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The application of deep learning in abdominal trauma diagnosis by CT imaging 深度学习在 CT 成像腹部创伤诊断中的应用
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-05-06 DOI: 10.1186/s13017-024-00546-7
Xinru Shen, Yixin Zhou, Xueyu Shi, Shiyun Zhang, Shengwen Ding, Liangliang Ni, Xiaobing Dou, Lin Chen
Abdominal computed tomography (CT) scan is a crucial imaging modality for creating cross-sectional images of the abdominal area, particularly in cases of abdominal trauma, which is commonly encountered in traumatic injuries. However, interpreting CT images is a challenge, especially in emergency. Therefore, we developed a novel deep learning algorithm-based detection method for the initial screening of abdominal internal organ injuries. We utilized a dataset provided by the Kaggle competition, comprising 3,147 patients, of which 855 were diagnosed with abdominal trauma, accounting for 27.16% of the total patient population. Following image data pre-processing, we employed a 2D semantic segmentation model to segment the images and constructed a 2.5D classification model to assess the probability of injury for each organ. Subsequently, we evaluated the algorithm’s performance using 5k-fold cross-validation. With particularly noteworthy performance in detecting renal injury on abdominal CT scans, we achieved an acceptable accuracy of 0.932 (with a positive predictive value (PPV) of 0.888, negative predictive value (NPV) of 0.943, sensitivity of 0.887, and specificity of 0.944). Furthermore, the accuracy for liver injury detection was 0.873 (with PPV of 0.789, NPV of 0.895, sensitivity of 0.789, and specificity of 0.895), while for spleen injury, it was 0.771 (with PPV of 0.630, NPV of 0.814, sensitivity of 0.626, and specificity of 0.816). The deep learning model demonstrated the capability to identify multiple organ injuries simultaneously on CT scans and holds potential for application in preliminary screening and adjunctive diagnosis of trauma cases beyond abdominal injuries.
腹部计算机断层扫描(CT)是绘制腹部横截面图像的重要成像方式,尤其是在腹部创伤的情况下,这在外伤中很常见。然而,解读 CT 图像是一项挑战,尤其是在紧急情况下。因此,我们开发了一种基于深度学习算法的新型检测方法,用于初步筛查腹部内脏损伤。我们利用了 Kaggle 竞赛提供的数据集,该数据集由 3,147 名患者组成,其中 855 人被诊断为腹部创伤,占患者总数的 27.16%。在对图像数据进行预处理后,我们采用二维语义分割模型对图像进行分割,并构建了一个二维半分类模型来评估每个器官的损伤概率。随后,我们使用 5k 倍交叉验证评估了算法的性能。在腹部 CT 扫描的肾脏损伤检测方面,我们的准确率达到了 0.932(阳性预测值为 0.888,阴性预测值为 0.943,灵敏度为 0.887,特异性为 0.944),表现尤为突出。此外,肝损伤检测的准确度为 0.873(PPV 为 0.789,NPV 为 0.895,灵敏度为 0.789,特异度为 0.895),而脾损伤检测的准确度为 0.771(PPV 为 0.630,NPV 为 0.814,灵敏度为 0.626,特异度为 0.816)。深度学习模型展示了在 CT 扫描中同时识别多个器官损伤的能力,有望应用于腹部损伤以外的创伤病例的初步筛查和辅助诊断。
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引用次数: 0
Systematic review and meta-analysis of endovascular therapy versus open surgical repair for the traumatic lower extremity arterial injury 创伤性下肢动脉损伤的血管内治疗与开放手术修复的系统回顾和荟萃分析
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-04-27 DOI: 10.1186/s13017-024-00544-9
Yuhan Qi, Jiarong Wang, Ding Yuan, Pengchao Duan, Li Hou, Tiehao Wang
For traumatic lower extremity artery injury, it is unclear whether it is better to perform endovascular therapy (ET) or open surgical repair (OSR). This study aimed to compare the clinical outcomes of ET versus OSR for traumatic lower extremity artery injury. The Medline, Embase, and Cochrane Databases were searched for studies. Cohort studies and case series reporting outcomes of ET or OSR were eligible for inclusion. Robins-I tool and an 18-item tool were used to assess the risk of bias. The primary outcome was amputation. The secondary outcomes included fasciotomy or compartment syndrome, mortality, length of stay and lower extremity nerve injury. We used the random effects model to calculate pooled estimates. A total of 32 studies with low or moderate risk of bias were included in the meta-analysis. The results showed that patients who underwent ET had a significantly decreased risk of major amputation (OR = 0.42, 95% CI 0.21–0.85; I2=34%) and fasciotomy or compartment syndrome (OR = 0.31, 95% CI 0.20–0.50, I2 = 14%) than patients who underwent OSR. No significant difference was observed between the two groups regarding all-cause mortality (OR = 1.11, 95% CI 0.75–1.64, I2 = 31%). Patients with ET repair had a shorter length of stay than patients with OSR repair (MD=-5.06, 95% CI -6.76 to -3.36, I2 = 65%). Intraoperative nerve injury was just reported in OSR patients with a pooled incidence of 15% (95% CI 6%–27%). Endovascular therapy may represent a better choice for patients with traumatic lower extremity arterial injury, because it can provide lower risks of amputation, fasciotomy or compartment syndrome, and nerve injury, as well as shorter length of stay.
