Pub Date : 2025-09-01Epub Date: 2025-07-25DOI: 10.1016/S1532-3382(25)00097-1
{"title":"Information for Readers","authors":"","doi":"10.1016/S1532-3382(25)00097-1","DOIUrl":"10.1016/S1532-3382(25)00097-1","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102182"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the efficacy of Hy-N spray in dry mouth patients.
Materials and Methods
A randomized double-blind crossover study was conducted on patients with dry mouth. They were given 3 saliva substitute sprays: Hy-N, placebo, and Biotène. The unstimulated whole saliva flow rate (UWSFR), salivary pH, and xerostomia questionnaire (XQ) were evaluated at baseline and after 1 week of treatment with each spray. Patient satisfaction was evaluated after each treatment period.
Results
Twenty-nine patients completed the study. After using the Hy-N and Biotène sprays for 1 week, the UWSFR significantly increased from 0.12 ± 0.16 at baseline to 0.16 ± 0.18 mL/min postspray usage (P = .04, P ≤ .01) with moderate improvement. None of the sprays affected salivary pH (P = .72). The mean XQ score also significantly decreased from 34.2 ± 21.4 at baseline to 23.7 ± 17.4, 23.1 ± 15.2, and 26.5 ± 17.7 after using Hy-N, Biotène, and placebo spray, respectively (P = .001, P = .011, P = .009) with moderate improvement. Biotène was the most preferred saliva substitute spray, followed by Hy-N spray.
Conclusion
Using the Hy-N and Biotène for 1 week relieves subjective and objective dry mouth. They can be a useful product in the management of dry mouth without causing side-effects.
目的评价Hy-N喷雾剂治疗口干患者的疗效。材料与方法对口干患者进行随机双盲交叉研究。给予3种唾液替代喷雾剂：Hy-N、安慰剂和biot。在基线和每次喷雾治疗1周后评估非刺激全唾液流率（UWSFR）、唾液pH值和口干问卷（XQ）。每个治疗期结束后评估患者满意度。结果29例患者完成了研究。使用Hy-N和biot喷雾剂1周后，UWSFR从基线时的0.12±0.16显著增加到喷雾剂使用后的0.16±0.18 mL/min （P = ）。04, P≤0.01)，有中度改善。喷雾剂均不影响唾液pH值（P = .72）。使用Hy-N、biot和安慰剂喷雾后，XQ平均评分也从基线时的34.2±21.4显著降低至23.7±17.4、23.1±15.2和26.5±17.7 （P = ）。001, P = 。011, P = .009)，有中度改善。biot是首选的唾液替代喷雾剂，其次是Hy-N喷雾剂。结论hyn联合biot治疗1周可缓解主客观口干症状。它们是治疗口干的有效产品，而且不会产生副作用。
{"title":"EFFICACY OF HYALURONIC NANOGEL SPRAY FOR TREATING DRY MOUTH: A RANDOMIZED CROSSOVER STUDY","authors":"NONGNAPAT EAKPUNYAKUL , PEERAWAS KOPONGPANICH , KANOKPORN BHALANG , JITTIMA AMIE LUCKANAGUL","doi":"10.1016/j.jebdp.2025.102142","DOIUrl":"10.1016/j.jebdp.2025.102142","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the efficacy of Hy-N spray in dry mouth patients.</div></div><div><h3>Materials and Methods</h3><div>A randomized double-blind crossover study was conducted on patients with dry mouth. They were given 3 saliva substitute sprays: Hy-N, placebo, and Biotène. The unstimulated whole saliva flow rate (UWSFR), salivary pH, and xerostomia questionnaire (XQ) were evaluated at baseline and after 1 week of treatment with each spray. Patient satisfaction was evaluated after each treatment period.</div></div><div><h3>Results</h3><div>Twenty-nine patients completed the study. After using the Hy-N and Biotène sprays for 1 week, the UWSFR significantly increased from 0.12 ± 0.16 at baseline to 0.16 ± 0.18 mL/min postspray usage (<em>P</em> = .04, <em>P</em> ≤ .01) with moderate improvement. None of the sprays affected salivary pH (<em>P</em> = .72). The mean XQ score also significantly decreased from 34.2 ± 21.4 at baseline to 23.7 ± 17.4, 23.1 ± 15.2, and 26.5 ± 17.7 after using Hy-N, Biotène, and placebo spray, respectively (<em>P</em> = .001, <em>P</em> = .011, <em>P</em> = .009) with moderate improvement. Biotène was the most preferred saliva substitute spray, followed by Hy-N spray.</div></div><div><h3>Conclusion</h3><div>Using the Hy-N and Biotène for 1 week relieves subjective and objective dry mouth. They can be a useful product in the management of dry mouth without causing side-effects.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102142"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-02-22DOI: 10.1016/j.jebdp.2025.102127
Tássia T. Machado , Ana Carolina S. Machado , Rodrigo L. Poluha , Leilane S. Proença , Nikolaos Christidis , Carlos A. Parada , Giancarlo De la Torre Canales , Cláudia H. Tambeli
Background
Temporomandibular disorders (TMD) refer to a range of conditions affecting the temporomandibular joints (TMJ), masticatory muscles, and related structures, bothering around 12% of the population. This systematic review aims to answer whether ozone therapy effectively reduces TMD-related symptoms.
