Pub Date : 2025-09-01DOI: 10.1016/j.anorl.2024.10.001
F. Rubin
{"title":"The heart of the citation black-market","authors":"F. Rubin","doi":"10.1016/j.anorl.2024.10.001","DOIUrl":"10.1016/j.anorl.2024.10.001","url":null,"abstract":"","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 5","pages":"Page 223"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.anorl.2024.11.008
M. Saro-Buendía , M. Mansilla-Polo , A. García-Piñero , M. Armengot-Carceller
Introduction
To document through a case report the ENT manifestations of the STING-associated vasculopathy with onset in infancy (SAVI) syndrome, remarking their value to achieve the diagnosis.
Case summary
A man in his forties presented with exercise-related dyspnoea and cold-exacerbated painful lesions over the nasal tip, cheeks, ears, and feet since his early childhood. The ENT manifestations included cartilaginous necrosis (both auricles and nasal tip) and a 1-cm anterior septal perforation. A familiar inheritance pattern was evident and genetic studies confirmed the diagnosis of a SAVI syndrome. Therapy with JAK inhibitors was implemented, resulting in a favorable response.
Discussion
SAVI syndrome is a recently described disease with recognizable otolaryngologic manifestations that may be key to clinical suspicion and genetic diagnosis.
{"title":"Stimulator of interferon genes-associated vasculopathy with onset in infancy (SAVI syndrome)","authors":"M. Saro-Buendía , M. Mansilla-Polo , A. García-Piñero , M. Armengot-Carceller","doi":"10.1016/j.anorl.2024.11.008","DOIUrl":"10.1016/j.anorl.2024.11.008","url":null,"abstract":"<div><h3>Introduction</h3><div>To document through a case report the ENT manifestations of the STING-associated vasculopathy with onset in infancy (SAVI) syndrome, remarking their value to achieve the diagnosis.</div></div><div><h3>Case summary</h3><div>A man in his forties presented with exercise-related dyspnoea and cold-exacerbated painful lesions over the nasal tip, cheeks, ears, and feet since his early childhood. The ENT manifestations included cartilaginous necrosis (both auricles<span> and nasal tip) and a 1-cm anterior septal perforation. A familiar inheritance pattern was evident and genetic studies confirmed the diagnosis of a SAVI syndrome. Therapy with JAK inhibitors was implemented, resulting in a favorable response.</span></div></div><div><h3>Discussion</h3><div>SAVI syndrome is a recently described disease with recognizable otolaryngologic manifestations that may be key to clinical suspicion and genetic diagnosis.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 5","pages":"Pages 244-246"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.anorl.2025.04.005
V. Malgorn , L. Dupont , M. Poncelet , L. Lieffrig , A. Lagier
Background
The Deglutition Handicap Index-Informal Caregiver (DHI-IC) questionnaire is a dysphagia assessment tool derived from the psychometrically validated Deglutition Handicap Index (DHI) self-reported dysphagia questionnaire in French. Like the DHI, the DHI-IC comprises 30 items, in 3 equal domains: Physical, Functional and Emotional.
Materials and methods
A prospective study included 61 patients and 61 caregivers recruited from an ENT clinic dedicated to dysphagia.
Objectives
To validate the DHI-IC as an assessment tool and to compare results with the DHI and swallowing endoscopy.
Conclusions
The DHI-IC, like the DHI, showed good internal consistency. The results indicate that it is an appropriate tool for assessing functional status, health and quality of life related to dysphagia in patients via caregiver reporting.
