Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova最新文献

The study was performed on a contagious behavior model based on drinking, behavior in rats. In the presence of familiar drink-motivated conspecific showing drinking behavior (rat-demonstrator), drink-unmotivated rat-viewer begins to demonstrate behavioral signs ofdrinking motivation that is the signs of behavioral contagion. In this paper; the changes in the ethogram of rats-viewers with behavioral contagion were studied by analyzing atransition probabilities matrix. Those animals showed a decrease in the frequency of aggression and defensive behavior patterns simultaneously with an increase in the frequency of exploratory activity, drinking and exploratory approaches to bottles as compared with the ethogram of rats-viewers with no signs of behavioral contagion when tested in the presence of familiar drink-unmotivated con specific-demonstrator.

This study represents the results of interdisciplinary (EEG and neuropsychological) examination of the limbic system non-optimal functioning influence on the cognitive activity regulation in 5-6, 7-8, 9-10-year- old children. Neuropsychological measures of cognitive activity regulation were compared between groups: children with EEG patterns of the limbic structures nonoptimal functioning (group 1); children without deviated EEG patterns (group 2); children with EEG patterns of the fronto-thalamic system nonoptimal func-. tioning (group 3). It was shown that children with EEG patterns of the limbic system non-optimal functioning, regardless of their age, demonstrate emotional and motivational deficits comparing with two other groups and, first of all, poor emotional and motivational regulation. Seven-to-eight-year-old children of experimental group have severe difficulties in understanding and recognizing other people's emotions and intentions. Children aged 5-6 of the same group were the only who demonstrated deficit of different executive functions. Children at the age 5-8 had low energy to fully complete the task, poor concentration and slow cognitive processing speed. However, those manifestations considered to be nonspecific for the poor limbic functioning and expand to the cases with the fronto-thalamic non-optimal functioning.

In this study EEG patterns ofsensorimotor rhythm were examined in 10 healthy subjects while perform- ing motor imagery of upper arm and hand movements. Participants received visual feedback through so called brain-computer interface (BCI) used for detection of user-specific spatio-temporal.EEG patterns associated with performed mental tasks. During the course study,.all of the subjects were able to modulate their sensorimotor EEG by performing motor imagery of shoulder and fingers movements. Patterns during imagery of shoulder movements were found to have more pronounced contralateral localization, than those during hand movements' imagery. That led to significantly better classification accuracies of the most lateralized patterns when discriminating between left and right hand (72 and 58% corresponding to shoulder and hand motor imagery). Value of difference of patterns' lateralization indexes had shown strong correlation with classification accuracy, suggests it could be used as a good ref- erence mark for.choosing optimal motor imagery tasks for BCI application.

Recent studies have revealed.that in contrast to invertebrate systems, the initiation of action potentials in vertebrate neurons significantly differ from the relatively slow exponential dynamics predicted by Hodgkin-Huxley equations, but rather is characterized by a sharp onset with a kink. These data provided new insights into the link between action potential initiation and abilities of neurons and neuronal networks to encode. high frequency signals. Here, we review recent models describing sharp onset dynamics of action potential initiation, including an alternative model of cooperative activation of sodium channels, as well as the influence of the dynamics of action potential initiation on computational abili- ties of neuronal networks. The importance this topic is due to the fact that, despite the rapid development of neuronal modeling during last decades, the well established models are unable to capture experimentally observed details of the onset dynamics of action potentials in mammalian neurons and the abilities of neurons to reliably encode code high frequency signals Recent advances of experimental and theoretical analysis of generation of action potentials and neuronal encoding, presented in this review, are ofgreat importance for better understanding of neuronal processing and development of a more precise and realistic neuronal model.

It has been shown by the method of frequency decomposition of conditional Granger causality that under the execution of conditioned avoidance reflex θ-rhythm from the ventral hippocampus concurrently influences the ventral tegmental area and the series-connected basolateral amygdala and medial prefrontal cortex. Under the expectation of conditioned signal δ-rhythm from the prefrontal cortex influ- ences the ventral tegmental area and the amygdala.

