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The effects of resistance exercises interventions on quality of life and glycemic control in patients with type 2 diabetes: Systematic review and meta-analysis of randomized controlled trials 阻力运动干预对 2 型糖尿病患者生活质量和血糖控制的影响:随机对照试验的系统回顾和荟萃分析
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2023.12.006
Jun Jia , Yuping Xue , Yu Chen Zhang , Yue Hu , Siqi Liu

Aims

The global burden of diabetes mellitus is escalating rapidly, and the complex comorbidities contribute to a marked decline in patients' quality of life. This review assesses the impact of resistance training on quality of life in type 2 diabetes patients, addressing the ongoing debate over its role in diabetes management and the potential to enhance clinical outcomes.

Methods

Systematic review and meta-analysis of randomized controlled trials regarding assessing effects from resistance training on quality of life among diabetic patients. We systematically searched PubMed, Medline, Web of Science and Embase and the register of controlled trials searched to February 2021. All included studies were randomized controlled trials in adults with type 2 diabetes that assessed the effect of a resistance training on glycemic control and change in health-related quality of life (HRQOL). The HRQOL was measured by validated questionnaires, covering physical and mental components scores, and pooled standardized effect sizes were calculated. Glycemic control measured by the level of Glycated Hemoglobin (HbA1c), and pooled weighted effect sizes were calculated.

Result

9 randomized controlled trials were eligible for the systematic review and our meta-analysis, with 557 participants completed randomized programs data. With random effects meta-analyses model, there was no significant pooled estimate of the standardized mean difference of PCS of quality of life (0.73, 95%CI: −1.19 to 2.65), while in our sensitivity analysis, resistance training had a marginally significantly positive effect on physical components among diabetic patients (0.21, 95%CI: −0.02 to 0.45). Additionally, resistance exercise was non-significantly related with improvement in mental components scores of HRQOL compared with control group (standardized mean difference, (−0.01 (95%CI: −1.25 to 1.23)). With random effects meta-analyses, constructed resistance training intervention did not significantly change the level of HbA1c compared with the control group (−0.22, 95%CI: −0.98 to 0.54)

Conclusion

The resistance/strength training might have the slight positive effect on the PCS of HRQOL among patients with type 2 diabetes, but was non-significantly beneficial for MCS of HRQOL and glycemic control.

目的糖尿病给全球带来的负担正在迅速增加,复杂的并发症导致患者的生活质量明显下降。本综述评估了阻力训练对 2 型糖尿病患者生活质量的影响,探讨了阻力训练在糖尿病管理中的作用以及提高临床疗效的潜力。方法对评估阻力训练对糖尿病患者生活质量影响的随机对照试验进行系统综述和荟萃分析。我们系统地检索了 PubMed、Medline、Web of Science 和 Embase 以及截至 2021 年 2 月的对照试验登记册。所有纳入的研究都是针对成人 2 型糖尿病患者的随机对照试验,这些试验评估了阻力训练对血糖控制和健康相关生活质量(HRQOL)变化的影响。健康相关生活质量(HRQOL)通过有效问卷进行测量,包括身体和精神方面的评分,并计算出汇总的标准化效应大小。通过糖化血红蛋白(HbA1c)水平测量血糖控制情况,并计算汇总加权效应大小。结果9项随机对照试验符合系统综述和荟萃分析的条件,557名参与者完成了随机项目数据。在随机效应荟萃分析模型下,生活质量 PCS 标准化均值差异(0.73,95%CI:-1.19 至 2.65)没有显著的集合估计值,而在我们的敏感性分析中,阻力训练对糖尿病患者的身体成分有轻微显著的积极影响(0.21,95%CI:-0.02 至 0.45)。此外,与对照组相比,阻力训练与改善 HRQOL 的心理因素得分无明显关系(标准化平均差,-0.01(95%CI:-1.25 至 1.23))。结论 阻力/力量训练可能对 2 型糖尿病患者的 HRQOL PCS 有轻微的积极影响,但对 HRQOL MCS 和血糖控制无显著益处。
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引用次数: 0
Editorial Board and Aims & Scopes 编辑委员会和目标与范围
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-04-01 DOI: 10.1016/S1751-9918(24)00046-9
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引用次数: 0
Perceived stress and progression of cardiometabolic risk factors among South Asians with prediabetes in a lifestyle intervention trial 生活方式干预试验中患有糖尿病前期的南亚人对压力的感知和心脏代谢风险因素的发展。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2023.12.002
Nicole D. Fields , K.M. Venkat Narayan , Harish Ranjani , Lisa R. Staimez , Ranjit Mohan Anjana , Shivani A. Patel , Viswanathan Mohan , Mohammed K. Ali , Mary Beth Weber

Aims

To examine associations between perceived stress and cardiometabolic risk factors in South Asians with prediabetes and assess whether a diabetes prevention program mitigates the impact of stress on cardiometabolic health.

