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Scaling the Heights: Rates of Pelvic Floor Dysfunction in Female Rock-Climbing Enthusiasts. 攀登高峰:女性攀岩爱好者的盆底功能障碍率。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-11-25 DOI: 10.1177/10806032241290804
Paulina C Altshuler, Iris M Burgard, James K Poling, Tyler Muffly

Introduction: Rock climbing has recently gained popularity, particularly among females. There are no current studies evaluating pelvic floor dysfunction among female climbers. This cross-sectional study seeks to investigate the prevalence of incontinence and pelvic floor disorders among female rock climbers in the United States.

Methods: This study utilized an online survey distributed via social media platforms to assess the prevalence of pelvic floor disorders. Participants were queried about demographic information, climbing habits, pregnancy history, and pelvic floor symptoms. Data analysis involved descriptive statistics and inferential analysis where applicable.

Results: A total of 343 participants completed the study, with a median age of 34 years, lean body mass, and the majority identifying as White or Caucasian. The most common pelvic floor disorder was overactive bladder (n = 314, 91.5%), and the least common was pelvic organ prolapse (n = 6, 1.7%). Rope climbers were significantly more bothered by pelvic organ prolapse and anal incontinence symptoms than boulderers (4, p < .01 and 1.44, p < .01, respectively). Parous climbers reported significantly higher bothersome symptoms of OAB and SUI (1.43, p = .01 and 2.71, p < .01, respectively) than their nulliparous counterparts.

Conclusions: Although rock climbing represents a relatively low-impact sport and our sample was largely comprised of young, healthy, nulliparous women, female rock climbers demonstrated higher rates of pelvic floor disorders than a normative population, with rope climbers at higher risk than boulderers. Clinicians should be aware of the need for more frequent pelvic floor disorder screening in active women.

简介攀岩运动最近越来越受欢迎,尤其是在女性中。目前还没有研究对女性攀岩者的盆底功能障碍进行评估。本横断面研究旨在调查美国女性攀岩者中尿失禁和盆底功能障碍的患病率:本研究通过社交媒体平台发布在线调查,以评估骨盆底障碍的患病率。调查询问了参与者的人口统计学信息、攀岩习惯、怀孕史和盆底症状。数据分析包括描述性统计和推论性分析(如适用):共有 343 名参与者完成了研究,他们的中位年龄为 34 岁,体型偏瘦,大多数人认为自己是白人或高加索人。最常见的盆底疾病是膀胱过度活动症(n = 314,91.5%),最不常见的是盆腔器官脱垂(n = 6,1.7%)。攀岩者受盆腔器官脱垂和肛门失禁症状困扰的程度明显高于攀石者(4,p p = .01 和 2.71,p 结论:攀岩者受盆腔器官脱垂和肛门失禁症状困扰的程度明显高于攀石者:虽然攀岩是一项冲击力相对较小的运动,而且我们的样本主要由年轻、健康、无子宫的女性组成,但女性攀岩者的盆底功能紊乱率高于正常人群,其中绳索攀岩者的风险高于抱石者。临床医生应该意识到,需要更频繁地对活跃的女性进行盆底障碍筛查。
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引用次数: 0
Comparison of Camera-Acquired Vital Signs to Conventional Vital Signs in a Space-Analog Environment. 空间模拟环境中相机获取的生命体征与传统生命体征的比较。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-11-10 DOI: 10.1177/10806032241291994
Carlo A Canepa, Dana R Levin, Amit S Padaki

Introduction: Vital sign acquisition is a key component of modern medical care. In wilderness and space medical settings, vital sign acquisition can be a difficult process because of limitations on available personnel or lack of access to the patient. Camera-acquired vital signs could address each of these difficulties.

Methods: Healthy volunteers used software designed by Presage Technologies to acquire heart rate and respiratory rate at the HI-SEAS space-analog site in Mauna Loa, Hawai'i. Camera-acquired vital signs were compared to more conventionally acquired vital signs.

Results: Camera-acquired heart rate showed high correlation to conventionally acquired heart rate (R ∼ 0.95). Camera-acquired respiratory rate showed moderate correlation (R ∼ 0.65).

