Matrix Biology最新文献_第4页

Basement membrane structure and function: Relating biology to mechanics 基膜结构与功能：生物学与力学的关系。

IF 4.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI: 10.1016/j.matbio.2025.08.004

Andrea Page-McCaw , Nicholas Ferrell

Basement membranes are key mediators of many biological processes such as epithelial morphogenesis, kidney filtration, and muscle function among others. Basement membranes provide structural support to tissues so understanding their mechanical properties is important for determining how they contribute to tissue form and function. Further, basement membranes are altered in many diseases including cancer, diabetes, and fibrosis, and these changes may contribute to disease pathogenesis and progression. Understanding how basement membrane mechanics integrate with tissue function is the work of both biologists and engineers/material scientists, yet these disciplines have very different foundations. This review discusses basement membrane macromolecular structure with a view to illuminate how this structure confers basement membranes with unique mechanical properties adapted to resisting physiological stresses. The pathological implications of altered basement membrane mechanics are discussed in the context of different diseases. Additionally, we survey methods used to measure basement membrane mechanical properties, including atomic force microscopy, tensile stiffness assays, and non-quantitative assays such as cell bursting, assessing their strengths and limitations and their accessibility for different types of in vivo studies. We focus on explaining and illuminating the complexities of basement membrane material properties for biologists, and explaining the biological aspects for engineers, with the goal of making interdisciplinary science more accessible to experimentalists and readers.

基底膜是许多生物过程的关键介质，如上皮形态发生、肾脏过滤和肌肉功能等。基底膜为组织提供结构支持，因此了解其力学特性对于确定它们如何影响组织形态和功能非常重要。此外，基底膜在许多疾病中发生改变，包括癌症、糖尿病和纤维化，这些改变可能有助于疾病的发病和进展。了解基底膜力学如何与组织功能相结合是生物学家和工程师/材料科学家的工作，然而这些学科有非常不同的基础。本文讨论了基底膜的大分子结构，以阐明这种结构如何赋予基底膜以适应生理应力的独特力学性能。在不同疾病的背景下讨论了基底膜力学改变的病理意义。此外，我们调查了用于测量基底膜力学性能的方法，包括原子力显微镜、拉伸刚度分析和非定量分析（如细胞破裂），评估了它们的优势和局限性，以及它们在不同类型体内研究中的可及性。我们专注于为生物学家解释和阐明基底膜材料特性的复杂性，并为工程师解释生物学方面的问题，目的是使实验家和读者更容易理解跨学科科学。

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引用次数: 0

Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease 斑马鱼col4a1的缺失再现了与单基因脑血管疾病相关的脑血管表型

IF 4.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-11-01 Epub Date: 2025-08-20 DOI: 10.1016/j.matbio.2025.08.005

Daisy Flatman , Richard W Naylor , Siobhan Crilly , Isabel Carter , Aleksandr Mironov , Emmanuel Pinteaux , Stuart M. Allan , Rachel Lennon , Paul R. Kasher

Cerebral small vessel disease (cSVD) is a major cause of vascular dementia and stroke. Our understanding of cSVD pathophysiology is incomplete and our ability to treat patients is limited. Pathogenic variants in type IV collagen alpha 1 (COL4A1) cause a monogenic form of cSVD with variable age of onset, via disturbance of cerebrovascular basement membranes. Zebrafish larvae are a powerful model organism for studying cerebrovascular disease due to their optical clarity and applicability for live imaging. In this study, we characterised a zebrafish crispant model for loss-of-function COL4A1-associated cSVD that successfully recapitulates key disease features, including spontaneous intracerebral haemorrhage and cerebrovascular abnormalities. We also identified evidence for abnormal cerebrovascular basement membranes and elevated matrix metalloproteinase 9 (mmp9) transcription associated with loss of col4a1. Pharmacological inhibition of mmp9 was sufficient to ameliorate some cerebrovascular phenotypes. Finally, we describe the generation of a mutant line carrying a germline-transmissible 20 bp deletion in zebrafish col4a1 (col4a1^Δ20) which is associated with cerebrovascular abnormalities, swimming defects and increased susceptibility to pharmacologically induced brain haemorrhages during larval stages. In adulthood, mutant col4a1^Δ20 animals developed spontaneous brain haemorrhages that were observable in free-swimming fish. Overall, this study validates the use of zebrafish disease modelling for preclinical COL4A1-associated cSVD research and highlights its potential for further understanding disease pathophysiology and future drug discovery projects.

