Pub Date : 2020-11-01DOI: 10.23736/S0392-0488.20.06738-3
E. Ozlu, A. Karadağ, B. Aksoy, Serap Gunes Bilgili, M. Gonul, I. Yavuz, E. Şenel, M. Polat, T. Akbulut, Deniz Aksu, Filiz Topaloğlu, B. Tekin, W. C. Chen
BACKGROUND Comparison between disease severity observed by inspectors and the disease burden assessed by patients is scanty in acne study. METHODS In a multicenter prospective hospital-based study, modified Comprehensive Acne Severity Scale (mCASS) and Cardiff Acne Disability Index (CADI) were employed to grade disease severity and to determine the quality of life, respectively. The average of the mCASS and CADI scores, with range at 0-25, was termed as Acne Severity and Impact Grading System (ASIG). RESULTS In 1331 evaluated patients (mean: 21,51±4,93 years), including 306 men and 1025 women, an overall significant, positive correlation was found between ASIG and mCASS (r:0.862), or CADI (r:0.686), respectively (p=0.001 each). Adult women with back acne and adolescent with décolleté expressed greater concern (higher CADI) than the clinical severity (lower mCASS). The overall prevalence of acne in décolleté area, including neck, was 32.3%. CONCLUSIONS Discrepancies in the acne severity between self-perception and objective evaluation exist in certain subgroups of patients. Décolleté acne deserves special attention in clinical assessment.
{"title":"Correlation study between clinical classification and disability index in a holistic evaluation of acne severity and impact in Turkey.","authors":"E. Ozlu, A. Karadağ, B. Aksoy, Serap Gunes Bilgili, M. Gonul, I. Yavuz, E. Şenel, M. Polat, T. Akbulut, Deniz Aksu, Filiz Topaloğlu, B. Tekin, W. C. Chen","doi":"10.23736/S0392-0488.20.06738-3","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06738-3","url":null,"abstract":"BACKGROUND\u0000Comparison between disease severity observed by inspectors and the disease burden assessed by patients is scanty in acne study.\u0000\u0000\u0000METHODS\u0000In a multicenter prospective hospital-based study, modified Comprehensive Acne Severity Scale (mCASS) and Cardiff Acne Disability Index (CADI) were employed to grade disease severity and to determine the quality of life, respectively. The average of the mCASS and CADI scores, with range at 0-25, was termed as Acne Severity and Impact Grading System (ASIG).\u0000\u0000\u0000RESULTS\u0000In 1331 evaluated patients (mean: 21,51±4,93 years), including 306 men and 1025 women, an overall significant, positive correlation was found between ASIG and mCASS (r:0.862), or CADI (r:0.686), respectively (p=0.001 each). Adult women with back acne and adolescent with décolleté expressed greater concern (higher CADI) than the clinical severity (lower mCASS). The overall prevalence of acne in décolleté area, including neck, was 32.3%.\u0000\u0000\u0000CONCLUSIONS\u0000Discrepancies in the acne severity between self-perception and objective evaluation exist in certain subgroups of patients. Décolleté acne deserves special attention in clinical assessment.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77670149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/S0392-0488.20.06537-2
G. Bandini, P. Bernardi, V. Grandi, C. Marchiani, M. Gagliano, S. Bellando Randone, A. Moggi Pignone
{"title":"Mycosis fungoides: from early stages to fatal central nervous system involvement.","authors":"G. Bandini, P. Bernardi, V. Grandi, C. Marchiani, M. Gagliano, S. Bellando Randone, A. Moggi Pignone","doi":"10.23736/S0392-0488.20.06537-2","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06537-2","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86235204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.20.06714-0
N. Milanesi, G. Tronconi, M. Gola, M. L. Flori, F. Russo
{"title":"Impact of dupilumab discontinuation in a patient with atopic prurigo.","authors":"N. Milanesi, G. Tronconi, M. Gola, M. L. Flori, F. Russo","doi":"10.23736/S0392-0488.20.06714-0","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06714-0","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74204455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.20.06683-3
G. Babino, E. Moscarella, M. Agozzino, R. Alfano, G. Argenziano
{"title":"Role of In Vivo Reflectance Confocal Microscopy in the diagnosis of a histopathologic difficult melanoma.","authors":"G. Babino, E. Moscarella, M. Agozzino, R. Alfano, G. Argenziano","doi":"10.23736/S0392-0488.20.06683-3","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06683-3","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77934881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.20.06736-X
C. Schepis, M. Lentini, F. Calì
{"title":"An odd precocious case of Progressive Osseous Heteroplasia.","authors":"C. Schepis, M. Lentini, F. Calì","doi":"10.23736/S0392-0488.20.06736-X","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06736-X","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81831591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.20.06717-6
P. Vitiello, A. Sica, A. Ronchi, Francesco Pastore, Beniamino Casale, G. Argenziano
{"title":"Cutaneous lymphomas management during a covid- 19 pandemic.","authors":"P. Vitiello, A. Sica, A. Ronchi, Francesco Pastore, Beniamino Casale, G. Argenziano","doi":"10.23736/S0392-0488.20.06717-6","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06717-6","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78273475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.20.06727-9
C. Conforti, E. Zelin, A. Dri, L. Toffoli, R. Giuffrida, I. Zalaudek, N. di Meo
