Journal of Evidence-Based Dental Practice最新文献

{"title":"Statement of Purpose/Levels of Evidence","authors":"","doi":"10.1016/S1532-3382(25)00094-6","DOIUrl":"10.1016/S1532-3382(25)00094-6","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102179"},"PeriodicalIF":4.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FLUORIDE APPEARS EFFECTIVE AGAINST RADIATION CARIES, BUT MORE RIGOROUS TRIALS ARE NEEDED","authors":"Linda L. Cheng (Reviewer)","doi":"10.1016/j.jebdp.2025.102174","DOIUrl":"10.1016/j.jebdp.2025.102174","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Luka B, Fiedler A, Ganss C, Soetedjo V, Vach K, Schlueter N. PREVENTING CARIES AFTER RADIOTHERAPY TO THE HEAD AND NECK REGION - A SYSTEMATIC REVIEW. J Evid Based Dent Pract. 2024;24(3):101989. <span><span>doi:10.1016/j.jebdp.2024.101989</span><svg><path></path></svg></span>.</div></div><div><h3>Source of Funding</h3><div>The Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review</div></div><div><h3>Conflict of interest</h3><div>The authors declare no conflicts of interest.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102174"},"PeriodicalIF":4.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAXILLARY EXPANSION MAY NOT LEAD TO SIGNIFICANT SAGITTAL EFFECTS IN GROWING CLASS II PATIENTS","authors":"XIAOJIN WU (Reviewers),&nbsp;WEI LU,&nbsp;FANG HUA","doi":"10.1016/j.jebdp.2025.102173","DOIUrl":"10.1016/j.jebdp.2025.102173","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Impact of maxillary expansion on the sagittal skeletal and dental parameters of growing Class II patients: A systematic review with meta-analysis. <strong><em>Cannatà D, Galdi M, Scelza C, Simeon V, Giordano F, Martina S</em></strong>. Orthod Craniofac Res. 2025 Feb;28(1):116-132.</div></div><div><h3>Source of Funding</h3><div>None.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with meta-analysis</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102173"},"PeriodicalIF":4.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ASSOCIATION BETWEEN PERIODONTAL DISEASE AND STROKE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"YUQING ZHANG ,&nbsp;CE BIAN ,&nbsp;CHAORAN YU ,&nbsp;MENGYAO ZHU ,&nbsp;MICHAEL D. WEIR ,&nbsp;HOCKIN H.K. XU ,&nbsp;YUXING BAI ,&nbsp;NING ZHANG","doi":"10.1016/j.jebdp.2025.102172","DOIUrl":"10.1016/j.jebdp.2025.102172","url":null,"abstract":"<div><h3>Objective</h3><div>The prevention of stroke is of paramount importance, and periodontal disease may play an important role in this process. This study aims to evaluate the association between periodontal disease and stroke risk.</div></div><div><h3>Methods</h3><div>The study was conducted in accordance with the PRISMA 2020 guidelines. We comprehensively searched PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library from inception to December 2024 to identify relevant studies. Quality assessment was conducted using both the original and modified versions of the Newcastle-Ottawa Scale as appropriate. Data such as sample size, region, age, and gender of participants were extracted. Odds ratios (OR) were pooled using a random-effects model, and 95% confidence intervals (CI) were calculated. Sensitivity analysis, cumulative meta-analysis, multiple subgroup analyses, and publication bias assessments were also performed to assess the stability of the results.</div></div><div><h3>Results</h3><div>A total of 36 studies, including 7,665,431 participants, were included in the meta-analysis, consisting of 20 cohort studies, 9 case-control studies, and 7 cross-sectional studies. The findings indicate that individuals with periodontal disease have a significantly higher risk of stroke compared to the healthy population (OR: 1.724, 95% CI: 1.481-2.008). This conclusion holds across different regions, genders, and age groups. Periodontitis patients exhibited a higher risk of stroke compared to those with gingivitis (OR: 2.008 vs 1.673), and the risk of ischemic stroke was higher in individuals with periodontal disease than the risk of hemorrhagic stroke (OR: 1.846 vs 1.476). Sensitivity analysis, cumulative meta-analysis, and publication bias detection further confirm that the conclusion remains stable (Egger’s tests, <em>P</em> = .280 and Begg’s tests <em>P</em> = .703), even after imputing missing studies using the trim-and-fill method. Meta-regression analysis suggested that age may contribute to the heterogeneity observed in the studies.</div></div><div><h3>Conclusions</h3><div>Periodontal disease has been identified as an independent risk factor for stroke. Regular and effective dental biofilm control may help reduce the risk of stroke in patients with periodontal disease. The underlying mechanisms by which periodontal disease increases stroke risk warrant further investigation.