Methods

We conducted a secondary analysis of the Diabetes Community Lifestyle Improvement Program, a lifestyle modification trial for diabetes prevention in India (n = 564). Indicators for cardiometabolic health (weight, waist circumference, blood pressure, glucose, HbA1c, and lipids) were measured at each visit while perceived stress was assessed via questionnaire at baseline. Multivariable linear regression assessed associations between stress and cardiometabolic parameters at baseline and 3-year follow up.

Results

At baseline, perceived stress was associated with higher weight (b=0.16; 95% CI: 0.04, 0.29) and waist circumference (b=0.11; 95% CI: 0.01, 0.21) but lower 30-minute postload glucose (b=−0.44; 95% CI: −0.76, −0.14) and LDL cholesterol (b=−0.40; 95% CI: −0.76, −0.03). Over the study period, perceived stress was associated with weight gain (b=0.20; 95% CI: 0.07, 0.33) and increased waist circumference (b=0.14; 95% CI: 0.04, 0.24). Additionally, higher perceived stress was associated with lower HDL cholesterol among the control arm (pinteraction = 0.02).

Conclusions

Baseline stress was associated with negative cardiometabolic risk factor outcomes over time in those with prediabetes.

目的:研究患有糖尿病前期的南亚人感知到的压力与心脏代谢风险因素之间的关系,并评估糖尿病预防计划是否能减轻压力对心脏代谢健康的影响:我们对 "糖尿病社区生活方式改善计划 "进行了二次分析,该计划是印度的一项糖尿病预防生活方式调整试验(n = 564)。在每次就诊时测量心脏代谢健康指标(体重、腰围、血压、血糖、HbA1c 和血脂),同时在基线时通过问卷评估感知压力。多变量线性回归评估了基线和三年随访时压力与心脏代谢参数之间的关系:结果:基线时,感知到的压力与体重(b=0.16;95% CI:0.04,0.29)和腰围(b=0.11;95% CI:0.01,0.21)升高有关,但与 30 分钟负荷后血糖(b=-0.44;95% CI:-0.76,-0.14)和低密度脂蛋白胆固醇(b=-0.40;95% CI:-0.76,-0.03)降低有关。在研究期间,感知到的压力与体重增加(b=0.20;95% CI:0.07,0.33)和腰围增加(b=0.14;95% CI:0.04,0.24)有关。此外,在对照组中,较高的压力感知与较低的高密度脂蛋白胆固醇有关(pinteraction = 0.02):结论:糖尿病前期患者的基线压力与心血管代谢风险因素的长期负面影响有关。
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引用次数: 0
Acanthosis nigricans independently predicts hepatic fibrosis in people with type 2 diabetes in North India 黑棘皮病可独立预测北印度 2 型糖尿病患者的肝纤维化程度
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.003
Koel Dutta , Surya Prakash Bhatt , Swati Madan , Irshad Ahmad Ansari , Kanika Tyagi , Shivam Pandey , Anoop Misra

Background

Acanthosis nigricans (AN) is a skin condition characterized by hyperpigmentation and thickening, often found in individuals with insulin resistance. Despite this well-established association, the potential link between AN and hepatic fibrosis in people with type 2 diabetes (T2D) has yet to be thoroughly explored.

Methodology

We recruited a total of 300 people with T2D, half of whom had AN (n, 150), and the other half without AN (n, 150). We evaluated body composition, biochemistry, and hepatic fat analysis (using the controlled attenuation parameter, CAP), as well as assessments of hepatic stiffness (using the kilopascal, kPa) using Fibroscan. We used multivariable regression analysis to find independent predictors of AN and their relationship to hepatic fibrosis. Furthermore, we developed a prediction equation and AUC for hepatic fibrosis.

Results

Upon comparison between AN vs. NAN group, following were significatly higher; weight, BMI, hepatic transaminases, liver span, CAP, and kPa. After adjusting for age, weight, body mass index, diabetes duration, and specific anti-hyperglycaemic drugs (gliclazide, DPP-4 inhibitors, pioglitazone, and Glucagon-like peptide-1 receptor agonists), adjusted OR for AN were, liver span, 1.78 (95% CI: 0.91–3.49, p = 0.09), CAP, 7.55 (95% CI: 0.93–61.1, p = 0.05), and kPa, 2.47 (95% CI: 1.50–4.06, p = 0.001). A ROC analysis of predictive score for hepatic fibrosis showed optimal sensitivity and specificity at a score cut-off of 25.2 (sensitivity 62%, specificity 63%), with an AUC of 0.6452 (95% CI: 0.61235–0.76420).

