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Preparation of skeletally diverse quinazoline-2,4(1H,3H)-diones using Na2SiO3/SnFe2O4 catalytic system through a four-component reaction Na2SiO3/SnFe2O4催化体系通过四组分反应制备骨架多样的喹唑啉-2,4(1H,3H)-二酮
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2020-01-01 DOI: 10.1515/mgmc-2020-0008
Fazilat Ayambekam, M. Ghashang
Abstract Sodium silicate with the formula of Na2SiO3 was used for the four-component reaction of ketones, aldehydes and cyanoacetamide. The effect of SnFe2O4 nano-particles on the catalytic potential of Na2SiO3 was investigated. The desired products synthesized by this method are 5-amino-7-aryl-2,4-dioxo-2,3,4,4a,7,7a,8,9,10,11-decahydro-1H-benzo[i]quinazoline-6-carbonitriles, 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,10,11-decahydropyrano[3,4-i] quinazoline-6-carbonitrile, 5-amino-9-methyl-2,4-dioxo-7-aryl-2,3,4,4a,7,7a,8,9,10,11-decahydro-1H-pyrido[3,4-i] quinazoline-6-carbonitrile and 5-amino-2,4-dioxo-7-aryl-1,2,3,4,4a,7,7a,8,10,11-decahydrothiopyrano[3,4-i]quinazo-line-6-carbonitrile derivatives. This method has advantages of high yields, simple procedure and easy work-up.
摘要采用Na2SiO3型硅酸钠进行酮、醛和氰基乙酰胺的四组分反应。研究了SnFe2O4纳米粒子对Na2SiO3催化电位的影响。通过该方法合成的所需产物是5-氨基-7-芳基-2,4-二氧代-2,3,4,4a,7,7a,8,9,10,11-十氢-1H-苯并[i]喹唑啉-6-腈,5-氨基-2,4-二氧代-7-芳基-1,2,3,4,4a、7,7a、8,10,11-十氢吡并[3,4-i]喹唑林-6-腈,8,9,10,11-十氢-1H-吡啶并[3,4-i]喹唑啉-6-腈和5-氨基-2,4-二氧代-7-芳基-1,2,3,4,4,4a,7,7a,8,10,11-十氢吡喃并[3,4-i]喹唑林-6-腈衍生物。该方法具有收率高、操作简便、后处理方便等优点。
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引用次数: 0
Topological properties of metal-organic frameworks 金属有机框架的拓扑性质
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2020-01-01 DOI: 10.1515/mgmc-2020-0007
H. Awais, Muhammad Jamal, M. Javaid
Abstract Metal-organic frameworks (MOFs) are porous materials formed by strong bonds between metal ions and organic ligands to represent very high surface area, large pore volume, excellent chemical stability and unique morphology. Work on synthesis, structures and characteristics of many MOFs shows the importance of these frameworks with versatile applications, such as energy storage devices of excellent electrode materials, gas storage, heterogeneous catalysis, environmental hazard, assessment of chemicals and sensing of different gases. A topological property or index is a numerical invariant that predicts the physicochemical properties of the chemical compounds of the underlying molecular graph or framework. Wiener (1947) created the practice of the topological indices (TI’s) in organic molecules with the reference of boiling point of paraffin. In this paper, we study the two different metal-organic frameworks with respect to the number of increasing layers with metal and organic ligands as well. We also compute the generalized Zagreb index and generalized Zagreb connection index of these frameworks. Moreover, the various indices and connection indices are obtained by using the aforesaid generalized versions. At the end, a comparison is also included between the indices and connection indices with the help of numerical values and their 3D plots.
摘要金属有机骨架(MOFs)是由金属离子和有机配体之间的强键形成的多孔材料,具有很高的表面积、大的孔体积、优异的化学稳定性和独特的形貌。对许多MOFs的合成、结构和特性的研究表明,这些框架具有广泛应用的重要性,如优秀电极材料的储能装置、气体储存、多相催化、环境危害、化学品评估和不同气体的传感。拓扑性质或指数是一种数值不变量,用于预测底层分子图或框架的化合物的物理化学性质。Wiener(1947)以石蜡的沸点为参考,创立了有机分子拓扑指数的实践。在本文中,我们研究了两种不同的金属-有机框架与金属和有机配体的增加层数。我们还计算了这些框架的广义Zagreb指数和广义Zagre布连接指数。此外,通过使用上述广义版本来获得各种索引和连接索引。最后,借助数值和它们的3D图,还包括索引和连接索引之间的比较。
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引用次数: 17
New insights into the oxidation of phenoxatellurine with sulfuric acid 硫酸氧化吩恶碲的新见解
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-10-01 DOI: 10.1515/mgmc-2019-0017
Farzin Mostaghimi, Jens Bolsinger, E. Lork, J. Beckmann
Abstract The oxidation of phenoxatellurine (PT) with conc. H2SO4 was reinvestigated. Two crystalline products, namely [PT2][H3O](SO4H)3 (1) and [PT](SO4) (2) were isolated and fully characterized by X-ray crystallography. The structure of 1 features [PT2]2+ dications giving rise to double-decker structures with two parallel PT layers that arise from dimerisation of two radical cations [PT]˙+. The [PT2]2+ dications and the hydrogensulfate ions are associated via secondary Te···O interations. The oxonium ion and the hydrogensulfate ions are involved in hydrogen bonding. The structure of 2 comprises ion pairs consisting of [PT]2+ dications and sulfate ions, which form a 2D coordination polymer. In addition, adjacent sulfate ions in the crystal lattice bind to tellurium atoms via secondary secondary Te···O interations.
