Pub Date : 2026-02-25DOI: 10.1186/s12931-025-03481-6
Stefanie Graeter, Nathalia Gonzalez-Jaramillo, Mattheus H E Wildschut, Luigi Capriotti, Moritz Saxenhofer, Jose Ramon Robador, Katherine Monaghan, Naomi Woodman, Judith Field, Nick Wilson, Megan Rees, Maria Hauswald, Carlos P Roca, Annette Feussner, Ilka Schulze, Alastair Stewart, Alexander Schaub, Samantha Chan, Jo A Douglass, Anna Schnell
{"title":"Distinct pulmonary pathophysiological mechanisms in COPD, bronchiectasis, and primary immunodeficiency: a multi-omics investigation of disease heterogeneity via sputum and blood profiling.","authors":"Stefanie Graeter, Nathalia Gonzalez-Jaramillo, Mattheus H E Wildschut, Luigi Capriotti, Moritz Saxenhofer, Jose Ramon Robador, Katherine Monaghan, Naomi Woodman, Judith Field, Nick Wilson, Megan Rees, Maria Hauswald, Carlos P Roca, Annette Feussner, Ilka Schulze, Alastair Stewart, Alexander Schaub, Samantha Chan, Jo A Douglass, Anna Schnell","doi":"10.1186/s12931-025-03481-6","DOIUrl":"https://doi.org/10.1186/s12931-025-03481-6","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-25DOI: 10.1186/s12931-026-03588-4
Eva Tosco-Herrera, Luis A Rubio-Rodríguez, Adrián Muñoz-Barrera, David Jáspez, Eva Suárez-Pajes, Almudena Corrales, Aitana Alonso-González, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Leonardo Lorente, María M Martín, Jordi Solé-Violán, Carlos Rodríguez-Gallego, Elena González-Higueras, Elena Espinosa, Arturo Muriel-Bombin, David Domínguez, Marina Soro, Tamara Hernández-Beeftink, José M Añón, Jesús Villar, Beatriz Guillén-Guio, Itahisa Marcelino-Rodríguez, José M Lorenzo-Salazar, Rafaela González-Montelongo, Carlos Flores
{"title":"Rare genetic variant risks in patients with sepsis-associated acute respiratory distress syndrome.","authors":"Eva Tosco-Herrera, Luis A Rubio-Rodríguez, Adrián Muñoz-Barrera, David Jáspez, Eva Suárez-Pajes, Almudena Corrales, Aitana Alonso-González, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Leonardo Lorente, María M Martín, Jordi Solé-Violán, Carlos Rodríguez-Gallego, Elena González-Higueras, Elena Espinosa, Arturo Muriel-Bombin, David Domínguez, Marina Soro, Tamara Hernández-Beeftink, José M Añón, Jesús Villar, Beatriz Guillén-Guio, Itahisa Marcelino-Rodríguez, José M Lorenzo-Salazar, Rafaela González-Montelongo, Carlos Flores","doi":"10.1186/s12931-026-03588-4","DOIUrl":"https://doi.org/10.1186/s12931-026-03588-4","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"National and provincial burden of interstitial lung disease mortality in China, 2013-2021: a nationwide analysis of trends and underlying cause of death.","authors":"Fanshu Yan, Lingling Yu, Zifang Zhou, Lijun Wang, Maigeng Zhou, Zhuoli Zhang, Peng Yin","doi":"10.1186/s12931-026-03580-y","DOIUrl":"https://doi.org/10.1186/s12931-026-03580-y","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-25DOI: 10.1186/s12931-026-03590-w
Dana Unninayar, Oluwafemi Segun-Ige, Luana Leticia Teixeira Nunes Porto, Beverley Shea, Donald William Cameron, Juthaporn Cowan
{"title":"Levels of immunoglobulin isotypes in serum and respiratory samples of patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.","authors":"Dana Unninayar, Oluwafemi Segun-Ige, Luana Leticia Teixeira Nunes Porto, Beverley Shea, Donald William Cameron, Juthaporn Cowan","doi":"10.1186/s12931-026-03590-w","DOIUrl":"https://doi.org/10.1186/s12931-026-03590-w","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-25DOI: 10.1186/s12931-025-03471-8
Sung Woo Moon, Minhong Kim, Eun Young Kim, Chaeeun Kang, Ju Hye Shin, Kangjin Kim, Sungho Won, Hana Yi, Ji Ye Jung
Background: The lung microbiome is increasingly implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. However, its long-term dynamics and interactions with key clinical features-including inhaled corticosteroid (ICS) use, smoking, and lung function-remain poorly defined.
Methods: We conducted a prospective two-year study of 43 Korean male patients with COPD who provided sputum samples annually (n = 129). Bacterial communities were profiled using 16S rRNA gene sequencing. Associations between microbial composition and clinical characteristics-including inhaled corticosteroid (ICS) use, smoking status, lung function (FEV₁), and recent exacerbations-were evaluated using negative binomial mixed models (NBMMs) with and without time interaction terms, adjusting for potential confounders.
Results: At baseline, overall microbial diversity did not significantly differ between patients with COPD and ex-smoker controls without airflow limitation; however, several low-abundance genera showed differential abundance. Cross-sectional NBMMs revealed that ICS use, current smoking, and reduced FEV₁ % predicted were associated with distinct taxonomic profiles. ICS use was associated with reduced relative abundances of Veillonella, Catonella, and Saccharimonas. Persistent smoking was linked to increased abundances of Actinomyces and Bulleidia and decreased Lautropia. Patients with FEV₁ % predicted < 50% exhibited lower Alloprevotella levels. In longitudinal models, ICS use was associated with increasing temporal trends in Megasphaera and Alloprevotella. Persistent smokers showed attenuated changes in Butyrivibrio and Pseudomonas, while those with severe airflow limitation exhibited increased Bacteroides and decreased Atopobium, Gemella, Kingella, and Tannerella over time. Acute exacerbations were not significantly associated with microbial composition at baseline or during follow-up.
