Pub Date : 2025-04-19DOI: 10.1016/j.jebdp.2025.102159
MARWA BARAKA, GHADA ELWARDANI, HAMS HAMED, SARAH I. ZEITOUN
Background
Hypersensitivity from Molar Incisor Hypomineralisation (MIH) negatively affects children's oral health-related quality of life (OHRQoL).
Aim
To evaluate and compare the effectiveness of photobiomodulation (PBM) by low-power laser, resin-based (Fisseal), and glass ionomer (Fuji TRIAGE) sealants on hypersensitivity in children with MIH and their impact on OHRQoL.
Design
Forty-five children aged 6-10 with one first permanent molar affected by MIH and hypersensitivity were randomly assigned to 3 groups: Group 1 (n = 15) PBM, Group 2 (n = 15) Fuji TRIAGE, and Group 3 (n = 15) Fisseal. Hypersensitivity was assessed before and 15 minutes postintervention, with follow-ups at 1 week, and 1, 3, and 6 months. Pain and sensitivity were measured using the Wong-Baker Faces Pain Rating Scale (FPS) and the Schiff Cold Air Sensitivity Scale (SCASS). OHRQoL was evaluated with the Child Perceptions Questionnaire (CPQ8-10).
Results
No significant differences in SCASS or FPS scores were found between groups. Significant reductions in SCASS and FPS were observed over time (P < .001), with PBM and Fisseal showing notable FPS improvements at 6 months. All groups showed significant OHRQoL improvements (P < .001), particularly Fisseal.
Conclusion
Both glass ionomer and resin-based sealants and PBM are effective in reducing hypersensitivity associated with MIH.
Clinical Significance
PBM is a noninvasive therapy for managing hypersensitivity in children with MIH offering an alternative for apprehensive patients.
{"title":"MANAGEMENT OF HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING PHOTOBIOMODULATION AND SEALANTS IN CHILDREN: A RANDOMIZED CLINICAL TRIAL","authors":"MARWA BARAKA, GHADA ELWARDANI, HAMS HAMED, SARAH I. ZEITOUN","doi":"10.1016/j.jebdp.2025.102159","DOIUrl":"10.1016/j.jebdp.2025.102159","url":null,"abstract":"<div><h3>Background</h3><div>Hypersensitivity from Molar Incisor Hypomineralisation (MIH) negatively affects children's oral health-related quality of life (OHRQoL).</div></div><div><h3>Aim</h3><div>To evaluate and compare the effectiveness of photobiomodulation (PBM) by low-power laser, resin-based (Fisseal), and glass ionomer (Fuji TRIAGE) sealants on hypersensitivity in children with MIH and their impact on OHRQoL.</div></div><div><h3>Design</h3><div>Forty-five children aged 6-10 with one first permanent molar affected by MIH and hypersensitivity were randomly assigned to 3 groups: Group 1 (<em>n</em> = 15) PBM, Group 2 (<em>n</em> = 15) Fuji TRIAGE, and Group 3 (<em>n</em> = 15) Fisseal. Hypersensitivity was assessed before and 15 minutes postintervention, with follow-ups at 1 week, and 1, 3, and 6 months. Pain and sensitivity were measured using the Wong-Baker Faces Pain Rating Scale (FPS) and the Schiff Cold Air Sensitivity Scale (SCASS). OHRQoL was evaluated with the Child Perceptions Questionnaire (CPQ8-10).</div></div><div><h3>Results</h3><div>No significant differences in SCASS or FPS scores were found between groups. Significant reductions in SCASS and FPS were observed over time (<em>P</em> < .001), with PBM and Fisseal showing notable FPS improvements at 6 months. All groups showed significant OHRQoL improvements (<em>P</em> < .001), particularly Fisseal.</div></div><div><h3>Conclusion</h3><div>Both glass ionomer and resin-based sealants and PBM are effective in reducing hypersensitivity associated with MIH.</div></div><div><h3>Clinical Significance</h3><div>PBM is a noninvasive therapy for managing hypersensitivity in children with MIH offering an alternative for apprehensive patients.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102159"},"PeriodicalIF":4.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.jebdp.2025.102158
AHMAD ABDUL KADER ABUOKAL , MOUHAMMED RIHAN , ABDULKARIM ALBACHA HJAZI , ABDALLA IBRAHEM MOHAMMED IBRAHEM ELEMAM , MAMDOUH MOHAMED RAGAEY AHMED EZZAT MOHAMED
Background
Dexmedetomidine (D) and ketamine are widely used for pediatric dental sedation, each presenting unique benefits and potential adverse effects. Combining these agents, referred to as DK, was suggested to provide a balanced approach to pediatric sedation. This is the first systematic review and meta-analysis to evaluate the efficacy and safety of DK versus dexmedetomidine alone in pediatric dental procedures.
Methods
A systematic search was conducted in PubMed, Scopus, Web of Science, Embase, and CENTRAL, identifying randomized controlled trials (RCTs) comparing DK to D alone. Eligible studies were screened, and data were extracted following PRISMA guidelines. Meta-analyses were conducted using random effects models through RevMan software.
Results
Five studies involving 308 pediatric patients were included. Meta-analysis showed no significant difference in onset of sedation time (MD = −0.02 minutes; 95% CI = [−3.27, 3.23]; P = .99; I² = 29%), duration of sedation (MD = −7.39 minutes; 95% CI = [−21.69, 6.91]; P = .31; I² = 95%), or recovery time (MD = 4.71 minutes; 95% CI = [−12.80, 22.23]; P = .60; I² = 92%). Analysis of Anxiety and pain scores favored DK (SMD = −0.67; 95% CI = [−1.20, −0.14]; P = .01; I² = 35%), (MD = −1.11; 95% CI = [−2.04, −0.19]; P = .02; I² = 20%), respectively. Adverse events, including bradycardia, hypotension, and agitation, vomiting, nausea showed no significant differences between groups.