Conclusion

Acanthosis nigricans has the potential to be used as an easy-to-identify clinical marker for risk of hepatic fat and fibrosis in Asian Indians with T2D, allowing for early detection and management strategies.

背景黑棘皮病(AN)是一种以色素沉着和增厚为特征的皮肤病,通常出现在胰岛素抵抗患者身上。我们共招募了 300 名 2 型糖尿病患者,其中一半患有黑棘皮病(150 人),另一半没有黑棘皮病(150 人)。我们评估了身体成分、生物化学和肝脏脂肪分析(使用受控衰减参数 CAP),并使用 Fibroscan 评估了肝脏硬度(使用千帕 kPa)。我们使用多变量回归分析找出 AN 的独立预测因素及其与肝纤维化的关系。此外,我们还建立了肝纤维化的预测方程和 AUC。结果在 AN 组与 NAN 组之间进行比较时,体重、体重指数、肝转氨酶、肝跨度、CAP 和 kPa 显著升高。在对年龄、体重、体重指数、糖尿病病程和特定抗高血糖药物(格列齐特、DPP-4 抑制剂、吡格列酮和胰高血糖素样肽-1 受体激动剂)进行调整后,AN 组的调整 OR 值为:肝跨度 1.78(95% CI:0.91-3.49,P = 0.09),CAP,7.55(95% CI:0.93-61.1,P = 0.05),kPa,2.47(95% CI:1.50-4.06,P = 0.001)。对肝纤维化预测评分的 ROC 分析表明,在评分临界值为 25.2 时,灵敏度和特异性最佳(灵敏度 62%,特异性 63%),AUC 为 0.6452(95% CI:0.61235-0.76420)。
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引用次数: 0
Tobacco smoking and diabetes. A comparative survey among diabetologists and smoking cessation specialists 吸烟与糖尿病。一项针对糖尿病专家和戒烟专家的比较调查。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.009
Ivan Berlin , Vincent Durlach , Daniel Thomas , Bruno Vergès , Anne-Laurence Le Faou , on behalf of the Working Group on Smoking and Diabetes

Aims

Because tobacco smoking is a major risk factor of mortality in diabetes and guidelines suggest evaluating smoking behavior among individuals with diabetes and helping smokers quit, we aimed to assess knowledge about the tobacco smoking – diabetes relationship among diabetologists and smoking cessation specialists (SCS).

Methods

An online cross sectional survey was conceived by the Working Group on Smoking and Diabetes, France. The questionnaire was tested by the members of the Working Group and deemed to be completed in less than 5 min. Only questions receiving the highest number of approval ratings were kept for the survey. The questionnaire was sent to all members of the French Language Society of Diabetes (Société Francophone du Diabète, SFD), N = 969 and the French Language Society on Tobacco (Société Francophone de Tabacologie, SFT), N = 307. The mailing lists of members were obtained with the previous agreement of the societies’ board.

Results

225 diabetologists and 97 SCS (response rate 23.2% and 31.5%, respectively) completed the questionnaire. Over 90% of the diabetologists reported recording smoking status of their patients. Although diabetologists were aware that smoking increases all-cause mortality of individuals with diabetes, only 29.3% were aware that smoking is a risk factor for type 2 diabetes (76.3% among SCS), for poor glycemic control: 32.9% (86.6% among SCS). Significantly less diabetologists (64%) than SCS (76.3%) were aware of smoking being a risk factor for microangiopathy. More diabetologists considered that smoking cessation is more important than optimizing glycemic control among individuals with type 2 (69.3%) than among those with type 1 diabetes (47.1%). Few diabetologists (11.1%) and SCS (14.4%) reported to be trained for smoking cessation among persons with diabetes.

Conclusion

Specific knowledge about the negative tobacco smoking – diabetes association seems to be insufficient among French diabetologists. Diabetologists but also other health care professionals should be trained to help individuals with diabetes who smoke to quit smoking.

