Respiratory Research最新文献

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Clinical subtypes of co-morbid insomnia and obstructive sleep apnea (COMISA): results of a cluster analysis. 失眠和阻塞性睡眠呼吸暂停（COMISA）共病的临床亚型：聚类分析的结果

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-12 DOI: 10.1186/s12931-026-03577-7

Yuan Shi, Xujun Feng, Fengyi Hao, Yuru Nie, Yihui Zhang, Zhaohua Chen, Siqi Guan, Larry D Sanford, Michael V Vitiello, Xiangdong Tang

引用次数: 0

The association between long-term exposure to ozone and respiratory morbidity in Chinese adults: a nationwide cross-sectional study. 中国成人长期接触臭氧与呼吸道疾病之间的关系：一项全国性的横断面研究。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-12 DOI: 10.1186/s12931-026-03549-x

Xinran Shan, Jisong Yan, Xueyan Han, Hailu Zhu, Zhaoyang Pan, Linhong Pang, Zijun Li, Yicong Wang, Qi Wang, Ke Huang, Tianjia Guan, Ting Yang, Chen Wang

Background: Long-term ozone (O₃) exposure is known to be associated with respiratory mortality and hospitalization, but its effects on respiratory morbidity, symptom severity, and quality of life remain undefined.

Methods: This study was conducted using data from the China Pulmonary Health (CPH) study. Respiratory morbidity was measured by the COPD Assessment Test (CAT) scores, the modified Medical Research Council (mMRC) dyspnea scale, and spirometry-defined COPD. Health-related quality of life was also considered. Long-term O₃ exposure was defined as the annual average of daily maximum 8-hour average (MDA8) O₃ concentrations in the year prior to the survey. Logistic and linear regression models were used to explore the association between long-term O₃ exposure and the health outcomes.

Results: Each 10 µg/m³ increase in O₃ was associated with increased odds of CAT ≥ 10 (measured in participants with a post-bronchodilator FEV₁/FVC ratio less than 0.8; OR = 1.09, 95% CI:1.00, 1.18), mMRC ≥ 1 (OR = 1.13, 95% CI:1.04, 1.22), and COPD (OR = 1.11, 95% CI:1.05, 1.17), as well as a 0.55-point decline in SF-12 PCS (95% CI: -0.71, -0.39). Positive associations were also observed for some single CAT items. Female and younger participants were identified as subgroups particularly vulnerable to O₃.

Conclusion: Long-term O₃ exposure was associated with the presence of respiratory symptoms, increased prevalence of spirometry-defined COPD, and poorer quality of life. These findings underscore the importance of raising awareness of the respiratory effects of O₃ exposure and the need for O₃ control.

Trial registration: Not applicable.

背景：已知长期臭氧（O3）暴露与呼吸系统死亡率和住院有关，但其对呼吸系统发病率、症状严重程度和生活质量的影响尚不明确。方法：本研究使用中国肺健康（CPH）研究的数据进行。通过COPD评估测试（CAT）评分、修改后的医学研究委员会（mMRC）呼吸困难量表和肺活量测定法定义的COPD来测量呼吸系统发病率。还考虑了与健康有关的生活质量。长期臭氧暴露定义为调查前一年每日最大8小时平均值（MDA8）臭氧浓度的年平均值。采用Logistic和线性回归模型探讨长期臭氧暴露与健康结果之间的关系。结果：O3每增加10µg/m3，与CAT≥10（在支气管扩张剂后FEV1/FVC比值小于0.8的受试者中测量；OR = 1.09, 95% CI:1.00, 1.18）、mMRC≥1 （OR = 1.13, 95% CI:1.04, 1.22）和COPD （OR = 1.11, 95% CI:1.05, 1.17）的几率增加相关，以及SF-12 PCS下降0.55点（95% CI: -0.71, -0.39）。在一些单一CAT项目中也观察到正相关。女性和更年轻的参与者被确定为特别容易受到O3影响的亚群体。结论：长期臭氧暴露与呼吸道症状的出现、肺活量测定定义的COPD患病率增加以及生活质量下降有关。这些发现强调了提高对臭氧暴露对呼吸系统影响的认识和控制臭氧的必要性的重要性。试验注册：不适用。

