Pub Date : 2020-11-12DOI: 10.23736/S0392-0488.20.06770-X
Sirui Hua, Pengfei Wen, Lin Wang
{"title":"Becker's nevus onset in an adult man on the temporo-parietal-occipital region.","authors":"Sirui Hua, Pengfei Wen, Lin Wang","doi":"10.23736/S0392-0488.20.06770-X","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06770-X","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78627347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-12DOI: 10.23736/S0392-0488.20.06759-0
M. Nocerino, E. Cinelli, M. Megna, G. Fabbrocini, L. Gallo
{"title":"16-year real-life study on the prevalence of mycoses in a paediatric population.","authors":"M. Nocerino, E. Cinelli, M. Megna, G. Fabbrocini, L. Gallo","doi":"10.23736/S0392-0488.20.06759-0","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06759-0","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79794009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-12DOI: 10.23736/S0392-0488.20.06753-X
P. Tschandl
Convolutional neural networks (CNN) have shown unprecedented accuracy in digital image analysis, which can be harnessed for melanoma recognition through automated evaluation of clinical and dermatoscopic images. In experimental studies, modern CNN architectures perform single image analysis at the level of dermatologists and domain-experts, also for multi-class predictions including a multitude of possible diagnoses. This may not necessarily translate to good clinical performance, and reliable randomised controlled prospective clinical trials for modern CNNs are essentially missing. Weaknesses of CNNs are that limitations of available training image datasets propagate to limitations of CNN predictions, and they can not provide a reliable estimate of uncertainty. Recent research focuses on human-computer collaboration, where gains in accuracy were measured even with imperfect CNNs. With missing academic and clinical agreement on equivocal melanocytic lesions, fully automating histologic assessment of them with CNNs appear problematic, and applications in the near future are probably limited to supporting, referencing or recommendation roles.
{"title":"Artificial intelligence for melanoma diagnosis: a review of published studies until 2020.","authors":"P. Tschandl","doi":"10.23736/S0392-0488.20.06753-X","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06753-X","url":null,"abstract":"Convolutional neural networks (CNN) have shown unprecedented accuracy in digital image analysis, which can be harnessed for melanoma recognition through automated evaluation of clinical and dermatoscopic images. In experimental studies, modern CNN architectures perform single image analysis at the level of dermatologists and domain-experts, also for multi-class predictions including a multitude of possible diagnoses. This may not necessarily translate to good clinical performance, and reliable randomised controlled prospective clinical trials for modern CNNs are essentially missing. Weaknesses of CNNs are that limitations of available training image datasets propagate to limitations of CNN predictions, and they can not provide a reliable estimate of uncertainty. Recent research focuses on human-computer collaboration, where gains in accuracy were measured even with imperfect CNNs. With missing academic and clinical agreement on equivocal melanocytic lesions, fully automating histologic assessment of them with CNNs appear problematic, and applications in the near future are probably limited to supporting, referencing or recommendation roles.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85071824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-12DOI: 10.23736/S0392-0488.20.06765-6
L. Tognetti, Corinne Orsini, E. Cinotti, P. Rubegni
{"title":"A strange annular eruption on the back.","authors":"L. Tognetti, Corinne Orsini, E. Cinotti, P. Rubegni","doi":"10.23736/S0392-0488.20.06765-6","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06765-6","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89291311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-12DOI: 10.23736/S0392-0488.20.06743-7
M. Papini, Ada Russo, Y. Natalini, L. Troiani, Lorenzo Cassiani
{"title":"Secukinumab is an effective and safe treatment for refractory pityriasis rubra pilaris: a case report and literature review.","authors":"M. Papini, Ada Russo, Y. Natalini, L. Troiani, Lorenzo Cassiani","doi":"10.23736/S0392-0488.20.06743-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06743-7","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73110599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/S0392-0488.20.06699-7