目的:由于吸烟是糖尿病患者死亡的主要风险因素,而指南建议评估糖尿病患者的吸烟行为并帮助吸烟者戒烟,因此我们旨在评估糖尿病医生和戒烟专家(SCS)对吸烟与糖尿病关系的认识:方法:法国吸烟与糖尿病工作组设计了一项在线横断面调查。工作组成员对问卷进行了测试,认为问卷可在 5 分钟内完成。调查中只保留了获得最高支持率的问题。调查问卷寄给了法语糖尿病学会(Société Francophone du Diabète,SFD)的所有会员(969 人)和法语烟草学会(Société Francophone de Tabacologie,SFT)的所有会员(307 人)。结果:225 名糖尿病医生和 97 名烟草学会会员(回复率分别为 23.2% 和 31.5%)完成了问卷调查。超过 90% 的糖尿病医生表示记录了患者的吸烟情况。虽然糖尿病医生知道吸烟会增加糖尿病患者的全因死亡率,但只有 29.3% 的糖尿病医生知道吸烟是 2 型糖尿病的危险因素(在 SCS 中为 76.3%),知道血糖控制不佳的糖尿病医生为 32.9%(在 SCS 中为 86.6%)。知道吸烟是微血管病变危险因素的糖尿病医生(64%)明显少于 SCS(76.3%)。在 2 型糖尿病患者中,认为戒烟比优化血糖控制更重要的糖尿病专家(69.3%)多于 1 型糖尿病患者(47.1%)。很少有糖尿病医生(11.1%)和 SCS(14.4%)表示接受过针对糖尿病患者的戒烟培训:结论:法国的糖尿病医生对吸烟与糖尿病的负面关系似乎缺乏足够的了解。糖尿病医生和其他医护人员都应接受培训,以帮助吸烟的糖尿病患者戒烟。
{"title":"Tobacco smoking and diabetes. A comparative survey among diabetologists and smoking cessation specialists","authors":"Ivan Berlin ,&nbsp;Vincent Durlach ,&nbsp;Daniel Thomas ,&nbsp;Bruno Vergès ,&nbsp;Anne-Laurence Le Faou ,&nbsp;on behalf of the Working Group on Smoking and Diabetes","doi":"10.1016/j.pcd.2024.01.009","DOIUrl":"10.1016/j.pcd.2024.01.009","url":null,"abstract":"<div><h3>Aims</h3><p>Because tobacco smoking is a major risk factor of mortality in diabetes and guidelines suggest evaluating smoking behavior among individuals with diabetes and helping smokers quit, we aimed to assess knowledge about the tobacco smoking – diabetes relationship among diabetologists and smoking cessation specialists (SCS).</p></div><div><h3>Methods</h3><p>An online cross sectional survey was conceived by the Working Group on Smoking and Diabetes, France. The questionnaire was tested by the members of the Working Group and deemed to be completed in less than 5 min. Only questions receiving the highest number of approval ratings were kept for the survey. The questionnaire was sent to all members of the French Language Society of Diabetes (Société Francophone du Diabète, SFD), N = 969 and the French Language Society on Tobacco (Société Francophone de Tabacologie, SFT), N = 307. The mailing lists of members were obtained with the previous agreement of the societies’ board.</p></div><div><h3>Results</h3><p>225 diabetologists and 97 SCS (response rate 23.2% and 31.5%, respectively) completed the questionnaire. Over 90% of the diabetologists reported recording smoking status of their patients. Although diabetologists were aware that smoking increases all-cause mortality of individuals with diabetes, only 29.3% were aware that smoking is a risk factor for type 2 diabetes (76.3% among SCS), for poor glycemic control: 32.9% (86.6% among SCS). Significantly less diabetologists (64%) than SCS (76.3%) were aware of smoking being a risk factor for microangiopathy. More diabetologists considered that smoking cessation is more important than optimizing glycemic control among individuals with type 2 (69.3%) than among those with type 1 diabetes (47.1%). Few diabetologists (11.1%) and SCS (14.4%) reported to be trained for smoking cessation among persons with diabetes.</p></div><div><h3>Conclusion</h3><p>Specific knowledge about the negative tobacco smoking – diabetes association seems to be insufficient among French diabetologists. Diabetologists but also other health care professionals should be trained to help individuals with diabetes who smoke to quit smoking.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 241-245"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S175199182400010X/pdfft?md5=37161c98aaaf0348698337b1dbfc120c&pid=1-s2.0-S175199182400010X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond diagnosis: Investigating factors influencing health-related quality of life in older people with type 2 diabetes in Slovenia 诊断之外:调查影响斯洛文尼亚 2 型糖尿病老年人健康相关生活质量的因素。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.010
Matic Mihevc , Tina Virtič Potočnik , Črt Zavrnik , Marija Petek Šter , Zalika Klemenc-Ketiš , Antonija Poplas Susič

Aims

To examine the present state of health-related quality of life (HRQOL) among elderly individuals with type 2 diabetes (T2D) receiving integrated care and identify risk factors associated with low HRQOL.

Methods

A multi-centre cross-sectional survey among elderly individuals with T2D, treated in Slovenian urban and rural primary care settings was performed. HRQOL was investigated using EuroQol 5-dimension (EQ-5D) questionnaire and Appraisal of Diabetes Scale (ADS). Furthermore, socio-demographic, clinical, and laboratory data were collected. Low HRQOL was defined as EQ-5D utility score <10%. Statistical analysis was performed using univariate and multivariate binary logistic regression statistics.