Conclusion
The combination of DK does not offer significant advantages over dexmedetomidine alone for pediatric dental sedation. However, DK showed a moderate reduction in anxiety and pain with a favorable safety profile, suggesting it is a viable option in clinical practice.
右美托咪定(D)和氯胺酮被广泛用于儿科牙科镇静，各自具有独特的益处和潜在的不良反应。联合这些药物，被称为DK，被建议提供一个平衡的方法，以儿童镇静。这是第一个系统评价和荟萃分析，以评估DK与单独使用右美托咪定在儿童牙科手术中的有效性和安全性。方法系统检索PubMed、Scopus、Web of Science、Embase、CENTRAL等数据库，找出比较丹参与丹参的随机对照试验（rct）。筛选符合条件的研究，并按照PRISMA指南提取数据。采用随机效应模型，通过RevMan软件进行meta分析。结果纳入5项研究，涉及308例儿科患者。meta分析显示，两组患者镇静起始时间无显著差异(MD = −0.02分钟；95% ci = [−3.27,3.23]；P = 获得;I² = 29%)、镇静时间(MD = −7.39分钟；95% ci = [−21.69,6.91]；P = 。31;I² = 95%)或恢复时间(MD = 4.71分钟；95% ci = [−12.80,22.23]；P = .60;我² = 92%)。焦虑和疼痛评分偏向DK (SMD = −0.67；95% ci = [−1.20,−0.14]；P = . 01;我² = 35%)、(MD = −1.11;95% ci = [−2.04,−0.19]；P = .02点;我² = 20%),分别为。不良事件，包括心动过缓、低血压、躁动、呕吐、恶心在两组间无显著差异。结论与单用右美托咪定相比，联合应用DK在小儿牙科镇静方面没有明显优势。然而，DK显示出焦虑和疼痛的适度减少，并具有良好的安全性，这表明它在临床实践中是一种可行的选择。
{"title":"SAFETY AND EFFICACY OF DEXMEDETOMIDINE-KETAMINE COMBINATION VS DEXMEDETOMIDINE ALONE FOR PEDIATRIC DENTAL SEDATION: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"AHMAD ABDUL KADER ABUOKAL , MOUHAMMED RIHAN , ABDULKARIM ALBACHA HJAZI , ABDALLA IBRAHEM MOHAMMED IBRAHEM ELEMAM , MAMDOUH MOHAMED RAGAEY AHMED EZZAT MOHAMED","doi":"10.1016/j.jebdp.2025.102158","DOIUrl":"10.1016/j.jebdp.2025.102158","url":null,"abstract":"<div><h3>Background</h3><div>Dexmedetomidine (D) and ketamine are widely used for pediatric dental sedation, each presenting unique benefits and potential adverse effects. Combining these agents, referred to as DK, was suggested to provide a balanced approach to pediatric sedation. This is the first systematic review and meta-analysis to evaluate the efficacy and safety of DK versus dexmedetomidine alone in pediatric dental procedures.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in PubMed, Scopus, Web of Science, Embase, and CENTRAL, identifying randomized controlled trials (RCTs) comparing DK to D alone. Eligible studies were screened, and data were extracted following PRISMA guidelines. Meta-analyses were conducted using random effects models through RevMan software.</div></div><div><h3>Results</h3><div>Five studies involving 308 pediatric patients were included. Meta-analysis showed no significant difference in onset of sedation time (MD = −0.02 minutes; 95% CI = [−3.27, 3.23]; <em>P</em> = .99; I² = 29%), duration of sedation (MD = −7.39 minutes; 95% CI = [−21.69, 6.91]; <em>P</em> = .31; I² = 95%), or recovery time (MD = 4.71 minutes; 95% CI = [−12.80, 22.23]; <em>P</em> = .60; I² = 92%). Analysis of Anxiety and pain scores favored DK (SMD = −0.67; 95% CI = [−1.20, −0.14]; <em>P</em> = .01; I² = 35%), (MD = −1.11; 95% CI = [−2.04, −0.19]; <em>P</em> = .02; I² = 20%), respectively. Adverse events, including bradycardia, hypotension, and agitation, vomiting, nausea showed no significant differences between groups.</div></div><div><h3>Conclusion</h3><div>The combination of DK does not offer significant advantages over dexmedetomidine alone for pediatric dental sedation. However, DK showed a moderate reduction in anxiety and pain with a favorable safety profile, suggesting it is a viable option in clinical practice.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102158"},"PeriodicalIF":4.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-10DOI: 10.1016/j.jebdp.2025.102143
MARYAM EMAMI , MEHDI AZIZMOHAMMAD LOOHA , KEITH DA-SILVA , MOHAMMADJAVAD SHIRANI
Objective
This systematic review and meta-analysis is the first to evaluate the impact of photobiomodulation therapy (PBMT) on objective and physiological measures of local anesthesia injection pain in children aged 3-12.
Methods
This review follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) guidelines and is registered in the International Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD42024549936. A systematic search was conducted in Embase, PubMed, and the Cochrane Library to locate relevant Randomized Clinical Trials (RCTs) between January 2000 to September 2024. Study screening, data extraction, risk of bias evaluation, and certainty of evidence grading were performed independently by 2 reviewers. Meta-analyses focused on the pain assessment using following measures: Wong-Baker Faces Pain Rating Scale (PRS), Sound, Eye, and Motor Scale (SEM), Face, Legs, Activity, Cry, Consolability Scale (FLACC), and heart rate (HR). Sensitivity analyses were conducted using a leave-one-study-out approach to assess the robustness of the findings, while publication bias and heterogeneity were evaluated through established statistical methods.
Results
Out of 1322 identified studies, 7 RCTs met inclusion criteria. PBMT significantly reduced pain, with moderate certainty, as measured by the objective FLACC scale (SMD = −0.41, 95% CI: −0.72, −0.09, P = .011) and the physiological HR method (SMD = −0.50, 95% CI: −0.86, −0.14, P = .006), demonstrating moderate and no heterogeneity, respectively. However, no statistically significant effect was observed on subjective measures using the PRS (SMD = −0.66, 95% CI: −1.63, 0.32, P = .185) and SEM (SMD = 0.18, 95% CI: −1.09, 1.45, P = .780) scales. Five studies had low risk of bias, and GRADE analysis indicated very low to moderate certainty. Funnel plots showed minimal publication bias, except for slight asymmetry in PRS.
