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Consultation-liaison psychiatry: how the intervention tested in The HOME Study differs from US practice – Authors' reply 咨询-联络精神病学:"居家 "研究中测试的干预措施与美国实践有何不同--作者的回复
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00326-2
Michael Sharpe, Jane Walker
No Abstract
无摘要
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引用次数: 0
Research on structural determinants and mental health in adolescents 关于结构性决定因素和青少年心理健康的研究
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00322-5
Abigail Casas-Muñoz, Aarón Rodríguez-Caballero, Ángel Eduardo Velasco-Rojano
No Abstract
无摘要
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引用次数: 0
Economic inequalities in adolescents’ internalising symptoms: longitudinal evidence from eight countries 青少年内化症状的经济不平等:来自八个国家的纵向证据
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00255-4
Thomas Steare, Sara Evans-Lacko, Mesele Araya, Santiago Cueto, Hai-Anh H Dang, Revathi Ellanki, Emily Garman, Gemma Lewis, Kelly Rose-Clarke, Praveetha Patalay
<h3>Background</h3>Research, mainly conducted in Europe and North America, has shown an inequitable burden of internalising mental health problems among adolescents from poorer households. We investigated whether these mental health inequalities differ across a diverse range of countries and multiple measures of economic circumstances.<h3>Methods</h3>In this longitudinal observational cohort study, we analysed data from studies conducted in eight countries (Australia, Ethiopia, India, Mexico, Peru, South Africa, the UK, and Viet Nam) across five global regions. All studies had self-reported measures of internalising symptoms using a validated scale at two timepoints in adolescence; a measure of household income, household consumption expenditure, or subjective wealth; and data collected between 2000 and 2019. Household income (measured in four countries), consumption expenditure (six countries), and adolescents’ subjective assessment of household wealth (five countries) were measured in mid-adolescence (14–17 years). The primary outcome (internalising symptoms, characterised by negative mood, affect, and anxiety) was measured later in adolescence between age 17 and 19 years. Analyses were linear regression models with adjustment. Effect estimates were added to random-effects meta-analyses to aid understanding of cross-country differences.<h3>Findings</h3>The overall pooled sample of eight studies featured 18 910 adolescents (9568 [50·6%] female and 9342 [49·4%] male). Household income had a small or null association with adolescents’ internalising symptoms. Heterogeneity (<em>I</em><sup>2</sup> statistic) was 71·04%, falling to 39·71% after adjusting for baseline symptoms. Household consumption expenditure had a stronger association with internalising symptoms (decreases of 0·075 SD in Peru [95% CI –0·136 to –0·013], 0·034 SD in South Africa [–0·061 to –0·006], and 0·141 SD in Viet Nam [–0·202 to –0·081] as household consumption expenditure doubled). The <em>I</em><sup>2</sup> statistic was 74·24%, remaining similar at 74·83% after adjusting for baseline symptoms. Adolescents’ subjective wealth was associated with internalising symptoms in four of the five countries where it was measured. The <em>I</em><sup>2</sup> statistic was 57·09% and remained similar after adjusting for baseline symptoms (53·25%). We found evidence for cross-country differences in economic inequalities in adolescents’ internalising symptoms, most prominently for inequalities according to household consumption expenditure. Subjective wealth explained greater variance in symptoms compared with the objective measures.