{"title":"Validation of the Deglutition Handicap Index-Informal Caregiver questionnaire","authors":"V. Malgorn , L. Dupont , M. Poncelet , L. Lieffrig , A. Lagier","doi":"10.1016/j.anorl.2025.04.005","DOIUrl":"10.1016/j.anorl.2025.04.005","url":null,"abstract":"<div><h3>Background</h3><div>The Deglutition Handicap Index-Informal Caregiver (DHI-IC) questionnaire is a dysphagia assessment tool derived from the psychometrically validated Deglutition Handicap Index (DHI) self-reported dysphagia questionnaire in French. Like the DHI, the DHI-IC comprises 30 items, in 3 equal domains: Physical, Functional and Emotional.</div></div><div><h3>Materials and methods</h3><div>A prospective study included 61 patients and 61 caregivers recruited from an ENT clinic dedicated to dysphagia.</div></div><div><h3>Objectives</h3><div>To validate the DHI-IC as an assessment tool and to compare results with the DHI and swallowing endoscopy.</div></div><div><h3>Conclusions</h3><div>The DHI-IC, like the DHI, showed good internal consistency. The results indicate that it is an appropriate tool for assessing functional status, health and quality of life related to dysphagia in patients via caregiver reporting.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 5","pages":"Pages 233-237"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.anorl.2025.06.005
E. Chabrillac , S. Vergez , B. Baujat , N. Fakhry
{"title":"Letter on the article “Deciding whether to do elective neck dissection in patients with salivary gland tumors with no evidence of neck lymph node metastasis” by Sanabria A, et al. Eur Ann Otorhinolaryngol Head Neck Dis 2025;142:135–42","authors":"E. Chabrillac , S. Vergez , B. Baujat , N. Fakhry","doi":"10.1016/j.anorl.2025.06.005","DOIUrl":"10.1016/j.anorl.2025.06.005","url":null,"abstract":"","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 4","pages":"Pages 221-222"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.anorl.2025.04.006
A. Boghossian, M.M. Cervinia, D.H. Nguyen, D. Garcia, H. Mirghani, O. Laccourreye
Objective
To compare 10-year oncologic results of supracricoid partial laryngectomy and cricohyoidoepiglottopexy (SCPL-CHEP) versus CO2 laser cordectomy (LC) for cT2N0M0 glottic squamous cell carcinoma (SCC).
Material and method
Retrospective observational analysis of an inception cohort of 57 patients with isolated cT2N0M0 glottic SCC consecutively managed at a French university teaching otorhinolaryngology department during the years 1993–2013: 33 with SCPL-CHEP and 24 with LC. In all, 93% and 81% of patients were followed for respectively at least 5 years, or 10 years or until death. The main endpoint was 10-year actuarial overall and disease-free survival. Secondary endpoints comprised cause of death, 10-year actuarial local control, and 10-year laryngeal preservation estimates.
Results
Ten-year survival was 58% whichever the surgical technique. Ten-year disease-free survival was 87% after SCPL-CHEP and 71% after LC (P = 0.15). Death related to SCC occurred in 3 patients after LC but was not encountered after SCPL-CHEP. Ten-year local control differed: 100% after SCPL-CHEP versus 65% after LC, with 96% overall local control after salvage treatment. Ten-year laryngeal preservation differed: 97% after SCPL-CHEP versus 74% after LC (P = 0.03).
Conclusions
In patients with cT2N0M0 glottic SCC considered amenable to partial laryngeal surgery, the present long-term data should lead head and neck surgeons to discuss the benefits and pitfalls of both LC and SCPL-CHEP.