R. Gallo, F. Guarneri, M. Corazza, D. Schena, L. Stingeni, C. Foti, C. Patruno, A. Signori, A. Parodi
BACKGROUND Sun exposure is the main external risk factor for keratinocytic non-melanoma skin cancer (NMSC). Outdoor workers are at increased risk but the relationship of NMSC with occupational solar exposure is often confounded by concurrent recreational sun exposure. We compared the percentage of outdoor workers in NMSC patients versus controls without history of NMSC and assessed occupational and recreational sun exposure in both groups, evaluating also other risk factors and use of protective measures. METHODS Adult NMSC patients and controls without history of NMSC or actinic keratoses, matched for sex and age range, were recruited in Dermatology Departments of seven Italian University Hospitals, with a 1:2 patient/control ratio whenever possible. Data were collected using specifically designed questionnaires. RESULTS 834 patients and 1563 controls were enrolled. History of outdoor work was significantly (p=0.033) more frequent in patients. Patients were more sun exposed from outdoor leisure activities (p=0.012) and sunbathed for longer periods (p=0.13) and between 12 pm and 3.30 pm (p=0.011). Cumulative sun exposure during hobbies was similar between patients and controls in outdoor workers, higher (p<0.05) in patients among indoor workers. Patients and controls with history of outdoor work were more sun exposed at work than during leisure activities (p<0.001). Use of sunscreens by outdoor workers was very low, particularly at work (19.9%). Patients used sunscreens more than controls (p=0.002). CONCLUSIONS Occupational and recreational sun exposure are relev ant risk factors for outdoor and indoor workers respectively. Sunscreens are alarmingly underused, particularly at work, and are used mainly by patients.
{"title":"Role of occupational and recreational sun exposure as a risk factor for keratinocytic non-melanoma skin cancers: an Italian multicentre case-control study.","authors":"R. Gallo, F. Guarneri, M. Corazza, D. Schena, L. Stingeni, C. Foti, C. Patruno, A. Signori, A. Parodi","doi":"10.23736/S0392-0488.20.06699-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06699-7","url":null,"abstract":"BACKGROUND\u0000Sun exposure is the main external risk factor for keratinocytic non-melanoma skin cancer (NMSC). Outdoor workers are at increased risk but the relationship of NMSC with occupational solar exposure is often confounded by concurrent recreational sun exposure. We compared the percentage of outdoor workers in NMSC patients versus controls without history of NMSC and assessed occupational and recreational sun exposure in both groups, evaluating also other risk factors and use of protective measures.\u0000\u0000\u0000METHODS\u0000Adult NMSC patients and controls without history of NMSC or actinic keratoses, matched for sex and age range, were recruited in Dermatology Departments of seven Italian University Hospitals, with a 1:2 patient/control ratio whenever possible. Data were collected using specifically designed questionnaires.\u0000\u0000\u0000RESULTS\u0000834 patients and 1563 controls were enrolled. History of outdoor work was significantly (p=0.033) more frequent in patients. Patients were more sun exposed from outdoor leisure activities (p=0.012) and sunbathed for longer periods (p=0.13) and between 12 pm and 3.30 pm (p=0.011). Cumulative sun exposure during hobbies was similar between patients and controls in outdoor workers, higher (p<0.05) in patients among indoor workers. Patients and controls with history of outdoor work were more sun exposed at work than during leisure activities (p<0.001). Use of sunscreens by outdoor workers was very low, particularly at work (19.9%). Patients used sunscreens more than controls (p=0.002).\u0000\u0000\u0000CONCLUSIONS\u0000Occupational and recreational sun exposure are relev ant risk factors for outdoor and indoor workers respectively. Sunscreens are alarmingly underused, particularly at work, and are used mainly by patients.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90438791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/S0392-0488.19.06213-8
S. Javor, P. L. Mandolini, R. Gianotti
{"title":"Trichilemmal tumor that arisen after the excision of the sebaceous cyst: come first, the chicken or the egg?","authors":"S. Javor, P. L. Mandolini, R. Gianotti","doi":"10.23736/S0392-0488.19.06213-8","DOIUrl":"https://doi.org/10.23736/S0392-0488.19.06213-8","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80168256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/S0392-0488.20.06760-7