摘要/ Abstract摘要:研究了苯草酸钠(PT)的氧化反应。重新研究H2SO4。分离出[PT2][h30](SO4H)3(1)和[PT](SO4)(2)两种结晶产物,并用x射线晶体学对其进行了全面表征。1的结构具有[PT2]2+指示,产生双层结构,两个平行的PT层是由两个自由基阳离子[PT]˙+二聚化产生的。[PT2]2+指示和硫酸氢离子通过Te···O介面结合。氧离子和硫酸氢离子参与了氢键。2的结构包括由[PT]2+指示物和硫酸盐离子组成的离子对,形成二维配位聚合物。此外,晶格中相邻的硫酸盐离子通过仲仲Te··O相互作用与碲原子结合。
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引用次数: 2
DFT/QTAIM analysis of favipiravir adsorption on pristine and silicon doped C20 fullerenes DFT/QTAIM分析favipiravir在原始和掺杂硅的C20富勒烯上的吸附
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-10-01 DOI: 10.1515/mgmc-2019-0016
Ö. Alver, C. Parlak, Y. Umar, P. Ramasami
Abstract Fullerenes have received attentions due to their versatile properties. Molecular structures and electronic properties namely binding energy, band gap, electrophilicity index and molecular topological analysis were studied for undoped and silicon doped C20 fullerenes and favipiravir in order to search for possible application of the systems as drug delivery vehicles. Density functional theory (DFT) and quantum theory of atoms in molecules (QTAIM) were used for the research. Molecular structures having the interaction edges of SiC19… OH in water and SiC19…C=O in gas phase were found as those most stable with binding energies of -57.28 kcal/mol and -43.46 kcal/mol correspondingly. The results and parameters found in this research may provide additional insights into drug delivery systems.
富勒烯由于其多用途的特性而受到人们的关注。研究了未掺杂和掺杂硅的C20富勒烯和favipiravir的分子结构和电子性质,即结合能、带隙、亲电性指数和分子拓扑分析,以寻找该体系作为药物传递载体的可能应用。采用密度泛函理论(DFT)和分子原子量子理论(QTAIM)进行研究。结果表明,水中SiC19. OH和气相SiC19. C=O相互作用边的分子结构最稳定,结合能分别为-57.28 kcal/mol和-43.46 kcal/mol。在这项研究中发现的结果和参数可能为药物输送系统提供额外的见解。
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引用次数: 24
Theoretical insight of alpha amino acid phenylalanine adsorption on pristine and decorated fullerenes α-氨基酸苯丙氨酸在原始富勒烯和修饰富勒烯上吸附的理论见解
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-08-23 DOI: 10.1515/mgmc-2019-0015
M. Kaya, Ö. Alver, C. Parlak, P. Ramasami
Abstract Fullerenes, with their extensive application potentials, have been receiving attention for their possible usage as drug delivery vehicles and devices for sensor technologies. In this work, the optimized molecular geometries, some diagnostic geometric parameters, electronic characteristics, natural bond orbital examinations and the interaction phenomena between C60, Si- or Al-doped C60 and phenylalanine amino acid molecule were investigated by the quantum mechanical calculations. It is observed that the impurity addition and using water as the solvent intensify the interaction between fullerene and amino acid system. These lead to various alterations in the electronic properties and NH stretching values of the clusters studied.