Conclusions: These results show that camera acquisition of vital signs is theoretically feasible in wilderness and space-analog environments. HR may be highly accurate even using current technology. Additional studies will be needed to further validate other types of camera sensors and other potential environments such as partial gravity and microgravity.

导言生命体征采集是现代医疗护理的关键组成部分。在野外和太空医疗环境中,由于可用人员有限或无法接近病人,生命体征采集可能是一个困难的过程。方法:健康志愿者使用 Presage 技术公司设计的软件,在夏威夷莫纳洛亚的 HI-SEAS 空间模拟站点采集心率和呼吸频率。将相机获取的生命体征与传统的生命体征进行比较:结果:照相机获得的心率与传统方法获得的心率具有很高的相关性(R ∼ 0.95)。结果:摄像头获取的心率与传统获取的心率呈高度相关性(R ∼ 0.95),摄像头获取的呼吸频率呈中度相关性(R ∼ 0.65):这些结果表明,在野外和空间模拟环境中,相机采集生命体征在理论上是可行的。即使使用目前的技术,心率也可能非常准确。还需要进行更多的研究,以进一步验证其他类型的相机传感器和其他潜在环境,如部分重力和微重力环境。
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引用次数: 0
Biopsychosocial Health Considerations for Astronauts in Long-Duration Spaceflight: A Narrative Review. 长期太空飞行中宇航员的生物心理社会健康考虑因素:叙述性评论。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-10-29 DOI: 10.1177/10806032241289106
Bradley N Barbour, Karolina Twardowska, Nicolò Favero, Payam Ghoddousi, Peter Hodkinson

Long-duration spaceflights beyond low-Earth orbit, including missions to the Moon and Mars, pose significant health risks. Although biomedical approaches commonly appear in the literature, considering psychological and social factors alongside physiologic health offers a more holistic approach to astronaut care. Integrating the biopsychosocial (BPS) framework into medical planning addresses complex spaceflight challenges and aids in developing mitigation strategies. This review examined health risks associated with long-duration spaceflight within a BPS framework. Sources included governmental space agencies, academic textbooks, and relevant publications from multiple databases. Considering the National Aeronautics and Space Administration's Human Research Program's 5 main hazards, a conceptual model was developed to highlight the multifactorial BPS effects of spaceflight. In space, astronauts face unique environments and biological adaptations, including fluid shift, plasma volume loss, bone density loss, and muscle atrophy. Noise and the absence of natural light disrupt circadian rhythms, causing sleep disturbances and fatigue, which affect physical and mental health. Studies on crews in isolated and confined extreme environments reveal psychosocial challenges, including impaired mood and cognition, interpersonal tension, and miscommunication. International collaboration in spaceflight introduces differences in communication, problem solving, and social customs due to diverse cultural backgrounds. Upcoming long-distance missions likely will amplify these challenges. This review emphasizes BPS health considerations in long-duration spaceflight. It highlights the interplay among psychological, social, and biological factors, advocating for multidisciplinary teams and a holistic approach to astronaut health and mission planning and the potential added value of BPS perspectives in considering countermeasures.

超越低地球轨道的长期太空飞行,包括飞往月球和火星的任务,都会带来巨大的健康风险。虽然生物医学方法通常出现在文献中,但在考虑生理健康的同时考虑心理和社会因素为宇航员的护理提供了一种更全面的方法。将生物-心理-社会(BPS)框架纳入医疗规划可应对复杂的太空飞行挑战,并有助于制定缓解策略。本综述在 BPS 框架内研究了与长期太空飞行相关的健康风险。资料来源包括政府航天机构、学术教科书以及多个数据库中的相关出版物。考虑到美国国家航空航天局人类研究计划的 5 种主要危害,我们建立了一个概念模型,以突出太空飞行的多因素 BPS 影响。在太空中,宇航员面临着独特的环境和生物适应性,包括液体转移、血浆量减少、骨密度下降和肌肉萎缩。噪音和缺乏自然光会扰乱昼夜节律,导致睡眠紊乱和疲劳,从而影响身心健康。对处于孤立和封闭极端环境中的机组人员进行的研究显示,他们面临着社会心理方面的挑战,包括情绪和认知能力受损、人际关系紧张和沟通不畅。由于文化背景不同,航天飞行中的国际合作在沟通、解决问题和社会习俗方面存在差异。即将进行的远距离飞行任务很可能会加剧这些挑战。本综述强调了长期太空飞行中的 BPS 健康考虑因素。它强调了心理、社会和生物因素之间的相互作用,提倡多学科团队和整体方法来解决宇航员的健康和任务规划问题,以及在考虑应对措施时从 BPS 角度看问题的潜在附加值。
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引用次数: 0
Wilderness Medicine Curricula in US Multidisciplinary Training Courses. 美国多学科培训课程中的野外医学课程。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-10-26 DOI: 10.1177/10806032241289315
Maria Holstrom-Mercader, Avram Flamm