脑血管病（cSVD）是血管性痴呆和中风的主要原因。我们对cSVD病理生理的理解是不完整的，我们治疗患者的能力是有限的。IV型胶原α 1 （COL4A1）的致病性变异通过扰乱脑血管基底膜导致单基因型cSVD，其发病年龄不同。斑马鱼幼鱼由于其光学清晰度和活体成像的适用性，是研究脑血管疾病的有力模式生物。在这项研究中，我们对col4a1相关的功能丧失cSVD的斑马鱼脆化模型进行了表征，该模型成功地概括了关键的疾病特征，包括自发性脑出血和脑血管异常。我们还发现了与col4a1缺失相关的脑血管基底膜异常和基质金属蛋白酶9 （mmp9）转录升高的证据。药理抑制mmp9足以改善一些脑血管表型。最后，我们描述了斑马鱼col4a1 （col4a1Δ20）中携带可种系传播的20bp缺失的突变系的产生，该缺失与幼虫期脑血管异常、游泳缺陷和对药物诱导的脑出血的易感性增加有关。成年后，突变col4a1Δ20动物发生自发性脑出血，在自由游动的鱼类中也可以观察到。总的来说，本研究验证了斑马鱼疾病模型在临床前col4a1相关cSVD研究中的应用，并强调了其在进一步了解疾病病理生理和未来药物发现项目方面的潜力。

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引用次数: 0

Mechanical control of breast cancer malignancy by promotion of mevalonate pathway enzyme synthesis 促进甲羟戊酸途径酶合成对乳腺癌恶性肿瘤的机械控制

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-06-12 DOI: 10.1016/j.matbio.2025.05.005

Sara Göransson , Helene Olofsson , Henrik J. Johansson , Feifei Yan , Christos Vogiatzakis , Shuo Liang , Hermano Martins Bellato , Laia Masvidal , Inci Aksoylu , Johan Hartman , Glaucia NM Hajj , Ola Larsson , Janne Lehtiö , Staffan Strömblad

In breast cancer, mechanotransduction from stiffened extracellular matrix (ECM) drives proliferation and invasion. Here, we use a model of matrix stiffening mimicking progression of breast ductal carcinoma in situ to invasive ductal carcinoma. Quantitative mass spectrometry identified enrichment of ECM-stiffness upregulated mevalonate pathway enzymes, indicating sterol/isoprenoid metabolism reprogramming. Consistently, the first committed mevalonate pathway enzyme, Hydroxymethylglutaryl-CoA Synthase (HMGCS1), was upregulated in human breast cancer specimens and spatially correlated with cross-linked ECM. ECM-stiffness promoted HMGCS1 protein synthesis without corresponding mRNA level alterations, indicating post-transcriptional regulation of mevalonate biosynthesis via microenvironmental mechanical cues to impose rapid metabolic alterations. Moreover, HMGCS1-RNAi blocked the stiffness-driven breast cancer proliferative and invasive phenotype. Mechanistically, mechanotransduction signaling, through integrin and Rac1 to promote HMGCS1 protein expression, drives the breast cancer malignant phenotype. Intriguingly, the Rac1-P29S cancer mutant promoted a malignant phenotype without stiff ECM in a mevalonate-dependent manner. In summary, we define a mechano-responsive pathway controlling mevalonate pathway enzyme synthesis that drives breast cancer malignant behaviors.