摘要富勒烯具有广泛的应用潜力,因其可能用作药物递送载体和传感器技术的设备而受到关注。本工作通过量子力学计算研究了C60、Si或Al掺杂C60与苯丙氨酸氨基酸分子之间的优化分子几何结构、一些诊断几何参数、电子特性、自然键轨道检查以及相互作用现象。观察到杂质的加入和以水为溶剂增强了富勒烯与氨基酸体系之间的相互作用。这些导致了所研究的团簇的电子性质和NH拉伸值的各种变化。
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引用次数: 2
Toxicity of arsenic on isolated human lymphocytes: The key role of cytokines and intracellular calcium enhancement in arsenic-induced cell death 砷对离体人淋巴细胞的毒性:细胞因子和细胞内钙增强在砷诱导的细胞死亡中的关键作用
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-08-23 DOI: 10.1515/mgmc-2019-0014
M. Zarei, J. Pourahmad, Ehsan Nassireslami
Abstract Arsenic (As) is a semi-metal which causes health problems in human, and immune system has been documented as one of the main target of arsenic toxicity. Apoptosis has a crucial role in regulation of immune system, but it can also have an important role in As immune suppression. So, we decided to assess the comprehensive mechanism of As cytotoxic effect on lymphocytes isolated from human blood. We determine the direct effect of arsenic on human lymphocytes which have a key role in immune system functionality. To evaluate the mechanism of arsenic toxicity on human lymphocytes, we use accelerated cytotoxicity mechanisms screening (ACMS) technique. Lymphocytes were isolated from blood of healthy persons using Ficoll-paque PLUS standard method. Following treatment of human lymphocytes with 0.05-50 μM of arsenic for 12 h, cell viability was measured. For determination of mechanistic parameters, isolated human lymphocytes incubated with 1/2IC5012h (7.5 μM), IC5012h (15 μM) and 2IC5012h (30 μM) for 2, 4 and 6 h. The results of this study demonstrate arsenic-associated apoptosis in human lymphocytes is mainly through enhancement of intracellular calcium which causes oxidative stress and following adverse effect on lymphocytes organelles (like mitochondria and lysosome). Involvement of cellular proteolysis, activation of caspase-3, lipid peroxidation and stimulation of cytokines (IL2, INF-gamma and TNF-alpha) production were also associated with arsenic induced lymphocyte toxicity.
砷是一种危害人体健康的半金属,免疫系统是砷中毒的主要靶点之一。细胞凋亡在免疫系统调控中具有重要作用,但在免疫抑制中也有重要作用。因此,我们决定评估砷对人血淋巴细胞毒性作用的综合机制。我们确定了砷对人体淋巴细胞的直接影响,而淋巴细胞在免疫系统功能中起着关键作用。为了评估砷对人淋巴细胞的毒性作用机制,我们采用了加速细胞毒性机制筛选(ACMS)技术。采用Ficoll-paque PLUS标准方法从健康人血液中分离淋巴细胞。用0.05 ~ 50 μM浓度的砷处理人淋巴细胞12 h后,测定细胞活力。为了确定机制参数,分离的人淋巴细胞在1/2IC5012h (7.5 μM)、IC5012h (15 μM)和2IC5012h (30 μM)下分别培养2、4和6 h。本研究结果表明,砷相关的人淋巴细胞凋亡主要是通过增强细胞内钙引起氧化应激,并对淋巴细胞细胞器(如线粒体和溶酶体)产生不良影响。细胞蛋白水解、caspase-3激活、脂质过氧化和细胞因子(il - 2、inf - γ和tnf - α)产生的刺激也与砷诱导的淋巴细胞毒性有关。
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引用次数: 17
Transition metals doped ZnO nanocluster for ethylene oxide detection: A DFT study 过渡金属掺杂ZnO纳米团簇检测环氧乙烷的DFT研究
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-07-16 DOI: 10.1515/mgmc-2019-0012
Tooba Afshari, M. Mohsennia
Abstract Density functional theory (DFT) studies at B3LYP/6-31G (d) (Becke, 3-parameter, Lee-Yang-Parr) level were performed to evaluate adsorption interactions between ethylene oxide (EO) molecule, and pristine and transition metals (TM) (i.e., Sc, Ti, V, Cr, Mn, Fe, Co, Ni, and Cu) doped ZnO nanocluster (TM-doped Zn12O12). The adsorption energy (Ead), band gap energy (Eg), Mulliken charge transfer (QT) and molecular electrostatic potential (MEP) were calculated to examine the sensitivity of the Zn12O12 and its TM-doped forms toward EO detection. It was found that in contrast to the pristine Zn12O12, the electronic properties of TM-doped Zn12O12 were sharply sensitive to the presence of EO gas molecules. The results revealed that among the studied TM-doped Zn12O12, Cr- and V-doped Zn12O12 have great potential applicability as EO sensor, due to their highest Eg change (ΔEg) values, after the EO adsorption. Moreover, the density of state (DOS) calculations confirmed that strong electronic interaction between Cr- and V-doped Zn12O12 and EO molecules can makes them interesting empirical candidate for detection and adsorptive removal of EO gas molecules.