{"title":"A comparative STROBE analysis of 10-year oncologic results of SCPL-CHEP and endoscopic CO2 laser cordectomy for cT2N0M0 glottic squamous cell carcinoma","authors":"A. Boghossian, M.M. Cervinia, D.H. Nguyen, D. Garcia, H. Mirghani, O. Laccourreye","doi":"10.1016/j.anorl.2025.04.006","DOIUrl":"10.1016/j.anorl.2025.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>To compare 10-year oncologic results of supracricoid partial laryngectomy and cricohyoidoepiglottopexy (SCPL-CHEP) versus CO<sub>2</sub> laser cordectomy (LC) for cT2N0M0 glottic squamous cell carcinoma (SCC).</div></div><div><h3>Material and method</h3><div>Retrospective observational analysis of an inception cohort of 57 patients with isolated cT2N0M0 glottic SCC consecutively managed at a French university teaching otorhinolaryngology department during the years 1993–2013: 33 with SCPL-CHEP and 24 with LC. In all, 93% and 81% of patients were followed for respectively at least 5 years, or 10 years or until death. The main endpoint was 10-year actuarial overall and disease-free survival. Secondary endpoints comprised cause of death, 10-year actuarial local control, and 10-year laryngeal preservation estimates.</div></div><div><h3>Results</h3><div>Ten-year survival was 58% whichever the surgical technique. Ten-year disease-free survival was 87% after SCPL-CHEP and 71% after LC (<em>P</em> <!-->=<!--> <!-->0.15). Death related to SCC occurred in 3 patients after LC but was not encountered after SCPL-CHEP. Ten-year local control differed: 100% after SCPL-CHEP versus 65% after LC, with 96% overall local control after salvage treatment. Ten-year laryngeal preservation differed: 97% after SCPL-CHEP versus 74% after LC (<em>P</em> <!-->=<!--> <!-->0.03).</div></div><div><h3>Conclusions</h3><div>In patients with cT2N0M0 glottic SCC considered amenable to partial laryngeal surgery, the present long-term data should lead head and neck surgeons to discuss the benefits and pitfalls of both LC and SCPL-CHEP.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 4","pages":"Pages 185-190"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.anorl.2025.06.006
C.-A. Righini , T. Doutrebente , C. Fabre
{"title":"Asbestos and head-and-neck cancer: An important association for patient monitoring and compensation","authors":"C.-A. Righini , T. Doutrebente , C. Fabre","doi":"10.1016/j.anorl.2025.06.006","DOIUrl":"10.1016/j.anorl.2025.06.006","url":null,"abstract":"","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 4","pages":"Pages 169-170"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.anorl.2024.07.011
O. Piccin , F. Contedini , V. Sciarretta , V. Pinto
The main goal for treatment of locally advanced thyroid carcinoma invading the laryngotracheal and esophageal complex, is radical surgical excision and reconstruction of a functional aerodigestive tract. We describe a challenging surgical technique in which a wide laryngotracheal and esophageal defect was functionally reconstructed using a single anterolateral thigh flap. This can represent a good option for a tailored functional reconstruction of extended defects of the aerodigestive tract.
{"title":"Laryngotracheal and esophageal functional reconstruction using a single anterolateral thigh flap","authors":"O. Piccin , F. Contedini , V. Sciarretta , V. Pinto","doi":"10.1016/j.anorl.2024.07.011","DOIUrl":"10.1016/j.anorl.2024.07.011","url":null,"abstract":"<div><div>The main goal for treatment of locally advanced thyroid carcinoma invading the laryngotracheal and esophageal complex, is radical surgical excision and reconstruction of a functional aerodigestive tract. We describe a challenging surgical technique in which a wide laryngotracheal and esophageal defect was functionally reconstructed using a single anterolateral thigh flap. This can represent a good option for a tailored functional reconstruction of extended defects of the aerodigestive tract.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 4","pages":"Pages 205-212"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.anorl.2025.04.001
E. Caillaud , L. Pellé-Boudeau , M. Férrandière , D. Bakhos , E. Lescanne , F. Micaletti
Objective
To evaluate the efficacy and safety of awake stapedectomy under hypnoanalgesia (HA) compared to general anesthesia (GA) and local anesthesia (LA) in patients with otosclerosis.
Methods
A single-center retrospective study included 131 adult patients (mean age: 49 years; 78% female) who underwent laser stapedectomy between 2020 and 2022: 58 GA, 23 LA, 50 HA. Primary outcome measures comprised operative room occupancy time, anesthetic consumption, and postoperative audiometric results.