Methods
A systematic electronic search of 6 databases was conducted on July 15th, 2021, and updated on November 17th, 2023. Only clinical trials published in Portuguese, English, or Spanish were selected, with no restriction to the year of publication. Animal studies, retrospective studies, case reports, review papers, meta-analysis, and ozone therapy applications outside the orofacial region were excluded. The risk of bias analysis was performed following the Cochrane Collaboration tool, RoB 2.
Results
Of the 315 articles identified in the search, only 7 studies were included in this review. Two studies were considered low risk of bias, 2 with some concerns, and 3 as high risk of bias. Ozone therapy, applied to both articular and muscular TMDs, has been shown to reduce pain intensity and palpatory pain, and improve pressure pain thresholds and mandibular range of motion.
Conclusion
Ozone therapy emerges as a potential therapy for reducing TMD-related symptoms. However, the current evidence lacks robustness, and further high-quality randomized controlled trials are necessary to enhance the existing evidence base.
{"title":"THE ROLE OF OZONE THERAPY IN THE TREATMENT OF TEMPOROMANDIBULAR DISORDERS: A SYSTEMATIC REVIEW","authors":"Tássia T. Machado , Ana Carolina S. Machado , Rodrigo L. Poluha , Leilane S. Proença , Nikolaos Christidis , Carlos A. Parada , Giancarlo De la Torre Canales , Cláudia H. Tambeli","doi":"10.1016/j.jebdp.2025.102127","DOIUrl":"10.1016/j.jebdp.2025.102127","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular disorders (TMD) refer to a range of conditions affecting the temporomandibular joints (TMJ), masticatory muscles, and related structures, bothering around 12% of the population. This systematic review aims to answer whether ozone therapy effectively reduces TMD-related symptoms.</div></div><div><h3>Methods</h3><div>A systematic electronic search of 6 databases was conducted on July 15th, 2021, and updated on November 17th, 2023. Only clinical trials published in Portuguese, English, or Spanish were selected, with no restriction to the year of publication. Animal studies, retrospective studies, case reports, review papers, meta-analysis, and ozone therapy applications outside the orofacial region were excluded. The risk of bias analysis was performed following the Cochrane Collaboration tool, RoB 2.</div></div><div><h3>Results</h3><div>Of the 315 articles identified in the search, only 7 studies were included in this review. Two studies were considered low risk of bias, 2 with some concerns, and 3 as high risk of bias. Ozone therapy, applied to both articular and muscular TMDs, has been shown to reduce pain intensity and palpatory pain, and improve pressure pain thresholds and mandibular range of motion.</div></div><div><h3>Conclusion</h3><div>Ozone therapy emerges as a potential therapy for reducing TMD-related symptoms. However, the current evidence lacks robustness, and further high-quality randomized controlled trials are necessary to enhance the existing evidence base.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102127"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-03-25DOI: 10.1016/j.jebdp.2025.102141
Mahmood Moosazadeh PhD , Mohammad A Sabeti DDS , Seyyed Mohammad Hashemi MD , Arezoo Ghazalgoo MD , Tahoora Mousavi PhD , Seifali Mahdavi PhD , Erfan Ghadirzadeh MD
Introduction
Despite numerous studies investigating the link between Entamoeba gingivalis and Trichomonas tenax and periodontal diseases, findings remain inconclusive. To resolve this inconsistency, we conducted a meta-analysis to assess the association between E. gingivalis and T. tenax with both gingivitis and periodontitis.
Methods
We searched Google Scholar, Medline/PubMed, Scopus, Web of Science, and Embase search engines and databases, as well as a bibliographic section of related articles from their dates of inception to 20 April 2024. The included studies were assessed for potential biases and the overall quality of the evidence using the Newcastle-Ottawa Scale. Finally, 20 studies entered the meta-analysis.