<h3>Interpretation</h3>Our study suggests that economic inequalities in adolescents’ mental health are prevalent in many but not all countries and vary by the economic measure considered. Variation in the magnitude of inequalities suggests that the wider context within countries plays an important role in the development of these inequalities.<h3>Funding</h3>Wellc
背景主要在欧洲和北美进行的研究表明,来自贫困家庭的青少年在内化性心理健康问题上承受着不公平的负担。在这项纵向观察性队列研究中,我们分析了来自全球五个地区八个国家(澳大利亚、埃塞俄比亚、印度、墨西哥、秘鲁、南非、英国和越南)的研究数据。所有研究都使用经过验证的量表对青少年时期两个时间点的内化症状进行了自我报告测量;对家庭收入、家庭消费支出或主观财富进行了测量;并收集了 2000 年至 2019 年期间的数据。家庭收入(在四个国家测量)、消费支出(在六个国家测量)和青少年对家庭财富的主观评估(在五个国家测量)是在青春期中期(14-17 岁)测量的。主要结果(以负面情绪、情感和焦虑为特征的内化症状)是在青春期后期(17 至 19 岁)进行测量的。分析采用调整线性回归模型。研究结果八项研究的总体样本包括18910名青少年(9568名[50-6%]女性和9342名[49-4%]男性)。家庭收入与青少年内化症状的相关性很小或为零。异质性(I2 统计量)为 71-04%,调整基线症状后降至 39-71%。家庭消费支出与内化症状的关系更为密切(随着家庭消费支出增加一倍,秘鲁的下降幅度为 0-075 SD [95% CI -0-136 to -0-013],南非为 0-034 SD [-0-061 to -0-006],越南为 0-141 SD [-0-202 to -0-081])。I2 统计量为 74-24%,调整基线症状后仍为 74-83%。在对青少年主观财富进行测量的五个国家中,有四个国家的青少年主观财富与内化症状相关。I2 统计量为 57-09%,在对基线症状进行调整后(53-25%)保持相似。我们发现有证据表明,在青少年内化症状方面存在经济不平等的跨国差异,其中最突出的是家庭消费支出方面的不平等。我们的研究表明,青少年心理健康方面的经济不平等现象在许多国家都普遍存在,但并非所有国家都是如此,而且因所考虑的经济措施而异。不平等程度的差异表明,国家内部的大环境在这些不平等的形成过程中起着重要作用。
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引用次数: 0
Ghana's law decriminalising attempted suicide needs revision 加纳将自杀未遂非刑罪化的法律需要修订
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00309-2
Emmanuel Nii-Boye Quarshie, Kwaku Oppong Asante
No Abstract
无摘要
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引用次数: 0
Correction to Lancet Psychiatry 2024; 11: 910–33 柳叶刀精神病学》更正 2024; 11: 910-33
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00328-6
Pinchuk I, Leventhal B L, Ladyk-Bryzghalova A, et al. The Lancet Psychiatry Commission on mental health in Ukraine. Lancet Psychiatry 2024; 11: 910–33—In this Commission, the value of the total health-care expenditure of US$ 13·5 per capita given in sentence five in paragraph two of Part 5: Resourcing the future of mental health section is incorrect. The number should be $6·75 per capita. The name of one of the authors should read Mariana Pinto da Costa not Pinto da Costa M. These corrections have been made to the online version as of Oct 15 and the printed version is correct.
Pinchuk I, Leventhal B L, Ladyk-Bryzghalova A, et al. Lancet Psychiatry Commission on mental health in Ukraine.Lancet Psychiatry 2024; 11: 910-33-在该委员会中,第 5 部分:为未来的精神健康提供资源部分第二段第五句中给出的人均 13-5 美元的医疗保健总支出值是不正确的。应为人均 6-75 美元。其中一位作者的姓名应为 Mariana Pinto da Costa,而不是 Pinto da Costa M。这些更正已在 10 月 15 日的在线版本中作出,印刷版本中的内容也是正确的。
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引用次数: 0
Consultation-liaison psychiatry: how the intervention tested in The HOME Study differs from US practice 咨询-联络精神病学:"居家 "研究中测试的干预措施与美国实践有何不同
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00279-7
Mark A Oldham, Patrick Triplett
No Abstract
无摘要
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引用次数: 0
Norbert Skokauskas: research is not just an academic exercise 诺伯特-斯科考斯卡斯:研究不仅仅是学术活动
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00318-3
Talha Burki
No Abstract
无摘要
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引用次数: 0
