原始版本和修改版本进行质量评估。提取了参与者的样本量、地区、年龄和性别等数据。使用随机效应模型合并优势比(OR),并计算95%置信区间(CI)。还进行敏感性分析、累积荟萃分析、多亚组分析和发表偏倚评估来评估结果的稳定性。结果meta分析共纳入36项研究,包括20项队列研究、9项病例对照研究和7项横断面研究,共计7665431名受试者。研究结果表明,与健康人群相比,牙周病患者中风的风险明显更高(OR: 1.724, 95% CI: 1.481-2.008)。这一结论适用于不同的地区、性别和年龄组。与牙龈炎患者相比,牙周炎患者卒中的风险更高(OR: 2.008 vs 1.673),牙周病患者缺血性卒中的风险高于出血性卒中的风险(OR: 1.846 vs 1.476)。敏感性分析、累积荟萃分析和发表偏倚检测进一步证实结论保持稳定(Egger检验,P = )。280和Begg的检验P = .703),即使在使用修剪填充方法输入缺失的研究之后。荟萃回归分析表明,年龄可能导致研究中观察到的异质性。结论牙周病是脑卒中的独立危险因素。定期和有效的牙齿生物膜控制可能有助于降低牙周病患者中风的风险。牙周病增加中风风险的潜在机制值得进一步研究。
{"title":"THE ASSOCIATION BETWEEN PERIODONTAL DISEASE AND STROKE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"YUQING ZHANG , CE BIAN , CHAORAN YU , MENGYAO ZHU , MICHAEL D. WEIR , HOCKIN H.K. XU , YUXING BAI , NING ZHANG","doi":"10.1016/j.jebdp.2025.102172","DOIUrl":"10.1016/j.jebdp.2025.102172","url":null,"abstract":"<div><h3>Objective</h3><div>The prevention of stroke is of paramount importance, and periodontal disease may play an important role in this process. This study aims to evaluate the association between periodontal disease and stroke risk.</div></div><div><h3>Methods</h3><div>The study was conducted in accordance with the PRISMA 2020 guidelines. We comprehensively searched PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library from inception to December 2024 to identify relevant studies. Quality assessment was conducted using both the original and modified versions of the Newcastle-Ottawa Scale as appropriate. Data such as sample size, region, age, and gender of participants were extracted. Odds ratios (OR) were pooled using a random-effects model, and 95% confidence intervals (CI) were calculated. Sensitivity analysis, cumulative meta-analysis, multiple subgroup analyses, and publication bias assessments were also performed to assess the stability of the results.</div></div><div><h3>Results</h3><div>A total of 36 studies, including 7,665,431 participants, were included in the meta-analysis, consisting of 20 cohort studies, 9 case-control studies, and 7 cross-sectional studies. The findings indicate that individuals with periodontal disease have a significantly higher risk of stroke compared to the healthy population (OR: 1.724, 95% CI: 1.481-2.008). This conclusion holds across different regions, genders, and age groups. Periodontitis patients exhibited a higher risk of stroke compared to those with gingivitis (OR: 2.008 vs 1.673), and the risk of ischemic stroke was higher in individuals with periodontal disease than the risk of hemorrhagic stroke (OR: 1.846 vs 1.476). Sensitivity analysis, cumulative meta-analysis, and publication bias detection further confirm that the conclusion remains stable (Egger’s tests, <em>P</em> = .280 and Begg’s tests <em>P</em> = .703), even after imputing missing studies using the trim-and-fill method. Meta-regression analysis suggested that age may contribute to the heterogeneity observed in the studies.</div></div><div><h3>Conclusions</h3><div>Periodontal disease has been identified as an independent risk factor for stroke. Regular and effective dental biofilm control may help reduce the risk of stroke in patients with periodontal disease. The underlying mechanisms by which periodontal disease increases stroke risk warrant further investigation.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102172"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-23DOI: 10.1016/S1532-3382(25)00129-0
{"title":"Information for Readers","authors":"","doi":"10.1016/S1532-3382(25)00129-0","DOIUrl":"10.1016/S1532-3382(25)00129-0","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102214"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-23DOI: 10.1016/S1532-3382(25)00130-7
{"title":"Information for Authors","authors":"","doi":"10.1016/S1532-3382(25)00130-7","DOIUrl":"10.1016/S1532-3382(25)00130-7","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102215"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-06-16DOI: 10.1016/j.jebdp.2025.102169
Óscar Rapado-González , Cristina Isabel Sevilla-García , Juan Pizcueta-Leirós , Ángel Salgado-Barreira , María Piñeiro-Lamas , Félix De Carlos-Villafranca , Rafael López-López , María Mercedes Suárez-Cunqueiro
Background
DNA promoter methylation is one of the main epigenetic mechanisms of silencing of tumor-suppressor genes in cancer. Accumulating scientific evidence has shown various genes with aberrant DNA methylation in oral cancer (OC), however, the magnitude of the association between DNA methylation and OC risk remains controversial.