对于创伤性下肢动脉损伤,目前尚不清楚是进行血管内治疗(ET)更好,还是进行开放手术修复(OSR)更好。本研究旨在比较创伤性下肢动脉损伤的 ET 与 OSR 的临床疗效。研究人员在 Medline、Embase 和 Cochrane 数据库中检索了相关研究。报告 ET 或 OSR 结果的队列研究和病例系列研究符合纳入条件。采用Robins-I工具和18项工具评估偏倚风险。主要结果为截肢。次要结果包括筋膜切开术或筋膜室综合征、死亡率、住院时间和下肢神经损伤。我们使用随机效应模型计算汇总估计值。共有32项存在低度或中度偏倚风险的研究被纳入荟萃分析。结果显示,与接受OSR的患者相比,接受ET的患者发生大截肢(OR=0.42,95% CI 0.21-0.85;I2=34%)和筋膜切开术或室间综合征(OR=0.31,95% CI 0.20-0.50,I2=14%)的风险明显降低。两组患者的全因死亡率无明显差异(OR = 1.11,95% CI 0.75-1.64,I2 = 31%)。ET修复术患者的住院时间短于OSR修复术患者(MD=-5.06,95% CI -6.76至-3.36,I2=65%)。据报道,OSR患者术中神经损伤的发生率为15%(95% CI 6%-27%)。血管内治疗可能是外伤性下肢动脉损伤患者的更好选择,因为它可以降低截肢、筋膜切开或筋膜室综合征和神经损伤的风险,并缩短住院时间。
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引用次数: 0
Comparing outcomes in patients with exsanguinating injuries: an Eastern Association for the Surgery of Trauma (EAST), multicenter, international trial evaluating prioritization of circulation over intubation (CAB over ABC) 比较外伤患者的预后:东部创伤外科协会 (EAST)、多中心国际试验,评估循环优先于插管(CAB 优先于 ABC)的情况
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-04-25 DOI: 10.1186/s13017-024-00545-8
Paula Ferrada, Alberto García, Juan Duchesne, Megan Brenner, Chang Liu, Carlos Ordóñez, Carlos Menegozzo, Juan Carlos Salamea, David Feliciano
Hemorrhage is a major cause of preventable trauma deaths, and the ABC approach is widely used during the primary survey. We hypothesize that prioritizing circulation over intubation (CAB) can improve outcomes in patients with exsanguinating injuries. A prospective observational study involving international trauma centers was conducted. Patients with systolic blood pressure below 90 who were intubated within 30 min of arrival were included. Prioritizing circulation (CAB) was defined as delaying intubation until blood products were started, and/or bleeding control was performed before securing the airway. Demographics, clinical data, and outcomes were recorded. The study included 278 eligible patients, with 61.5% falling within the “CAB” cohort and 38.5% in the “ABC” cohort. Demographic and disease characteristics, including age, sex, ISS, use of blood products, and other relevant factors, exhibited comparable distributions between the two cohorts. The CAB group had a higher proportion of penetrating injuries and more patients receiving intubation in the operating room. Notably, patients in the CAB group demonstrated higher GCS scores, lower SBP values before intubation but higher after intubation, and a significantly lower incidence of cardiac arrest and post-intubation hypotension. Key outcomes revealed significantly lower 24-hour mortality in the CAB group (11.1% vs. 69.2%), a lower rate of renal failure, and a higher rate of ARDS. Multivariable logistic regression models showed a 91% reduction in the odds of mortality within 24 h and an 89% reduction at 30 days for the CAB cohort compared to the ABC cohort. These findings suggest that prioritizing circulation before intubation is associated with improved outcomes in patients with exsanguinating injuries. Post-intubation hypotension is observed to be correlated with worse outcomes. The consideration of prioritizing circulation over intubation in patients with exsanguinating injuries, allowing for resuscitation, or bleeding control, appears to be associated with potential improvements in survival. Emphasizing the importance of circulation and resuscitation is crucial, and this approach might offer benefits for various bleeding-related conditions.
