European Annals of Otorhinolaryngology-Head and Neck Diseases最新文献

英文中文

Scientific and skeptical medical writing 科学和怀疑的医学写作。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-07-01 DOI: 10.1016/j.anorl.2024.11.002

F. Simon

引用次数: 0

Acute intestinal obstruction due to duodenal metastasis of laryngeal squamous cell carcinoma: A CARE case report 喉鳞癌十二指肠转移致急性肠梗阻1例。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-07-01 DOI: 10.1016/j.anorl.2025.02.004

Y. Lelonge , A. Havasi , N. Williet , B. Le Roy

Objective

To report a case of duodenal metastasis of laryngeal squamous cell carcinoma revealed by acute intestinal obstruction.

Case report

A 55-year-old male was initially treated for cT4N1M0 laryngeal squamous cell carcinoma, with total laryngectomy, bilateral neck dissection, total thyroidectomy and pectoralis major flap. Subsequently, he received radiotherapy and chemotherapy. Then, he was periodically monitored, with clinical examination and cervicothoracic CT, according to guidelines. Three years later, he presented acute intestinal obstruction. Abdominal CT revealed a 35 mm obstructive duodenal tumor involving the head of the pancreas. Gastroscopy enabled biopsies, which confirmed metastasis of the laryngeal carcinoma. After gastro-entero-anastomosis, a first line treatment with cisplatin, 5-fluorouracile and pembrozilumab was started. It was complicated by abdominal bleeding, which required inferior duodenopancreatic artery embolization and colic perforation requiring colectomy. Due to deterioration in general health, 2 injections of pembrozilumab alone were made. Then, because of progression, the patient received 1 second-line injection of docetaxel. He finally died of acute pancreatitis, 7 months after diagnosis.

Conclusion

Duodenal metastasis of squamous cell carcinoma of the larynx is rare but possible. This case report highlights the importance of clinical and radiological monitoring, particularly in locally advanced tumor.

目的：报告一例因急性肠梗阻而发现的喉鳞癌十二指肠转移病例：报告一例因急性肠梗阻而发现的喉鳞癌十二指肠转移病例：一名 55 岁男性最初因 cT4N1M0 喉鳞状细胞癌接受全喉切除术、双侧颈部切除术、全甲状腺切除术和胸大肌皮瓣术。随后，他接受了放疗和化疗。之后，他根据指南定期接受临床检查和颈胸部 CT 监测。三年后，他出现了急性肠梗阻。腹部 CT 发现了一个 35 毫米的十二指肠阻塞性肿瘤，肿瘤累及胰腺头部。胃镜活检证实了喉癌转移。胃肠吻合术后，患者开始接受顺铂、5-氟尿嘧啶和培美曲塞单抗的一线治疗。腹部出血使病情复杂化，需要进行十二指肠胰下动脉栓塞术，结肠穿孔需要进行结肠切除术。由于全身健康状况恶化，又单独注射了 2 次彭布罗齐单抗。随后，由于病情进展，患者接受了一次多西他赛二线注射。最终，他在确诊 7 个月后死于急性胰腺炎：结论：喉鳞癌的十二指肠转移虽然罕见，但却有可能发生。本病例报告强调了临床和放射学监测的重要性，尤其是对局部晚期肿瘤的监测。

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引用次数: 0

Cervical resection of Zenker's diverticulum 宫颈Zenker憩室切除术。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-07-01 DOI: 10.1016/j.anorl.2025.05.001

C.-A. Righini , C. Fabre , M. Makeieff

Treatment for symptomatic Zenker's diverticulum is surgical. This has greatly progressed in recent years and two surgical approaches are possible: the external or cervical approach, and the other, more recent, endoscopic approach. Both are based on sectioning the cricopharyngeal muscle. The majority of authors recommend an endoscopic approach in first line, reserving open surgery for cases in which exposure of the diverticular collar is impossible or endoscopic surgery has failed. There are therefore still indications for open surgery, and this technique must be perfectly mastered.