Objective
To evaluate the overall and specific impact of DNA promoter methylation on the risk of OC development.
Material and methods
PubMed, EMBASE, Web of Science, and the Cochrane Library were searched for eligible studies. The Newcastle-Ottawa Scale (NOS) was used to evaluate the methodological quality of the included studies with a case-control design. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations with R software; and Egger’s test was used to detect publication bias.
Results
A total of 41 studies including 4218 OC patients and 3478 noncancer controls were included in the meta-analysis. Overall, a significant association was found between DNA promoter methylation and OC risk (OR = 5.83, 95% CI 4.14-8.20; P < .001). In addition, the pooled ORs showed a significant association between specific tumor-related genes and OC risk: p16 (5.77; 95% CI 3.95-8.45; P < .001), ECAD (4.47; 95% CI 2.77-7.21; P < .001), MGMT (3.85; 95% CI 2.48-5.97; P < .001), DAPK (5.58; 95% CI 2.14-14.56; P < .001), hMLH1 (10.48; 95% CI 1.04-106.1; P = .047), p14 (3.21; 95% CI 1.78-5.78; P < .001), and p15 (5.02; 95% CI 2.76-9.12; P < .001).
Conclusion
A significant overall association was found between gene promoter methylation and OC risk. Specifically, the promoter methylation of p16, ECAD, MGMT, DAPK, hMLH1, p15, and p14 displayed a significant role in oral carcinogenesis, acting as promising biomarkers for OC prediction and prognosis.
dna启动子甲基化是肿瘤抑制基因沉默的主要表观遗传机制之一。越来越多的科学证据表明,口腔癌(OC)中存在多种异常DNA甲基化基因,然而,DNA甲基化与OC风险之间的关联程度仍存在争议。目的评价DNA启动子甲基化对卵巢癌发生风险的总体和特异性影响。材料和方法检索spubmed、EMBASE、Web of Science和Cochrane Library,寻找符合条件的研究。采用纽卡斯尔-渥太华量表(NOS)评价纳入研究的方法学质量,采用病例对照设计。用R软件计算合并优势比(or)和95%置信区间(ci)来估计相关性的强度;用Egger检验来检测发表偏倚。结果共纳入41项研究,包括4218例OC患者和3478例非癌对照。总体而言,DNA启动子甲基化与OC风险之间存在显著关联(OR = 5.83,95% CI 4.14-8.20;P & lt;措施)。此外,合并的or显示特定肿瘤相关基因与OC风险之间存在显著关联:p16 (5.77;95% ci 3.95-8.45;P & lt;.001), ecad (4.47;95% ci 2.77-7.21;P & lt;.001), MGMT (3.85;95% ci 2.48-5.97;P & lt;.001), dapk (5.58;95% ci 2.14-14.56;P & lt;.001), hMLH1 (10.48;95% ci 1.04-106.1;P = .047),p14 (3.21;95% ci 1.78-5.78;P & lt;.001), p15 (5.02;95% ci 2.76-9.12;P & lt;措施)。结论基因启动子甲基化与卵巢癌风险存在显著的整体相关性。具体而言,p16、ECAD、MGMT、DAPK、hMLH1、p15和p14的启动子甲基化在口腔癌发生中发挥了重要作用,是预测OC和预后的有希望的生物标志物。
{"title":"ASSOCIATION OF DNA METHYLATION AND ORAL CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"Óscar Rapado-González , Cristina Isabel Sevilla-García , Juan Pizcueta-Leirós , Ángel Salgado-Barreira , María Piñeiro-Lamas , Félix De Carlos-Villafranca , Rafael López-López , María Mercedes Suárez-Cunqueiro","doi":"10.1016/j.jebdp.2025.102169","DOIUrl":"10.1016/j.jebdp.2025.102169","url":null,"abstract":"<div><h3>Background</h3><div>DNA promoter methylation is one of the main epigenetic mechanisms of silencing of tumor-suppressor genes in cancer. Accumulating scientific evidence has shown various genes with aberrant DNA methylation in oral cancer (OC), however, the magnitude of the association between DNA methylation and OC risk remains controversial.</div></div><div><h3>Objective</h3><div>To evaluate the overall and specific impact of DNA promoter methylation on the risk of OC development.