大出血是可预防的创伤死亡的主要原因,ABC 法在初级调查中被广泛使用。我们假设,优先循环而非插管(CAB)可以改善外伤患者的预后。我们开展了一项由国际创伤中心参与的前瞻性观察研究。研究对象包括收缩压低于 90 且在到达后 30 分钟内插管的患者。循环优先(CAB)的定义是,在确保气道安全之前,延迟插管直到开始使用血液制品和/或进行出血控制。研究记录了人口统计学、临床数据和结果。研究共纳入了 278 名符合条件的患者,其中 61.5% 属于 "CAB "队列,38.5% 属于 "ABC "队列。两组患者的人口统计学特征和疾病特征,包括年龄、性别、ISS、血液制品使用情况和其他相关因素,分布情况相当。CAB组的穿透性损伤比例更高,在手术室接受插管治疗的患者也更多。值得注意的是,CAB 组患者的 GCS 评分较高,插管前 SBP 值较低,但插管后 SBP 值较高,心脏骤停和插管后低血压的发生率明显较低。主要结果显示,CAB 组 24 小时死亡率明显较低(11.1% 对 69.2%),肾功能衰竭发生率较低,ARDS 发生率较高。多变量逻辑回归模型显示,与 ABC 组相比,CAB 组 24 小时内的死亡率降低了 91%,30 天内的死亡率降低了 89%。这些研究结果表明,在插管前优先考虑循环与改善外伤患者的预后有关。据观察,插管后低血压与较差的预后有关。对有外伤的患者来说,优先考虑血液循环而不是插管,以便进行复苏或控制出血,似乎与生存率的潜在提高有关。强调循环和复苏的重要性至关重要,这种方法可能对各种与出血有关的情况有益。
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引用次数: 0
Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago 再见哈特曼试验:一项前瞻性、国际性、多中心、观察性研究,研究一个世纪前开发的外科手术方法的当前使用情况
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-04-16 DOI: 10.1186/s13017-024-00543-w
Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F. Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W. C. A. Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan P. Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M. Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P. Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L. Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konst..
Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. After 100 years since the first Hartmann’s procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment’s choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception.
文献建议用结肠切除和原位吻合术(RPA)代替哈特曼手术(HP)来治疗左侧结肠急症。我们旨在评估全球用于治疗急性左侧结肠急症患者的手术方案,以及导致选择治疗方案的因素,并对 HP 和 RPA 进行比较。这是一项在 ClinicalTrials.gov 上注册的前瞻性国际多中心观察性研究。在 2020 年 3 月 1 日至 2020 年 5 月 31 日期间,共有来自 204 个中心的 1215 名需要手术治疗的左侧结肠急症患者被纳入研究,并进行了为期 1 年的随访。564名患者(43.1%)为女性。平均年龄为 65.9 ± 15.6 岁。697例(57.3%)患者接受了HP手术,384例(31.6%)患者接受了RPA手术。并发急性憩室炎是左侧结肠急症最常见的病因(40.2%),其次是结肠直肠恶性肿瘤(36.6%)。HP组的严重并发症(Clavien-Dindo≥3b)更高(P < 0.001)。HP患者的30天死亡率较高(13.7%),尤其是肠穿孔和弥漫性腹膜炎。1 年随访结果显示,HP 组和 RPA 组的造口翻转率没有差异(P = 0.127)。(P = 0.127).后向似然逻辑回归模型显示,对于年龄较小、ASA评分较低(≤ 3)、大肠梗阻、无结肠缺血、从入院到手术时间较长、白天工作时间较早、由实施过 50 例以上结直肠切除术的外科医生进行手术的患者,RPA 更受青睐。自第一例哈特曼手术以来,100 年过去了,HP 仍然是治疗左侧结直肠急症最常用的方法。治疗方法的选择取决于患者的特征、手术时间和外科医生的经验。RPA应被视为手术的黄金标准,而HP则是例外。
{"title":"Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago","authors":"Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F. Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W. C. A. Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan P. Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M. Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P. Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L. Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konst..","doi":"10.1186/s13017-024-00543-w","DOIUrl":"https://doi.org/10.1186/s13017-024-00543-w","url":null,"abstract":"Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. After 100 years since the first Hartmann’s procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment’s choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"120 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140557229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can small bowel obstruction during pregnancy be treated with conservative management? A review 妊娠期小肠梗阻可以通过保守治疗吗?综述
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-04-10 DOI: 10.1186/s13017-024-00541-y
Xiao Shuang Ling, Wei Cheng Anthony Brian Tian, Goran Augustin, Fausto Catena
Small bowel obstruction can occur during pregnancy, which, if missed, can lead to dire consequences for both the mother and foetus. Management of this condition usually requires surgical intervention. However, only a small number of patients are treated conservatively. The objective was to review the literature to determine the feasibility of conservative management for small bowel obstruction. A systematic search of the PubMed and Embase databases was performed using the keywords [small bowel obstruction AND pregnancy]. All original articles were then reviewed and included in this review if deemed suitable. Conservative management of small bowel obstruction in pregnant women is feasible if the patient is clinically stable and after ruling out bowel ischaemia and closed-loop obstruction.
