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Detailing the biomedical aspects of geroscience by molecular data and large-scale "deep" bioinformatics analyses. 通过分子数据和大规模 "深度 "生物信息学分析,详述地球科学的生物医学方面。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-01 DOI: 10.1007/s00391-024-02329-w
Andreas Simm, Anne Großkopf, Georg Fuellen

As scientists investigated the molecular mechanisms of the biology of aging, they discovered that these are malleable and can enhance healthy longevity by intervening in the drivers of aging, which are leading to disease, dysfunction and death. These exciting observations gave birth to the field of geroscience. As the mechanisms of aging affect almost all mechanisms of life, detailed molecular mechanistic knowledge must be gained or expanded by considering and integrating as many types of data as possible, from genes and transcripts to socioenvironmental factors. Such a large-scale integration of large amounts of data will in turn profit from "deep" bioinformatics analyses that provide insights beyond contextualizing and interpreting the data in the light of knowledge from databases such as the Gene Ontology. The authors suggest that "deep" bioinformatics, employing methods based on artificial intelligence, will be a key ingredient of future analyses.

随着科学家们对衰老生物学分子机制的研究,他们发现这些机制具有可塑性,可以通过干预导致疾病、功能障碍和死亡的衰老驱动因素来提高健康长寿。这些令人兴奋的观察结果催生了地球科学领域。由于衰老机制影响着几乎所有的生命机制,因此必须通过考虑和整合从基因和转录本到社会环境因素等尽可能多的数据类型来获得或扩展详细的分子机制知识。这种对大量数据的大规模整合反过来又将得益于 "深度 "生物信息学分析,这种分析除了根据基因本体论等数据库的知识对数据进行上下文关联和解释之外,还能提供更多的见解。作者认为,采用人工智能方法的 "深度 "生物信息学将成为未来分析的关键要素。
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引用次数: 0
Older adults' communication with an interactive humanoid robot : Expectations and experiences of older adults in verbal and nonverbal communication with a socially interactive humanoid robot: a mixed methods design in Germany. 老年人与交互式仿人机器人的交流:老年人与社交互动仿人机器人进行语言和非语言交流的期望和经验:德国的混合方法设计。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-01 Epub Date: 2024-01-05 DOI: 10.1007/s00391-023-02268-y
Nicole Strutz, Luis Perotti, Anika Heimann-Steinert, Robert Klebbe

Background and objective: One possible approach to counter singularization and loneliness of older adults is the development and implementation of socially interactive robots. Little is known about the expectations and experiences of older adults with socially interactive humanoid robots.

Material and methods: In a mixed-methods design study, user expectations before interaction and the experience and evaluation of verbal and non-verbal communication after interaction with a robot were assessed. Semi-structured interviews were conducted after the interaction.

Results: The majority of older adults expected verbal communication. After the interaction the evaluation of the quality of verbal communication differed. Participants did not expect any form of nonverbal communication. Nonverbal communication was highlighted as particularly positive. Gestures, facial expressions, and body movements were described as confidence building.

Conclusion: The robot's ability to communicate nonverbally might positively influence older adults' experience of communication with the robot. In the development of socially interactive robots non-verbal communication should be given more consideration in order to contribute to successful human-robot interaction.

背景和目的:解决老年人孤独和寂寞问题的一个可行方法是开发和使用社交互动机器人。但人们对老年人对社交互动仿人机器人的期望和体验知之甚少:在一项混合方法设计的研究中,评估了用户在互动前的期望以及与机器人互动后对语言和非语言交流的体验和评价。互动后进行了半结构式访谈:结果:大多数老年人期望进行语言交流。结果:大多数老年人期望进行语言交流,但在互动后,他们对语言交流质量的评价有所不同。参与者没有期待任何形式的非语言交流。非语言交流被认为是特别积极的。手势、面部表情和肢体动作被描述为建立信心的方式:机器人的非语言交流能力可能会对老年人与机器人交流的体验产生积极影响。在开发社交互动机器人的过程中,应更多地考虑非语言交流,以促进成功的人机交互。
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引用次数: 0
Mitteilungen der DGG. DGG 的公告。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-01 DOI: 10.1007/s00391-024-02333-0
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引用次数: 0
Geroscience in the continuum from healthy longevity to frailty. 从健康长寿到体弱多病的老年科学。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI: 10.1007/s00391-024-02331-2
M Cristina Polidori

The socioeconomic and technological developments of the past decades have enabled unique progress associated to increased life expectancy and better health for a large part of the world's population; however, multimorbidity, frailty and disability are also on the rise. Geroscience as the new biology of aging is based on the evidence that the main risk factor for noncommunicable chronic diseases (NCD) is the aging process; however, its technology is mostly used for the scientific study of longevity and its interaction with aging medicine and geriatrics is still limited. In this perspective, the need for a tighter exchange between geroscience and geriatrics for longer health span and intrinsic capacity is discussed in the context of existing evidence and knowledge gaps.