Conclusions
PBMT demonstrates potential as a nonpharmacological method to reduce injection pain in children, as reflected in FLACC and HR outcomes. However, no significant effect of PBMT was observed on the SEM scale. Further research is needed to clarify its impact on subjective pain measures (PRS) and to optimize PBMT protocols.
{"title":"EFFICACY OF PHOTOBIOMODULATION THERAPY ON PAIN PERCEPTION DURING LOCAL ANESTHESIA IN CHILDREN: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"MARYAM EMAMI , MEHDI AZIZMOHAMMAD LOOHA , KEITH DA-SILVA , MOHAMMADJAVAD SHIRANI","doi":"10.1016/j.jebdp.2025.102143","DOIUrl":"10.1016/j.jebdp.2025.102143","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis is the first to evaluate the impact of photobiomodulation therapy (PBMT) on objective and physiological measures of local anesthesia injection pain in children aged 3-12.</div></div><div><h3>Methods</h3><div>This review follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) guidelines and is registered in the International Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD42024549936. A systematic search was conducted in Embase, PubMed, and the Cochrane Library to locate relevant Randomized Clinical Trials (RCTs) between January 2000 to September 2024. Study screening, data extraction, risk of bias evaluation, and certainty of evidence grading were performed independently by 2 reviewers. Meta-analyses focused on the pain assessment using following measures: Wong-Baker Faces Pain Rating Scale (PRS), Sound, Eye, and Motor Scale (SEM), Face, Legs, Activity, Cry, Consolability Scale (FLACC), and heart rate (HR). Sensitivity analyses were conducted using a leave-one-study-out approach to assess the robustness of the findings, while publication bias and heterogeneity were evaluated through established statistical methods.</div></div><div><h3>Results</h3><div>Out of 1322 identified studies, 7 RCTs met inclusion criteria. PBMT significantly reduced pain, with moderate certainty, as measured by the objective FLACC scale (SMD = −0.41, 95% CI: −0.72, −0.09, <em>P</em> = .011) and the physiological HR method (SMD = −0.50, 95% CI: −0.86, −0.14, <em>P</em> = .006), demonstrating moderate and no heterogeneity, respectively. However, no statistically significant effect was observed on subjective measures using the PRS (SMD = −0.66, 95% CI: −1.63, 0.32, <em>P</em> = .185) and SEM (SMD = 0.18, 95% CI: −1.09, 1.45, <em>P</em> = .780) scales. Five studies had low risk of bias, and GRADE analysis indicated very low to moderate certainty. Funnel plots showed minimal publication bias, except for slight asymmetry in PRS.</div></div><div><h3>Conclusions</h3><div>PBMT demonstrates potential as a nonpharmacological method to reduce injection pain in children, as reflected in FLACC and HR outcomes. However, no significant effect of PBMT was observed on the SEM scale. Further research is needed to clarify its impact on subjective pain measures (PRS) and to optimize PBMT protocols.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102143"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the efficacy of Hy-N spray in dry mouth patients.
Materials and Methods
A randomized double-blind crossover study was conducted on patients with dry mouth. They were given 3 saliva substitute sprays: Hy-N, placebo, and Biotène. The unstimulated whole saliva flow rate (UWSFR), salivary pH, and xerostomia questionnaire (XQ) were evaluated at baseline and after 1 week of treatment with each spray. Patient satisfaction was evaluated after each treatment period.
Results
Twenty-nine patients completed the study. After using the Hy-N and Biotène sprays for 1 week, the UWSFR significantly increased from 0.12 ± 0.16 at baseline to 0.16 ± 0.18 mL/min postspray usage (P = .04, P ≤ .01) with moderate improvement. None of the sprays affected salivary pH (P = .72). The mean XQ score also significantly decreased from 34.2 ± 21.4 at baseline to 23.7 ± 17.4, 23.1 ± 15.2, and 26.5 ± 17.7 after using Hy-N, Biotène, and placebo spray, respectively (P = .001, P = .011, P = .009) with moderate improvement. Biotène was the most preferred saliva substitute spray, followed by Hy-N spray.
Conclusion
Using the Hy-N and Biotène for 1 week relieves subjective and objective dry mouth. They can be a useful product in the management of dry mouth without causing side-effects.