怀孕期间可能会发生小肠梗阻,如果漏诊,可能会对母亲和胎儿造成严重后果。这种情况通常需要手术治疗。然而,只有少数患者可以接受保守治疗。我们的目的是回顾文献,确定保守治疗小肠梗阻的可行性。我们使用关键词[小肠梗阻和妊娠]对 PubMed 和 Embase 数据库进行了系统性检索。然后对所有原始文章进行了审查,如果认为合适,则将其纳入本综述。如果患者的临床情况稳定,并排除了肠缺血和闭环阻塞的可能性,那么孕妇小肠梗阻的保守治疗是可行的。
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引用次数: 0
Textbook outcome in urgent early cholecystectomy for acute calculous cholecystitis: results post hoc of the S.P.Ri.M.A.C.C study 急性结石性胆囊炎早期紧急胆囊切除术的教科书结果:S.P.Ri.M.A.C.C 研究的后期结果
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-03-21 DOI: 10.1186/s13017-024-00539-6
Paola Fugazzola, Silvia Carbonell-Morote, Lorenzo Cobianchi, Federico Coccolini, Juan Jesús Rubio-García, Massimo Sartelli, Walter Biffl, Fausto Catena, Luca Ansaloni, Jose Manuel Ramia
A textbook outcome patient is one in which the operative course passes uneventful, without complications, readmission or mortality. There is a lack of publications in terms of TO on acute cholecystitis. The objective of this study is to analyze the achievement of TO in patients with urgent early cholecystectomy (UEC) for Acute Cholecystitis. and to identify which factors are related to achieving TO. This is a post hoc study of the SPRiMACC study. It´s a prospective multicenter observational study run by WSES. The criteria to define TO in urgent early cholecystectomy (TOUEC) were no 30-day mortality, no 30-day postoperative complications, no readmission within 30 days, and hospital stay ≤ 7 days (75th percentile), and full laparoscopic surgery. Patients who met all these conditions were taken as presenting a TOUEC. 1246 urgent early cholecystectomies for ACC were included. In all, 789 patients (63.3%) achieved all TOUEC parameters, while 457 (36.6%) failed to achieve one or more parameters and were considered non-TOUEC. The patients who achieved TOUEC were younger had significantly lower scores on all the risk scales analyzed. In the serological tests, TOUEC patients had lower values for in a lot of variables than non-TOUEC patients. The TOUEC group had lower rates of complicated cholecystitis. Considering operative time, a shorter duration was also associated with a higher probability of reaching TOUEC. Knowledge of the factors that influence the TOUEC can allow us to improve our results in terms of textbook outcome.