Results
HA significantly reduced operative room occupancy time (73.5 ± 18.6 min vs 103.7 ± 24.6 min in GA, P < 0.001; vs 81.8 ± 20.5 min in LA, P = 0.092), stapedectomy duration (39.9 ± 12.4 min vs 48.9 ± 21.5 min in GA, P = 0.0252; vs 38.9 ± 13.2 min in LA, P = 0.4601), preoperative time (30.2 ± 9.5 min vs 45.7 ± 9.5 min in GA, P < 0.001; vs 38.6 ± 12.2 min in LA, P = 0.0022), and recovery room time (26 ± 15.1 min vs 67.5 ± 20.7 min in GA, P < 0.001; vs 47.4 ± 20.7 min in LA, P < 0.001). HA also significantly reduced remifentanil consumption (169.8 ± 101.6 μg vs 848.6 ± 308.8 μg in GA, P < 0.001; vs 323.9 ± 94.4 μg in LA, P < 0.001). Postoperative audiometric outcomes showed no significant differences between groups.
Conclusion
Hypnoanalgesia for awake stapedectomy provided significantly greater efficacy compared to general anesthesia, reducing operative time and anesthetic consumption, with comparable audiometric outcomes.
目的：比较催眠镇痛（HA）与全麻（GA）、局麻（LA）对耳硬化患者行清醒镫骨切除术的疗效和安全性。方法：单中心回顾性研究纳入131例成人患者(平均年龄49岁；在2020年至2022年间接受激光镫骨切除术的患者（78%为女性）：58名GA， 23名LA， 50名HA。主要指标包括手术室占用时间、麻醉消耗和术后听力学结果。结果：透明质酸显著减少了手术时间（73.5±18.6min vs 103.7±24.6min）。结论：与全麻相比，醒时镫骨切除术的催眠镇痛效果明显更好，减少了手术时间和麻醉消耗，听力指标相当。
{"title":"Awake stapedectomy under hypnoanalgesia: Efficacy and safety in the treatment of otosclerosis","authors":"E. Caillaud , L. Pellé-Boudeau , M. Férrandière , D. Bakhos , E. Lescanne , F. Micaletti","doi":"10.1016/j.anorl.2025.04.001","DOIUrl":"10.1016/j.anorl.2025.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of awake stapedectomy under hypnoanalgesia (HA) compared to general anesthesia (GA) and local anesthesia (LA) in patients with otosclerosis.</div></div><div><h3>Methods</h3><div>A single-center retrospective study included 131 adult patients (mean age: 49 years; 78% female) who underwent laser stapedectomy between 2020 and 2022: 58 GA, 23 LA, 50 HA. Primary outcome measures comprised operative room occupancy time, anesthetic consumption, and postoperative audiometric results.</div></div><div><h3>Results</h3><div>HA significantly reduced operative room occupancy time (73.5<!--> <!-->±<!--> <!-->18.6<!--> <!-->min vs 103.7<!--> <!-->±<!--> <!-->24.6<!--> <!-->min in GA, <em>P</em> <!--><<!--> <!-->0.001; vs 81.8<!--> <!-->±<!--> <!-->20.5<!--> <!-->min in LA, <em>P</em> <!-->=<!--> <!-->0.092), stapedectomy duration (39.9<!--> <!-->±<!--> <!-->12.4<!--> <!-->min vs 48.9<!--> <!-->±<!--> <!-->21.5<!--> <!-->min in GA, <em>P</em> <!-->=<!--> <!-->0.0252; vs 38.9<!--> <!-->±<!--> <!-->13.2<!--> <!-->min in LA, <em>P</em> <!-->=<!--> <!-->0.4601), preoperative time (30.2<!--> <!-->±<!--> <!-->9.5<!--> <!-->min vs 45.7<!--> <!-->±<!--> <!-->9.5<!--> <!-->min in GA, <em>P</em> <!--><<!--> <!-->0.001; vs 38.6<!--> <!-->±<!--> <!-->12.2<!--> <!-->min in LA, <em>P</em> <!-->=<!--> <!-->0.0022), and recovery room time (26<!--> <!-->±<!--> <!-->15.1<!--> <!-->min vs 67.5<!--> <!-->±<!--> <!-->20.7<!--> <!-->min in GA, <em>P</em> <!--><<!--> <!-->0.001; vs 47.4<!--> <!-->±<!--> <!-->20.7<!--> <!-->min in LA, <em>P</em> <!--><<!--> <!-->0.001). HA also significantly reduced remifentanil consumption (169.8<!--> <!-->±<!--> <!-->101.6<!--> <!-->μg vs 848.6<!--> <!-->±<!--> <!-->308.8<!--> <!-->μg in GA, <em>P</em> <!--><<!--> <!-->0.001; vs 323.9<!--> <!-->±<!--> <!-->94.4<!--> <!-->μg in LA, <em>P</em> <!--><<!--> <!-->0.001). Postoperative audiometric outcomes showed no significant differences between groups.</div></div><div><h3>Conclusion</h3><div>Hypnoanalgesia for awake stapedectomy provided significantly greater efficacy compared to general anesthesia, reducing operative time and anesthetic consumption, with comparable audiometric outcomes.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 4","pages":"Pages 179-184"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.anorl.2024.09.008
F. Bou Malhab , J. Hosri , G. Zaytoun , U. Hadi
Objectives
To introduce the trigeminal cervical complex (TCC) as a comprehensive framework for understanding the anatomical and functional scope of the afferences and efferences of the trigeminal nerve and explaining common otolaryngologic symptoms, including head and neck myofascial pain syndrome. Additionally, it explores how the bidirectional transmission of neurotransmitters contributes to the sensitization of the TCC and motor nuclei.