目的评价Hy-N喷雾剂治疗口干患者的疗效。材料与方法对口干患者进行随机双盲交叉研究。给予3种唾液替代喷雾剂：Hy-N、安慰剂和biot。在基线和每次喷雾治疗1周后评估非刺激全唾液流率（UWSFR）、唾液pH值和口干问卷（XQ）。每个治疗期结束后评估患者满意度。结果29例患者完成了研究。使用Hy-N和biot喷雾剂1周后，UWSFR从基线时的0.12±0.16显著增加到喷雾剂使用后的0.16±0.18 mL/min （P = ）。04, P≤0.01)，有中度改善。喷雾剂均不影响唾液pH值（P = .72）。使用Hy-N、biot和安慰剂喷雾后，XQ平均评分也从基线时的34.2±21.4显著降低至23.7±17.4、23.1±15.2和26.5±17.7 （P = ）。001, P = 。011, P = .009)，有中度改善。biot是首选的唾液替代喷雾剂，其次是Hy-N喷雾剂。结论hyn联合biot治疗1周可缓解主客观口干症状。它们是治疗口干的有效产品，而且不会产生副作用。
{"title":"EFFICACY OF HYALURONIC NANOGEL SPRAY FOR TREATING DRY MOUTH: A RANDOMIZED CROSSOVER STUDY","authors":"NONGNAPAT EAKPUNYAKUL , PEERAWAS KOPONGPANICH , KANOKPORN BHALANG , JITTIMA AMIE LUCKANAGUL","doi":"10.1016/j.jebdp.2025.102142","DOIUrl":"10.1016/j.jebdp.2025.102142","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the efficacy of Hy-N spray in dry mouth patients.</div></div><div><h3>Materials and Methods</h3><div>A randomized double-blind crossover study was conducted on patients with dry mouth. They were given 3 saliva substitute sprays: Hy-N, placebo, and Biotène. The unstimulated whole saliva flow rate (UWSFR), salivary pH, and xerostomia questionnaire (XQ) were evaluated at baseline and after 1 week of treatment with each spray. Patient satisfaction was evaluated after each treatment period.</div></div><div><h3>Results</h3><div>Twenty-nine patients completed the study. After using the Hy-N and Biotène sprays for 1 week, the UWSFR significantly increased from 0.12 ± 0.16 at baseline to 0.16 ± 0.18 mL/min postspray usage (<em>P</em> = .04, <em>P</em> ≤ .01) with moderate improvement. None of the sprays affected salivary pH (<em>P</em> = .72). The mean XQ score also significantly decreased from 34.2 ± 21.4 at baseline to 23.7 ± 17.4, 23.1 ± 15.2, and 26.5 ± 17.7 after using Hy-N, Biotène, and placebo spray, respectively (<em>P</em> = .001, <em>P</em> = .011, <em>P</em> = .009) with moderate improvement. Biotène was the most preferred saliva substitute spray, followed by Hy-N spray.</div></div><div><h3>Conclusion</h3><div>Using the Hy-N and Biotène for 1 week relieves subjective and objective dry mouth. They can be a useful product in the management of dry mouth without causing side-effects.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102142"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-25DOI: 10.1016/j.jebdp.2025.102141
Mahmood Moosazadeh PhD , Mohammad A Sabeti DDS , Seyyed Mohammad Hashemi MD , Arezoo Ghazalgoo MD , Tahoora Mousavi PhD , Seifali Mahdavi PhD , Erfan Ghadirzadeh MD
Introduction
Despite numerous studies investigating the link between Entamoeba gingivalis and Trichomonas tenax and periodontal diseases, findings remain inconclusive. To resolve this inconsistency, we conducted a meta-analysis to assess the association between E. gingivalis and T. tenax with both gingivitis and periodontitis.
Methods
We searched Google Scholar, Medline/PubMed, Scopus, Web of Science, and Embase search engines and databases, as well as a bibliographic section of related articles from their dates of inception to 20 April 2024. The included studies were assessed for potential biases and the overall quality of the evidence using the Newcastle-Ottawa Scale. Finally, 20 studies entered the meta-analysis.
Results
20 studies were qualified to be included in the current study. The prevalence of T. tenax was estimated to be 14% (95% CI: 8-20) among gingivitis patients and 26% (95% CI: 12-40) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with T. tenax infection than in the control group (OR: 2.30; 95% CI: 1.21-4.35, and OR: 2.90; 95% CI: 1.01-8.37, respectively). Also, the prevalence of E. gingivalis was estimated to be 45% (95% CI: 32-58) among gingivitis patients and 55% (95% CI: 35-75) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with E. gingivalis infection than in the control group (OR: 4.08; 95% CI: 2.36-7.06, and OR: 8.33; 95% CI: 3.04-22.81, respectively).
Conclusion
Our analysis shows that individuals infected with E. gingivalis or T. tenax are more prone to periodontal diseases than noninfected individuals.
PROSPERO Registration ID
CRD42024551772
引言尽管有许多研究调查了齿龈内阿米巴和肌腱毛滴虫与牙周疾病之间的联系，但研究结果仍不确定。为了解决这种不一致性，我们进行了一项荟萃分析，以评估牙龈卟啉单胞菌和T.tenax与牙龈炎和牙周炎之间的关联。方法我们搜索了Google Scholar、Medline/PubMed、Scopus、Web of Science和Embase搜索引擎和数据库，以及自其成立之日起至2024年4月20日的相关文章的书目部分。使用纽卡斯尔-渥太华量表对纳入的研究进行了潜在偏差和证据总体质量的评估。最后，20项研究进入了荟萃分析。结果20项研究符合纳入本研究的条件。在牙龈炎患者中，T.tenax的患病率估计为14%（95%CI:8-20），在牙周炎患者中为26%（95%CI:12-40）。据估计，T.tenax感染患者患牙龈炎和牙周炎的几率明显高于对照组（OR:2.30；95%CI:1.21-4.35，OR:2.90；95%CI：1.01-8.37）。此外，牙龈炎患者中牙龈单胞菌的患病率估计为45%（95%CI:32-58），牙周炎患者中为55%（95%CI:35-75）。据估计，感染牙龈单胞菌的患者患牙龈炎和牙周炎的几率明显高于对照组（OR:4.08；95%CI:2.36-7.06，OR:8.33；95%CI:3.04-22.81）。结论我们的分析表明，感染牙龈卟啉单胞菌或T.tenax的人比非感染者更容易患牙周病。PROSPERO注册号CRD42024551772
{"title":"THE RELATIONSHIP BETWEEN ENTAMOEBA GINGIVALIS AND TRICHOMONAS TENAX WITH PERIODONTITIS AND GINGIVITIS: A SYSTEMATIC REVIEW, META-ANALYSIS, AND META-REGRESSION","authors":"Mahmood Moosazadeh PhD , Mohammad A Sabeti DDS , Seyyed Mohammad Hashemi MD , Arezoo Ghazalgoo MD , Tahoora Mousavi PhD , Seifali Mahdavi PhD , Erfan Ghadirzadeh MD","doi":"10.1016/j.jebdp.2025.102141","DOIUrl":"10.1016/j.jebdp.2025.102141","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite numerous studies investigating the link between <em>Entamoeba gingivalis</em> and <em>Trichomonas tenax</em> and periodontal diseases, findings remain inconclusive. To resolve this inconsistency, we conducted a meta-analysis to assess the association between <em>E. gingivalis</em> and <em>T. tenax</em> with both gingivitis and periodontitis.</div></div><div><h3>Methods</h3><div>We searched Google Scholar, Medline/PubMed, Scopus, Web of Science, and Embase search engines and databases, as well as a bibliographic section of related articles from their dates of inception to 20 April 2024. The included studies were assessed for potential biases and the overall quality of the evidence using the Newcastle-Ottawa Scale. Finally, 20 studies entered the meta-analysis.