Results
20 studies were qualified to be included in the current study. The prevalence of T. tenax was estimated to be 14% (95% CI: 8-20) among gingivitis patients and 26% (95% CI: 12-40) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with T. tenax infection than in the control group (OR: 2.30; 95% CI: 1.21-4.35, and OR: 2.90; 95% CI: 1.01-8.37, respectively). Also, the prevalence of E. gingivalis was estimated to be 45% (95% CI: 32-58) among gingivitis patients and 55% (95% CI: 35-75) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with E. gingivalis infection than in the control group (OR: 4.08; 95% CI: 2.36-7.06, and OR: 8.33; 95% CI: 3.04-22.81, respectively).
Conclusion
Our analysis shows that individuals infected with E. gingivalis or T. tenax are more prone to periodontal diseases than noninfected individuals.
PROSPERO Registration ID
CRD42024551772
引言尽管有许多研究调查了齿龈内阿米巴和肌腱毛滴虫与牙周疾病之间的联系，但研究结果仍不确定。为了解决这种不一致性，我们进行了一项荟萃分析，以评估牙龈卟啉单胞菌和T.tenax与牙龈炎和牙周炎之间的关联。方法我们搜索了Google Scholar、Medline/PubMed、Scopus、Web of Science和Embase搜索引擎和数据库，以及自其成立之日起至2024年4月20日的相关文章的书目部分。使用纽卡斯尔-渥太华量表对纳入的研究进行了潜在偏差和证据总体质量的评估。最后，20项研究进入了荟萃分析。结果20项研究符合纳入本研究的条件。在牙龈炎患者中，T.tenax的患病率估计为14%（95%CI:8-20），在牙周炎患者中为26%（95%CI:12-40）。据估计，T.tenax感染患者患牙龈炎和牙周炎的几率明显高于对照组（OR:2.30；95%CI:1.21-4.35，OR:2.90；95%CI：1.01-8.37）。此外，牙龈炎患者中牙龈单胞菌的患病率估计为45%（95%CI:32-58），牙周炎患者中为55%（95%CI:35-75）。据估计，感染牙龈单胞菌的患者患牙龈炎和牙周炎的几率明显高于对照组（OR:4.08；95%CI:2.36-7.06，OR:8.33；95%CI:3.04-22.81）。结论我们的分析表明，感染牙龈卟啉单胞菌或T.tenax的人比非感染者更容易患牙周病。PROSPERO注册号CRD42024551772
{"title":"THE RELATIONSHIP BETWEEN ENTAMOEBA GINGIVALIS AND TRICHOMONAS TENAX WITH PERIODONTITIS AND GINGIVITIS: A SYSTEMATIC REVIEW, META-ANALYSIS, AND META-REGRESSION","authors":"Mahmood Moosazadeh PhD , Mohammad A Sabeti DDS , Seyyed Mohammad Hashemi MD , Arezoo Ghazalgoo MD , Tahoora Mousavi PhD , Seifali Mahdavi PhD , Erfan Ghadirzadeh MD","doi":"10.1016/j.jebdp.2025.102141","DOIUrl":"10.1016/j.jebdp.2025.102141","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite numerous studies investigating the link between <em>Entamoeba gingivalis</em> and <em>Trichomonas tenax</em> and periodontal diseases, findings remain inconclusive. To resolve this inconsistency, we conducted a meta-analysis to assess the association between <em>E. gingivalis</em> and <em>T. tenax</em> with both gingivitis and periodontitis.</div></div><div><h3>Methods</h3><div>We searched Google Scholar, Medline/PubMed, Scopus, Web of Science, and Embase search engines and databases, as well as a bibliographic section of related articles from their dates of inception to 20 April 2024. The included studies were assessed for potential biases and the overall quality of the evidence using the Newcastle-Ottawa Scale. Finally, 20 studies entered the meta-analysis.</div></div><div><h3>Results</h3><div>20 studies were qualified to be included in the current study. The prevalence of <em>T. tenax</em> was estimated to be 14% (95% CI: 8-20) among gingivitis patients and 26% (95% CI: 12-40) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with <em>T. tenax</em> infection than in the control group (OR: 2.30; 95% CI: 1.21-4.35, and OR: 2.90; 95% CI: 1.01-8.37, respectively). Also, the prevalence of <em>E. gingivalis</em> was estimated to be 45% (95% CI: 32-58) among gingivitis patients and 55% (95% CI: 35-75) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with <em>E. gingivalis</em> infection than in the control group (OR: 4.08; 95% CI: 2.36-7.06, and OR: 8.33; 95% CI: 3.04-22.81, respectively).</div></div><div><h3>Conclusion</h3><div>Our analysis shows that individuals infected with <em>E. gingivalis</em> or <em>T. tenax</em> are more prone to periodontal diseases than noninfected individuals.</div></div><div><h3>PROSPERO Registration ID</h3><div>CRD42024551772</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102141"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-07-25DOI: 10.1016/S1532-3382(25)00098-3
{"title":"Information for Authors","authors":"","doi":"10.1016/S1532-3382(25)00098-3","DOIUrl":"10.1016/S1532-3382(25)00098-3","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102183"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-05-08DOI: 10.1016/j.jebdp.2025.102165
IMAN ABD-ELWAHAB RADI (Reviewer), ABDULRAHMAN HISHAM MOHAMED EL GARHY (Reviewer)
Article Title and Bibliographic Information
Glossop S, Duffaydar H, Jones H, Peters E, Ryan T, Saleh F, Scourfield L, Poacher A. Oral and maxillofacial surgery and dental health education in undergraduate medicine: a systematic review. B J Oral Maxillofac Surg. 2024:62;882-888.1
Source of Funding
Not applicable.