在乳腺癌中，硬化细胞外基质（ECM）的机械转导驱动增殖和侵袭。在这里，我们使用基质硬化模型模拟乳腺导管原位癌向浸润性导管癌的进展。定量质谱鉴定出ecm僵硬度上调的甲戊酸途径酶的富集，表明甾醇/类异戊二烯代谢重编程。一致地，甲羟戊酸途径酶羟甲基戊二酰辅酶a合成酶（HMGCS1）在人类乳腺癌标本中上调，并与交联ECM在空间上相关。ecm刚度促进了HMGCS1蛋白的合成，但没有相应的mRNA水平改变，表明甲羟戊酸生物合成的转录后调控通过微环境机械线索施加快速代谢改变。HMGCS1-RNAi阻断了刚性驱动的乳腺癌增生性和侵袭性表型。机制上，机械转导信号通过整合素和Rac1促进HMGCS1蛋白表达，驱动乳腺癌恶性表型。有趣的是，Rac1-P29S癌症突变体以甲羟戊酸依赖的方式促进了没有僵硬ECM的恶性表型。总之，我们定义了一种机械反应途径，控制甲羟戊酸途径酶合成，驱动乳腺癌恶性行为。

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引用次数: 0

Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases 围绕胶原蛋白三螺旋：介绍研究相关的遗传和获得性疾病。

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-07-07 DOI: 10.1016/j.matbio.2025.07.003

Sergei P. Boudko

The triple helix structure of collagen is the most abundant motif found in our bodies. It is believed to have emerged during the transition from unicellular to multicellular animal organisms, known as metazoans, and has evolved into various proteins that contribute to the development and function of diverse animal tissues, organs, and systems. Once synthesized, these collagenous proteins undergo post-translational modifications and proper folding inside the cell, after which they primarily function outside the cell. Over 80 collagenous proteins are categorized into two main groups: collagens and collagen-like proteins. However, the distinction between these groups is not clearly defined. Within these categories, there are various types of proteins, including soluble proteins, transmembrane proteins, and those that form the extracellular matrix. Multiple genetic diseases highlight the significance of collagenous proteins, which can be affected by defects in their primary structure, post-translational modifications, or complete loss. While fixing the gene defect may seem like a straightforward solution, we currently lack the capability to do so. Moreover, acquired diseases caused or accompanied by adverse processes in the collagen triple helix are generally not suitable for gene therapy at all. Understanding the pathogenicity of a defective polypeptide chain can provide valuable insights into strategies for mitigating negative consequences for both genetic and acquired diseases. This review highlights the current state of research in the collagen triple helix field, offering insights into how to study specific defects and deepen our understanding of their underlying pathogenic mechanisms.

胶原蛋白的三螺旋结构是我们体内发现的最丰富的基序。它被认为是在从单细胞动物有机体向多细胞动物有机体过渡的过程中出现的，被称为后生动物，并已进化成各种蛋白质，这些蛋白质有助于各种动物组织、器官和系统的发育和功能。一旦合成，这些胶原蛋白在细胞内进行翻译后修饰和适当折叠，之后它们主要在细胞外发挥作用。超过80种胶原蛋白被分为两大类：胶原蛋白和胶原样蛋白。然而，这些群体之间的区别并没有明确界定。在这些类别中，有各种类型的蛋白质，包括可溶性蛋白质，跨膜蛋白质和那些形成细胞外基质的蛋白质。多种遗传疾病突出了胶原蛋白的重要性，胶原蛋白可能受到其初级结构缺陷、翻译后修饰或完全丢失的影响。虽然修复基因缺陷似乎是一个直截了当的解决方案，但我们目前缺乏这样做的能力。此外，由胶原蛋白三螺旋不良过程引起或伴随的获得性疾病，一般根本不适合进行基因治疗。了解缺陷多肽链的致病性可以为减轻遗传和获得性疾病的负面后果提供有价值的见解。本文综述了胶原蛋白三螺旋领域的研究现状，为如何研究特定缺陷和加深对其潜在致病机制的理解提供了新的见解。

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引用次数: 0

Role of extracellular space and matrix remodeling in cardiac amyloidosis 细胞外空间和基质重塑在心脏淀粉样变性中的作用

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI: 10.1016/j.matbio.2025.07.004