Introduction: Wilderness medicine (WM) is the study of medicine in austere environments. There are several US multidisciplinary courses that teach WM to people from varying medical backgrounds. However, WM topics are covered to different extents. This study's purpose was to compare WM components among US multidisciplinary training courses.

Methods: The American College of Emergency Physicians WM fellowship curriculum's 19 components and the Fellowship of the Academy of Wilderness Medicine's 12 core and 16 elective competencies and their credits were used as two control lists. Curricula from 10 US multidisciplinary courses were analyzed for WM components. Using descriptive analysis, each course curriculum was compared with the controls.

Results: This study examines WM components in 10 courses. The greatest number of American College of Emergency Physicians WM fellowship topics (14 of 19) was covered by the Paramedic course and the fewest number (4 of 19) by the Tactical Combat Casualty Care-Combat Lifesaver course. The greatest number of Fellowship of the Academy of Wilderness Medicine core credits (56) was offered by the Paramedic course and the fewest number (24) by the Tactical Combat Casualty Care-Medical Personnel course. The greatest number of Fellowship of the Academy of Wilderness Medicine elective credits (83) was offered by the Paramedic course and the fewest number (25) by the Tactical Combat Casualty Care-Combat Lifesaver course.

Conclusion: This research analyzed WM components in US multidisciplinary courses and demonstrated that each covers WM topics to varying extents. This shows an opportunity for these courses to expand their WM education within their scope. It also demonstrates competencies offered by different courses for interested trainees.

导言:荒野医学(WM)是一门在艰苦环境中研究医学的学科。美国有几门多学科课程向不同医学背景的人教授荒野医学。然而,WM 主题的覆盖范围各不相同。本研究旨在比较美国多学科培训课程中的 WM 内容:方法:将美国急诊医师学院 WM 奖学金课程的 19 个组成部分和荒野医学学会奖学金的 12 个核心能力和 16 个选修能力及其学分作为两个对照清单。对美国 10 门多学科课程的 WM 内容进行了分析。通过描述性分析,将每门课程的课程表与对照表进行了比较:本研究考察了 10 门课程中的 WM 内容。美国急诊医师学会 WM 研究金课程中,辅助医务人员课程涵盖的 WM 课题最多(19 个中的 14 个),而战术战斗伤员护理-战斗救生员课程涵盖的 WM 课题最少(19 个中的 4 个)。辅助医务人员课程提供了最多的野外医学学院研究金核心学分(56 个),战术战斗伤员救护-医务人员课程提供的学分最少(24 个)。野外医学学院研究员选修课学分最多的是辅助医务人员课程(83 个),最少的是战术战斗伤员救护课程(25 个):这项研究分析了美国多学科课程中的野外医疗内容,并表明每门课程都在不同程度上涵盖了野外医疗主题。这表明这些课程有机会在其范围内扩展 WM 教育。它还展示了不同课程为感兴趣的学员提供的能力。
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引用次数: 0
Space Radiology: Emerging Nonsonographic Medical Imaging Techniques and the Potential Applications for Human Spaceflight. 太空放射学:新兴的 Nonsonographic 医学成像技术及其在载人航天飞行中的潜在应用。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-10-03 DOI: 10.1177/10806032241283380
Michael Pohlen