Type of Study/Design
Systematic review (SR).
lossop S, Duffaydar H, Jones H, Peters E, Ryan T, Saleh F, Scourfield L, Poacher a .口腔颌面外科与口腔健康教育的系统回顾。中华口腔颌面外科杂志，2014:62;882-888.1。研究类型/设计系统评价（SR）。
{"title":"INTEGRATING ORAL MAXILLOFACIAL SURGERY EDUCATION INTO UK MEDICAL CURRICULA IS A KEY TO ADDRESS KNOWLEDGE GAPS AND IMPROVE EARLY DIAGNOSIS","authors":"IMAN ABD-ELWAHAB RADI (Reviewer), ABDULRAHMAN HISHAM MOHAMED EL GARHY (Reviewer)","doi":"10.1016/j.jebdp.2025.102165","DOIUrl":"10.1016/j.jebdp.2025.102165","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Glossop S, Duffaydar H, Jones H, Peters E, Ryan T, Saleh F, Scourfield L, Poacher A. Oral and maxillofacial surgery and dental health education in undergraduate medicine: a systematic review. B J Oral Maxillofac Surg. 2024:62;882-888.<span><span><sup>1</sup></span></span></div></div><div><h3>Source of Funding</h3><div>Not applicable.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review (SR).</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102165"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2024-10-22DOI: 10.1016/j.jebdp.2024.102046
MARIANA DE ALMEIDA BARBOSA , SANDRA REGINA SANTOS MEYFARTH , FLÁVIA SENS FAGUNDES TOMAZINHO , LÍVIA AZEREDO ALVES ANTUNES , LEONARDO SANTOS ANTUNES , MARILISA CARNEIRO LEÃO GABARDO
Background
This systematic review addresses the clinical question: Does calcium hydroxide (CH) paste interfere with endodontic sealer penetration in dentinal tubules?
Methods
An extensive search was conducted in PubMed, Scopus, Web of Science, Embase, and LILACS electronic databases until June 2022, and it was updated in September 2024. The grey literature was searched through OpenGrey, Google Scholar, and ProQuest. In vitro studies were selected according to eligibility criteria, participants, interventions, study appraisal, and synthesis methods. Two investigators extracted the data extraction and assessed the risk of bias independently. A random-effects model was used for the meta-analysis, evaluating sealer penetration considering root canal cervical, medium, and apical thirds.
Results
Seven studies were included, and 5 were considered for the meta-analysis. One study was classified as a high risk of bias, and the others as a medium risk of bias. The meta-analysis that evaluated resin-based sealer penetration after passive ultrasonic activation showed no statistical differences (P >.05) between the groups in the cervical third (OR: −291.12; 95% CI: −853.26 to 271.03; P >.05). The middle third presented statistical differences between the groups (OR: −240.24; 95% CI: −352.05 to −128.42; P <.05) and the apical third did not (OR: −121.00; 95% CI: −462.60 to 220.60; P >.05). The meta-analysis that evaluated resin-based sealer penetration showed statistical differences between the groups in the cervical third (OR: −249.55; 95% CI: −315.00 to −184.11; P <.05) and the middle third (OR: −195.71; 95% CI: −369.53 to −21.88; P <.05), but not in the apical third (OR: −125.07; 95% CI: −300.58 to 50.45; P >.05).