N. Cassano, G. Genovese, R. Asero, N. Crimi, A. Cristaudo, P. Dapavo, O. De Pità, S. Ferrucci, M. Fierro, C. Foti, G. Girolomoni, E. Nettis, A. Offidani, A. Patrizi, P. Pepe, P. Pigatto, L. Stingeni, A. Marzano, G. Vena
BACKGROUND Chronic spontaneous urticaria (CSU) is a heterogeneous condition whose management can be complex and challenging. The 0bjectives is to evaluate physicians' attitudes regarding practical aspects of CSU management, including adherence to international guidelines, criteria and instruments for CSU assessment, prescription of laboratory investigations and role of dietary measures. METHODS A cross-sectional survey was conducted using a study-specific questionnaire. It was administered to a group of physicians with a specialist interest in CSU from different areas of Italy definable as "CSU experts" (Group A; n=21) and subsequently to other physicians who managed CSU only occasionally in their clinical activity (Group B; n=25). RESULTS The EAACI/GA²LEN/EDF/WAO guidelines were considered very or moderately useful by the majority of participants. Significantly more physicians in group A reported that such guidelines were always followed in clinical practice (P=0.0008). Instruments for the assessment of CSU severity/activity and quality of life were used in clinical practice significantly more often by CSU experts as compared to group B. Dietary measures were frequently suggested for CSU patients by nearly three quarters of group B members and by only 5% of CSU experts (P<0.00001). When physicians were asked to indicate the type of laboratory examinations that were commonly performed in patients with longstanding and/or uncontrolled CSU, regardless of history, the investigations most frequently reported were full blood count and thyroid autoantibodies, followed by erythrosedimentation rate and/or C-reactive protein and thyroid function tests. CONCLUSIONS The results of the present pilot survey seem to suggest the heterogeneity of the approaches used for CSU management in clinical practice.
{"title":"Chronic spontaneous urticaria in clinical practice: a pilot survey about attitudes and perceptions on assessment, diagnostic work-up and dietary management.","authors":"N. Cassano, G. Genovese, R. Asero, N. Crimi, A. Cristaudo, P. Dapavo, O. De Pità, S. Ferrucci, M. Fierro, C. Foti, G. Girolomoni, E. Nettis, A. Offidani, A. Patrizi, P. Pepe, P. Pigatto, L. Stingeni, A. Marzano, G. Vena","doi":"10.23736/S0392-0488.20.06760-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06760-7","url":null,"abstract":"BACKGROUND\u0000Chronic spontaneous urticaria (CSU) is a heterogeneous condition whose management can be complex and challenging. The 0bjectives is to evaluate physicians' attitudes regarding practical aspects of CSU management, including adherence to international guidelines, criteria and instruments for CSU assessment, prescription of laboratory investigations and role of dietary measures.\u0000\u0000\u0000METHODS\u0000A cross-sectional survey was conducted using a study-specific questionnaire. It was administered to a group of physicians with a specialist interest in CSU from different areas of Italy definable as \"CSU experts\" (Group A; n=21) and subsequently to other physicians who managed CSU only occasionally in their clinical activity (Group B; n=25).\u0000\u0000\u0000RESULTS\u0000The EAACI/GA²LEN/EDF/WAO guidelines were considered very or moderately useful by the majority of participants. Significantly more physicians in group A reported that such guidelines were always followed in clinical practice (P=0.0008). Instruments for the assessment of CSU severity/activity and quality of life were used in clinical practice significantly more often by CSU experts as compared to group B. Dietary measures were frequently suggested for CSU patients by nearly three quarters of group B members and by only 5% of CSU experts (P<0.00001). When physicians were asked to indicate the type of laboratory examinations that were commonly performed in patients with longstanding and/or uncontrolled CSU, regardless of history, the investigations most frequently reported were full blood count and thyroid autoantibodies, followed by erythrosedimentation rate and/or C-reactive protein and thyroid function tests.\u0000\u0000\u0000CONCLUSIONS\u0000The results of the present pilot survey seem to suggest the heterogeneity of the approaches used for CSU management in clinical practice.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90864401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/S0392-0488.20.06761-9