Results

Examining 358 people with median age of 72 (range 65–98) years and with a mean EQ-5D utility score of 0.80, the study found that lower HRQOL correlated with older age, higher body mass index (BMI), lower education, elevated depressive symptoms, increased challenges across all EQ-5D dimensions, and less favourable appraisal of diabetes. When considering age, gender, education, and HbA1c, the main predictors of low HRQOL were BMI (OR 1.35, 95% CI 1.04–1.76, p = 0.025) and ADS score (OR 1.63, 95% CI 1.13–2.35, p = 0.009).

Conclusions

To improve HRQOL, integrated care models should consider interventions that target mental health, obesity prevention, chronic pain management, diabetes education, self-management, and treatment plan personalisation.

目的:研究接受综合护理的 2 型糖尿病(T2D)老年患者与健康相关的生活质量(HRQOL)现状,并确定与低 HRQOL 相关的风险因素:方法:对在斯洛文尼亚城乡基层医疗机构接受治疗的 2 型糖尿病老年患者进行了一项多中心横断面调查。方法:对在斯洛文尼亚城市和农村初级医疗机构接受治疗的 T2D 老年患者进行了一项多中心横断面调查,并使用 EuroQol 5 维(EQ-5D)问卷和糖尿病评估量表(ADS)对 HRQOL 进行了调查。此外,还收集了社会人口学、临床和实验室数据。EQ-5D效用得分越高,HRQOL越低:研究发现,较低的 HRQOL 与年龄较大、体重指数(BMI)较高、教育程度较低、抑郁症状加重、EQ-5D 各维度的挑战增加以及对糖尿病的评价较差有关。当考虑到年龄、性别、教育程度和 HbA1c 时,低 HRQOL 的主要预测因素是体重指数(OR 1.35,95% CI 1.04-1.76,p = 0.025)和 ADS 评分(OR 1.63,95% CI 1.13-2.35,p = 0.009):为改善患者的 HRQOL,综合护理模式应考虑针对心理健康、肥胖预防、慢性疼痛管理、糖尿病教育、自我管理和治疗方案个性化的干预措施。
{"title":"Beyond diagnosis: Investigating factors influencing health-related quality of life in older people with type 2 diabetes in Slovenia","authors":"Matic Mihevc ,&nbsp;Tina Virtič Potočnik ,&nbsp;Črt Zavrnik ,&nbsp;Marija Petek Šter ,&nbsp;Zalika Klemenc-Ketiš ,&nbsp;Antonija Poplas Susič","doi":"10.1016/j.pcd.2024.01.010","DOIUrl":"10.1016/j.pcd.2024.01.010","url":null,"abstract":"<div><h3>Aims</h3><p>To examine the present state of health-related quality of life (HRQOL) among elderly individuals with type 2 diabetes (T2D) receiving integrated care and identify risk factors associated with low HRQOL.</p></div><div><h3>Methods</h3><p>A multi-centre cross-sectional survey among elderly individuals with T2D, treated in Slovenian urban and rural primary care settings was performed. HRQOL was investigated using EuroQol 5-dimension (EQ-5D) questionnaire and Appraisal of Diabetes Scale (ADS). Furthermore, socio-demographic, clinical, and laboratory data were collected. Low HRQOL was defined as EQ-5D utility score &lt;10%. Statistical analysis was performed using univariate and multivariate binary logistic regression statistics.</p></div><div><h3>Results</h3><p>Examining 358 people with median age of 72 (range 65–98) years and with a mean EQ-5D utility score of 0.80, the study found that lower HRQOL correlated with older age, higher body mass index (BMI), lower education, elevated depressive symptoms, increased challenges across all EQ-5D dimensions, and less favourable appraisal of diabetes. When considering age, gender, education, and HbA1c, the main predictors of low HRQOL were BMI (OR 1.35, 95% CI 1.04–1.76, p = 0.025) and ADS score (OR 1.63, 95% CI 1.13–2.35, p = 0.009).</p></div><div><h3>Conclusions</h3><p>To improve HRQOL, integrated care models should consider interventions that target mental health, obesity prevention, chronic pain management, diabetes education, self-management, and treatment plan personalisation.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 2","pages":"Pages 157-162"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751991824000111/pdfft?md5=ebcc2f0c82a2f4765703883fbe5d70ff&pid=1-s2.0-S1751991824000111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicausal analysis of mortality due to diabetes mellitus in Spain, 2016-2018 2016-2018年西班牙糖尿病死亡率的多因分析。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-04-01 DOI: 10.1016/j.pcd.2024.01.013
Fernando Álvarez-Guisasola , José A. Quesada , Adriana López-Pineda , Rauf Nouni García , Concepción Carratalá-Munuera , Vicente F. Gil-Guillén , Domingo Orozco-Beltrán

Objectives

This study aimed to assess multicausal mortality due to diabetes from 2016–2018 in Spain. Specific objectives were to quantify the occurrence of diabetes as an underlying cause or as any registered cause on the death certificate.