Conclusion
CH paste interfered negatively with the penetration of resin-based sealers in dentinal tubules in the middle third of the root canal.
{"title":"DOES CALCIUM HYDROXIDE INTERFERE WITH ROOT CANAL SEALER PENETRATION IN DENTINAL TUBULES? A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"MARIANA DE ALMEIDA BARBOSA , SANDRA REGINA SANTOS MEYFARTH , FLÁVIA SENS FAGUNDES TOMAZINHO , LÍVIA AZEREDO ALVES ANTUNES , LEONARDO SANTOS ANTUNES , MARILISA CARNEIRO LEÃO GABARDO","doi":"10.1016/j.jebdp.2024.102046","DOIUrl":"10.1016/j.jebdp.2024.102046","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review addresses the clinical question: Does calcium hydroxide (CH) paste interfere with endodontic sealer penetration in dentinal tubules?</div></div><div><h3>Methods</h3><div>An extensive search was conducted in PubMed, Scopus, Web of Science, Embase, and LILACS electronic databases until June 2022, and it was updated in September 2024. The grey literature was searched through OpenGrey, Google Scholar, and ProQuest. <em>In vitro</em> studies were selected according to eligibility criteria, participants, interventions, study appraisal, and synthesis methods. Two investigators extracted the data extraction and assessed the risk of bias independently. A random-effects model was used for the meta-analysis, evaluating sealer penetration considering root canal cervical, medium, and apical thirds.</div></div><div><h3>Results</h3><div>Seven studies were included, and 5 were considered for the meta-analysis. One study was classified as a high risk of bias, and the others as a medium risk of bias. The meta-analysis that evaluated resin-based sealer penetration after passive ultrasonic activation showed no statistical differences (<em>P</em> >.05) between the groups in the cervical third (OR: −291.12; 95% CI: −853.26 to 271.03; <em>P</em> >.05). The middle third presented statistical differences between the groups (OR: −240.24; 95% CI: −352.05 to −128.42; <em>P</em> <.05) and the apical third did not (OR: −121.00; 95% CI: −462.60 to 220.60; <em>P</em> >.05). The meta-analysis that evaluated resin-based sealer penetration showed statistical differences between the groups in the cervical third (OR: −249.55; 95% CI: −315.00 to −184.11; <em>P</em> <.05) and the middle third (OR: −195.71; 95% CI: −369.53 to −21.88; <em>P</em> <.05), but not in the apical third (OR: −125.07; 95% CI: −300.58 to 50.45; <em>P</em> >.05).</div></div><div><h3>Conclusion</h3><div>CH paste interfered negatively with the penetration of resin-based sealers in dentinal tubules in the middle third of the root canal.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102046"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-06-09DOI: 10.1016/j.jebdp.2025.102171
NIKOLA STANISIC , OVIDIU IONUT SARACUTU , ANNA COLONNA , WENDY WU , DANIELE MANFREDINI , BIRGITTA HÄGGMAN-HENRIKSON
Objectives
Bruxism significantly affects oral health, with consequences such as tooth wear and restoration failures. Additionally, it is linked to various risk factors and co-occurring disorders. Unlike sleep bruxism, awake bruxism (AB) is more strongly associated with psychosocial factors. This review aimed to evaluate the prevalence of AB in the general population and specific subpopulations.
Methods
The review followed PRISMA guidelines and was registered in PROSPERO (CRD42023398868). A literature search in PubMed, Scopus, and Web of Science until April 8, 2025 identified studies that fulfilled the inclusion criteria of reporting AB prevalence in adult populations. Risk of bias was assessed with Joanna Briggs Institute Prevalence Critical Appraisal Tool and a random-effects meta-analysis determined prevalence in various subpopulations.
Results
The search yielded 8,818 records, with 5,408 abstracts screened after duplicate removal. Of these, 4,473 were excluded. Full-text assessment led to the exclusion of 843 articles that did not meet inclusion criteria. A hand search identified 5 additional studies. Ultimately, 94 studies involving 49,163 individuals were included, with 66 studies (39,823 individuals) analyzed in the meta-analysis. In the general population, self-reported “possible” AB had a mean prevalence of 25.9% (95% CI 22.2-29.9), and clinically based “probable” AB 16.0% (95% CI 10.0-24.5). Prevalence was significantly higher in specific subpopulations, such as individuals with temporomandibular disorders (50.0%, 95% CI 41.1-58.9) and systemic conditions (40.1%, 95% CI 31.4-49.5). Risk of bias was mainly related to assessment of AB.