Francesca Lavatelli , Loredana Marchese , Palma Patrizia Mangione , Sara Raimondi , Diana Canetti , Guglielmo Verona , Lucia Venneri , Eloisa Arbustini , Laura Obici , Alessandra Corazza , Vittorio Bellotti , Sofia Giorgetti

The hallmark of amyloid diseases is deposition of misfolded proteins as amyloid fibrils in the interstitium of target organs. Amyloid deposits surround cells, distorting the micro and macro-architecture of the extracellular space and profoundly changing the physical and molecular properties of this compartment. In the heart, extracellular matrix (ECM) remodeling has a profound impact on the mechanical properties of this target organ and on the physiology and metabolism of resident cells. This review critically summarizes the available knowledge on ECM alterations in cardiac amyloidosis, with the goal of providing an overview on how biochemical, biophysical and anatomical modifications are interrelated, and how ECM remodeling participates in the pathophysiology of this unique type of cardiopathy.

淀粉样蛋白疾病的标志是错误折叠的蛋白作为淀粉样原纤维沉积在靶器官间质中。淀粉样蛋白沉积在细胞周围，扭曲了细胞外空间的微观和宏观结构，并深刻地改变了细胞外空间的物理和分子特性。在心脏中，细胞外基质（extracellular matrix， ECM）重构对靶器官的力学特性以及常驻细胞的生理和代谢具有深远的影响。这篇综述批判性地总结了心肌淀粉样变性中ECM改变的现有知识，目的是概述生化，生物物理和解剖改变是如何相互关联的，以及ECM重塑如何参与这种独特类型的心脏病的病理生理学。

引用次数: 0

Paracrine regulations of IFN-γ secreting CD4+ T cells by lumican and biglycan are protective in allergic contact dermatitis lumican和biglycan对IFN-γ分泌CD4+ T细胞的旁分泌调节在过敏性接触性皮炎中具有保护作用

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-06-14 DOI: 10.1016/j.matbio.2025.06.002

George Maiti , Jihane Frikeche , Cynthia Loomis , Michael Cammer , Stephanie L Eichman , Shukti Chakravarti

Allergic contact dermatitis (ACD) is a delayed-type IV hypersensitivity response driven by innate and adaptive immune cells. While specific immune regulations of these cell types are amply elucidated, their regulations by extracellular matrix (ECM) components and T cell mediated adaptive immunity in ACD remains unclear. Lumican and biglycan are ECM proteoglycans abundant in the dermis and lymph node, known to regulate innate immune myeloid cells, but have not been investigated in lymphoid cell regulations in ACD. By immunohistology we localized lumican and biglycan in skin biopsies of psoriatic patients. Using wild type (WT), lumican and biglycan knockout mice, we investigated CD4⁺T cell infiltration, activation and proliferation in the skin and draining lymph node (dLN) of contact hypersensitivity (CHS)-challenged mice by immunohistochemistry and flow cytometry. We used the OT-II adoptive transfer model to test antigen specific CD4⁺T cell activation. We assessed interactions of the proteoglycans with LFA-1 on T cells by confocal microscopy. Compared to WTs, the knockouts showed severe ear inflammation, with increased CD4⁺T cells infiltration in the dermis. CHS-challenged knockout mice dLN showed increased T-bet, STAT1 and -STAT4 signaling, indicating enhanced Th1 commitment and proliferation. We found that WT lymph node fibroblastic reticular cells (FRCs) secrete lumican, biglycan and decorin, a related proteoglycan, while none are expressed by naive or activated T cells. Lumican and biglycan interact with LFA-1 on T cell surfaces, and in vitro all three proteoglycans suppress CD4⁺T cell activation. Secreted by dLN FRCs, lumican, biglycan, and possibly decorin interact with LFA-1 on CD4⁺T cells to restrict their activation and reduce dermatitis severity.