</div></div><div><h3>Results</h3><div>20 studies were qualified to be included in the current study. The prevalence of <em>T. tenax</em> was estimated to be 14% (95% CI: 8-20) among gingivitis patients and 26% (95% CI: 12-40) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with <em>T. tenax</em> infection than in the control group (OR: 2.30; 95% CI: 1.21-4.35, and OR: 2.90; 95% CI: 1.01-8.37, respectively). Also, the prevalence of <em>E. gingivalis</em> was estimated to be 45% (95% CI: 32-58) among gingivitis patients and 55% (95% CI: 35-75) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with <em>E. gingivalis</em> infection than in the control group (OR: 4.08; 95% CI: 2.36-7.06, and OR: 8.33; 95% CI: 3.04-22.81, respectively).</div></div><div><h3>Conclusion</h3><div>Our analysis shows that individuals infected with <em>E. gingivalis</em> or <em>T. tenax</em> are more prone to periodontal diseases than noninfected individuals.</div></div><div><h3>PROSPERO Registration ID</h3><div>CRD42024551772</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102141"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jebdp.2025.102140
IBRAHIM OGHLI PhD , BIRGITTA HÄGGMAN-HENRIKSON PhD , ERIC L. SCHIFFMAN MS , THOMAS LIST PhD
Objectives
This study aimed to identify baseline factors that predict Health-Related Quality of Life (HRQoL) in patients with TMD 8 years later.
Materials and Methods
401 participants (333 women, mean age 45.8 years) from a multicenter cohort were examined using the Diagnostic Criteria for TMD (DC/TMD) and questionnaires. The main outcome was the 12-item Short Form Health Survey (SF-12), a HRQoL measure that provides physical (PCS) and mental (MCS) summaries. Baseline predictors included age, gender, self-reported health, Jaw Functional Limitation Scale (JFLS), pain intensity, pain frequency, and pain duration. Regression analysis with stepwise modeling identified predictive factors.
Results
54.3% had painful TMD, 15.7% had nonpainful TMD, and 27.7% were healthy controls. For the painful TMD group, the regression model was significant (R² = .25, F = 4.3, P < .01), with age and favorable general health predicting PCS scores. In the nonpainful TMD group, the model was significant (R² = .58, F = 3.8, P < .01), with JFLS and favorable general health (predicting PCS scores. The MCS model was significant in healthy controls (R2 = .22, F = 1.8, P = .05), with JFLS as only predictor.
Conclusion
Predictors of mental HRQoL: JFLS in healthy controls, but no predictors were found in TMD groups. Predictors of physical HRQoL: General health in both TMD groups, JFLS in the nonpainful TMD group, and age in the painful TMD group.
{"title":"PREDICTORS OF HEALTH-RELATED QUALITY OF LIFE IN TEMPOROMANDIBULAR DISORDER PATIENTS: 8-YEAR COHORT STUDY","authors":"IBRAHIM OGHLI PhD , BIRGITTA HÄGGMAN-HENRIKSON PhD , ERIC L. SCHIFFMAN MS , THOMAS LIST PhD","doi":"10.1016/j.jebdp.2025.102140","DOIUrl":"10.1016/j.jebdp.2025.102140","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to identify baseline factors that predict Health-Related Quality of Life (HRQoL) in patients with TMD 8 years later.</div></div><div><h3>Materials and Methods</h3><div>401 participants (333 women, mean age 45.8 years) from a multicenter cohort were examined using the Diagnostic Criteria for TMD (DC/TMD) and questionnaires. The main outcome was the 12-item Short Form Health Survey (SF-12), a HRQoL measure that provides physical (PCS) and mental (MCS) summaries. Baseline predictors included age, gender, self-reported health, Jaw Functional Limitation Scale (JFLS), pain intensity, pain frequency, and pain duration. Regression analysis with stepwise modeling identified predictive factors.</div></div><div><h3>Results</h3><div>54.3% had painful TMD, 15.7% had nonpainful TMD, and 27.7% were healthy controls. For the painful TMD group, the regression model was significant (<em>R²</em> = .25, <em>F</em> = 4.3, <em>P</em> < .01), with age and favorable general health predicting PCS scores. In the nonpainful TMD group, the model was significant (<em>R²</em> = .58, <em>F</em> = 3.8, <em>P</em> < .01), with JFLS and favorable general health (predicting PCS scores. The MCS model was significant in healthy controls (<em>R<sup>2</sup></em> = .22<em>, F</em> = 1.8<em>, P</em> = .<em>05</em>), with JFLS as only predictor.</div></div><div><h3>Conclusion</h3><div>Predictors of mental HRQoL: JFLS in healthy controls, but no predictors were found in TMD groups. Predictors of physical HRQoL: General health in both TMD groups, JFLS in the nonpainful TMD group, and age in the painful TMD group.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102140"},"PeriodicalIF":4.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jebdp.2025.102138
Luis Limo , Ronald Espíritu Ayala-Mendívil , Juliana Gabrielle Martins
Objective
To assess the effectiveness of an intervention on caregivers' assisted toothbrushing techniques and oral health maintenance for preschool-aged children, and to determine whether these effects differ by age.
Methods
A single group pre/post intervention study was conducted among children aged 3-5 years and their caregivers in Callao, Peru. Eligible caregivers were trained on assisted toothbrushing using large and real-scale typodonts, along with practical demonstrations by a dentist. Additionally, they were instructed on healthy practices and oral health in children. Children's oral hygiene status (OHS) was assessed using the Simplified Oral Hygiene Index (OHI-S) at baseline and three months postintervention. To assess the effectiveness and quantify the magnitude of the difference between the OHI-S before and after the intervention, we used Wilcoxon signed-rank test and the Cliff's Delta test, respectively. Results were stratified by age group to examine potential differences.