Conclusions
The variability between subpopulations highlights the importance of considering patient-specific factors and a targeted clinical approach in AB management.
目的磨牙严重影响口腔健康，导致牙齿磨损和修复失败。此外，它还与各种危险因素和共同发生的疾病有关。与睡眠磨牙症不同，清醒磨牙症（AB）与社会心理因素的关系更密切。本综述旨在评估AB在普通人群和特定亚人群中的患病率。方法该综述遵循PRISMA指南，在PROSPERO注册（CRD42023398868）。在PubMed、Scopus和Web of Science进行文献检索，直到2025年4月8日，确定了符合报告成人AB患病率纳入标准的研究。采用乔安娜布里格斯研究所流行关键评估工具评估偏倚风险，并采用随机效应荟萃分析确定不同亚群的流行程度。结果共检索到8818条记录，剔除重复后筛选出5408条摘要。其中，4473人被排除在外。全文评估导致843篇不符合纳入标准的文章被排除。手工搜索确定了另外5项研究。最终，纳入了94项研究，涉及49,163人，其中66项研究（39,823人）在荟萃分析中进行了分析。在一般人群中，自我报告的“可能”AB的平均患病率为25.9% (95% CI为22.2-29.9)，而基于临床的“可能”AB的平均患病率为16.0% （95% CI为10.0-24.5）。在特定亚群中患病率明显更高，例如患有颞下颌疾病（50.0%,95% CI 41.1-58.9）和全身性疾病（40.1%,95% CI 31.4-49.5）的个体。偏倚风险主要与AB的评估有关。结论亚人群之间的差异强调了在AB管理中考虑患者特异性因素和有针对性的临床方法的重要性。
{"title":"AWAKE BRUXISM PREVALENCE ACROSS POPULATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"NIKOLA STANISIC , OVIDIU IONUT SARACUTU , ANNA COLONNA , WENDY WU , DANIELE MANFREDINI , BIRGITTA HÄGGMAN-HENRIKSON","doi":"10.1016/j.jebdp.2025.102171","DOIUrl":"10.1016/j.jebdp.2025.102171","url":null,"abstract":"<div><h3>Objectives</h3><div>Bruxism significantly affects oral health, with consequences such as tooth wear and restoration failures. Additionally, it is linked to various risk factors and co-occurring disorders. Unlike sleep bruxism, awake bruxism (AB) is more strongly associated with psychosocial factors. This review aimed to evaluate the prevalence of AB in the general population and specific subpopulations.</div></div><div><h3>Methods</h3><div>The review followed PRISMA guidelines and was registered in PROSPERO (CRD42023398868). A literature search in PubMed, Scopus, and Web of Science until April 8, 2025 identified studies that fulfilled the inclusion criteria of reporting AB prevalence in adult populations. Risk of bias was assessed with Joanna Briggs Institute Prevalence Critical Appraisal Tool and a random-effects meta-analysis determined prevalence in various subpopulations.</div></div><div><h3>Results</h3><div>The search yielded 8,818 records, with 5,408 abstracts screened after duplicate removal. Of these, 4,473 were excluded. Full-text assessment led to the exclusion of 843 articles that did not meet inclusion criteria. A hand search identified 5 additional studies. Ultimately, 94 studies involving 49,163 individuals were included, with 66 studies (39,823 individuals) analyzed in the meta-analysis. In the general population, self-reported “possible” AB had a mean prevalence of 25.9% (95% CI 22.2-29.9), and clinically based “probable” AB 16.0% (95% CI 10.0-24.5). Prevalence was significantly higher in specific subpopulations, such as individuals with temporomandibular disorders (50.0%, 95% CI 41.1-58.9) and systemic conditions (40.1%, 95% CI 31.4-49.5). Risk of bias was mainly related to assessment of AB.</div></div><div><h3>Conclusions</h3><div>The variability between subpopulations highlights the importance of considering patient-specific factors and a targeted clinical approach in AB management.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102171"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-03-11DOI: 10.1016/j.jebdp.2025.102136
Yule Su , Yuhang Cao , Xingtao Bing , Chen Chen , Hongli Yan , Hongjiao Zhao , Yilin Wang , Shixin Liu , Yuchen Xie , Chanjuan Li , Yaqin Wang , Junhua Yuan
Background
Periodontitis is closely related to the occurrence and development of coronary artery disease (CAD) and metabolic syndrome (MetS). However, the role of nonsurgical periodontal therapy (NSPT) in these 2 diseases is still controversial. To investigate the efficacy of NSPT in managing individuals with CAD or MetS and the differences in effects and benefits of NSPT between the 2 patient populations.