手术过程顺利、无并发症、无再入院或无死亡病例的患者即为 "教科书式结果 "患者。关于急性胆囊炎的TO,目前还缺乏相关文献。本研究的目的是分析急性胆囊炎急诊早期胆囊切除术(UEC)患者达到TO的情况,并确定哪些因素与达到TO有关。这是 SPRiMACC 研究的一项事后研究。这是一项由 WSES 开展的前瞻性多中心观察研究。界定紧急早期胆囊切除术(TOUEC)的标准是:30 天内无死亡、30 天内无术后并发症、30 天内无再入院、住院时间不超过 7 天(第 75 百分位数),以及全腹腔镜手术。符合所有这些条件的患者均被视为 TOUEC 患者。共纳入了1246例ACC早期紧急胆囊切除术。共有 789 名患者(63.3%)达到了所有 TOUEC 参数,457 名患者(36.6%)未能达到一个或多个参数,被视为非 TOUEC 患者。达到 TOUEC 指标的患者年龄更小,在所有分析的风险量表中得分明显更低。在血清学测试中,TOUEC 患者的许多变量值都低于非 TOUEC 患者。TOUEC组患复杂性胆囊炎的比例较低。考虑到手术时间,手术时间越短,达到TOUEC的概率越高。了解影响TOUEC的因素可以让我们改善教科书中的结果。
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引用次数: 0
A meta-analysis and trial sequential analysis of randomised controlled trials comparing nonoperative and operative management of chest trauma with multiple rib fractures 随机对照试验的荟萃分析和试验顺序分析,比较胸部创伤伴多发性肋骨骨折的非手术和手术治疗方法
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-03-19 DOI: 10.1186/s13017-024-00540-z
Ryo Hisamune, Mako Kobayashi, Karin Nakasato, Taiga Yamazaki, Noritaka Ushio, Katsunori Mochizuki, Akira Takasu, Kazuma Yamakawa
Operative treatment of traumatic rib fractures for better outcomes remains under debate. Surgical stabilization of rib fractures has dramatically increased in the last decade. This study aimed to perform a systematic review and meta-analysis of randomised controlled trials (RCTs) to assess the effectiveness and safety of operative treatment compared to conservative treatment in adult patients with traumatic multiple rib fractures. A systematic literature review was performed according to the preferred reporting items for systematic reviews and meta-analyses guidelines. We searched MEDLINE, Scopus, and Cochrane Central Register of Controlled Trials and used the Cochrane Risk-of-Bias 2 tool to evaluate methodological quality. Relative risks with 95% confidence interval (CI) were calculated for outcomes: all-cause mortality, pneumonia incidence, and number of mechanical ventilation days. Overall certainty of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, with trial sequential analysis performed to establish implications for further research. From 719 records, we included nine RCTs, which recruited 862 patients. Patients were assigned to the operative group (received surgical stabilization of chest wall injury, n = 423) or control group (n = 439). All-cause mortality was not significantly different (RR = 0.53; 95% CI 0.21 to 1.38, P = 0.35, I2 = 11%) between the two groups. However, in the operative group, duration of mechanical ventilation (mean difference -4.62; 95% CI -7.64 to -1.60, P < 0.00001, I2 = 94%) and length of intensive care unit stay (mean difference -3.05; 95% CI -5.87 to -0.22; P < 0.00001, I2 = 96%) were significantly shorter, and pneumonia incidence (RR = 0.57; 95% CI 0.35 to 0.92; P = 0.02, I2 = 57%) was significantly lower. Trial sequential analysis for mortality indicated insufficient sample size for a definitive judgment. GRADE showed this meta-analysis to have very low to low confidence. Meta-analysis of large-scale trials showed that surgical stabilization of multiple rib fractures shortened the duration of mechanical ventilation and reduced the incidence of pneumonia but lacked clear evidence for improvement of mortality compared to conservative treatment. Trial sequential analysis suggested the need for more cases, and GRADE highlighted low certainty, emphasizing the necessity for further targeted RCTs, especially in mechanically ventilated patients. Systematic review registration: UMIN Clinical Trials Registry UMIN000049365.