摘要在B3LYP/6-31G(d)(Becke,3-参数,Lee Yang-Parr)水平上进行了密度泛函理论(DFT)研究,以评估环氧乙烷(EO)分子与原始和过渡金属(TM)(即Sc、Ti、V、Cr、Mn、Fe、Co、Ni和Cu)掺杂的ZnO纳米团簇(TM掺杂的Zn12O12)之间的吸附相互作用。计算了吸附能(Ead)、带隙能(Eg)、穆利肯电荷转移(QT)和分子静电势(MEP),以检验Zn12O12及其TM掺杂形式对EO检测的敏感性。研究发现,与原始的Zn12O12相比,TM掺杂的Zn12O2的电子性质对EO气体分子的存在非常敏感。结果表明,在所研究的TM掺杂的Zn12O12中,Cr和V掺杂的Zn12 O12在EO吸附后具有最高的Eg变化(ΔEg)值,因此具有很大的EO传感器应用潜力。此外,态密度(DOS)计算证实,Cr和V掺杂的Zn12O12与EO分子之间的强电子相互作用可以使它们成为检测和吸附去除EO气体分子的有趣的经验候选者。
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引用次数: 12
Study of solvent effect on structural and photoconductive behavior of ternary chalcogenides InBiS3-In2S3-Bi2S3 composite thin films deposited via AACVD 溶剂对AACVD沉积三元硫族化合物InBiS3-In2S3-Bi2S3复合薄膜结构和光电导行为的影响研究
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-07-16 DOI: 10.1515/mgmc-2019-0011
U. Daraz, T. Ansari, Shafique Ahmad Arain, M. Mansoor, M. Mazhar
Abstract In the present work ternary composite InBiS3-In2S3-Bi2S3 (IBS) thin films are developed using a homogeneous mixture of precursors [Bi(S2CN(C2H5)2)3]2 (1) and [In(S2CNCy2)3]‧2py (2), separately in toluene and chloroform solutions at 500°C under an inert atmosphere of argon gas via aerosol assisted chemical vapor deposition (AACVD) technique. The phase purity, chemical composition and morphological study of both the films deposited from toluene and chloroform solutions are characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and Field emission scanning electron microscopy (FESEM). The surface morphology showed rod like structure of the films developed from toluene while the films grown from chloroform solution give flake like shapes. The UV-visible spectroscopy explicated that the thin films developed from toluene and chloroform solutions show wide range absorption in whole visible region. Linear Scan voltammetry results show that both the films give negligible dark current, however, the films fabricated from toluene solution give a sharp steep curve with maximum photocurrent density of 2.3 mA‧cm-2 at 0.75 V vs Ag/AgCl/3M KCl using 0.05 M sodium sulphide solution under AM 1.5 G illumination (100 mW‧cm-2), while the film grown from chloroform generates a photocurrent density of 2.1 mA‧cm-2 under similar conditions. The LSV outcomes are further supported by electrochemical impedance spectroscopy (EIS) that gives charge transfer resistance (Rct) value of 8,571 Ω for the films developed from toluene as compared to films fabricated from chloroform with Rct value of 12,476 Ω. Graphical Abstract
摘要本文采用气溶胶辅助化学气相沉积(AACVD)技术,将前驱体[Bi(S2CN(C2H5)2)3]2(1)和[In(S2CNCy2)3] 2py(2)的均匀混合物分别置于500°C的甲苯和氯仿溶液中,在惰性氩气气氛下制备了三元复合材料InBiS3-In2S3-Bi2S3 (IBS)薄膜。采用x射线衍射(XRD)、x射线光电子能谱(XPS)、拉曼光谱(Raman spectroscopy)和场发射扫描电镜(FESEM)对甲苯和氯仿溶液制备的膜的相纯度、化学成分和形貌进行了表征。在甲苯溶液中生长的膜表面形貌为棒状,而在氯仿溶液中生长的膜表面形貌为片状。紫外可见光谱分析表明,由甲苯和氯仿溶液制备的薄膜在整个可见光区都有较宽的吸收范围。线性扫描伏安法结果表明,两种薄膜的暗电流均可忽略,但在0.75 V vs Ag/AgCl/3M KCl下,在0.05 M硫化钠溶液下,在AM 1.5 G照明(100 mW·cm-2)下,甲苯溶液制备的薄膜曲线陡峭,最大光电流密度为2.3 mA·cm-2,而氯仿生长的薄膜在相同条件下产生的光电流密度为2.1 mA·cm-2。电化学阻抗谱(EIS)进一步支持了LSV结果,甲苯制备的膜的电荷转移电阻(Rct)值为8,571 Ω,而氯仿制备的膜的Rct值为12,476 Ω。图形抽象
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引用次数: 13