Results
The sample (n = 210) predominantly comprised 3-year-old Peruvian females, primarily cared for by their mothers, who identified as single mothers who had not previously received instruction in oral hygiene practices. We found improvement in children's OHI-S in most age groups. Specifically, among 3-year-olds, the OHI-S score improved significantly from 'fair' (m = 2.6, ± 0.2, range 2.4-2.8) to 'good' (m = 1.1, ± 0.2, range 0.9-1.3). The intervention showed a moderate effect size (δ = −0.15, 95% CI −0.18, −0.10) in the 3-year-olds and a moderate effect size (δ = −0.05, 95% CI −0.08, −0.01) in the 4-year-olds. No significant improvements were observed in the 5-year-old group.
Conclusion
A caregiver-focused intervention significantly improved OHS among preschool-aged children, particularly in younger age groups. Substantial improvements in OHI-S scores were noted for 3- and 4-year-olds, while age-specific factors may have limited efficacy in the 5-year-old group. These findings highlight the importance of early, targeted oral health education for caregivers.
{"title":"EFFECTIVENESS OF ASSISTED TOOTHBRUSHING ON PRESCHOOLERS’ ORAL HYGIENE: A CAREGIVER-INTERVENTION APPROACH","authors":"Luis Limo , Ronald Espíritu Ayala-Mendívil , Juliana Gabrielle Martins","doi":"10.1016/j.jebdp.2025.102138","DOIUrl":"10.1016/j.jebdp.2025.102138","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effectiveness of an intervention on caregivers' assisted toothbrushing techniques and oral health maintenance for preschool-aged children, and to determine whether these effects differ by age.</div></div><div><h3>Methods</h3><div>A single group pre/post intervention study was conducted among children aged 3-5 years and their caregivers in Callao, Peru. Eligible caregivers were trained on assisted toothbrushing using large and real-scale typodonts, along with practical demonstrations by a dentist. Additionally, they were instructed on healthy practices and oral health in children. Children's oral hygiene status (OHS) was assessed using the Simplified Oral Hygiene Index (OHI-S) at baseline and three months postintervention. To assess the effectiveness and quantify the magnitude of the difference between the OHI-S before and after the intervention, we used Wilcoxon signed-rank test and the Cliff's Delta test, respectively. Results were stratified by age group to examine potential differences.</div></div><div><h3>Results</h3><div>The sample (<em>n</em> = 210) predominantly comprised 3-year-old Peruvian females, primarily cared for by their mothers, who identified as single mothers who had not previously received instruction in oral hygiene practices. We found improvement in children's OHI-S in most age groups. Specifically, among 3-year-olds, the OHI-S score improved significantly from 'fair' (m = 2.6, ± 0.2, range 2.4-2.8) to 'good' (m = 1.1, ± 0.2, range 0.9-1.3). The intervention showed a moderate effect size (δ = −0.15, 95% CI −0.18, −0.10) in the 3-year-olds and a moderate effect size (δ = −0.05, 95% CI −0.08, −0.01) in the 4-year-olds. No significant improvements were observed in the 5-year-old group.</div></div><div><h3>Conclusion</h3><div>A caregiver-focused intervention significantly improved OHS among preschool-aged children, particularly in younger age groups. Substantial improvements in OHI-S scores were noted for 3- and 4-year-olds, while age-specific factors may have limited efficacy in the 5-year-old group. These findings highlight the importance of early, targeted oral health education for caregivers.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102138"},"PeriodicalIF":4.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-14DOI: 10.1016/j.jebdp.2025.102139
Nouran Nabil , Aly A. Sharaf , Marwa M. Essawy , Reham S. Soliman
Objectives
Molar-incisor hypomineralization (MIH) can cause hypersensitivity. This study compared nanosilver fluoride (NSF) and photobiomodulation therapy (PBMT) regarding desensitization in MIH-affected first permanent molars (FPMs) and plaque reduction.
Methods
Children aged 7-10 years, with 120 hypersensitive MIH-affected FPMs, were randomly assigned to receive NSF or PBMT. Hypersensitivity was assessed using the Schiff Cold Air Sensitivity Scale (SCASS) at baseline, after 15 minutes and 1 month. Plaque accumulation was assessed using the modified plaque index (PlI) of Silness and Löe at baseline and after 1 month. T-test and Mann–Whitney U test were used to compare groups. Intragroup comparisons were done using paired t-test and Friedman test. Multilevel ordinal logistic regression analysis was used to assess the effect of treatment on the outcomes, controlling for confounders.
Results
The study included 40 children, mean ± SD age = 8.03 ± 1.13 years. There was significantly less sensitivity and greater plaque reduction in the NSF than the PBMT group after 1 month (P < .05). NSF and PBMT significantly reduced sensitivity over time (P < .001), with the lowest scores after 1 month. In multilevel regression, NSF was associated with significantly less sensitivity than PBMT after 1 month (AOR = 0.18, 95% CI: 0.07, 0.51, P = .001). While both groups had reduced plaque accumulation, the decrease was significant only in the NSF group (P < .001).
Conclusion
NSF and PBMT reduced sensitivity associated with MIH and provided immediate pain relief. However, NSF was superior due to its longer-lasting effects on sensitivity and additional benefit in plaque reduction.
Clinical significance
NSF offers a promising alternative to PBMT in desensitizing MIH-related hypersensitivity, particularly for patients with limited access to laser therapy.
Trial registration
The trial was registered in the clinicaltrials.gov registry (# NCT06348849).