Materials and methods

A cross-sectional descriptive study taking a multicausal approach.

Results

Diabetes appears as an underlying cause of 2.3% of total deaths in Spain, and as any cause in 6.2%. In patients in whom Diabetes appears as an underlying cause on the death certificates, the 15 most frequent immediate causes are cardiovascular diseases in men(prevalence ratio 1,59)and women (PR1,31). In men, the causes associated with diabetes as any cause were skin diseases(prevalence ratio 1.33), followed by endocrine diseases(prevalence ratio 1.26)and genitourinary diseases (prevalence ratio1.14). In women, the causes associated with the presence of diabetes as any cause were endocrine (prevalence ratio 1.13)and genitourinary (prevalence ratio 1.04)diseases.

Conclusions

In patients in whom diabetes appears as an underlying cause on the death certificates, the 15 most frequent immediate causes are cardiovascular diseases. In men, the causes associated with the presence of diabetes as any cause of death are skin, endocrine and genitourinary diseases. In women, the causes associated with diabetes as any cause are endocrine and genitourinary.

目的:本研究旨在评估2016-2018年西班牙因糖尿病导致的多病因死亡率。具体目标是量化糖尿病作为根本原因或作为死亡证明上任何登记原因的发生率:采用多病因方法进行横断面描述性研究:在西班牙,2.3%的死亡病例的根本原因是糖尿病,6.2%的死亡病例的根本原因是糖尿病。在死亡证明上以糖尿病为根本原因的患者中,15 个最常见的直接原因是心血管疾病,男性(发病率为 1.59),女性(发病率为 1.31)。在男性中,与糖尿病相关的任何病因都是皮肤病(发病率比 1.33),其次是内分泌疾病(发病率比 1.26)和泌尿生殖系统疾病(发病率比 1.14)。在女性患者中,与糖尿病任何病因相关的病因是内分泌疾病(发病率比为 1.13)和泌尿生殖系统疾病(发病率比为 1.04):结论:在死亡证明上以糖尿病为基本病因的患者中,15种最常见的直接病因是心血管疾病。男性死因中与糖尿病相关的是皮肤、内分泌和泌尿生殖系统疾病。在女性中,与糖尿病任何死因相关的病因是内分泌和泌尿生殖系统疾病。
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引用次数: 0
Effects of GLP-1 receptor agonists on the degree of liver fibrosis and CRP in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis GLP-1 受体激动剂对非酒精性脂肪肝和非酒精性脂肪性肝炎患者肝纤维化程度和 CRP 的影响:系统综述和荟萃分析。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-03-30 DOI: 10.1016/j.pcd.2024.03.005
Lixuan Fang , Jine Li , Haixia Zeng , Jianping Liu

Background

Based on the rapidly growing global burden of non-alcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), in order to evaluate the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in the treatment of NAFLD or NASH this paper presents a systematic review and meta-analysis of randomized controlled trials(RCTs).

Methods

In this systematic review and meta-analysis, We searched PubMed, Medline, Web of Science and The Cochrane Library databases. All randomized controlled trials involving GLP-1RAs and NAFLD or NASH were collected since the database was established. A meta-analysis of proportions was done with the generalised linear mixed model. Continuous variables were represented by Mean and Standard Deviation (SD), and binary variable were represented by Relative Risk (RR) and 95% Confidence Interval (CI) as effect indicators. The research results were presented by Revman 5.4. This study is registered with PROSPERO (CRD42023390735).

Finding

We included 16 placebo-controlled or active drug-controlled randomized controlled trials (involving 2178 patients) that used liraglutide, exenatide, dulaglutide, or semaglutie in the treatment of NAFLD or NASH, as measured by liver biopsy or imaging techniques. This study found that the effect of GLP-1RAs on histologic resolution of NASH with no worsening of liver fibrosis (n=2 RCTs; WMD:4.08, 95%CI 2.54–6.56, p < 0.00001) has statistically significant. At the same time, GLP-1RAs affected CRP (n = 7 RCTs; WMD:−0.41, 95% CI-0.78 to −0.04, p =0.002) and other serological indicators were significantly improved.

Conclusion

This study evaluated the efficacy of GLP-1RAs in patients with NAFLD and NASH. These results suggest that GLP-1RAs may be a potential and viable therapeutic approach as a targeted agent to intervene in disease progression of NAFLD and NASH.