过敏性接触性皮炎（ACD）是一种由先天和适应性免疫细胞驱动的延迟型IV超敏反应。虽然这些细胞类型的特异性免疫调节已被充分阐明，但它们在ACD中由细胞外基质（ECM）成分和T细胞介导的适应性免疫的调节尚不清楚。Lumican和biglycan是真皮和淋巴结中丰富的ECM蛋白聚糖，已知可调节先天性免疫髓细胞，但尚未研究ACD中淋巴样细胞的调节。通过免疫组织学方法，我们在银屑病患者的皮肤活检中定位了lumican和biglycan。以野生型（WT）、lumican和biglycan敲除小鼠为实验对象，采用免疫组织化学和流式细胞术研究了CD4+T细胞在chs小鼠皮肤和引流淋巴结（dLN）中的浸润、活化和增殖情况。我们使用OT-II过继转移模型来检测抗原特异性CD4+T细胞活化。我们通过共聚焦显微镜评估了蛋白聚糖与LFA-1在T细胞上的相互作用。与WTs相比，敲除组表现出严重的耳部炎症，真皮中CD4+T细胞浸润增加。chs敲除小鼠dLN显示T-bet、STAT1和-STAT4信号增加，表明Th1承诺和增殖增强。我们发现WT淋巴结成纤维网状细胞（FRCs）分泌lumican， biglycan和decorin，一种相关的蛋白聚糖，而未被初始或活化的T细胞表达。Lumican和biglycan在T细胞表面与LFA-1相互作用，并且这三种蛋白多糖在体外都能抑制CD4+T细胞的激活。由dLN FRCs分泌的lumican、biglycan和可能的decorin与CD4+T细胞上的LFA-1相互作用，限制其激活，降低皮炎的严重程度。

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引用次数: 0

A complex relationship between the architecture of the basement membrane, its mechanical properties, and its ability to shape the Drosophila egg 基膜的结构，它的机械特性，和它塑造果蝇卵的能力之间的复杂关系

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-06-13 DOI: 10.1016/j.matbio.2025.06.001

Mitchell T. Anderson , Sally Horne-Badovinac

Basement membranes (BMs) are planar extracellular matrices that line the basal surfaces of epithelia and are essential components of most organs. During development, BMs can also play instructive roles in shaping the tissues to which they belong, but how they do so is incompletely understood. The Drosophila egg chamber has become a premier system to study this aspect of BM biology due to the ostensible simplicity of the BM’s role in morphogenesis. The prevailing model posits that the egg chamber’s outer layer of epithelial cells creates a symmetric stiffness gradient in the surrounding BM that preferentially channels egg chamber growth along one axis to create the elongated shape of the egg. There is evidence that the stiffening of the BM depends, in part, on a polarized array of fibrils that form within the BM network, and yet the exact role the BM fibrils play in egg chamber elongation has remained unclear. Here, we use genetic conditions that abrogate fibril formation to different extents to probe the relationship between the BM’s fibril content, its mechanical properties, and the shape of the egg. The results of these experiments are consistent with a model in which BM fibrils influence egg shape by directly augmenting the mechanical properties of the BM. However, we then examine a final genetic condition that does not fit this simple narrative. We propose that the role of the BM in conferring final egg shape is more complicated than previously thought and that some approaches used to study this role should be re-evaluated for their efficacy.

基底膜是排列在上皮基底表面的平面细胞外基质，是大多数器官的重要组成部分。在发育过程中，脑转移瘤也可以在塑造它们所属的组织方面发挥指导作用，但它们是如何做到的还不完全清楚。由于果蝇卵室在形态发生中的作用表面上很简单，因此它已成为研究线粒体生物学这方面的首要系统。流行的模型假设，卵腔上皮细胞的外层在周围的BM中产生对称的刚度梯度，该梯度优先引导卵腔沿着一个轴生长，从而形成卵的细长形状。有证据表明，骨髓的硬化部分取决于骨髓网络中形成的原纤维的极化阵列，然而骨髓原纤维在卵室伸长中所起的确切作用仍不清楚。在这里，我们使用在不同程度上废除原纤维形成的遗传条件来探索BM的原纤维含量，其机械性能和卵的形状之间的关系。这些实验结果与BM原纤维通过直接增加BM的力学性能来影响卵形的模型一致。然而，我们接着检查一个最终的遗传条件，不符合这个简单的叙述。我们认为，卵细胞基质在决定最终卵子形状中的作用比以前认为的要复杂得多，一些用于研究这一作用的方法应该重新评估其有效性。