对症性Zenker憩室的治疗是手术。近年来有了很大的进展，有两种手术入路：外入路或颈椎入路，以及最近的内窥镜入路。两者都是基于环咽肌的切片。大多数作者建议在一线采用内窥镜入路，对于不可能暴露憩室环或内窥镜手术失败的病例保留开放手术。因此，仍然有开放手术的适应症，这项技术必须完全掌握。

引用次数: 0

IgG4-related disease of the middle ear in a pediatric patient 一名儿童患者的中耳 IgG4 相关疾病。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-07-01 DOI: 10.1016/j.anorl.2025.03.002

L. Kusevic , M. Ulamec , T. Greguric , J. Ajduk

引用次数: 0

A case of recalcitrant epistaxis 顽固性鼻出血1例。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-07-01 DOI: 10.1016/j.anorl.2025.03.003

E. Al Hakim , P. Beyssen , X. Dufour , F. Carsuzaa

引用次数: 0

Audiometric results of tympanoplasty with stapedectomy and synthetic total ossicular replacement prosthesis: A STROBE analysis 鼓室成形术合并镫骨切除术和人工全听骨置换术的听力学结果：一个STROBE分析。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.anorl.2024.11.006

C. Guigou , M. Folia , B. Reliquet , A. Lalande , M. Brisson , A. Bozorg Grayeli

Aim

To evaluate the audiometric results of tympanoplasty with stapedectomy and insertion of a synthetic total ossicular replacement prosthesis (TORP).

Material and methods

Retrospective observational study conducted on a cohort of 15 patients (16 ears) aged 10 to 58 years (mean: 36 years) with chronic otitis media (COM) and tympanosclerosis (n = 9), stapediovestibular ankylosis (n = 3), minor aplasia (n = 3) or post-traumatic ossicular dislocation (n = 1). Treatment consisted in tympanoplasty with stapedectomy and TORP placement by the same operator, between December 1, 2012 and January 30, 2023, in a French university hospital department, with follow-up ranging from 2 to 92 months (mean: 24 months). The primary endpoint was postoperative change in air conduction (AC) threshold and air-bone gap (ABG). Secondary endpoints comprised change in speech recognition threshold (SRT) and speech discrimination score (SDS) and analysis of complications. The STROBE editorial line was followed and the significance threshold was set at P < 0.005.

Results

There was significant improvement in AC threshold (−2 to 25 dB, mean: 10 dB; P = 0.001), ABG (−8 to 26 dB, mean: 10 dB), SRT (2 to 30 dB, mean: 13 dB; P < 0.0001) and SDS (P = 0.001). No patients showed vestibular symptoms postoperatively.

Conclusion

This study suggests that this technique is a possible and safe therapeutic option in selected cases of stapes footplate fixation associated with other ossicular anomalies.

目的：评价镫骨切除鼓室成形术置入人工全听骨置换术（TORP）的听力学效果。材料与方法：对慢性中耳炎（COM）合并鼓室硬化（9例）、镫骨前叶强直（3例）、轻度发育不全（3例）、创伤后听骨脱位（1例）患者15例（16耳），年龄10 ~ 58岁（平均36岁）进行回顾性观察研究。2012年12月1日至2023年1月30日，在法国一所大学医院进行鼓室成形术、镫骨切除术和TORP放置，随访时间为2至92个月（平均24个月）。主要终点是术后空气传导（AC）阈值和气骨间隙（ABG）的变化。次要终点包括语音识别阈值（SRT）和语音识别评分（SDS）的变化以及并发症分析。遵循STROBE编辑线，显著性阈值设置于：结果：交流阈值显著改善(-2至25dB，平均值：10dB；P=0.001), ABG (-8 ~ 26dB，平均值：10dB), SRT (2 ~ 30dB，平均值：13dB；结论：本研究表明，对于镫骨足板固定合并其他听骨异常的病例，该技术是一种可能且安全的治疗选择。

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引用次数: 0

Asthenia, insomnia, malaise and high blood pressure during nasal spray corticotherapy in an adult 成人鼻喷皮质治疗期间的虚弱、失眠、不适和高血压。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.anorl.2025.03.001

J. De Mestier, J.-B. Lecanu, O. Laccourreye

引用次数: 0

The Auxiliary Report Book: A glimpse of surgical activity in a pediatric ENT department in Paris in the 1920s 辅助报告册：二十世纪二十年代巴黎小儿耳鼻喉科手术活动一瞥。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.anorl.2024.09.007

N. Leboulanger , C. Celerier , M. Parodi , F. Denoyelle , B. Thierry

A report book unearthed in our archives contained 352 operative reports from the otorhinolaryngology department of the Armand-Trousseau Children's Hospital in Paris, dated from January 1912 to August 1920. These documents provide a snapshot of surgical activity in this field at the time. Mastoidectomy for mastoiditis was by far the most common procedure. This incomplete but original snapshot bears witness to the habits and working conditions of our predecessors, as well as to the progress made in just over a century.