背景:鉴于非酒精性脂肪肝(NAFLD)或脂肪性肝炎(NASH)的全球负担迅速增加,为了评估胰高血糖素样肽-1受体激动剂(GLP-1RAs)治疗非酒精性脂肪肝或NASH的疗效,本文对随机对照试验(RCTs)进行了系统综述和荟萃分析:在本系统综述和荟萃分析中,我们检索了 PubMed、Medline、Web of Science 和 Cochrane Library 数据库。收集了自数据库建立以来所有涉及 GLP-1RAs 和非酒精性脂肪肝或 NASH 的随机对照试验。采用广义线性混合模型对比例进行了荟萃分析。连续变量以平均值和标准差(SD)表示,二元变量以相对风险(RR)和95%置信区间(CI)作为效应指标。研究结果由 Revman 5.4 显示。本研究已在 PROSPERO 注册(CRD42023390735):我们纳入了 16 项安慰剂对照或活性药物对照的随机对照试验(涉及 2178 名患者),这些试验使用利拉鲁肽、艾塞那肽、度拉鲁肽或塞马鲁肽治疗非酒精性脂肪肝或非酒精性脂肪肝,以肝脏活检或成像技术进行测量。该研究发现,GLP-1RAs 对 NASH 的组织学缓解、肝纤维化无恶化(n=2 项 RCTs;WMD:4.08,95%CI 2.54-6.56,p <0.00001)具有显著的统计学意义。同时,GLP-1RAs对CRP(n=7 RCTs;WMD:-0.41,95%CI-0.78~-0.04,p=0.002)和其他血清学指标的影响也有明显改善:本研究评估了GLP-1RA对非酒精性脂肪肝和NASH患者的疗效。这些结果表明,作为一种靶向药物,GLP-1RAs 可能是干预非酒精性脂肪肝和 NASH 疾病进展的一种潜在可行的治疗方法。
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引用次数: 0
Diabetes mellitus as a cause of premature death in small areas of Spain by socioeconomic level from 2016 to 2020: A multiple-cause approach 从 2016 年到 2020 年,按社会经济水平划分的糖尿病作为西班牙小地区过早死亡的原因:多原因分析法。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-03-21 DOI: 10.1016/j.pcd.2024.03.004
José A. Quesada , Adriana López-Pineda , Domingo Orozco-Beltrán , Concepción Carratalá-Munuera , Xavier Barber-Vallés , Vicente F. Gil-Guillén , Rauf Nouni-García , Álvaro Carbonell- Soliva

Objective

This study aimed to assess premature mortality due to Diabetes in small areas of Spain between 2016 and 2020, and its relationship with socioeconomic level and the immediate cause of death. As a secondary objective, we evaluated the effect of the Covid 19 pandemic.

Methods

This was an ecological study of premature mortality due to Diabetes from 2016 to 2020, with a focus on small areas. All deaths in people under 75 years of age due to Diabetes as the underlying cause were included

Results

The final sample comprised 7382 premature deaths in 5967 census tracts. Women living in census tracts with an high level of deprivation(RR=2.40) were at a significantly higher risk. Mortality from Diabetes increased with deprivation, especially people aged 0–54(RR=2.40). People with an immediate cause of death related to a circulatory disease, living in census tracts with an high level of deprivation(RR=3.86) was associated with a significantly greater risk of death with underlying Diabetes. When a disease of the circulatory system was recorded as the immediate cause of death, being 65–74 years (RR=71.01) was associated with a significantly higher risk of premature mortality.

Conclusions

Living in geographic areas with higher levels of socioeconomic deprivation is associated with a higher risk of premature death from Diabetes in Spain. This relationship has a greater impact on women, people under 54 years, and people at risk of death caused directly by diseases of the circulatory system. Premature mortality due to diabetes saw a modest increase in 2020.

研究目的本研究旨在评估 2016 年至 2020 年间西班牙小地区因糖尿病导致的过早死亡率,以及该死亡率与社会经济水平和直接死因之间的关系。作为次要目标,我们评估了 Covid 19 大流行的影响:这是一项关于 2016 年至 2020 年糖尿病导致的过早死亡的生态研究,重点关注小地区。结果:最终样本包括 5967 个人口普查区中的 7382 例过早死亡病例。生活在贫困程度较高(RR=2.40)的人口普查区的女性风险明显更高。糖尿病死亡率随着贫困程度的增加而增加,尤其是 0-54 岁的人群(RR=2.40)。直接死因与循环系统疾病有关的人,如果生活在贫困程度较高的人口普查区(RR=3.86),则患潜在糖尿病的死亡风险明显更高。当循环系统疾病被记录为直接死因时,65-74 岁(RR=71.01)的人过早死亡的风险明显更高:结论:在西班牙,生活在社会经济贫困程度较高的地区与较高的糖尿病过早死亡风险有关。这种关系对女性、54 岁以下人群以及循环系统疾病直接导致死亡的高危人群影响更大。2020 年,糖尿病导致的过早死亡人数略有增加。
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引用次数: 0
Compliance with eye and foot preventive care in people with self-reported diabetes in Latin America and the Caribbean: Pooled, cross-sectional analysis of nine national surveys 拉丁美洲和加勒比地区自述糖尿病患者对眼部和足部预防护理的依从性:对九个国家调查的汇总横截面分析。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-03-19 DOI: 10.1016/j.pcd.2024.03.001
Rodrigo M. Carrillo-Larco , Wilmer Cristobal Guzman-Vilca , Jithin Sam Varghese , Francisco J. Pasquel , Roberta Caixeta , Carmen Antini , Antonio Bernabé-Ortiz

Aims

To estimate the proportion of people with self-reported diabetes receiving eye and foot examinations in Latin America and the Caribbean (LAC).