{"title":"The Desensitizing Effect of Nanosilver Fluoride Compared to Photobiomodulation Therapy in Molar-Incisor Hypomineralization: A Randomized Clinical Trial","authors":"Nouran Nabil , Aly A. Sharaf , Marwa M. Essawy , Reham S. Soliman","doi":"10.1016/j.jebdp.2025.102139","DOIUrl":"10.1016/j.jebdp.2025.102139","url":null,"abstract":"<div><h3>Objectives</h3><div>Molar-incisor hypomineralization (MIH) can cause hypersensitivity. This study compared nanosilver fluoride (NSF) and photobiomodulation therapy (PBMT) regarding desensitization in MIH-affected first permanent molars (FPMs) and plaque reduction.</div></div><div><h3>Methods</h3><div>Children aged 7-10 years, with 120 hypersensitive MIH-affected FPMs, were randomly assigned to receive NSF or PBMT. Hypersensitivity was assessed using the Schiff Cold Air Sensitivity Scale (SCASS) at baseline, after 15 minutes and 1 month. Plaque accumulation was assessed using the modified plaque index (PlI) of Silness and Löe at baseline and after 1 month. T-test and Mann–Whitney U test were used to compare groups. Intragroup comparisons were done using paired t-test and Friedman test. Multilevel ordinal logistic regression analysis was used to assess the effect of treatment on the outcomes, controlling for confounders.</div></div><div><h3>Results</h3><div>The study included 40 children, mean ± SD age = 8.03 ± 1.13 years. There was significantly less sensitivity and greater plaque reduction in the NSF than the PBMT group after 1 month (<em>P</em> < .05). NSF and PBMT significantly reduced sensitivity over time (<em>P</em> < .001), with the lowest scores after 1 month. In multilevel regression, NSF was associated with significantly less sensitivity than PBMT after 1 month (AOR = 0.18, 95% CI: 0.07, 0.51, <em>P</em> = .001). While both groups had reduced plaque accumulation, the decrease was significant only in the NSF group (<em>P</em> < .001).</div></div><div><h3>Conclusion</h3><div>NSF and PBMT reduced sensitivity associated with MIH and provided immediate pain relief. However, NSF was superior due to its longer-lasting effects on sensitivity and additional benefit in plaque reduction.</div></div><div><h3>Clinical significance</h3><div>NSF offers a promising alternative to PBMT in desensitizing MIH-related hypersensitivity, particularly for patients with limited access to laser therapy.</div></div><div><h3>Trial registration</h3><div>The trial was registered in the clinicaltrials.gov registry (# NCT06348849).</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102139"},"PeriodicalIF":4.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1016/j.jebdp.2025.102136
Yule Su , Yuhang Cao , Xingtao Bing , Chen Chen , Hongli Yan , Hongjiao Zhao , Yilin Wang , Shixin Liu , Yuchen Xie , Chanjuan Li , Yaqin Wang , Junhua Yuan
Background
Periodontitis is closely related to the occurrence and development of coronary artery disease (CAD) and metabolic syndrome (MetS). However, the role of nonsurgical periodontal therapy (NSPT) in these 2 diseases is still controversial. To investigate the efficacy of NSPT in managing individuals with CAD or MetS and the differences in effects and benefits of NSPT between the 2 patient populations.
Methods
Literature was searched in PubMed, Embase, Cochrane, CNKI, VIP, and Wanfang databases from their inception to August 2024. The effect measures were mean differences (MD) and 95% confidence interval (95% CI). Meta-analyses were performed using random-effects models. Subgroup analysis of health status, follow-up time, antibiotic use and periodontitis severity were performed.
Results
Twenty-one publications involving 1619 subjects were included. Comparing to the control, NSPT significantly reduced the levels of CRP ([MD] -0.61 mg/L; 95% CI -1.11 to -0.12), TNF-α ([MD] -3.48 pg/mL; 95% CI -4.49 to -2.48), IL-6 ([MD] -1.56 pg/mL; 95% CI -2.30 to -0.83), IL-8 ([MD] -1.56 pg/mL; 95% CI -3.95 to -1.59; I2 = 56%) and fasting blood glucose ([MD] -5.81 mg/dL; 95% CI -9.96 to -1.67).
Conclusions
Meta-analysis showed that NSPT exerted beneficial effects on CAD by controlling systemic inflammation levels, which was not observed in patients with MetS.
背景牙周炎与冠状动脉疾病（CAD）和代谢综合征（MetS）的发生发展密切相关。然而，非手术牙周治疗（NSPT）在这两种疾病中的作用仍存在争议。目的：探讨NSPT治疗CAD或MetS患者的疗效，以及NSPT在两种患者群体中的效果和益处的差异。方法检索PubMed、Embase、Cochrane、CNKI、VIP、万方等数据库自建站至2024年8月的文献。效果测量为平均差异（MD）和95%置信区间（95% CI）。采用随机效应模型进行meta分析。对健康状况、随访时间、抗生素使用情况和牙周炎严重程度进行亚组分析。结果共纳入文献21篇，涉及受试者1619名。与对照组相比，NSPT显著降低CRP水平([MD] -0.61 mg/L；95% CI为-1.11 ~ -0.12),TNF-α ([MD] -3.48 pg/mL；95% CI -4.49 ~ -2.48), IL-6 ([MD] -1.56 pg/mL；95% CI -2.30 ~ -0.83), IL-8 ([MD] -1.56 pg/mL；95% CI -3.95 ~ -1.59；I2 = 56%)和空腹血糖([MD] -5.81 mg/dL；95% CI -9.96 ~ -1.67)。结论meta分析显示，NSPT通过控制全身炎症水平对CAD有有益作用，而在MetS患者中未观察到这一点。