过去几十年的社会经济和技术发展取得了独特的进步,延长了世界大部分人口的预期寿命,改善了他们的健康状况;然而,多病、虚弱和残疾现象也在增加。老年科学作为老龄化的新生物学,是基于非传染性慢性疾病(NCD)的主要风险因素是老龄化过程的证据;然而,其技术主要用于长寿的科学研究,与老龄医学和老年医学的互动仍然有限。从这一角度出发,结合现有证据和知识差距,讨论了为延长健康寿命和提高内在能力而加强老龄科学与老年医学之间交流的必要性。
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引用次数: 0
Mitteilungen des BV Geriatrie. BV Geriatrie 的通讯。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-01 DOI: 10.1007/s00391-024-02330-3
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引用次数: 0
Mitteilungen der DGGG. DGGG 通信。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-08-01 DOI: 10.1007/s00391-024-02334-z
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引用次数: 0
[Geriatric ophthalmologic co-management : A case report of interdisciplinary collaboration]. [老年眼科共同管理 :跨学科合作病例报告]。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI: 10.1007/s00391-024-02311-6
Jan-Niklas Krohn, Mohammed Almaqadma, Josef Schmidbauer, Markus Gosch, Katrin Singler

This case report details the assessment and interdisciplinary collaboration in the management of an 81-year-old patient presenting with acute visual impairment, dizziness, general weakness, gait disturbances and fear of falling. A holistic geriatric evaluation revealed orthostatic dysregulation and an underlying multifactorial gait disorder exacerbated by visual impairment. Ophthalmological findings included left central retinal artery branch occlusion and cataracts. A comprehensive geriatric assessment showed frailty, impaired mobility and decreased functional abilities. Subsequent patient-centered interdisciplinary approaches included treatment for retinal ischemia, orthostatic testing, medication reconciliation, physiotherapy and occupational therapy. This case emphasizes how interdisciplinary collaboration between ophthalmology and geriatrics enables proactive assessment and intervention to reduce the risk of functional decline and loss of autonomy in visually impaired patients, which is of particular relevance considering the increasing prevalence of visual impairment in the ageing population.

本病例报告详细介绍了对一名 81 岁患者进行评估和跨学科合作治疗的过程,患者表现为急性视力障碍、头晕、全身无力、步态障碍和害怕跌倒。全面的老年病学评估显示,患者存在正张力失调和潜在的多因素步态障碍,而视力损伤又加剧了这种障碍。眼科检查结果包括左视网膜中央动脉分支闭塞和白内障。全面的老年病学评估显示,患者体质虚弱、活动能力受损、功能减退。随后,以患者为中心的跨学科治疗方法包括视网膜缺血治疗、正压测试、药物调节、物理治疗和职业治疗。本病例强调了眼科和老年病科之间的跨学科合作如何通过积极的评估和干预来降低视力受损患者功能衰退和丧失自主能力的风险,考虑到老龄化人口中视力受损的发生率越来越高,这一点尤为重要。
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引用次数: 0
[Implementation of fall sensors in long-term care : An interview study to identify promoting and inhibiting factors from the perspective of professional caregivers]. [跌倒传感器在长期护理中的应用:从专业护理人员的角度确定促进和抑制因素的访谈研究]。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-01 Epub Date: 2023-11-08 DOI: 10.1007/s00391-023-02255-3
Marie-Christin Redlich, Florian Fischer

Background and objective: Digital support systems are becoming increasingly more important in long-term inpatient care facilities. Welfare technologies have the potential to make a valuable contribution to maintaining independence in advanced age. At the same time the technologies can support professional caregivers. The aim of the study was to describe the expectations and experiences with a new technology, using the example of a fall sensor system, from the perspective of professional caregivers.

Method: We used a qualitative design with semistructured interviews in two long-term inpatient care facilities. In one facility, three individual interviews took place, while in the other long-term care facility, a group interview with three nursing professionals was conducted. Additionally, one individual interview was conducted with a person in a leadership role in each facility. The time from implementation of the fall sensors to the interviews was between 1 and 3 months. Data were analyzed using qualitative content analysis in MAXQDA.