Associations between white matter microstructure and cognitive decline in major depressive disorder versus controls in Germany: a prospective case-control cohort study 德国重度抑郁症患者与对照组的白质微结构和认知能力下降之间的关系:一项前瞻性病例对照队列研究
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-16 DOI: 10.1016/s2215-0366(24)00291-8
Kira Flinkenflügel, Susanne Meinert, Christopher Hirtsiefer, Dominik Grotegerd, Marius Gruber, Janik Goltermann, Nils R Winter, Frederike Stein, Katharina Brosch, Elisabeth J Leehr, Joscha Böhnlein, Katharina Dohm, Jochen Bauer, Ronny Redlich, Tim Hahn, Jonathan Repple, Nils Opel, Robert Nitsch, Hamidreza Jamalabadi, Benjamin Straube, Udo Dannlowski
<h3>Background</h3>Cognitive deficits are a key source of disability in individuals with major depressive disorder (MDD) and worsen with disease progression. Despite their clinical relevance, the underlying mechanisms of cognitive deficits remain poorly elucidated, hampering effective treatment strategies. Emerging evidence suggests that alterations in white matter microstructure might contribute to cognitive dysfunction in MDD. We aimed to investigate the complex association between changes in white matter integrity, cognitive decline, and disease course in MDD in a comprehensive longitudinal dataset.<h3>Methods</h3>In the naturalistic, observational, prospective, case-control Marburg-Münster Affective Disorders Cohort Study, individuals aged 18–65 years and of Caucasian ancestry were recruited from local psychiatric hospitals in Münster and Marburg, Germany, and newspaper advertisements. Individuals diagnosed with MDD and individuals without any history of psychiatric disorder (ie, healthy controls) were included in this subsample analysis. Participants had diffusion-weighted imaging, a battery of neuropsychological tests, and detailed clinical data collected at baseline and at 2 years of follow-up. We used linear mixed-effect models to compare changes in cognitive performance and white matter integrity between participants with MDD and healthy controls. Diffusion-weighted imaging analyses were conducted using tract-based spatial statistics. To correct for multiple comparisons, threshold free cluster enhancement (TFCE) was used to correct α-values at the family-wise error rate (FWE; p<sub><em>tfce-FWE</em></sub>). Effect sizes were estimated by conditional, partial R<sup>2</sup> values (<em>sr</em><sup>2</sup>) following the Nakagawa and Schielzeth method to quantify explained variance. The association between changes in cognitive performance and changes in white matter integrity was analysed. Finally, we examined whether the depressive disease course between assessments predicted cognitive performance at follow-up and whether white matter integrity mediated this association. People with lived experience were not involved in the research and writing process.<h3>Findings</h3>881 participants were selected for our study, of whom 418 (47%) had MDD (mean age 36·8 years [SD 13·4], 274 [66%] were female, and 144 [34%] were male) and 463 (53%) were healthy controls (mean age 35·6 years [13·5], 295 [64%] were female, and 168 [36%] were male). Baseline assessments were done between Sept 11, 2014, and June 3, 2019, and after a mean follow-up of 2·20 years (SD 0·19), follow-up assessments were done between Oct 6, 2016, and May 31, 2021. Participants with MDD had lower cognitive performance than did healthy controls (p<0·0001, <em>sr</em><sup>2</sup>=0·056), regardless of timepoint. Analyses of diffusion-weighted imaging indicated a significant diagnosis × time interaction with a steeper decline in white matter integrity of the superior longitudinal fas