如何通过手术治疗创伤性肋骨骨折以获得更好的疗效,目前仍存在争议。近十年来,通过手术稳定肋骨骨折的患者急剧增加。本研究旨在对随机对照试验(RCT)进行系统回顾和荟萃分析,以评估手术治疗与保守治疗相比,对创伤性多发性肋骨骨折成年患者的有效性和安全性。我们根据系统性综述和荟萃分析指南的首选报告项目进行了系统性文献综述。我们检索了 MEDLINE、Scopus 和 Cochrane Central Register of Controlled Trials,并使用 Cochrane Risk-of-Bias 2 工具评估方法学质量。计算了全因死亡率、肺炎发病率和机械通气天数等结果的相对风险和 95% 置信区间 (CI)。采用建议评估、发展和评价分级法(GRADE)评估了证据的总体确定性,并进行了试验顺序分析,以确定进一步研究的意义。从 719 份记录中,我们纳入了 9 项 RCT,共招募了 862 名患者。患者被分配到手术组(接受手术稳定胸壁损伤,n = 423)或对照组(n = 439)。两组患者的全因死亡率无明显差异(RR = 0.53;95% CI 0.21 至 1.38,P = 0.35,I2 = 11%)。但在手术组,机械通气时间(平均差异-4.62;95% CI -7.64至-1.60,P < 0.00001,I2 = 94%)和重症监护室住院时间(平均差异-3.05;95% CI -5.87至-0.22;P < 0.00001,I2 = 96%)明显缩短,肺炎发病率(RR = 0.57;95% CI 0.35至0.92;P = 0.02,I2 = 57%)明显降低。对死亡率的试验序列分析表明样本量不足,无法做出明确判断。GRADE 显示该荟萃分析的置信度为极低至低。大规模试验的荟萃分析表明,手术稳定多发性肋骨骨折缩短了机械通气的时间,降低了肺炎的发生率,但与保守治疗相比,缺乏明确的证据表明死亡率有所改善。试验序列分析表明需要更多的病例,而 GRADE 强调确定性较低,强调有必要进一步开展有针对性的 RCT,尤其是针对机械通气患者。系统回顾注册:UMIN 临床试验注册中心 UMIN000049365。
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引用次数: 0
Effectiveness and safety of tourniquet utilization for civilian vascular extremity trauma in the pre-hospital settings: a systematic review and meta-analysis 在院前环境中使用止血带治疗平民四肢血管创伤的有效性和安全性:系统回顾和荟萃分析
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-03-19 DOI: 10.1186/s13017-024-00536-9
Ying-Chih Ko, Tou-Yuan Tsai, Chien-Kai Wu, Kai-Wei Lin, Ming-Ju Hsieh, Tzu-Pin Lu, Tasuku Matsuyama, Wen-Chu Chiang, Matthew Huei-Ming Ma
Tourniquets (TQ) have been increasingly adopted in pre-hospital settings recently. This study examined the effectiveness and safety of applying TQ in the pre-hospital settings for civilian patients with traumatic vascular injuries to the extremities. We systematically searched the Ovid Embase, PubMed, and Cochrane Central Register of Controlled Trials databases from their inception to June 2023. We compared pre-hospital TQ (PH-TQ) use to no PH-TQ, defined as a TQ applied after hospital arrival or no TQ use at all, for civilian vascular extremity trauma patients. The primary outcome was overall mortality rate, and the secondary outcomes were blood product use and hospital stay. We analyzed TQ-related complications as safety outcomes. We tried to include randomized controlled trials (RCTs) and non-randomized studies (including non-RCTs, interrupted time series, controlled before-and-after studies, cohort studies, and case-control studies), if available. Pooled odds ratios (ORs) were calculated and the certainty of evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. Seven studies involving 4,095 patients were included. In the primary outcome, pre-hospital TQ (PH-TQ) use significantly decrease mortality rate in patients with extremity trauma (odds ratio [OR], 0.48, 95% confidence interval [CI] 0.27–0.86, I2 = 47%). Moreover, the use of PH-TQ showed the decreasing trend of utilization of blood products, such as packed red blood cells (mean difference [MD]: -2.1 [unit], 95% CI: -5.0 to 0.8, I2 = 99%) or fresh frozen plasma (MD: -1.0 [unit], 95% CI: -4.0 to 2.0, I2 = 98%); however, both are not statistically significant. No significant differences were observed in the lengths of hospital and intensive care unit stays. For the safety outcomes, PH-TQ use did not significantly increase risk of amputation (OR: 0.85, 95% CI: 0.43 to 1.68, I2 = 60%) or compartment syndrome (OR: 0.94, 95% CI: 0.37 to 2.35, I2 = 0%). The certainty of the evidence was very low across all outcomes. The current data suggest that, in the pre-hospital settings, PH-TQ use for civilian patients with vascular traumatic injury of the extremities decreased mortality and tended to decrease blood transfusions. This did not increase the risk of amputation or compartment syndrome significantly.