Space medicine is a multidisciplinary field that requires the integration of medical imaging techniques and expertise in diagnosing and treating a wide range of acute and chronic conditions to maintain astronaut health. Medical imaging within this domain has been viewed historically through the lens of inflight point-of-care ultrasound and predominantly research uses of cross-sectional imaging before and after flight. However, space radiology, a subfield defined here as the applications of imaging before, during, and after spaceflight, will grow to necessitate the involvement of more advanced imaging techniques and subspecialist expertise as missions increase in length and complexity. While the performance of imaging in spaceflight is limited by equipment mass and volume, power supply, radiation exposure, communication delays, and personnel training, recent developments in nonsonographic modalities have opened the door to their potential for in-mission use. Additionally, improved exam protocols and scanner technology in combination with artificial intelligence algorithms have greatly advanced the utility of possible pre- and postflight studies. This article reviews the past and present of space radiology and discusses possible use cases, knowledge gaps, and future research directions for radiography, fluoroscopy, computed tomography, and magnetic resonance imaging within space medicine, including both the performance of new exam types for new indications and the increased extraction of information from exams already routinely obtained. Through thoughtfully augmenting the use of these tools, medical mission risk may be reduced substantially through preflight screening, inflight diagnosis and management, and inflight and postflight surveillance.

空间医学是一个多学科领域,需要整合医学成像技术和专业知识,诊断和治疗各种急慢性疾病,以维护宇航员的健康。这一领域的医学成像历来是通过机上护理点超声波和飞行前后横断面成像的主要研究用途来看待的。然而,随着飞行任务时间的延长和复杂程度的增加,空间放射学(这里定义为飞行前、飞行中和飞行后成像应用的子领域)的发展将需要更先进的成像技术和亚专科专业知识的参与。虽然航天成像的性能受到设备质量和体积、电源、辐射暴露、通信延迟和人员培训等因素的限制,但最近在非超声成像模式方面的发展为其在飞行任务中的应用潜力打开了大门。此外,改进的检查方案和扫描仪技术与人工智能算法相结合,大大提高了飞行前和飞行后研究的实用性。本文回顾了空间放射学的过去和现在,并讨论了空间医学中放射学、透视学、计算机断层扫描和磁共振成像的可能用例、知识差距和未来研究方向,包括针对新适应症的新检查类型的性能和从已常规获得的检查中提取更多信息。通过深思熟虑地加强这些工具的使用,可以通过飞行前筛查、飞行中诊断和管理以及飞行中和飞行后监测,大大降低医疗飞行任务的风险。
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引用次数: 0
Creation of an Emergency Care Capacity Assessment Tool for Facilities in Austere Environments. 为环境恶劣的设施创建紧急救护能力评估工具。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-12 DOI: 10.1177/10806032241278982
Vijay Christopher Kannan,Geoff Comp,Stephanie Lareau
INTRODUCTIONFacilities in austere environments may consider emergency care beyond their scope. Often patients with high-acuity conditions have no other choice than to present to these facilities. The disconnect between the intent of health systems planners and the reality faced by providers manifests as facilities unable to manage such cases.The Indian Health Service, with a range of stakeholders, developed an emergency care delivery assessment tool for facilities in austere environments, designed to identify deficiencies in facility readiness for emergency care delivery across four areas: 1. Procedural2. Human resources3. Non-pharmacologic material resources4. Pharmacologic material resources.METHODSThe tool's underlying architecture is a resource matrix similar to hospital-based tools, using the "Facility" component of the WHO Emergency Care Systems Framework as the Y-axis and undifferentiated presentations taught by the WHO basic emergency care course, advanced trauma life support, and advanced life support in obstetrics as the X-axis. The tool was piloted at a remote frontier clinic.RESULTSWe found 48 deficiencies: 7 procedural, 1 human resources, 31 non-pharmacologic materials, and 9 pharmacologic materials. We aggregated deficiencies by facility function to assess the capacity to perform each. We also aggregated deficiencies by clinical presentation to identify targets for educational interventions.CONCLUSIONWe successfully created a novel emergency care capacity assessment tool for use in austere environments using materials with broad international consensus. The successful pilot found deficiencies across all 4 areas. This tool may be useful in many other remote domestic facilities and rural health posts in low- and middle-income countries.