Methods
The study was conducted as a narrative review. The authors performed a comprehensive search of multiple databases, including Medline/OVID, Embase, Scopus, and PubMed, covering publications from inception until August 2023. Both keywords and medical subject headings related to the TCC were utilized in the search. Information from 66 studies was extracted based on predetermined inclusion and exclusion criteria.
Results
This review discusses the multiple afferent connections from cranial nerves, specifically VII, IX, X, and XI, to the TCC, and their respective efferent pathways. These connections may explain various clinical manifestations in the head and neck that cannot be attributed to other medical conditions. Additionally, the review highlights the dual sensory and motor nature of cranial nerves, emphasizing the bidirectional transmission of neurotransmitters in head and neck areas, which leads to the sensitization of both the TCC and motor nuclei innervating the cervicofacial muscles.
Conclusion
The authors hypothesize that the central and peripheral sensitization and the intricate connections of the TCC can elucidate the pathophysiology of conditions such as otalgia, tinnitus, hearing loss, vertigo, headache, cervicogenic dizziness, bruxism, and other symptoms affecting the head and neck.
{"title":"Trigeminal cervical complex: A neural network affecting the head and neck","authors":"F. Bou Malhab , J. Hosri , G. Zaytoun , U. Hadi","doi":"10.1016/j.anorl.2024.09.008","DOIUrl":"10.1016/j.anorl.2024.09.008","url":null,"abstract":"<div><h3>Objectives</h3><div>To introduce the trigeminal cervical complex (TCC) as a comprehensive framework for understanding the anatomical and functional scope of the afferences and efferences of the trigeminal nerve and explaining common otolaryngologic symptoms, including head and neck myofascial pain syndrome. Additionally, it explores how the bidirectional transmission of neurotransmitters contributes to the sensitization of the TCC and motor nuclei.</div></div><div><h3>Methods</h3><div>The study was conducted as a narrative review. The authors performed a comprehensive search of multiple databases, including Medline/OVID, Embase, Scopus, and PubMed, covering publications from inception until August 2023. Both keywords and medical subject headings related to the TCC were utilized in the search. Information from 66 studies was extracted based on predetermined inclusion and exclusion criteria.</div></div><div><h3>Results</h3><div>This review discusses the multiple afferent connections from cranial nerves, specifically VII, IX, X, and XI, to the TCC, and their respective efferent pathways. These connections may explain various clinical manifestations in the head and neck that cannot be attributed to other medical conditions. Additionally, the review highlights the dual sensory and motor nature of cranial nerves, emphasizing the bidirectional transmission of neurotransmitters in head and neck areas, which leads to the sensitization of both the TCC and motor nuclei innervating the cervicofacial muscles.</div></div><div><h3>Conclusion</h3><div>The authors hypothesize that the central and peripheral sensitization and the intricate connections of the TCC can elucidate the pathophysiology of conditions such as otalgia, tinnitus, hearing loss, vertigo, headache, cervicogenic dizziness, bruxism, and other symptoms affecting the head and neck.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 4","pages":"Pages 191-200"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.anorl.2025.01.001
S. Saeedi , M. Aghajanzadeh
Purpose
User-friendly artificial intelligence (AI) chatbots are increasingly being explored to assist healthcare teams in their decision-making processes. As accurate diagnosis in all medical fields is vital in treatment planning, this research seeks to explore the function of two specific AI chatbots, ChatGPT and Perplexity AI, in distinguishing the various types of dysphonia (organic, functional, and neurological).