Methods
Literature was searched in PubMed, Embase, Cochrane, CNKI, VIP, and Wanfang databases from their inception to August 2024. The effect measures were mean differences (MD) and 95% confidence interval (95% CI). Meta-analyses were performed using random-effects models. Subgroup analysis of health status, follow-up time, antibiotic use and periodontitis severity were performed.
Results
Twenty-one publications involving 1619 subjects were included. Comparing to the control, NSPT significantly reduced the levels of CRP ([MD] -0.61 mg/L; 95% CI -1.11 to -0.12), TNF-α ([MD] -3.48 pg/mL; 95% CI -4.49 to -2.48), IL-6 ([MD] -1.56 pg/mL; 95% CI -2.30 to -0.83), IL-8 ([MD] -1.56 pg/mL; 95% CI -3.95 to -1.59; I2 = 56%) and fasting blood glucose ([MD] -5.81 mg/dL; 95% CI -9.96 to -1.67).
Conclusions
Meta-analysis showed that NSPT exerted beneficial effects on CAD by controlling systemic inflammation levels, which was not observed in patients with MetS.
背景牙周炎与冠状动脉疾病（CAD）和代谢综合征（MetS）的发生发展密切相关。然而，非手术牙周治疗（NSPT）在这两种疾病中的作用仍存在争议。目的：探讨NSPT治疗CAD或MetS患者的疗效，以及NSPT在两种患者群体中的效果和益处的差异。方法检索PubMed、Embase、Cochrane、CNKI、VIP、万方等数据库自建站至2024年8月的文献。效果测量为平均差异（MD）和95%置信区间（95% CI）。采用随机效应模型进行meta分析。对健康状况、随访时间、抗生素使用情况和牙周炎严重程度进行亚组分析。结果共纳入文献21篇，涉及受试者1619名。与对照组相比，NSPT显著降低CRP水平([MD] -0.61 mg/L；95% CI为-1.11 ~ -0.12),TNF-α ([MD] -3.48 pg/mL；95% CI -4.49 ~ -2.48), IL-6 ([MD] -1.56 pg/mL；95% CI -2.30 ~ -0.83), IL-8 ([MD] -1.56 pg/mL；95% CI -3.95 ~ -1.59；I2 = 56%)和空腹血糖([MD] -5.81 mg/dL；95% CI -9.96 ~ -1.67)。结论meta分析显示，NSPT通过控制全身炎症水平对CAD有有益作用，而在MetS患者中未观察到这一点。
{"title":"Effect of nonsurgical periodontal therapy on coronary artery disease or metabolic syndrome: a systematic review and meta-analysis","authors":"Yule Su , Yuhang Cao , Xingtao Bing , Chen Chen , Hongli Yan , Hongjiao Zhao , Yilin Wang , Shixin Liu , Yuchen Xie , Chanjuan Li , Yaqin Wang , Junhua Yuan","doi":"10.1016/j.jebdp.2025.102136","DOIUrl":"10.1016/j.jebdp.2025.102136","url":null,"abstract":"<div><h3>Background</h3><div>Periodontitis is closely related to the occurrence and development of coronary artery disease (CAD) and metabolic syndrome (MetS). However, the role of nonsurgical periodontal therapy (NSPT) in these 2 diseases is still controversial. To investigate the efficacy of NSPT in managing individuals with CAD or MetS and the differences in effects and benefits of NSPT between the 2 patient populations.</div></div><div><h3>Methods</h3><div>Literature was searched in PubMed, Embase, Cochrane, CNKI, VIP, and Wanfang databases from their inception to August 2024. The effect measures were mean differences (<em>MD</em>) and 95% confidence interval (95% <em>CI</em>). Meta-analyses were performed using random-effects models. Subgroup analysis of health status, follow-up time, antibiotic use and periodontitis severity were performed.</div></div><div><h3>Results</h3><div>Twenty-one publications involving 1619 subjects were included. Comparing to the control, NSPT significantly reduced the levels of CRP ([<em>MD</em>] -0.61 mg/L; 95% <em>CI</em> -1.11 to -0.12), TNF-α ([<em>MD</em>] -3.48 pg/mL; 95% <em>CI</em> -4.49 to -2.48), IL-6 ([<em>MD</em>] -1.56 pg/mL; 95% <em>CI</em> -2.30 to -0.83), IL-8 ([<em>MD</em>] -1.56 pg/mL; 95% <em>CI</em> -3.95 to -1.59; <em>I<sup>2</sup></em> = 56%) and fasting blood glucose ([<em>MD</em>] -5.81 mg/dL; 95% <em>CI</em> -9.96 to -1.67).</div></div><div><h3>Conclusions</h3><div>Meta-analysis showed that NSPT exerted beneficial effects on CAD by controlling systemic inflammation levels, which was not observed in patients with MetS.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102136"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-04-19DOI: 10.1016/j.jebdp.2025.102159
MARWA BARAKA, GHADA ELWARDANI, HAMS HAMED, SARAH I. ZEITOUN
Background
Hypersensitivity from Molar Incisor Hypomineralisation (MIH) negatively affects children's oral health-related quality of life (OHRQoL).