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102172"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF DNA METHYLATION AND ORAL CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"Óscar Rapado-González ,&nbsp;Cristina Isabel Sevilla-García ,&nbsp;Juan Pizcueta-Leirós ,&nbsp;Ángel Salgado-Barreira ,&nbsp;María Piñeiro-Lamas ,&nbsp;Félix De Carlos-Villafranca ,&nbsp;Rafael López-López ,&nbsp;María Mercedes Suárez-Cunqueiro","doi":"10.1016/j.jebdp.2025.102169","DOIUrl":"10.1016/j.jebdp.2025.102169","url":null,"abstract":"<div><h3>Background</h3><div>DNA promoter methylation is one of the main epigenetic mechanisms of silencing of tumor-suppressor genes in cancer. Accumulating scientific evidence has shown various genes with aberrant DNA methylation in oral cancer (OC), however, the magnitude of the association between DNA methylation and OC risk remains controversial.</div></div><div><h3>Objective</h3><div>To evaluate the overall and specific impact of DNA promoter methylation on the risk of OC development.</div></div><div><h3>Material and methods</h3><div>PubMed, EMBASE, Web of Science, and the Cochrane Library were searched for eligible studies. The Newcastle-Ottawa Scale (NOS) was used to evaluate the methodological quality of the included studies with a case-control design. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations with R software; and Egger’s test was used to detect publication bias.</div></div><div><h3>Results</h3><div>A total of 41 studies including 4218 OC patients and 3478 noncancer controls were included in the meta-analysis. Overall, a significant association was found between DNA promoter methylation and OC risk (OR = 5.83, <em>95% CI</em> 4.14-8.20; <em>P</em> &lt; .001). In addition, the pooled ORs showed a significant association between specific tumor-related genes and OC risk: <em>p16</em> (5.77; <em>95% CI</em> 3.95-8.45; <em>P</em> &lt; .001), <em>ECAD</em> (4.47; <em>95% CI</em> 2.77-7.21; <em>P</em> &lt; .001), <em>MGMT</em> (3.85; <em>95% CI</em> 2.48-5.97; <em>P</em> &lt; .001), <em>DAPK</em> (5.58; <em>95% CI</em> 2.14-14.56; <em>P</em> &lt; .001), <em>hMLH1</em> (10.48; <em>95% CI</em> 1.04-106.1; <em>P = .047</em>), <em>p14</em> (3.21; <em>95% CI</em> 1.78-5.78; <em>P</em> &lt; .001), and <em>p15</em> (5.02; <em>95% CI</em> 2.76-9.12; <em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>A significant overall association was found between gene promoter methylation and OC risk. Specifically, the promoter methylation of <em>p16, ECAD, MGMT, DAPK, hMLH1, p15,</em> and <em>p14</em> displayed a significant role in oral carcinogenesis, acting as promising biomarkers for OC prediction and prognosis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102169"},"PeriodicalIF":4.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AWAKE BRUXISM PREVALENCE ACROSS POPULATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"NIKOLA STANISIC ,&nbsp;OVIDIU IONUT SARACUTU ,&nbsp;ANNA COLONNA ,&nbsp;WENDY WU ,&nbsp;DANIELE MANFREDINI ,&nbsp;BIRGITTA HÄGGMAN-HENRIKSON","doi":"10.1016/j.jebdp.2025.102171","DOIUrl":"10.1016/j.jebdp.2025.102171","url":null,"abstract":"<div><h3>Objectives</h3><div>Bruxism significantly affects oral health, with consequences such as tooth wear and restoration failures. Additionally, it is linked to various risk factors and co-occurring disorders. Unlike sleep bruxism, awake bruxism (AB) is more strongly associated with psychosocial factors. This review aimed to evaluate the prevalence of AB in the general population and specific subpopulations.</div></div><div><h3>Methods</h3><div>The review followed PRISMA guidelines and was registered in PROSPERO (CRD42023398868). A literature search in PubMed, Scopus, and Web of Science until April 8, 2025 identified studies that fulfilled the inclusion criteria of reporting AB prevalence in adult populations. Risk of bias was assessed with Joanna Briggs Institute Prevalence Critical Appraisal Tool and a random-effects meta-analysis determined prevalence in various subpopulations.</div></div><div><h3>Results</h3><div>The search yielded 8,818 records, with 5,408 abstracts screened after duplicate removal. Of these, 4,473 were excluded. Full-text assessment led to the exclusion of 843 articles that did not meet inclusion criteria. A hand search identified 5 additional studies. Ultimately, 94 studies involving 49,163 individuals were included, with 66 studies (39,823 individuals) analyzed in the meta-analysis. In the general population, self-reported “possible” AB had a mean prevalence of 25.9% (95% CI 22.2-29.9), and clinically based “probable” AB 16.0% (95% CI 10.0-24.5). Prevalence was significantly higher in specific subpopulations, such as individuals with temporomandibular disorders (50.0%, 95% CI 41.1-58.9) and systemic conditions (40.1%, 95% CI 31.4-49.5). Risk of bias was mainly related to assessment of AB.