Methods

Cross-sectional analysis of national health surveys in nine countries. Adults aged 25–64 years with self-reported diabetes. We quantified the proportion who reported having an eye examination in the last two years or a foot examination in the last year. We fitted multilevel Poisson regressions to assess socio-demographic (age and sex) and clinical (oral hypoglycemic medication and insulin treatment) variables associated with having had examinations.

Results

There were 7435 people with self-reported diabetes included in the analysis. In three countries (Chile [64%; 95% CI: 56%-71%], British Virgin Islands [58%; 95% CI: 51%-65%], and Brazil [54%; 95% CI: 50%-58%]), >50% of people with diabetes reported having had an eye examination in the last two years. Fewer participants (<50% across all countries) reported having had a foot examination in the last year, with Ecuador having the lowest proportion (12%; 95% CI: 8%-17%). Older people, and those taking oral medication or insulin, were more likely to have eye/foot examinations.

Conclusions

The proportion of eye and foot examinations in people with self-reported diabetes across nine countries in LAC is low.

目的:估算拉丁美洲和加勒比地区(LAC)自我报告的糖尿病患者接受眼部和足部检查的比例:方法:对九个国家的全国健康调查进行横断面分析。调查对象为 25-64 岁自述患有糖尿病的成年人。我们对报告在过去两年中接受过眼科检查或在过去一年中接受过足部检查的比例进行了量化。我们进行了多层次泊松回归,以评估与接受过检查相关的社会人口(年龄和性别)和临床(口服降糖药和胰岛素治疗)变量:共有 7435 名自我报告的糖尿病患者参与了分析。在三个国家(智利[64%;95% CI:56%-71%]、英属维尔京群岛[58%;95% CI:51%-65%]和巴西[54%;95% CI:50%-58%]),超过 50% 的糖尿病患者表示在过去两年中接受过眼科检查。较少参与者(结论:在拉丁美洲和加勒比地区的九个国家中,自我报告的糖尿病患者接受眼部和足部检查的比例较低。
{"title":"Compliance with eye and foot preventive care in people with self-reported diabetes in Latin America and the Caribbean: Pooled, cross-sectional analysis of nine national surveys","authors":"Rodrigo M. Carrillo-Larco ,&nbsp;Wilmer Cristobal Guzman-Vilca ,&nbsp;Jithin Sam Varghese ,&nbsp;Francisco J. Pasquel ,&nbsp;Roberta Caixeta ,&nbsp;Carmen Antini ,&nbsp;Antonio Bernabé-Ortiz","doi":"10.1016/j.pcd.2024.03.001","DOIUrl":"10.1016/j.pcd.2024.03.001","url":null,"abstract":"<div><h3>Aims</h3><p>To estimate the proportion of people with self-reported diabetes receiving eye and foot examinations in Latin America and the Caribbean (LAC).</p></div><div><h3>Methods</h3><p>Cross-sectional analysis of national health surveys in nine countries. Adults aged 25–64 years with self-reported diabetes. We quantified the proportion who reported having an eye examination in the last two years or a foot examination in the last year. We fitted multilevel Poisson regressions to assess socio-demographic (age and sex) and clinical (oral hypoglycemic medication and insulin treatment) variables associated with having had examinations.</p></div><div><h3>Results</h3><p>There were 7435 people with self-reported diabetes included in the analysis. In three countries (Chile [64%; 95% CI: 56%-71%], British Virgin Islands [58%; 95% CI: 51%-65%], and Brazil [54%; 95% CI: 50%-58%]), &gt;50% of people with diabetes reported having had an eye examination in the last two years. Fewer participants (&lt;50% across all countries) reported having had a foot examination in the last year, with Ecuador having the lowest proportion (12%; 95% CI: 8%-17%). Older people, and those taking oral medication or insulin, were more likely to have eye/foot examinations.</p></div><div><h3>Conclusions</h3><p>The proportion of eye and foot examinations in people with self-reported diabetes across nine countries in LAC is low.</p></div>","PeriodicalId":48997,"journal":{"name":"Primary Care Diabetes","volume":"18 3","pages":"Pages 374-379"},"PeriodicalIF":2.9,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Primary Care Diabetes
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