近来,止血带(TQ)在院前环境中的应用越来越广泛。本研究探讨了在院前环境中对四肢创伤性血管损伤的平民患者使用止血带的有效性和安全性。我们系统地检索了 Ovid Embase、PubMed 和 Cochrane Central Register of Controlled Trials 数据库从开始到 2023 年 6 月的数据。我们比较了平民四肢血管创伤患者使用院前TQ(PH-TQ)和不使用PH-TQ(定义为到达医院后使用TQ或根本不使用TQ)的情况。主要结果是总死亡率,次要结果是血液制品使用量和住院时间。我们将 TQ 相关并发症作为安全结果进行分析。如果有随机对照试验(RCT)和非随机研究(包括非 RCT、间断时间序列、前后对照研究、队列研究和病例对照研究),我们尽量将其纳入研究范围。采用建议评估、发展和评价分级(GRADE)方法计算汇总的几率比(ORs)并评估证据的确定性。共纳入七项研究,涉及 4095 名患者。在主要结果中,院前TQ(PH-TQ)的使用显著降低了四肢创伤患者的死亡率(几率比[OR],0.48,95%置信区间[CI]0.27-0.86,I2 = 47%)。此外,使用PH-TQ后,血液制品的使用率呈下降趋势,如包装红细胞(平均差[MD]:-2.1[单位],95% CI:-5.0至0.8,I2 = 99%)或新鲜冰冻血浆(MD:-1.0[单位],95% CI:-4.0至2.0,I2 = 98%);但两者均无统计学意义。在住院时间和重症监护室停留时间方面未观察到明显差异。在安全性结果方面,PH-TQ 的使用并未显著增加截肢风险(OR:0.85,95% CI:0.43 至 1.68,I2 = 60%)或间室综合征风险(OR:0.94,95% CI:0.37 至 2.35,I2 = 0%)。所有结果的证据确定性都很低。目前的数据表明,在院前环境中,对四肢血管外伤的平民患者使用 PH-TQ 可降低死亡率,并有减少输血的趋势。这并没有显著增加截肢或室间综合征的风险。
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引用次数: 0
The rise of ACS and its importance ACS 的兴起及其重要性
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-03-08 DOI: 10.1186/s13017-024-00538-7
Brian WCA Tian
<p>Acute care surgery [ACS] as a model of care and a focused area of specialisation is gaining traction globally [1,2,3]. ACS is seen as a natural evolution of the specialty of trauma. If anything, this restructuring is desperately needed.</p><p>In the ideal ACS system, I propose that surgeons will be:</p><ol><li><span>1)</span><p>Exposed to a wide variety of operative procedures and techniques, including the latest laparoscopic and robotic skill sets .</p></li><li><span>2)</span><p>The trauma surgeon will get a high operative load weekly, if not daily, to remain fresh and sharp.</p></li><li><span>3)</span><p>The ACS surgeon should constantly advance research and development in emergency work, which is often neglected [4].</p></li></ol><p>Globally, every country runs its own version of the ACS model. Despite the variation in systems, the ACS model has generally been shown to reduce time to surgery and complication rates, particularly for common conditions such as appendicitis and cholecystitis [5,6,7]. The productivity of the department as a whole also improves, with greater utilisation of the theatre and intensive care unit (ICU) [8]. Some studies reported reductions in length of stay (LOS), complications and costs compared to those in standard care units [9, 10]. Apart from patient driven outcomes, some studies have also shown improvements in inhouse operative teaching, and greater consultant presence in the theatre [11].</p><p>To date, there has yet to be a universal gold standard as to how to run the ACS system. Although ACS is beginning to show positive results from a systems and workflow point of view; its future is uncertain.</p><p>It is therefore imperative to gain insights into ACS systems round the world, to form the basis for learning and comparison. This will ultimately bring the global community together, and will eventually help to foster the development of a universal gold standard system.</p><ol data-track-component="outbound reference"><li data-counter="1."><p>Stawicki SP, Brooks A, Bilski J, et al. The concept of damage control: extending the paradigm to emergency general surgery. Injury. 2008;39:93–101.</p><p>Article PubMed Google Scholar </p></li><li data-counter="2."><p>van der Wee MJL, van der Wilden G, Hoencamp R. Acute Care surgery models Worldwide: a systematic review. World J Surg. 2020;44(8):2622–37. https://doi.org/10.1007/s00268-020-05536-9. PMID: 32377860; PMCID: PMC7326827.</p><p>Article PubMed PubMed Central Google Scholar </p></li><li data-counter="3."><p>Hollands M. Acute care surgery and trauma: a marriage of convenience. Injury. 2008;39(1):90 – 2. https://doi.org/10.1016/j.injury.2007.11.023. PMID: 18164302.</p></li><li data-counter="4."><p>de’Angelis N, Khan J, Marchegiani F, Bianchi G, Aisoni F, Alberti D, Ansaloni L, Biffl W, Chiara O, Ceccarelli G, Coccolini F, Cicuttin E, D’Hondt M, Di Saverio S, Diana M, De Simone B, Espin-Basany E, Fichtner-Feigl S, Kashuk J, Kouwenhoven E, Leppaniemi A, Beg