</div></div><div><h3>Conclusions</h3><div>The variability between subpopulations highlights the importance of considering patient-specific factors and a targeted clinical approach in AB management.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102171"},"PeriodicalIF":4.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF DIFFERENT SURFACE MODIFICATIONS ON THE OSSEOINTEGRATION OF DENTAL IMPLANT UNDER DIABETIC CONDITIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF IN VITRO RESEARCH","authors":"LE HONG ,&nbsp;HAO LI","doi":"10.1016/j.jebdp.2025.102170","DOIUrl":"10.1016/j.jebdp.2025.102170","url":null,"abstract":"<div><h3>Background</h3><div>Osseointegration, the direct connection between bone and implant, is crucial for dental implant success, particularly in patients with diabetes mellitus (DM) where impaired bone healing poses a challenge. Surface modifications of dental implants have emerged as an effective strategy to enhance osseointegration in such compromised conditions. This systematic review aimed to evaluate the impact of various surface modifications on the osseointegration of dental implants under diabetic conditions, with a focus on alkaline phosphatase (ALP) activity, osteopontin (OPN) and osteocalcin (OCN) as markers of osteogenic potential.</div></div><div><h3>Methods</h3><div>This review was conducted following PRISMA guidelines and included studies assessing surface modifications on dental implants in diabetic models. A comprehensive literature search was performed across PubMed, Embase, and Web of Science up to July 2024. Inclusion criteria focused on studies that incorporated in vitro experiments with quantitative measurements of bone formation. Data extraction and quality assessment were performed on eight selected studies. Statistical analysis included the calculation of Response Ratios (RR) for ALP activity, and meta-analyses of OCN and OPN expression levels measured at certain time point. The pooled results were visualized using forest plots.</div></div><div><h3>Results</h3><div>The included studies demonstrated a consistent increase in ALP activity across surface-modified implants, particularly at 7 and 14 days postimplantation. The 7-day RR was 2.02 (95% CI: 1.76-2.29), and the 14-day RR was 1.36 (95% CI: 1.18-1.55), indicating enhanced osteogenic potential. Similarly, OCN expression at day 7 showed a significant pooled standardized mean difference (SMD) of 11.01 (95% CI: 3.02-19.00), and OPN expression at day 7 demonstrated a more consistent effect, with a pooled SMD of 3.76 (95% CI: 2.46-5.06), all suggesting a marked upregulation of osteogenic differentiation markers. However, significant heterogeneity was observed, attributed primarily to differences in cell lines and experimental conditions.</div></div><div><h3>Conclusion</h3><div>Surface modifications significantly enhance osseointegration of dental implants in diabetic conditions, as evidenced by increased ALP activity and elevated expression levels of key osteogenic markers such as OCN and OPN. Despite the promising results, future research should address the heterogeneity by standardizing methodologies and expanding the number of included studies to refine these techniques and their clinical applicability.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102170"},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYTOTOXICITY OF ORTHODONTICS ALIGNERS: AN UMBRELLA REVIEW","authors":"CATARINA NUNES ,&nbsp;BEATRIZ ORNELAS ,&nbsp;CARLOS MIGUEL MARTO ,&nbsp;ANABELA PAULA ,&nbsp;MAFALDA LARANJO ,&nbsp;CATARINA MESTRE ,&nbsp;RAQUEL TRAVASSOS ,&nbsp;INÊS FRANCISCO ,&nbsp;FRANCISCO VALE","doi":"10.1016/j.jebdp.2025.102168","DOIUrl":"10.1016/j.jebdp.2025.102168","url":null,"abstract":"<div><h3>Objective</h3><div>This umbrella review aims to determine if clear aligners promote cytotoxic and estrogenic effects.</div></div><div><h3>Methodology</h3><div>The review was conducted in conformity with the PRISMA statement. A systematic search was carried out in March of 2025 in 5 databases (Medline through PubMed, Web of Science (all databases), Cochrane Library, Embase, and Epistemonikos). All systematic reviews (SRs) that reported the cytotoxicity and/or estrogenicity of orthodontic aligners were included. The quality of the included studies was evaluated using AMSTAR-2 and the degree of overlap was analysed using Corrected Covered Area (CCA).