Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-96-105
A. V. Stepanenko, K. A. Denisova, V. V. Stepanenko, A. S. Shapovalov, K. V. Sysoev, A. V. Kim
Cervico-medullary compression and atlantoaxial dislocation syndromes are the dominant clinical manifestations of mucopolysaccharidoses at the craniovertebral level. The review provides an analysis of international literary sources concerning modern aspects of diagnosis and neurosurgical correction of the foramen magnum stenosis in patients with different types of mucopolysaccharidoses. The existing surgical approaches to determining the indications and choosing the method of surgical treatment and some aspects of the use of enzyme replacement therapy and hematopoietic stem cell transplantation are presented. A variety of options for surgical correction of pathology at the craniovertebral level have been demonstrated in patients with different types of mucopolysaccharidosis, however the described recommendations can be considered from the point of view of traditions of the hospitals or personal experience of surgeons, but not as recognized standards of treatment this pathology. Further accumulation of individual observations or clinical series is required to conduct a comparative analysis of the effectiveness of various approaches on a sufficiently large and homogeneous material to determine standards for the diagnosis and treatment of craniovertebral junction pathology in patients with mucopolysaccharidoses.
{"title":"Foramen magnum stenosis in patients with mucopolysaccharidoses: diagnosis and surgical treatment. Review of literature","authors":"A. V. Stepanenko, K. A. Denisova, V. V. Stepanenko, A. S. Shapovalov, K. V. Sysoev, A. V. Kim","doi":"10.18705/2782-3806-2024-4-2-96-105","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-96-105","url":null,"abstract":"Cervico-medullary compression and atlantoaxial dislocation syndromes are the dominant clinical manifestations of mucopolysaccharidoses at the craniovertebral level. The review provides an analysis of international literary sources concerning modern aspects of diagnosis and neurosurgical correction of the foramen magnum stenosis in patients with different types of mucopolysaccharidoses. The existing surgical approaches to determining the indications and choosing the method of surgical treatment and some aspects of the use of enzyme replacement therapy and hematopoietic stem cell transplantation are presented. A variety of options for surgical correction of pathology at the craniovertebral level have been demonstrated in patients with different types of mucopolysaccharidosis, however the described recommendations can be considered from the point of view of traditions of the hospitals or personal experience of surgeons, but not as recognized standards of treatment this pathology. Further accumulation of individual observations or clinical series is required to conduct a comparative analysis of the effectiveness of various approaches on a sufficiently large and homogeneous material to determine standards for the diagnosis and treatment of craniovertebral junction pathology in patients with mucopolysaccharidoses.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"46 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-12-18
I. A. Turchinskaya, S. R. Sheriev, A. Efimtsev, G. E. Trufanov
The article is devoted to the review of the most promising MRI techniques in the diagnosis of multiple sclerosis as part of personalized medicine. A brief description of the current state of the problem is provided. Examples of promising MR research techniques are considered. The issues of clinical importance and expediency of using these techniques are discussed. The existing approaches in the diagnosis of multiple sclerosis are summarized. In conclusion, the prospects and importance of the considered methods in the structure of healthcare are summarized.