</div></div><div><h3>Material and methods</h3><div>PubMed, EMBASE, Web of Science, and the Cochrane Library were searched for eligible studies. The Newcastle-Ottawa Scale (NOS) was used to evaluate the methodological quality of the included studies with a case-control design. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations with R software; and Egger’s test was used to detect publication bias.</div></div><div><h3>Results</h3><div>A total of 41 studies including 4218 OC patients and 3478 noncancer controls were included in the meta-analysis. Overall, a significant association was found between DNA promoter methylation and OC risk (OR = 5.83, <em>95% CI</em> 4.14-8.20; <em>P</em> < .001). In addition, the pooled ORs showed a significant association between specific tumor-related genes and OC risk: <em>p16</em> (5.77; <em>95% CI</em> 3.95-8.45; <em>P</em> < .001), <em>ECAD</em> (4.47; <em>95% CI</em> 2.77-7.21; <em>P</em> < .001), <em>MGMT</em> (3.85; <em>95% CI</em> 2.48-5.97; <em>P</em> < .001), <em>DAPK</em> (5.58; <em>95% CI</em> 2.14-14.56; <em>P</em> < .001), <em>hMLH1</em> (10.48; <em>95% CI</em> 1.04-106.1; <em>P = .047</em>), <em>p14</em> (3.21; <em>95% CI</em> 1.78-5.78; <em>P</em> < .001), and <em>p15</em> (5.02; <em>95% CI</em> 2.76-9.12; <em>P</em> < .001).</div></div><div><h3>Conclusion</h3><div>A significant overall association was found between gene promoter methylation and OC risk. Specifically, the promoter methylation of <em>p16, ECAD, MGMT, DAPK, hMLH1, p15,</em> and <em>p14</em> displayed a significant role in oral carcinogenesis, acting as promising biomarkers for OC prediction and prognosis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102169"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-08-22DOI: 10.1016/j.jebdp.2025.102194
Eman Bakhurji BDS, DScD (Reviewer)
Article Title and Bibliographic Information
Prevalence of caries patterns in the 21st century preschool children: a systematic review and meta-analysiS, Shuyang He, Madeline Jun Yu Yon, Fei Liu, Edward Chin Man Lo, Cynthia Kar Yung Yiu, Chun Hung Chu, Phoebe Pui Ying Lam. J Evid Based Dent Pract. 2024 Sep;24(3): 101992.
Source of Funding
Not reported.
Type of Study/Design
Systematic review with meta-analysis of data.
21世纪学龄前儿童龋病流行趋势的系统回顾与元分析,何淑阳,杨娟,刘飞,卢庆文,姚嘉荣,朱俊鸿,林培英。[J] Based Dent practice . 2024年9月;24(3): 101992。资金来源未报道。研究类型/设计系统评价,数据荟萃分析。
{"title":"PATTERNS OF DENTAL CARIES IN PRIMARY TEETH MAY REFLECT ANATOMICAL TRENDS AND AGE-RELATED VARIABILITY","authors":"Eman Bakhurji BDS, DScD (Reviewer)","doi":"10.1016/j.jebdp.2025.102194","DOIUrl":"10.1016/j.jebdp.2025.102194","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Prevalence of caries patterns in the 21st century preschool children: a systematic review and meta-analysiS, Shuyang He, Madeline Jun Yu Yon, Fei Liu, Edward Chin Man Lo, Cynthia Kar Yung Yiu, Chun Hung Chu, Phoebe Pui Ying Lam. J Evid Based Dent Pract. 2024 Sep;24(3): 101992.</div></div><div><h3>Source of Funding</h3><div>Not reported.</div></div><div><h3>Type of Study/Design</h3><div><em>Systematic review with meta-analysis of data</em>.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102194"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}