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引用次数: 0

Collagen diversity in human skin: Aging, wound healing, and disorders 胶原蛋白在人类皮肤的多样性：老化，伤口愈合和疾病。

IF 4.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1016/j.matbio.2025.07.006

Mélanie Salamito , Valérie Haydont , Hervé Pageon , Florence Ruggiero , Sarah Girardeau-Hubert

Collagen is an essential skin protein, accounting for 75 % of the skin’s dry weight. The collagen superfamily encompasses a diverse group of proteins with a variety of structures that fulfil a wide range of functions. The half-life of collagen in the skin is generally estimated at 10 to 15 years; however, the expression pattern of the different types of skin collagen varies throughout life. Both intrinsic and extrinsic factors influence collagen turn-over within the different skin layers. In this review, we discuss current knowledge of the different types of collagen present in human skin, focusing on insights gained from research exploring the dynamic roles of these proteins in skin development, homeostasis including aging, collagen-linked pathologies, adaptability in response to stress, and wound healing-related processes and disorders. Specificities of skin diversity due to ancestral origin and gender will also be discussed.

胶原蛋白是一种重要的皮肤蛋白质，占皮肤干重的75%。胶原蛋白超家族包括一组具有多种结构的蛋白质，这些蛋白质具有广泛的功能。皮肤中胶原蛋白的半衰期一般估计为10至15年；然而，不同类型的皮肤胶原蛋白的表达模式在人的一生中是不同的。内在和外在因素都会影响不同皮肤层内的胶原蛋白周转。在这篇综述中，我们讨论了目前对人类皮肤中不同类型胶原蛋白的了解，重点介绍了这些蛋白质在皮肤发育、体内平衡（包括衰老）、胶原相关病理、应激适应性以及伤口愈合相关过程和疾病中的动态作用。由于祖先起源和性别的皮肤多样性的特殊性也将被讨论。

引用次数: 0

Basement membranes in lung development, disease, and repair 基底膜在肺发育、疾病和修复中的作用。

IF 4.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1016/j.matbio.2025.07.007

Matilda Thuringer , Roy Zent , Rachel Lennon , Erin J. Plosa

The primary function of the respiratory system is the exchange of oxygen and carbon dioxide across the alveolar-capillary barrier in the distal lung. This structure is composed of alveolar epithelial cells (type 1 and type 2) and capillary endothelial cells, separated by a thin, fused alveolar basement membrane. The developmental programming that creates this specialized niche is largely unexplored and the role of lung basement membranes in respiratory disease pathogenesis and repair remains an emerging field of study. Thus, in this review, we discuss the distribution, composition, and function of the alveolar basement membrane, as well as the other three lung basement membranes that support the airway epithelium, airway smooth muscles, and the endothelium of the macrovasculature in lung development and disease.

呼吸系统的主要功能是通过远端肺的肺泡-毛细血管屏障交换氧气和二氧化碳。该结构由肺泡上皮细胞（1型和2型）和毛细血管内皮细胞组成，由一层薄薄的融合肺泡基底膜隔开。创造这种特殊生态位的发育程序在很大程度上尚未被探索，肺基底膜在呼吸系统疾病发病机制和修复中的作用仍然是一个新兴的研究领域。因此，在这篇综述中，我们讨论了肺泡基底膜的分布、组成和功能，以及在肺发育和疾病中支持气道上皮、气道平滑肌和大血管内皮的其他三种肺基底膜。

引用次数: 0

Retraction Notice for “Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy” [Matrix Biology, Volume 105, January 2022, Pages 53-71] “富含亮氨酸的小蛋白聚糖在妊娠期子宫颈重塑中的新调控作用”的撤回通知[基质生物学，第105卷，2022年1月，53-71页]

IF 4.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology

Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.1016/j.matbio.2025.08.001

Mariano Colon-Caraballo , Nicole Lee , Shanmugasundaram Nallasamy , Kristin Myers , David Hudson , Renato V. Iozzo , Mala Mahendroo

引用次数: 0