Synthesis, structural characterization, cytotoxicity and encapsulation studies of N,Nʹ-(1, 2-dicyano-1,2-vinylene)-bis(4-hydroxysalicylideneaminato) di(p-chlorobenzyl)tin as potential anticancer drug 潜在抗癌药物N,N′-(1,2-二氰-1,2-乙烯基)-双(4-羟基水杨酸基氨基)二(对氯苯)锡的合成、结构表征、细胞毒性和包封研究
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-07-16 DOI: 10.1515/mgmc-2019-0010
N.A.A. Mohd Amin, Rusnah Syahila Duali Hussen, See Mun Lee, K. Sim, S. Navanesan
Abstract Two new diorganotin(IV) complexes with the general formula (RC7H6)2Sn(L) (where RC7H6 = p-ClBn, C1; and p-FBn, C2) were prepared based on the reaction of 2,3-bis(4-hydroxysalicylidene-amino)-maleic nitrile (L) with substituted dibenzyltin(IV) dichloride. The structures were confirmed by elemental analysis, Fourier transform infrared (FT-IR), proton and carbon nuclear magnetic resonance (1H and 13C NMR). They were tested against several cancer cell lines by using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. C1, which was most effective against MCF-7 breast cancer cell line, was further investigated in formulation and encapsulation studies, including drug encapsulation efficiency, particle size, morphology and in vitro drug release. An encapsulation of about 90% was achieved with particles of 128 nm average diameter. Field emission scanning electron microscopy (FESEM) confirmed a spherical shape for the encapsulated C1. The cumulative drug release over a period of 60 days in phosphate buffered saline (PBS) at pH 7.4 was 75%. Based on these results, the formulated drug has the potential of a slow release drug for cancer chemotherapy.
两种新的二有机锡(IV)配合物,通式为(RC7H6)2Sn(L)(其中RC7H6 = p-ClBn, C1;以2,3-二(4-羟基水杨基-氨基)-马来腈(L)与取代的二氯化二苄基锡(IV)为原料,制备了对- fbn, C2)。通过元素分析、傅里叶红外(FT-IR)、质子核磁共振和碳核磁共振(1H和13C NMR)对其结构进行了确证。使用MTT(3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑)测定法对几种癌细胞系进行了测试。C1对MCF-7乳腺癌细胞系最有效,我们进一步对其进行了配方和包封研究,包括药物包封效率、粒径、形态和体外释药。平均直径为128 nm的颗粒包封率约为90%。场发射扫描电子显微镜(FESEM)证实了封装的C1为球形。在pH 7.4的磷酸盐缓冲盐水(PBS)中,60天的累积药物释放量为75%。基于这些结果,该制剂具有作为癌症化疗缓释药物的潜力。
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引用次数: 3
Thermal rearrangement of a 1,2-bis(silylene): Synthesis and crystal structure of a silyl-silylene 1,2-二(硅烯)的热重排:硅基硅烯的合成和晶体结构
IF 1.8 3区 化学 Q2 Materials Science Pub Date : 2019-07-16 DOI: 10.1515/mgmc-2019-0013
Anastas Sidiropoulos, A. Stasch, Cameron Jones
Abstract Thermal rearrangement of the 1,2-bis(silylene), [{(4-ButPh)C(NDip)2}Si−]2 (Dip = 2,6-diisopropylphenyl, leads to the silyl-silylene, {(4-ButPh)C(NDip)2}Si−Si(H) {N(Dip)C(=NDip)(4-ButPh-H)}, via an intramolecular C−H activation reaction. The X-ray crystal structure, and limited spectroscopic data, for the compound are reported. The structure of the silyl-silylene incorporates an exocyclic imine fragment, which is unprecedented for this compound class.
摘要1,2-双(硅烯)[{(4-ButPh)C(NDip)2}Si−]2 (Dip = 2,6-二异丙基苯基)通过分子内C−H活化反应,热重排得到硅基硅烯{(4-ButPh)C(NDip)2}Si−Si(H) {N(Dip)C(=NDip)(4-ButPh-H)}。报道了该化合物的x射线晶体结构和有限光谱数据。硅基硅烯的结构包含一个外环亚胺片段,这是前所未有的这类化合物。
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引用次数: 2
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Main Group Metal Chemistry
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