引言环境恶劣的医疗机构可能会认为急诊护理超出了他们的范围。通常情况下,病情危重的病人除了到这些机构就诊别无选择。医疗系统规划者的意图与医疗服务提供者所面临的现实之间的脱节,表现为医疗机构无法处理此类病例。印第安人医疗服务机构与一系列利益相关者共同开发了一种针对艰苦环境下医疗机构的急诊医疗服务评估工具,旨在从四个方面确定医疗机构在急诊医疗服务准备方面的不足:1.程序2.人力资源3.非药物物质资源4.该工具的基本架构是一个资源矩阵,类似于基于医院的工具,以世界卫生组织紧急救护系统框架的 "设施 "部分为 Y 轴,以世界卫生组织基本紧急救护课程、高级创伤生命支持和产科高级生命支持所教授的无差别演示为 X 轴。该工具在一家偏远的边疆诊所试用:我们发现了 48 项缺陷:7 项程序性缺陷、1 项人力资源缺陷、31 项非药物性缺陷和 9 项药物性缺陷。我们按设施功能汇总了缺陷,以评估执行每项功能的能力。我们还按临床表现汇总了不足之处,以确定教育干预的目标。结论我们成功地创建了一种新型急救能力评估工具,该工具可在艰苦环境中使用,使用的材料已在国际上达成广泛共识。成功的试点发现了所有 4 个方面的不足。该工具可能适用于中低收入国家的许多其他偏远国内设施和农村医疗站。
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引用次数: 0
Catfish Puncture Wound and Retained Spine Management in the ED Setting: A Case Report. 急诊室中的鲶鱼刺伤和脊柱留置治疗:病例报告。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-10 DOI: 10.1177/10806032241273505
Spencer J Carbone,Jennifer L Jozefick,Adam P Sigal,Robert H Nordell
Fishing is a common recreational activity in the United States, with over 29 million registered fishers. Although not inherently dangerous, commonly seen injuries from fishing include embedded fishhooks and injury from flora and fauna. Emergency department (ED) physicians need a basic understanding of how to treat these less-than-frequent injuries. We present a case report of a patient who presented with a catfish spine lodged in her leg. These spines not only cause puncture wounds but can result in lacerations and venom release as well. Our patient presented 6 hours after the initial injury for spine removal and symptom management. Plain radiographs of the affected extremity demonstrated a 2 cm foreign body consistent with a catfish spine. The wound was expanded, and the spine successfully removed. The patient was discharged on levofloxacin and reported a healing wound without complications nearly 2 weeks after the injury.
在美国,钓鱼是一项常见的娱乐活动,注册钓鱼者超过 2900 万。尽管钓鱼本身并不危险,但常见的钓鱼伤害包括鱼钩嵌入和动植物造成的伤害。急诊科(ED)医生需要对如何治疗这些不太常见的损伤有一个基本的了解。我们报告了一例鲶鱼刺扎入腿部的病例。这些刺不仅会造成穿刺伤,还可能导致撕裂伤和毒液释放。我们的病人是在最初受伤 6 小时后就诊的,需要移除鱼刺并对症治疗。患肢的平片显示有一个 2 厘米长的异物,与鲶鱼脊柱一致。伤口被扩大,脊柱被成功取出。患者出院后服用左氧氟沙星,伤口愈合,伤后近两周未出现并发症。
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引用次数: 0
Backward and in Heels . . . Mabel Purefoy FitzGerald's Extraordinary Journey to Discovery at High Altitudes. 后退并穿着高跟鞋 . .梅布尔-普尔福伊-菲茨杰拉德在高海拔地区的非凡发现之旅.
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-02 DOI: 10.1177/10806032241272125
Martha Tissot van Patot

In 1911, Mabel Purefoy FitzGerald (1872-1973) conducted a study in the mountains of Colorado that offered invaluable insights into how the body responds to chronic hypoxia. Researchers awarded the Nobel Prize for Physiology or Medicine 2019 cited her work as critical in unravelling the hypoxia sensing system. The astounding career situation in which FitzGerald found herself while conducting this study offers important insights into the challenges faced by women in science at the turn of the twentieth century. Like Ginger Rogers dancing with Fred Astaire, FitzGerald did the equivalent of everything her male colleagues did, only backward and in high heels. Although it is tempting to believe that such inequities for women are relegated to history, the career challenges faced by 2023 Nobel Laureate Katalin Karikó highlight evidence that the struggle for equality of women in science remains a significant problem.