N. Cassano, G. Genovese, R. Asero, N. Crimi, A. Cristaudo, P. Dapavo, O. De Pità, S. Ferrucci, M. Fierro, C. Foti, G. Girolomoni, E. Nettis, A. Offidani, A. Patrizi, P. Pepe, P. Pigatto, L. Stingeni, A. Marzano, G. Vena
BACKGROUND The therapeutic approaches to patients with chronic spontaneous urticaria (CSU) differ among health care professionals and may be influenced by many factors. OBJECTIVES This cross-sectional survey was aimed at evaluating physicians' attitudes regarding therapeutic management of CSU on clinical practice. METHODS A study-specific questionnaire was administered to a group of physicians (n=21) with a specialist interest in CSU from different areas of Italy (Group A) and also to other physicians (n=25) who manage CSU only occasionally in their clinical activity (Group B). RESULTS In case of ineffectiveness of second-generation antihistamines at standard doses, higher doses of the same drug were always or frequently prescribed by most physicians in both groups, and 64% in group B and one third in group A usually increased the dose up to twice. Old-generation antihistamines were never used in clinical practice by 14% of survey participants in group A and 24% in group B, with the remaining physicians reporting rare or occasional uses. The prescription of systemic corticosteroids appeared to be more common among physicians in group B. The question concerning the use of alternative drugs in refractory CSU produced different answers between the two groups. Costs and access to specialist reference centers were indicated as the most important barriers to the use of medications different from antihistamines. CONCLUSIONS These preliminary results suggest that therapeutic approaches to CSU seem to be heterogeneous in clinical practice and could be at least in part conditioned by the different medical settings where physicians usually work.
{"title":"Therapeutic management of chronic spontaneous urticaria in clinical practice: results from a pilot survey.","authors":"N. Cassano, G. Genovese, R. Asero, N. Crimi, A. Cristaudo, P. Dapavo, O. De Pità, S. Ferrucci, M. Fierro, C. Foti, G. Girolomoni, E. Nettis, A. Offidani, A. Patrizi, P. Pepe, P. Pigatto, L. Stingeni, A. Marzano, G. Vena","doi":"10.23736/S0392-0488.20.06761-9","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06761-9","url":null,"abstract":"BACKGROUND\u0000The therapeutic approaches to patients with chronic spontaneous urticaria (CSU) differ among health care professionals and may be influenced by many factors.\u0000\u0000\u0000OBJECTIVES\u0000This cross-sectional survey was aimed at evaluating physicians' attitudes regarding therapeutic management of CSU on clinical practice.\u0000\u0000\u0000METHODS\u0000A study-specific questionnaire was administered to a group of physicians (n=21) with a specialist interest in CSU from different areas of Italy (Group A) and also to other physicians (n=25) who manage CSU only occasionally in their clinical activity (Group B).\u0000\u0000\u0000RESULTS\u0000In case of ineffectiveness of second-generation antihistamines at standard doses, higher doses of the same drug were always or frequently prescribed by most physicians in both groups, and 64% in group B and one third in group A usually increased the dose up to twice. Old-generation antihistamines were never used in clinical practice by 14% of survey participants in group A and 24% in group B, with the remaining physicians reporting rare or occasional uses. The prescription of systemic corticosteroids appeared to be more common among physicians in group B. The question concerning the use of alternative drugs in refractory CSU produced different answers between the two groups. Costs and access to specialist reference centers were indicated as the most important barriers to the use of medications different from antihistamines.\u0000\u0000\u0000CONCLUSIONS\u0000These preliminary results suggest that therapeutic approaches to CSU seem to be heterogeneous in clinical practice and could be at least in part conditioned by the different medical settings where physicians usually work.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82936027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.23736/S0392-0488.20.06871-6
F. Filippi, C. Zengarini, L. Sacchelli, F. Bardazzi
{"title":"Unexpected improvements of Parkinson's symptoms in a psoriatic patient during dimethyl fumarate therapy.","authors":"F. Filippi, C. Zengarini, L. Sacchelli, F. Bardazzi","doi":"10.23736/S0392-0488.20.06871-6","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06871-6","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79508957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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