开放存取 本文采用知识共享署名 4.0 国际许可协议进行许可,该协议允许以任何媒介或格式使用、共享、改编、分发和复制本文,但必须注明原作者和出处,提供知识共享许可协议的链接,并说明是否进行了修改。本文中的图片或其他第三方材料均包含在文章的知识共享许可协议中,除非在材料的署名栏中另有说明。如果材料未包含在文章的知识共享许可协议中,且您打算使用的材料不符合法律规定或超出许可使用范围,您需要直接从版权所有者处获得许可。如需查看该许可的副本,请访问 http://creativecommons.org/licenses/by/4.0/。除非在数据的信用行中另有说明,否则创作共用公共领域专用免责声明(http://creativecommons.org/publicdomain/zero/1.0/)适用于本文提供的数据。转载与许可引用本文Tian, B.W. The rise of ACS and its importance.World J Emerg Surg 19, 9 (2024). https://doi.org/10.1186/s13017-024-00538-7Download citationReceived:26 February 2024Accepted: 29 February 2024Published: 08 March 2024DOI: https://doi.org/10.1186/s13017-024-00538-7Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KeywordsAcute careTraumHealth systems
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引用次数: 0
Intraoperative transcystic laparoscopic common bile duct stone clearance with SpyGlass™ discover during emergency and elective cholecystectomy: a single-center case series 在急诊和择期胆囊切除术中使用 SpyGlass™ 发现经囊腹腔镜胆总管结石:单中心病例系列
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-03-04 DOI: 10.1186/s13017-023-00529-0
Paola Fugazzola, Carlo Maria Bianchi, Francesca Calabretto, Enrico Cicuttin, Francesca Dal Mas, Tommaso Dominioni, Marcello Maestri, Aurelio Mauro, Alice Podestà, Matteo Tomasoni, Francesco Brucchi, Jacopo Viganò, Luca Ansaloni, Andrea Anderloni, Lorenzo Cobianchi
The development of a new cholangioscope, the SpyGlass™ Discover (Boston Scientific), has allowed the laparoscopic transcystic common bile duct exploration and stone clearance. The possibility of simultaneous treatment of choledocholithiasis during early laparoscopic cholecystectomy offers the opportunity to enormously reduce the time between acute cholecystitis diagnosis and the execution of cholecystectomy with better outcomes for patients. Furthermore, an altered anatomy of the gastrointestinal tract is not an obstacle to this technique. The aim of the study was to determine whether this new procedure is feasible, safe, and effective. The investigation employs a retrospective case series study including all consecutive patients with a diagnosis of common bile duct stones undergoing cholecystectomy and intraoperative laparoscopic common bile duct clearance using SpyGlass™ Discover at IRCCS Policlinico San Matteo in Pavia (Italy). Eighteen patients were included from May 2022 to May 2023. A complete clearance of the common bile duct was obtained in 88.9% of patients. The mean postoperative length of stay was 3 days. No major complications occurred. After a median follow-up of 8 months, no recurrence of biliary events or readmissions occurred. This procedure has proven to be feasible, safe, and effective.
新型胆道镜 SpyGlass™ Discover(波士顿科学公司)的问世使腹腔镜经囊总胆管探查和结石清除成为可能。在早期腹腔镜胆囊切除术中同时治疗胆总管结石的可能性为大大缩短急性胆囊炎诊断与实施胆囊切除术之间的时间提供了机会,从而为患者带来更好的治疗效果。此外,胃肠道解剖结构的改变也不会成为这项技术的障碍。这项研究的目的是确定这种新手术是否可行、安全和有效。调查采用了回顾性病例系列研究,包括在意大利帕维亚的IRCCS Policlinico San Matteo接受胆囊切除术和使用SpyGlass™ Discover术中腹腔镜胆总管清理术的所有确诊为胆总管结石的连续患者。从 2022 年 5 月到 2023 年 5 月,共纳入了 18 名患者。88.9%的患者完全清除了胆总管。术后平均住院时间为 3 天。无重大并发症发生。中位随访 8 个月后,未再发生胆道事件或再入院。事实证明,这种手术是可行、安全和有效的。
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引用次数: 0
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World Journal of Emergency Surgery
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