Aim
To evaluate and compare the effectiveness of photobiomodulation (PBM) by low-power laser, resin-based (Fisseal), and glass ionomer (Fuji TRIAGE) sealants on hypersensitivity in children with MIH and their impact on OHRQoL.
Design
Forty-five children aged 6-10 with one first permanent molar affected by MIH and hypersensitivity were randomly assigned to 3 groups: Group 1 (n = 15) PBM, Group 2 (n = 15) Fuji TRIAGE, and Group 3 (n = 15) Fisseal. Hypersensitivity was assessed before and 15 minutes postintervention, with follow-ups at 1 week, and 1, 3, and 6 months. Pain and sensitivity were measured using the Wong-Baker Faces Pain Rating Scale (FPS) and the Schiff Cold Air Sensitivity Scale (SCASS). OHRQoL was evaluated with the Child Perceptions Questionnaire (CPQ8-10).
Results
No significant differences in SCASS or FPS scores were found between groups. Significant reductions in SCASS and FPS were observed over time (P < .001), with PBM and Fisseal showing notable FPS improvements at 6 months. All groups showed significant OHRQoL improvements (P < .001), particularly Fisseal.
Conclusion
Both glass ionomer and resin-based sealants and PBM are effective in reducing hypersensitivity associated with MIH.
Clinical Significance
PBM is a noninvasive therapy for managing hypersensitivity in children with MIH offering an alternative for apprehensive patients.
{"title":"MANAGEMENT OF HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING PHOTOBIOMODULATION AND SEALANTS IN CHILDREN: A RANDOMIZED CLINICAL TRIAL","authors":"MARWA BARAKA, GHADA ELWARDANI, HAMS HAMED, SARAH I. ZEITOUN","doi":"10.1016/j.jebdp.2025.102159","DOIUrl":"10.1016/j.jebdp.2025.102159","url":null,"abstract":"<div><h3>Background</h3><div>Hypersensitivity from Molar Incisor Hypomineralisation (MIH) negatively affects children's oral health-related quality of life (OHRQoL).</div></div><div><h3>Aim</h3><div>To evaluate and compare the effectiveness of photobiomodulation (PBM) by low-power laser, resin-based (Fisseal), and glass ionomer (Fuji TRIAGE) sealants on hypersensitivity in children with MIH and their impact on OHRQoL.</div></div><div><h3>Design</h3><div>Forty-five children aged 6-10 with one first permanent molar affected by MIH and hypersensitivity were randomly assigned to 3 groups: Group 1 (<em>n</em> = 15) PBM, Group 2 (<em>n</em> = 15) Fuji TRIAGE, and Group 3 (<em>n</em> = 15) Fisseal. Hypersensitivity was assessed before and 15 minutes postintervention, with follow-ups at 1 week, and 1, 3, and 6 months. Pain and sensitivity were measured using the Wong-Baker Faces Pain Rating Scale (FPS) and the Schiff Cold Air Sensitivity Scale (SCASS). OHRQoL was evaluated with the Child Perceptions Questionnaire (CPQ8-10).</div></div><div><h3>Results</h3><div>No significant differences in SCASS or FPS scores were found between groups. Significant reductions in SCASS and FPS were observed over time (<em>P</em> < .001), with PBM and Fisseal showing notable FPS improvements at 6 months. All groups showed significant OHRQoL improvements (<em>P</em> < .001), particularly Fisseal.</div></div><div><h3>Conclusion</h3><div>Both glass ionomer and resin-based sealants and PBM are effective in reducing hypersensitivity associated with MIH.</div></div><div><h3>Clinical Significance</h3><div>PBM is a noninvasive therapy for managing hypersensitivity in children with MIH offering an alternative for apprehensive patients.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102159"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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