{"title":"Hypomelanotic halo melanoma: dermoscopic findings and review.","authors":"C. Conforti, E. Zelin, A. Dri, L. Toffoli, R. Giuffrida, I. Zalaudek, N. di Meo","doi":"10.23736/S0392-0488.20.06727-9","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06727-9","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74208162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.19.06403-4
V. Bolcato, S. Barruscotti, A. de Silvestri, C. Tomasini, V. Brazzelli
BACKGROUND Sézary Syndrome (SS) is a rare and aggressive variant of cutaneous T-cell lymphoma characterized by erythroderma, generalized lymphadenopathy and atypical lymphocytes in peripheral blood. The aim of the study is to describe our experience with SS patients. METHODS 9 SS patients were retrospectively identified within 288 patients with cutaneous Tcell lymphomas (CTCLs) followed from 1977 to 2017 in the Unit of Dermatology, IRCCS Policlinico San Matteo Foundation, Pavia. RESULTS 9 SS patients were described: 5 males and 4 females, mean age at diagnosis 66.1 years (49-87 ys), overall survival (OS) after SS diagnosis was 2.6 years (31.5 ms). All the patients showed erythroderma, pruritus and lymphadenopathy. Palmo-plantar hyperkeratosis, nail lesions, alopecia and ectropion were also present. One patient was excluded for significative differences in management. Three lines treatment -extracorporeal photopheresis plus immunomodulator/s plus photo-photochemotherapy- was the most used first-line option for induction of remission, reached in 4 patients out of 8: 3 with Complete Remission (CR), 1 with Partial Remission (PR). Prognostic variables were investigated by univariate analysis: hypereosinophilia, highly elevated β2μglobulin >3500 μg/l, male sex and highly elevated LDH >450 U/l resulted with statistical power. CONCLUSIONS The improved comprehension of SS pathogenesis is progressively increasing the -still poor- survival: 38.5 months (3.2 years) considering only the 6 patients followed in the last five years, versus overall 31.5 months (2.6 years). The correct identification of SS patients remains determinant for the proper overall management. Among unfavorable prognostic markers, levels of β2μglobulin allow stratification of patients.
{"title":"Sézary Syndrome: a clinico-pathological study of 9 cases and review of the literature.","authors":"V. Bolcato, S. Barruscotti, A. de Silvestri, C. Tomasini, V. Brazzelli","doi":"10.23736/S0392-0488.19.06403-4","DOIUrl":"https://doi.org/10.23736/S0392-0488.19.06403-4","url":null,"abstract":"BACKGROUND\u0000Sézary Syndrome (SS) is a rare and aggressive variant of cutaneous T-cell lymphoma characterized by erythroderma, generalized lymphadenopathy and atypical lymphocytes in peripheral blood. The aim of the study is to describe our experience with SS patients.\u0000\u0000\u0000METHODS\u00009 SS patients were retrospectively identified within 288 patients with cutaneous Tcell lymphomas (CTCLs) followed from 1977 to 2017 in the Unit of Dermatology, IRCCS Policlinico San Matteo Foundation, Pavia.\u0000\u0000\u0000RESULTS\u00009 SS patients were described: 5 males and 4 females, mean age at diagnosis 66.1 years (49-87 ys), overall survival (OS) after SS diagnosis was 2.6 years (31.5 ms). All the patients showed erythroderma, pruritus and lymphadenopathy. Palmo-plantar hyperkeratosis, nail lesions, alopecia and ectropion were also present. One patient was excluded for significative differences in management. Three lines treatment -extracorporeal photopheresis plus immunomodulator/s plus photo-photochemotherapy- was the most used first-line option for induction of remission, reached in 4 patients out of 8: 3 with Complete Remission (CR), 1 with Partial Remission (PR). Prognostic variables were investigated by univariate analysis: hypereosinophilia, highly elevated β2μglobulin >3500 μg/l, male sex and highly elevated LDH >450 U/l resulted with statistical power.\u0000\u0000\u0000CONCLUSIONS\u0000The improved comprehension of SS pathogenesis is progressively increasing the -still poor- survival: 38.5 months (3.2 years) considering only the 6 patients followed in the last five years, versus overall 31.5 months (2.6 years). The correct identification of SS patients remains determinant for the proper overall management. Among unfavorable prognostic markers, levels of β2μglobulin allow stratification of patients.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75117527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.20.06701-2
M. Mazzeo, D. Silvaggio, F. Lozzi, G. Spallone, P. Lombardo, C. Di Raimondo, L. Cerroni, L. Bianchi
{"title":"A case of spontaneous regression of metastatic skin undifferentiated carcinoma.","authors":"M. Mazzeo, D. Silvaggio, F. Lozzi, G. Spallone, P. Lombardo, C. Di Raimondo, L. Cerroni, L. Bianchi","doi":"10.23736/S0392-0488.20.06701-2","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06701-2","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90633534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-21DOI: 10.23736/S0392-0488.20.06585-2
G. Spallone, A. Ventura, M. Mazzeo, C. Di Raimondo, P. Lombardo, D. Silvaggio, L. Bianchi
{"title":"Cancer duplicity: a case of chronic lymphocytic leukemia and metastatic melanoma treated with Ipilimumab.","authors":"G. Spallone, A. Ventura, M. Mazzeo, C. Di Raimondo, P. Lombardo, D. Silvaggio, L. Bianchi","doi":"10.23736/S0392-0488.20.06585-2","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06585-2","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74820711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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