1911 年,梅布尔-普雷福伊-菲茨杰拉德(1872-1973 年)在科罗拉多州山区进行了一项研究,对人体如何应对慢性缺氧提出了宝贵的见解。获得 2019 年诺贝尔生理学或医学奖的研究人员认为,她的工作对于揭示缺氧感知系统至关重要。菲茨杰拉德在进行这项研究时所处的令人震惊的职业境遇,为我们了解二十世纪之交科学界女性所面临的挑战提供了重要启示。就像金格-罗杰斯(Ginger Rogers)与弗雷德-阿斯泰尔(Fred Astaire)共舞一样,菲茨杰拉德做了她的男同事们所做的一切,只不过是倒着穿高跟鞋而已。尽管人们很容易相信,这种对女性的不平等已经成为历史,但 2023 年诺贝尔奖得主卡塔琳-卡里科(Katalin Karikó)所面临的职业挑战突出表明,争取科学界女性平等的斗争仍然是一个重大问题。
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引用次数: 0
A Comprehensive Pathophysiologic, Histologic, and Biochemical Analysis of Buthus paris (C. L. Koch, 1839) Venom. Buthus paris(C. L. Koch,1839 年)毒液的病理生理学、组织学和生化综合分析。
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI: 10.1177/10806032241249748
Abdessamad Elmourid, My Abdelmonaim Elhidan, Samia Boussaa, Mehdi Ait Laaradia, Btissam Bouimeja, Omar Amahmid, Mohamed Merzouki, Oulaid Touloun

Introduction: Buthus species, including B paris, are classified as one of the most dangerous scorpion genera in Morocco, implicated in several cases of human death. Our objective is to characterize, for the first time, the toxicity and histopathologic and biochemical impacts of B paris venom.

Methods: We investigated the experimental pathophysiology of B paris venom by examining histologic changes in vital organs (heart, kidneys, liver, and lungs) and assessing biochemical enzymatic markers (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, creatine phosphokinase, urea, and creatinine) in mice injected subcutaneously with 2 doses of 400 and 450 mg·kg-1.

Results: Our results showed that the subcutaneous median lethal dose of B paris venom was around 0.52 mg·kg-1. Histologic findings revealed significant tissue damage in the previously mentioned vital organs, confirmed through biochemical analysis indicating impaired heart and liver functions. Additionally, an increase in urea, creatinine, and glucose levels occurred following B paris venom injection.

Conclusion: Our findings show that B paris venom exhibits a high level of experimental toxicity. These results highlight the potentially lethal nature of this venom and emphasize the potential medical importance of this species.

导言:包括B paris在内的Buthus种被列为摩洛哥最危险的蝎属之一,曾多次造成人类死亡。我们的目的是首次描述 B paris 毒液的毒性、组织病理学和生化影响:方法:我们对小鼠皮下注射 400 毫克和 450 毫克-千克-1 两种剂量的 B paris 毒液,通过检查重要器官(心脏、肾脏、肝脏和肺部)的组织学变化和评估生化酶标记物(丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、乳酸脱氢酶、肌酸磷酸激酶、尿素和肌酐),研究了 B paris 毒液的实验病理生理学:结果表明,B paris 毒液皮下注射的中位致死剂量约为 0.52 mg-kg-1。组织学研究结果表明,上述重要器官的组织受到严重破坏,生化分析表明心脏和肝脏功能受损也证实了这一点。此外,在注射 B paris 毒液后,尿素、肌酐和葡萄糖水平也有所上升:我们的研究结果表明,B paris 毒液具有很高的实验毒性。结论:我们的研究结果表明,B paris 毒液具有很高的实验毒性,这些结果突显了该毒液的潜在致命性,并强调了该物种潜在的医学重要性。
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引用次数: 0
In Reply to Dr Gupta et al. 答复古普塔博士等人
IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-06-05 DOI: 10.1177/10806032241260347
Stefan Cowtan, Jonathon Broughton, Sarvesh Logsetty
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引用次数: 0
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Wilderness & Environmental Medicine
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