{"title":"Effect of nonsurgical periodontal therapy on coronary artery disease or metabolic syndrome: a systematic review and meta-analysis","authors":"Yule Su , Yuhang Cao , Xingtao Bing , Chen Chen , Hongli Yan , Hongjiao Zhao , Yilin Wang , Shixin Liu , Yuchen Xie , Chanjuan Li , Yaqin Wang , Junhua Yuan","doi":"10.1016/j.jebdp.2025.102136","DOIUrl":"10.1016/j.jebdp.2025.102136","url":null,"abstract":"<div><h3>Background</h3><div>Periodontitis is closely related to the occurrence and development of coronary artery disease (CAD) and metabolic syndrome (MetS). However, the role of nonsurgical periodontal therapy (NSPT) in these 2 diseases is still controversial. To investigate the efficacy of NSPT in managing individuals with CAD or MetS and the differences in effects and benefits of NSPT between the 2 patient populations.</div></div><div><h3>Methods</h3><div>Literature was searched in PubMed, Embase, Cochrane, CNKI, VIP, and Wanfang databases from their inception to August 2024. The effect measures were mean differences (<em>MD</em>) and 95% confidence interval (95% <em>CI</em>). Meta-analyses were performed using random-effects models. Subgroup analysis of health status, follow-up time, antibiotic use and periodontitis severity were performed.</div></div><div><h3>Results</h3><div>Twenty-one publications involving 1619 subjects were included. Comparing to the control, NSPT significantly reduced the levels of CRP ([<em>MD</em>] -0.61 mg/L; 95% <em>CI</em> -1.11 to -0.12), TNF-α ([<em>MD</em>] -3.48 pg/mL; 95% <em>CI</em> -4.49 to -2.48), IL-6 ([<em>MD</em>] -1.56 pg/mL; 95% <em>CI</em> -2.30 to -0.83), IL-8 ([<em>MD</em>] -1.56 pg/mL; 95% <em>CI</em> -3.95 to -1.59; <em>I<sup>2</sup></em> = 56%) and fasting blood glucose ([<em>MD</em>] -5.81 mg/dL; 95% <em>CI</em> -9.96 to -1.67).</div></div><div><h3>Conclusions</h3><div>Meta-analysis showed that NSPT exerted beneficial effects on CAD by controlling systemic inflammation levels, which was not observed in patients with MetS.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102136"},"PeriodicalIF":4.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1016/j.jebdp.2025.102135
SOO-HO KIM , SOMI KIM , YOON-SEON KIM , MI-KYOUNG SONG , JI-YEON KANG
Objectives
This study aimed to assess the efficacy and safety of adding single-dose preemptive celecoxib 200 mg (Cc) or tramadol 37.5 mg/acetaminophen 325.0 mg (T/A) to standard postoperative analgesia after impacted mandibular third molar extraction, a design not previously explored.
Methods
In this multicenter, prospective, randomized, double-blind, placebo-controlled, crossover within-subject study, participants were randomly assigned to 2 groups (Cc or placebo for group A; T/A or placebo for group B) and underwent impacted mandibular third molar extraction on both sides at 1-month intervals. Along with baseline characteristics, pain intensity in Visual Analogue Scale (VAS), first perceived pain occurrence, rescue medication use, and adverse events were evaluated.
Results
A total of 33 participants per group completed the trial. Cc reduced pain at 3 (−0.91 ± 2.17; P = .011) and 6 hours (−0.85 ± 2.24; P = .018), while T/A reduced pain at 1 (−1.40 ± 2.37; P < .001), 2 (−0.79 ± 2.32; P = .030), and 6 hours (−0.91 ± 1.94; P = .006) postextraction, with some insignificant reductions at other times. Both Cc and T/A were effective in reducing the first perceived pain. Notably, Cc significantly decreased pain intensity, T/A significantly delayed the pain perception. Both drugs had no significant effect on the need for rescue medication or adverse event rates.
Conclusions
Based on these results, both Cc and T/A appears to aid in reducing postoperative pain following impacted mandibular third molar extraction without significant adverse effects.
{"title":"ANALGESIC EFFECTS OF PREEMPTIVE CELECOXIB OR TRAMADOL/ACETAMINOPHEN ADDED TO STANDARD POSTOPERATIVE PAIN MANAGEMENT IN IMPACTED MANDIBULAR THIRD MOLAR EXTRACTION: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL","authors":"SOO-HO KIM , SOMI KIM , YOON-SEON KIM , MI-KYOUNG SONG , JI-YEON KANG","doi":"10.1016/j.jebdp.2025.102135","DOIUrl":"10.1016/j.jebdp.2025.102135","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the efficacy and safety of adding single-dose preemptive celecoxib 200 mg (<em>Cc</em>) or tramadol 37.5 mg/acetaminophen 325.0 mg (<em>T/A</em>) to standard postoperative analgesia after impacted mandibular third molar extraction, a design not previously explored.</div></div><div><h3>Methods</h3><div>In this multicenter, prospective, randomized, double-blind, placebo-controlled, crossover within-subject study, participants were randomly assigned to 2 groups (<em>Cc</em> or placebo for group A; <em>T/A</em> or placebo for group B) and underwent impacted mandibular third molar extraction on both sides at 1-month intervals. Along with baseline characteristics, pain intensity in Visual Analogue Scale (VAS), first perceived pain occurrence, rescue medication use, and adverse events were evaluated.</div></div><div><h3>Results</h3><div>A total of 33 participants per group completed the trial. <em>Cc</em> reduced pain at 3 (−0.91 ± 2.17; <em>P</em> = .011) and 6 hours (−0.85 ± 2.24; <em>P</em> = .018), while <em>T/A</em> reduced pain at 1 (−1.40 ± 2.37; <em>P</em> < .001), 2 (−0.79 ± 2.32; <em>P</em> = .030), and 6 hours (−0.91 ± 1.94; <em>P</em> = .006) postextraction, with some insignificant reductions at other times. Both <em>Cc</em> and <em>T/A</em> were effective in reducing the first perceived pain. Notably, <em>Cc</em> significantly decreased pain intensity, <em>T/A</em> significantly delayed the pain perception. Both drugs had no significant effect on the need for rescue medication or adverse event rates.</div></div><div><h3>Conclusions</h3><div>Based on these results, both <em>Cc</em> and <em>T/A</em> appears to aid in reducing postoperative pain following impacted mandibular third molar extraction without significant adverse effects.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102135"},"PeriodicalIF":4.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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