背景认知缺陷是重度抑郁障碍(MDD)患者致残的主要原因,并随着病情的发展而恶化。尽管认知障碍具有临床意义,但其潜在机制仍未得到充分阐明,从而阻碍了有效的治疗策略。新的证据表明,白质微观结构的改变可能是导致 MDD 认知功能障碍的原因之一。我们的目的是通过一个全面的纵向数据集来研究白质完整性变化、认知能力下降和 MDD 病程之间的复杂关联。方法在自然观察、前瞻性、病例对照的马尔堡-明斯特情感障碍队列研究中,我们从德国明斯特和马尔堡当地的精神病院和报纸广告中招募了 18-65 岁的白种人。被诊断为 MDD 的患者和无任何精神障碍病史的患者(即健康对照组)均被纳入该次样本分析。我们对参与者进行了弥散加权成像、一系列神经心理学测试,并在基线和随访两年时收集了详细的临床数据。我们使用线性混合效应模型来比较 MDD 患者和健康对照组患者在认知能力和白质完整性方面的变化。弥散加权成像分析采用了基于道的空间统计方法。为了校正多重比较,采用了无阈集群增强(TFCE)技术,以家族误差率(FWE;ptfce-FWE)校正α值。根据 Nakagawa 和 Schielzeth 方法,通过条件部分 R2 值 (sr2) 估算效应大小,以量化解释方差。我们还分析了认知能力变化与白质完整性变化之间的关联。最后,我们研究了两次评估之间的抑郁病程是否会预测随访时的认知表现,以及白质完整性是否会调节这种关联。我们选择了881名参与者进行研究,其中418人(47%)患有MDD(平均年龄36-8岁[SD 13-4],274人[66%]为女性,144人[34%]为男性),463人(53%)为健康对照组(平均年龄35-6岁[13-5],295人[64%]为女性,168人[36%]为男性)。基线评估在 2014 年 9 月 11 日至 2019 年 6 月 3 日期间进行,平均随访 2-20 年(SD 0-19)后,随访评估在 2016 年 10 月 6 日至 2021 年 5 月 31 日期间进行。与健康对照组相比,患有 MDD 的参与者认知能力较低(p<0-0001,sr2=0-056),与时间点无关。对弥散加权成像的分析表明,诊断与时间之间存在显著的交互作用,随着时间的推移,MDD 患者的上纵筋束白质完整性比健康对照组下降得更快(ptfce-FWE=0-026,sr2=0-002)。此外,随着时间的推移,两组患者认知能力的下降与白质完整性的下降密切相关(ptfce-FWE<0-0001,sr2=0-004)。在MDD患者中,白质完整性的变化(p=0-0040,β=0-071)和不良抑郁病程(p=0-0022,β=-0-073)可独立预测随访时认知能力的下降。我们的研究结果强调了白质微观结构和疾病进展在抑郁症相关认知功能障碍中的关键作用,使两者成为未来治疗发展的优先目标。
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引用次数: 0
Concerns about genetic risk testing for opioid use disorder 对阿片类药物使用障碍基因风险检测的担忧
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-13 DOI: 10.1016/s2215-0366(24)00310-9
Alexander S Hatoum, Christal N Davis, Rachel L Kember, Mandy Johnstone, David W Oslin, Janneke R Zinkstok, Margit Burmeister, Arpana Agrawal, Henry R Kranzler, Howard J Edenberg, Joel Gelernter, Anna R Docherty, Todd Lencz
No Abstract
无摘要
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引用次数: 0
Estimating adolescent mental health in the general population: current challenges and opportunities 估算普通人群中的青少年心理健康状况:当前的挑战与机遇
IF 64.3 1区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-09 DOI: 10.1016/s2215-0366(24)00254-2
Louise Black, Margarita Panayiotou, Neil Humphrey
Adolescence is a period of change and increased mental health difficulties, which are important for lifetime outcomes. Adolescent mental health is therefore an active research area, with large samples often drawing on self-report general measures (ie, not disorder-specific or focused on a narrow outcome). We argue that these measures have a key role in our understanding of issues such as prevalence, antecedents, prevention, and intervention, however, measurement has been given little attention and high-quality measures do not tend to be available or used. We offer insights into historical and psychometric challenges that have contributed to current problems and highlight the implications of relying on poor measures, which at their worst can be biased and unethical. We make recommendations for research and practice on selecting measures and improving the evidence base and make a call to action to reject low-quality measurement in this field.
青春期是一个变化和心理健康困难增加的时期,这对一生的结果都很重要。因此,青少年心理健康是一个活跃的研究领域,其大量样本通常采用自我报告的一般测量方法(即不针对特定疾病或侧重于狭隘的结果)。我们认为,这些测量方法对于我们了解诸如患病率、前因、预防和干预等问题具有关键作用,然而,测量方法却很少受到重视,高质量的测量方法往往并不存在或未被使用。我们深入探讨了导致当前问题的历史和心理测量挑战,并强调了依赖不良测量方法的影响,因为最糟糕的测量方法可能存在偏见和不道德。我们就选择测量方法和改进证据基础的研究和实践提出了建议,并呼吁采取行动,摒弃该领域的低质量测量方法。
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引用次数: 0
期刊
Lancet Psychiatry
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