The inhibitors of proline specific peptidase dipeptidyl peptidase-IV (DPP-IV, CD 26; EC 3.4.14.5) diprotin A (2 mg/kg) and sitagliptin (4 mg/kg) upon daily systemic exposure in rat pups on postnatal days 1-7 induced emotional and motivational disorders in one- and two-month-old rats. In adolescent rats, both the inhibitors produced a decreased locomotion in the automated open field test and an in- creased depression-like behavior in the Forced Swimming Test. At the same time, diprotin A increased sucrose consumption (a percent of the body weight) while sitagliptin decreased anxiety in the Elevated Plus Maze (EPM). In adult rats, diprotin A caused an increase in anxiety according to the reduced pref- erence for open arms of the maze and both the inhibitors decreased the percentage of rats entering open. arms in the EPM. Adult diprotin A-treated animals demonstrated increased aggression in social contact test. as compared to sitagliptin-treated rats. The one-and two-month-old animals in both experimental groups exhibited a decreased weight as compared to the controls. The results of the study show that diprotin A compared with sitagliptin negatively affects emotional and motivational behavior in adolescent and adult rats by increased number of indices increasing depression, anxiety, and aggression, while the main result of sitagliptin is increased depression when the animals were treated with the DPP-IV inhibitors in the first postnatal week. The findings support the hypothesis that DPPIV is involved in the genesis of emotional-motivational disorders.

The article aims to systematically review recent studies on early symptoms of autism developmental dis- orders. Autism spectrum disorders is a group of neurodevelopmental disorders that is characterized by impairment of communication and social interaction. Nevertheless, the earliest detected features of ASD are impairments of attention disengagement and orientation to novel stimulus, perception abnor- malities of stimuli of magnocellular visual pathway and executive control deficit. The role of attention impairment for manifestation of other symptom of ASD including social deficit is discussed. Early ex- ecutive control deficit may in its turn be associated with symptoms of hyperactivity.

We analyzed the specific brain activity, measured by fMRI in spatial and verbal tasks, in 15 healthy sub- jects and in 9 patients with dysarthria or mild sensorimotor aphasia. In healthy participants, verbal thinking was characterized by activation in Brodmann area 19 and Broca area while specific activation for spatial thinking was observed in bilateral temporal-occipital-parietal areas, left insula, left visual fields 17 and 18. In patients with impaired speech, this distribution of networks specific to a particular type of task underwent significant changes with deactivation of the brain areas, as compared to healthy subjects. Despite the absence of clinical manifestations of cognitive impairment, the average time .to solve verbal tasks was significantly higher, and the percentage of correct answers was less in patients as compared to these values for a group of healthy subjects.

We investigated behavioral changes in male mice DBA/2J after the acquisition of a long experience of social defeats in agonistic interactions with aggressive partners of C57BL/6J and DBA/2J lines. The long experience of social defeat in DBA/2J mice did not change the strategy of theirbehavi6r during agonistic interactions. Reduced communicativeness and increased level of anxiety were found in the "partition" and "elevated plus maze" tests. There were no changes in locomotor activity in the "open field" test. After 20-30 days of social defeat stress there were no signs of depression, determined by the behavior during confrontations and in the Porsolt test. There was no sign of catalepsy, decreased exploratory be- havior and impaired social recognition. Thus, the mice of this strain can be considered relatively resis- tant to the development of depressive-like state under chronic social stress and may be used for the study of the mechanisms of such stability.

Animals can associate memory of a context with unconditioned stimuli even if there is a long time in- terval between acquisition of contextual memory and its subsequent reinforcement. This phenomenon of context preexposure effect was first described and investigated in rats. Here we studied the possibility of associating previously acquired memory about a context with unconditioned stimulus (immediate shock) in mice. We showed that fear memory in this model was specific for the previously explored context but not for the context of immediate shock. Associative learning was possible when acquisition of contextual memory and presentation unconditioned stimulus (immediate shock) were spaced in the range of 30 min-30 days interval. Resulting memory was stable and persisted for at least 30 days. Our results open new avenues for studies of neuronal mechanisms of associative memory using transgenic re- porter mice.