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引用次数: 0

Multi-omics integration study of vascular smooth muscle cell phenotypic conversion identified novel biomarkers in idiopathic pulmonary arterial hypertension. 血管平滑肌细胞表型转化的多组学整合研究发现了特发性肺动脉高压的新生物标志物。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-12 DOI: 10.1186/s12931-026-03568-8

Ruhao Wu, Ke Wang, Mingwei Fan, Ruohan Jia, Yuanying Ma, Congying Yuan, Meichen Yu, Mingzhou Guo, Tianci Jiang, Yu Wang, Yue Li, Pengfei Li, Yichen Liu, Youyou Gong, Zhe Cheng

引用次数: 0

SPECT as a translational non-invasive method to assess occupancy of the tissue transglutaminase-2 by zampilimab in the mouse lung. SPECT作为一种翻译的无创方法来评估赞匹利单抗在小鼠肺组织中谷氨酰胺转氨酶-2的占用。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-12 DOI: 10.1186/s12931-026-03566-w

Pierre-Simon Bellaye, Erica Ferrini, Michaël Claron, Alexandre Dias, Costanza Bonfini, Gino Villetti, Anna Maria Capelli, Timothy Johnson, Bertrand Collin, Franco Fabio Stellari

引用次数: 0

Serum CA125 is independently associated with adverse outcomes in primary Sjögren's syndrome-associated interstitial lung disease: a prospective multicenter cohort study. 血清CA125与原发性Sjögren综合征相关性间质性肺病的不良结局独立相关：一项前瞻性多中心队列研究

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-12 DOI: 10.1186/s12931-026-03573-x

Wenyan Meng, Jing Geng, Xueying Chen, Huaping Dai

Background: Primary Sjögren's syndrome-associated interstitial lung disease (pSS-ILD) shows heterogeneous patterns and variable prognosis. We previously observed elevated serum CA125 in pSS-ILD. This study investigated whether CA125 predicts adverse outcomes in pSS-ILD.

Methods: Data were derived from the ILD-China cohort (ClinicalTrials.gov: NCT04370158). Among enrolled pSS-ILD patients, a total of 395 with follow-up data were included. The adverse outcomes were death or lung transplantation (LTx). Associations were evaluated using Cox proportional hazards models, with restricted cubic splines to assess nonlinearity.

Results: Among 395 patients, 87 experienced adverse outcomes (83 deaths and 4 LTx). CA125 levels were higher in patients with adverse outcomes and were associated with indices of disease severity. In ROC analysis, CA125 showed the highest discrimination among the evaluated biomarkers (AUC 0.764), with a higher AUC than KL-6 (0.580). In multivariable Cox models, higher CA125 modeled as a continuous biomarker was independently associated with adverse outcomes (adjusted HR 1.005 per 1 U/mL increase, 95% CI 1.002-1.007; P < 0.001), corresponding to an approximately 5% higher hazard per 10 U/mL increase. Spline analysis supported a nonlinear relationship between CA125 and hazard.

Conclusions: Higher serum CA125 is independently associated with adverse outcomes in pSS-ILD, with evidence of a nonlinear exposure-hazard relationship. CA125 may aid prognostic assessment in pSS-ILD.

Trial registration: Clinical trials.govs: NCT04370158, Registration date: 30 April 2020.