Material and methods
In experiment 1, a script combining voice self-assessments plus the acoustic analysis, and in experiment 2, only the acoustic analysis of 37 dysphonic patients was fed into the ChatGPT and Perplexity AI chatbots specifying the type and asked to develop a complex AI-based model to determine dysphonia type. Then, the same process was redone with data from a sample of 27 other patients as a test.
Results
Although ChatGPT could not analyze the data and only provided guidance, the Cohen's Kappa agreement between experts’ diagnoses and Perplexity AI diagnoses in experiment 1 (P = 0.773) and experiment 2 (P = 0.067) lacked statistically significance.
Conclusion
Regarding the preliminary poor performance of AI chatbots in differential diagnosis of dysphonia type, it is not currently recommended to use them in clinical settings. However, modifications in AI chatbots in the future might provide more promising results in determining the dysphonia type. Further research is needed to shed light on AI chatbots ability in voice clinics.
{"title":"Assessing the diagnostic capacity of artificial intelligence chatbots for dysphonia types: Model development and validation","authors":"S. Saeedi , M. Aghajanzadeh","doi":"10.1016/j.anorl.2025.01.001","DOIUrl":"10.1016/j.anorl.2025.01.001","url":null,"abstract":"<div><h3>Purpose</h3><div>User-friendly artificial intelligence (AI) chatbots are increasingly being explored to assist healthcare teams in their decision-making processes. As accurate diagnosis in all medical fields is vital in treatment planning, this research seeks to explore the function of two specific AI chatbots, ChatGPT and Perplexity AI, in distinguishing the various types of dysphonia (organic, functional, and neurological).</div></div><div><h3>Material and methods</h3><div>In experiment 1, a script combining voice self-assessments plus the acoustic analysis, and in experiment 2, only the acoustic analysis of 37 dysphonic patients was fed into the ChatGPT and Perplexity AI chatbots specifying the type and asked to develop a complex AI-based model to determine dysphonia type. Then, the same process was redone with data from a sample of 27 other patients as a test.</div></div><div><h3>Results</h3><div>Although ChatGPT could not analyze the data and only provided guidance, the Cohen's Kappa agreement between experts’ diagnoses and Perplexity AI diagnoses in experiment 1 (<em>P</em> <!-->=<!--> <!-->0.773) and experiment 2 (<em>P</em> <!-->=<!--> <!-->0.067) lacked statistically significance.</div></div><div><h3>Conclusion</h3><div>Regarding the preliminary poor performance of AI chatbots in differential diagnosis of dysphonia type, it is not currently recommended to use them in clinical settings. However, modifications in AI chatbots in the future might provide more promising results in determining the dysphonia type. Further research is needed to shed light on AI chatbots ability in voice clinics.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 4","pages":"Pages 171-178"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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