在我们的档案中发现了一本报告册，其中包含巴黎阿尔芒-特鲁索儿童医院耳鼻喉科的 352 份手术报告，日期为 1912 年 1 月至 1920 年 8 月。这些文件为当时该领域的手术活动提供了一个缩影。乳突炎的乳突切除术是迄今为止最常见的手术。这份不完整但原始的快照见证了我们前辈的生活习惯和工作条件，以及在短短一个多世纪里取得的进步。

引用次数: 0

First example of airway restoration using cryopreserved aortic allograft after total laryngectomy: CARE case report 全喉切除术后使用低温保存的同种异体主动脉瓣修复气道的首例：CARE病例报告。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.anorl.2024.11.007

C. Debry , E. Brenet , E. Martinod , P. Lavalle , A. Dupret-Bories , P. Schultz , L. Fath

Case description

A 70 year-old woman presenting T4aN2cM0 laryngeal carcinoma first underwent total laryngectomy with airway reconstruction by cryopreserved aortic allograft. Six months after chemoradiotherapy, she underwent endoscopic surgery to create a neo-laryngopharynx.

Results

At 13 months after primary surgery, day- and night-time breathing was effectively restored, with a little persistent salivary false passage, and a whispering but comprehensible voice after tracheostomy closure. Swallowing was possible for small amounts of soft food, thanks to sustained rehabilitation, although normal feeding was not achieved. The patient showed no episodes of pneumopathy. General health status was good, with no oncologic relapse.

Discussion

This was the first case of laryngeal replacement by cryopreserved aortic allograft, showing progress in the decades-long aim of final tracheostomy closure. The ultimate objective is to achieve swallowing without false passage, by improving various aspects of surgical technique,without, so far as possible, making the procedures more complex by active airway protection systems.

病例描述：一名70岁的女性因T4aN2cM0喉癌首次接受了全喉切除术和低温保存的同种异体主动脉移植气道重建。放化疗六个月后，她接受了内窥镜手术，创造了一个新的喉咽。结果：初次手术后13个月，患者昼夜呼吸得到有效恢复，有少量持续的唾液假通道，气管造口术结束后声音低语但可理解。由于持续的康复，吞咽少量软性食物是可能的，尽管正常的进食没有实现。患者未出现肺病发作。总体健康状况良好，无肿瘤复发。讨论：这是首例通过低温保存的同种异体主动脉移植进行喉置换的病例，显示了在长达数十年的气管造口术最终闭合的目标上取得的进展。最终目标是通过改进手术技术的各个方面，尽可能避免主动气道保护系统使手术过程更加复杂，从而实现无假通道吞咽。

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引用次数: 0

Middle-ear osteolytic transthyretin amyloidosis: A CARE case report 中耳溶骨性转甲状腺素淀粉样变性病：CARE病例报告。

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

European Annals of Otorhinolaryngology-Head and Neck Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.anorl.2024.09.002

C. Maquet , A. Willemet , A. Francois , F. Crampon , S. Deneuve

Introduction

Wild-type transthyretin amyloidosis (ATTRwt) is a rare but serious disease that is underestimated due to asymptomatic progression. Cardiac deposits worsen prognosis, highlighting the importance of early detection for preventive treatment.

Case report

An elderly patient presented with an osteolytic lesion of the middle ear. Pathology diagnosed amyloid transthyretin deposits associated with cholesteatoma.

Discussion

Identifying reliable markers to screen for risk of cardiac amyloidosis is important, due to poor prognosis. Recent studies found higher prevalence of hearing loss in ATTRwt than in the general population. The present case identified the middle ear as a target of ATTR, which could improve our understanding of the pathophysiology.

简介野生型转甲状腺素淀粉样变性（ATTRwt）是一种罕见但严重的疾病，由于无症状进展而被低估。心脏沉积物会使预后恶化，这突出了早期检测对预防性治疗的重要性：病例报告：一名老年患者出现中耳溶骨性病变。病理诊断为胆脂瘤相关的淀粉样转甲状腺素沉积：讨论：由于心脏淀粉样变性的预后较差，因此确定可靠的标志物来筛查心脏淀粉样变性的风险非常重要。最近的研究发现，ATTRwt 患者听力损失的发生率高于普通人群。本病例确定了中耳是 ATTR 的靶点，这有助于加深我们对病理生理学的理解。

引用次数: 0

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