Results and discussion: The study demonstrated that there was a correspondence between expectations of and retrospective experiences with the new technology among professional nurses. The main facilitating factors of the implementation that were identified were timely information about the risk of falling or a fall that has occurred, maintenance of residents' autonomy and freedom of movement as well as the enhancement of the sense of security among nursing professionals and the associated psychological relief effect. The inhibiting factors of the implementation were compulsory presetting, false alarms and faulty handling of the technology due to missing knowledge.

背景和目标:数字支持系统在长期住院护理机构中变得越来越重要。福利技术有可能为老年人保持独立做出宝贵贡献。同时,这些技术可以支持专业护理人员。该研究的目的是从专业护理人员的角度,以跌倒传感器系统为例,描述对新技术的期望和体验。方法:我们在两个长期住院护理机构中采用了半结构访谈的定性设计。在一个机构中,进行了三次个人访谈,而在另一个长期护理机构中,对三名护理专业人员进行了集体访谈。此外,还对每个设施的一名领导人员进行了一次单独访谈。从实施跌倒传感器到访谈的时间在1到3个月之间。使用MAXQDA中的定性内容分析对数据进行分析。结果与讨论:研究表明,专业护士对新技术的期望与回顾性经验之间存在一致性。已确定的实施的主要促进因素是及时了解跌倒或已发生跌倒的风险,维护居民的自主性和行动自由,以及增强护理专业人员的安全感和相关的心理缓解效果。实施的抑制因素是强制预设、错误警报和由于知识缺失而导致的技术处理错误。
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引用次数: 0
[Journal Club]. [期刊俱乐部]
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-01 Epub Date: 2024-04-16 DOI: 10.1007/s00391-024-02301-8
Anna Maria Meyer
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引用次数: 0
Negotiating vulnerability and attractiveness through dress. 通过着装商讨脆弱性和吸引力。
IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1007/s00391-024-02312-5
Julia Hahmann, Miranda Leontowitsch

Background: The ageing female body is particularly exposed to the social gaze. While it should remain fit and durable as well as attractive and desirable, there is the danger of ridicule through supposedly too youthful or too outlandish performance. Women's clothing practices can conform to social expectations, can circumvent them, can actively protest against them, and possibly change social demands. In every part of the process, i.e., the experience of bodily changes, the experience of social expectations, consumer choices, the practices of clothing and reactions to clothing choices, the body and getting dressed becomes a site of new feelings of vulnerability.

Objective: This article asks how these vulnerabilities are presented in the clothing practices of older women, are expressed in the materiality of clothes and in the practices of getting dressed.

Material and methods: Data from a study that followed a situational analysis methodology and used semi-structured interviews and photo elicitation, were re-examined through the lens of vulnerability.

Results: Different aspects to vulnerability are presented in this article. Interviewees had to come to terms with bodily changes and made arrangement to the way they dressed that in turn could collide with subjective and social expectations of normative femininity. In this process of acquiescing, new vulnerabilities were produced; however, interviewees developed clothing strategies that provided them with experiences of their own attractiveness. They also had to adapt to changing circumstances to present themselves as fashionable and attractive due to age.

Conclusion: Practitioners can address feelings of vulnerabilities when talking about gendered clothing practices, for example through biographical work.

背景:衰老的女性身体特别容易受到社会的注视。虽然女性的身体应保持健美、耐久、迷人和令人向往,但也有可能因为所谓的过于年轻或过于离奇的表现而受到嘲笑。女性的服装实践既可以符合社会期望,也可以规避社会期望,还可以积极抗议社会期望,并有可能改变社会需求。在这一过程的每一个部分,即身体变化的体验、社会期望的体验、消费者的选择、服装的实践以及对服装选择的反应,身体和着装都成为新的脆弱感的场所:本文探讨了这些脆弱性如何在老年妇女的着装实践中表现出来,如何在服装的物质性和着装实践中表达出来:通过脆弱性的视角重新审视了一项采用情景分析方法、半结构式访谈和照片征集的研究数据:本文介绍了脆弱性的不同方面。受访者不得不接受身体的变化,并对自己的着装方式做出安排,而这又可能与主观和社会对规范女性的期望相冲突。在这一默认的过程中,产生了新的脆弱性;然而,受访者制定的服装策略使她们体验到了自身的吸引力。她们还必须适应不断变化的环境,以展现自己因年龄而具有的时尚魅力:实践者在讨论性别服装实践时,可以通过传记工作等方式来解决脆弱感问题。
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Zeitschrift Fur Gerontologie Und Geriatrie
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