背景：原发性Sjögren综合征相关性间质性肺疾病（pSS-ILD）表现出异质性模式和不同的预后。我们之前观察到pSS-ILD患者血清CA125升高。本研究探讨CA125是否能预测pSS-ILD的不良结局。方法：数据来自ILD-China队列（ClinicalTrials.gov: NCT04370158）。在入组的pSS-ILD患者中，共纳入395例随访数据。不良结局为死亡或肺移植（LTx）。使用Cox比例风险模型评估相关性，限制三次样条评估非线性。结果：395例患者中，87例出现不良结局（83例死亡，4例LTx）。不良结局患者的CA125水平较高，且与疾病严重程度指标相关。在ROC分析中，CA125在评价的生物标志物中具有最高的区分性（AUC为0.764），其AUC高于KL-6（0.580）。在多变量Cox模型中，较高的CA125作为连续生物标志物建模与不良结局独立相关(每增加1 U/mL调整HR 1.005, 95% CI 1.002-1.007； P结论：血清CA125升高与pSS-ILD的不良结局独立相关，有证据表明存在非线性暴露-危害关系。CA125可能有助于pSS-ILD的预后评估。试验注册：Clinical trials.gov: NCT04370158，注册日期：2020年4月30日。

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引用次数: 0

E-cigarette switching in COPD: reduced cardiovascular events without improvement in respiratory outcomes. COPD患者改用电子烟：减少心血管事件，但不改善呼吸预后。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-12 DOI: 10.1186/s12931-026-03545-1

Taeyun Kim, Hyunsoo Kim, Sun Hye Shin, Seoyoung Choi, Eunji Jeong, Chaiyoung Lee, Danbee Kang, Hye Yun Park

引用次数: 0

Estimation of the global chronic obstructive pulmonary disease attributable to air pollution and projection in 2030: an analysis for the global burden of disease study 2021. 2030年由空气污染导致的全球慢性阻塞性肺病的估计和预测：对2021年全球疾病负担研究的分析

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-11 DOI: 10.1186/s12931-026-03550-4

Dong-Xue Ruan, Jian-Sen Li, De-Jian Zhao, Yong-Cheng Li, Shu-Jun Guo, Hong-Jun Huang, Wei-Jie Guan, Xue-Yan Zheng

引用次数: 0

Ultra-high-resolution synchrotron phase-contrast CT enables microstructural pulmonary imaging at clinical dose levels. 超高分辨率同步加速器相衬CT可实现临床剂量水平的肺微结构成像。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-11 DOI: 10.1186/s12931-026-03561-1

Claudia Victoria Benke, Johanna Reiser, Lorenzo D'Amico, Md Motiur Rahman Sagar, Nicola Sodini, Diego Dreossi, Adriano Contillo, Elena Longo, Marko Prašek, Stephan Stern, Elisa Baratella, Maria Assunta Cova, Marco Confalonieri, Paola Confalonieri, Fabrizio Zanconati, Stefano D'Errico, Davide Radaelli, Tommaso Bruscagin, Deborah Bonazza, Sam Bayat, Philipp Nolte, Lavinia Neubert, Christina Petzold-Mügge, Christopher Werlein, Lars Knudsen, Hoen-Oh Shin, Jan-Christopher Kamp, Ali Seif Amir Hosseini, Willi Linus Wagner, Mark Oliver Wielpütz, Jürgen Biederer, Hans-Ulrich Kauczor, Frauke Alves, Giuliana Tromba, Christian Dullin

引用次数: 0

EIF3B regulates the cell cycle of lung adenocarcinoma cells by activating the GTSE1 mediated ERK/MAPK pathway. EIF3B通过激活GTSE1介导的ERK/MAPK通路调控肺腺癌细胞的细胞周期。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-11 DOI: 10.1186/s12931-026-03559-9

Yingru Xing, Zhao Feng, Ying Zhang, Jing Dai, Zichao Bao, Cheng Tao, Jingjing Dai, Haizhou Wang

引用次数: 0

A deep learning model based on ultrasound imaging to differentiate malignant from benign pleural effusion: a multicenter cohort study. 基于超声成像的深度学习模型鉴别恶性与良性胸腔积液：一项多中心队列研究。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research

Pub Date : 2026-02-11 DOI: 10.1186/s12931-026-03574-w

Chang-Wei Wu, Chia-Suan Yu, Yen-Lin Chen, Po-Chih Kuo, Meng-Rui Lee, Jann-Yuan Wang, Chao-Chi Ho, Jin-Yuan Shih, Hao-Chien Wang

引用次数: 0

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