Conclusions: Clinical factors in COPD are associated with distinct temporal shifts in the airway microbiome of patients with COPD. Longitudinal profiling combined with NBMMs with time-interaction terms revealed subtle microbial shifts with potential clinical implications that were not evident in cross-sectional analyses. These findings underscore the potential utility of temporal microbiome signatures in stratifying COPD patients and guiding future therapeutic strategies.
{"title":"Longitudinal change of lung microbiome in chronic obstructive pulmonary disease: a prospective cohort study.","authors":"Sung Woo Moon, Minhong Kim, Eun Young Kim, Chaeeun Kang, Ju Hye Shin, Kangjin Kim, Sungho Won, Hana Yi, Ji Ye Jung","doi":"10.1186/s12931-025-03471-8","DOIUrl":"https://doi.org/10.1186/s12931-025-03471-8","url":null,"abstract":"<p><strong>Background: </strong>The lung microbiome is increasingly implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. However, its long-term dynamics and interactions with key clinical features-including inhaled corticosteroid (ICS) use, smoking, and lung function-remain poorly defined.</p><p><strong>Methods: </strong>We conducted a prospective two-year study of 43 Korean male patients with COPD who provided sputum samples annually (n = 129). Bacterial communities were profiled using 16S rRNA gene sequencing. Associations between microbial composition and clinical characteristics-including inhaled corticosteroid (ICS) use, smoking status, lung function (FEV₁), and recent exacerbations-were evaluated using negative binomial mixed models (NBMMs) with and without time interaction terms, adjusting for potential confounders.</p><p><strong>Results: </strong>At baseline, overall microbial diversity did not significantly differ between patients with COPD and ex-smoker controls without airflow limitation; however, several low-abundance genera showed differential abundance. Cross-sectional NBMMs revealed that ICS use, current smoking, and reduced FEV₁ % predicted were associated with distinct taxonomic profiles. ICS use was associated with reduced relative abundances of Veillonella, Catonella, and Saccharimonas. Persistent smoking was linked to increased abundances of Actinomyces and Bulleidia and decreased Lautropia. Patients with FEV₁ % predicted < 50% exhibited lower Alloprevotella levels. In longitudinal models, ICS use was associated with increasing temporal trends in Megasphaera and Alloprevotella. Persistent smokers showed attenuated changes in Butyrivibrio and Pseudomonas, while those with severe airflow limitation exhibited increased Bacteroides and decreased Atopobium, Gemella, Kingella, and Tannerella over time. Acute exacerbations were not significantly associated with microbial composition at baseline or during follow-up.</p><p><strong>Conclusions: </strong>Clinical factors in COPD are associated with distinct temporal shifts in the airway microbiome of patients with COPD. Longitudinal profiling combined with NBMMs with time-interaction terms revealed subtle microbial shifts with potential clinical implications that were not evident in cross-sectional analyses. These findings underscore the potential utility of temporal microbiome signatures in stratifying COPD patients and guiding future therapeutic strategies.</p>","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-24DOI: 10.1186/s12931-026-03576-8
May-Lin Wilgus, Andrew Edmonds, Kayleigh P Keller, Jessica L Elf, Alison G Abraham, Surya P Bhatt, Russell G Buhr, Mardge H Cohen, Roger Detels, M Bradley Drummond, Margaret A Fischl, Robert Foronjy, H Dean Hosgood, Laurence Huang, Ken M Kunisaki, Meredith McCormack, Alison Morris, Sarath Raju, Catalina Ramirez, Jacqueline Rudolph, Valentina Stosor, Donald P Tashkin, Adam Visconti, Sheri D Weiser, Gina Wingood, Igor Barjaktarevic
{"title":"Correction to: Greater ambient air pollution exposure is associated with worse respiratory symptoms in men and women with HIV and chronic lung disease: a cohort study.","authors":"May-Lin Wilgus, Andrew Edmonds, Kayleigh P Keller, Jessica L Elf, Alison G Abraham, Surya P Bhatt, Russell G Buhr, Mardge H Cohen, Roger Detels, M Bradley Drummond, Margaret A Fischl, Robert Foronjy, H Dean Hosgood, Laurence Huang, Ken M Kunisaki, Meredith McCormack, Alison Morris, Sarath Raju, Catalina Ramirez, Jacqueline Rudolph, Valentina Stosor, Donald P Tashkin, Adam Visconti, Sheri D Weiser, Gina Wingood, Igor Barjaktarevic","doi":"10.1186/s12931-026-03576-8","DOIUrl":"10.1186/s12931-026-03576-8","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":"27 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-21DOI: 10.1186/s12931-026-03587-5
Yunjuan Wang, Xuan Liu, Xiaoqian Li, Juan Liu, Zili Lei, Yanhong Yang
{"title":"EpCAM deficiency causes the inflammation of lungs due to the reduction of pIgR in airway epithelium.","authors":"Yunjuan Wang, Xuan Liu, Xiaoqian Li, Juan Liu, Zili Lei, Yanhong Yang","doi":"10.1186/s12931-026-03587-5","DOIUrl":"https://doi.org/10.1186/s12931-026-03587-5","url":null,"abstract":"","PeriodicalId":49131,"journal":{"name":"Respiratory Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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