</div></div><div><h3>Results</h3><div>The literature search resulted in 394 articles. Screening by title and abstract, resulted in 13 articles for full reading, and 4 articles were included in the umbrella review. According to the AMSTAR-2, all reviews were of low quality. The degree of overlap among SRs is high.</div></div><div><h3>Discussion</h3><div>The included SRs indicate that aligners do not have significant estrogenic/cytotoxic capacity and, even in cases of bisphenol A (BPA) leaching, this occurs at levels well below what is considered toxic. The low quality, high risk of bias, considerable overlap, and significant heterogeneity among the included studies impacts the obtained results.</div></div><div><h3>Conclusion</h3><div>It is not possible to affirm or refute the presence of estrogenic or cytotoxic effects or the leaching of monomers such as BPA. In the future, it is recommended that studies adopt a more detailed and prolonged analysis of BPA leaching and it is necessary to carry out clinical studies that evaluate the safety and biocompatibility of orthodontic aligners.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102168"},"PeriodicalIF":4.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL EFFECT OF LOCAL ALOE VERA USE AS AN ADJUNCT TO PERIODONTAL THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"CHENGZHI XIE ,&nbsp;ZHIHUI JING ,&nbsp;MINGYU XUE","doi":"10.1016/j.jebdp.2025.102167","DOIUrl":"10.1016/j.jebdp.2025.102167","url":null,"abstract":"<div><h3>Objectives</h3><div>Aloe Vera might be beneficial to improve periodontal condition. This systematic review and meta-analysis aimed to investigate Aloe Vera’s clinical efficacy as an adjunct to scaling and root planning (SRP) for nonsurgical periodontal therapy.</div></div><div><h3>Methods</h3><div>We included relevant randomized controlled trials (RCTs) comparing the effectiveness of Aloe Vera (I) with a (placebo) control (C) on periodontal parameters (O) in in adults with periodontitis (P) (registration number: CRD42022336946). PubMed, Cochrane Library, Embase, and Web of Science were searched. Mean difference (MD) with standard deviations of clinical outcomes were extracted and pooled from three studies.</div></div><div><h3>Results</h3><div>Three studies were included in the systematic review and meta-analysis. Adjunctive Aloe Vera treatment reduced probing pocket depth (PPD), with MD = −0.47 (−0.78/−0.16) at 3 months, MD = −0.29 (−0.53/−0.06) at 6 months, and MD: −1.06 (−2.04/−0.08) at 12 months, compared to the control group. Overall differences for clinical attachment level (CAL) were found to be −0.56 (−0.85/−0.27) at 6 months and −0.98 (−1.28/−0.68) at 12 months, which indicated a statistically significant result favoring the test group over the control group. No significant differences were observed in reducing plaque index (PI), bleeding index (BI) at 6 months and CAL at 3 months in the local administration of Aloe Vera to SRP. Adjunctive Aloe Vera treatment reduced BI (MD: −0.40; −0.62/−0.18) at 12 months with respect to the control group.</div></div><div><h3>Conclusions</h3><div>In comparison to SRP alone/placebo, the supplementary use of Aloe Vera in SRP results in improved periodontal treatment outcomes.</div></div><div><h3>Limitations</h3><div>Limited by the quality and number of studies, the evidence was not reliable enough to support any clinical advice.</div></div><div><h3>Clinical significance</h3><div>The subgingival administration of Aloe Vera may be clinically efficacious for managing periodontal diseases.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102167"},"PeriodicalIF":4.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADJUNCTIVE PROBIOTICS SHOW A POSITIVE TREND BUT INCONCLUSIVE CLINICAL BENEFIT IN PERI-IMPLANTITIS MANAGEMENT","authors":"I-TING HSIEH (Reviewers),&nbsp;LING-CHENG MONG,&nbsp;CHIN-WEI WANG,&nbsp;FLAVIA PIRIH","doi":"10.1016/j.jebdp.2025.102166","DOIUrl":"10.1016/j.jebdp.2025.102166","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Lo´ pez-Valverde N, Lo´ pez-Valverde A and Blanco Rueda JA (2024) The role of probiotic therapy on clinical parameters and human immune response in peri‑implant diseases: a systematic review and meta-analysis of randomized clinical studies. Front. Immunol. 15:1371072. <span><span>doi: 10.3389/fimmu.2024.1371072</span><svg><path></path></svg></span></div></div><div><h3>Source of Funding</h3><div>No financial support.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with meta-analysis of data.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102166"},"PeriodicalIF":4.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}