Shijiazhuang City (Hebei Province, China) experienced two COVID-19 outbreaks: January 2021 and November 2022. Differences in the prevention and control measures implemented during the two outbreaks led to significantly distinct epidemic evolutions. During the first outbreak, these measures were implemented throughout the epidemic duration. During the second outbreak, attention was paid only at the initial epidemic stage, followed by a laissez-faire management that led to a rapid epidemic development, and only then control measures were re-implemented. In the present work, epidemic-related data during the two outbreaks and relevant risk area data during the atypical November 2022 outbreak were collected from Nation-, Hebei Province-, and Shijiazhuang City-level Health Commission sources. The study of the outbreaks involved a preliminary long time-series analysis followed by a novel synthesis of Susceptible-Exposed-Infected-Removed (SEIR) modeling with Bayesian Maximum Entropy (BME) mapping of the spatiotemporal COVID-19 spread during the November 2022 outbreak (a severe data deficiency occurred this month due to normalized management). An important advantage of the proposed SEIR-BME synthesis is that it compensated for the individual shortcomings of its components: Using SEIR we constructed transmission models of the outbreaks, while BME effectively filled in the missing data during November 2022 and subsequently generated accurate spatiotemporal disease risk maps. Our results confirmed the powerful transmission capability of COVID-19 and the considerable prevention and control progress made by the authorities from January 2021 to November 2022. We also found that during the exponential growth period of the epidemic, the COVID-19 variation results of this work closely followed the empirical COVID-19 law of He et al. (2020). Lastly, our analysis provided data support for subsequent studies of the COVID-19 spread, and suggested optimal infectious disease prevention and control measures. It is hoped that the present work would laid the methodological foundations for future developments in spatiotemporal infectious disease modeling and mapping.
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