{"title":"Special methods of magnetic resonance in diagnosis of multiple sclerosis.","authors":"I. A. Turchinskaya, S. R. Sheriev, A. Efimtsev, G. E. Trufanov","doi":"10.18705/2782-3806-2024-4-1-12-18","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-12-18","url":null,"abstract":"The article is devoted to the review of the most promising MRI techniques in the diagnosis of multiple sclerosis as part of personalized medicine. A brief description of the current state of the problem is provided. Examples of promising MR research techniques are considered. The issues of clinical importance and expediency of using these techniques are discussed. The existing approaches in the diagnosis of multiple sclerosis are summarized. In conclusion, the prospects and importance of the considered methods in the structure of healthcare are summarized.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140212996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-58-6
M. Dudina, S. Dogadin, A. A. Savchenko, I. Gvozdev
Background. Conservative therapy with thiamazole in Graves’ disease helps to reduce the level of oxidative stress by restoring euthyroidism and the total reactive antioxidant potential of plasma. However, until now, in patients with Graves’ disease, the radical-producing ability of neutrophils remains unexplored at the initial stage of free radical conversion at different durations of drug-induced euthyroidism, which seems significant in revealing the mechanisms of disease recurrence. The aim is to study the level of production of primary reactive oxygen species in peripheral blood neutrophils depending on the duration of drug — induced euthyroidism in patients with Graves’ disease. Materials and methods. A single-center, prospective, controlled study was conducted with the participation of patients with laboratory-confirmed Graves’ disease. Subgroups of patients with Graves’ disease were formed depending on the duration of achieved drug-induced euthyroidism with continuous conservative therapy with thiamazole. The level of ROS production in peripheral blood neutrophils was determined by chemiluminescence. The assessment of spontaneous and zymosan-induced chemiluminescence was carried out for 90 minutes on a 36-channel chemiluminescence analyzer BLM-3607 (Medbiotech LLC, Krasnoyarsk). Results. The study included 102 Graves’ disease women with an average age of 47.54 ± 15.47 years. Of these, 75 (73.5 %) with relapse and 27 (26.47 %) with newly diagnosed disease. The total synthesis of (S) primary ROS increased statistically significantly relative to the control values in the examined patients with a duration of the euthyroid state of 5–8 and 9–12 months. It was found that in patients with Graves’ disease with stable drug-induced euthyroidism for 5–8 and 9–12 months, the S index of zymosan-induced lucigenin-dependent chemiluminescence of neutrophils increased statistically significantly, respectively, by 10.7 and 7.4 times relative to the control values. Conclusion. The restoration and maintenance of drug-induced euthyroidism for more than 12 months against the background of conservative thiamazole therapy in patients with Graves’ disease reduces the load of systemic oxidative stress on the immune system. However, the high total production of primary ROS in neutrophils of patients with Graves’ disease in a state of drug-induced euthyroidism with conservative thiamazole therapy may play a significant role in disconnecting the functioning of the NADPH oxidase complex and determine the functional capabilities of neutrophils in case of disease recurrence.
{"title":"The level of blood neutrophils primary reactive oxygen species production in Graves’ disease patients undergoing conservative therapy with thiamazole.","authors":"M. Dudina, S. Dogadin, A. A. Savchenko, I. Gvozdev","doi":"10.18705/2782-3806-2024-4-1-58-6","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-58-6","url":null,"abstract":"Background. Conservative therapy with thiamazole in Graves’ disease helps to reduce the level of oxidative stress by restoring euthyroidism and the total reactive antioxidant potential of plasma. However, until now, in patients with Graves’ disease, the radical-producing ability of neutrophils remains unexplored at the initial stage of free radical conversion at different durations of drug-induced euthyroidism, which seems significant in revealing the mechanisms of disease recurrence. The aim is to study the level of production of primary reactive oxygen species in peripheral blood neutrophils depending on the duration of drug — induced euthyroidism in patients with Graves’ disease. Materials and methods. A single-center, prospective, controlled study was conducted with the participation of patients with laboratory-confirmed Graves’ disease. Subgroups of patients with Graves’ disease were formed depending on the duration of achieved drug-induced euthyroidism with continuous conservative therapy with thiamazole. The level of ROS production in peripheral blood neutrophils was determined by chemiluminescence. The assessment of spontaneous and zymosan-induced chemiluminescence was carried out for 90 minutes on a 36-channel chemiluminescence analyzer BLM-3607 (Medbiotech LLC, Krasnoyarsk). Results. The study included 102 Graves’ disease women with an average age of 47.54 ± 15.47 years. Of these, 75 (73.5 %) with relapse and 27 (26.47 %) with newly diagnosed disease. The total synthesis of (S) primary ROS increased statistically significantly relative to the control values in the examined patients with a duration of the euthyroid state of 5–8 and 9–12 months. It was found that in patients with Graves’ disease with stable drug-induced euthyroidism for 5–8 and 9–12 months, the S index of zymosan-induced lucigenin-dependent chemiluminescence of neutrophils increased statistically significantly, respectively, by 10.7 and 7.4 times relative to the control values. Conclusion. The restoration and maintenance of drug-induced euthyroidism for more than 12 months against the background of conservative thiamazole therapy in patients with Graves’ disease reduces the load of systemic oxidative stress on the immune system. However, the high total production of primary ROS in neutrophils of patients with Graves’ disease in a state of drug-induced euthyroidism with conservative thiamazole therapy may play a significant role in disconnecting the functioning of the NADPH oxidase complex and determine the functional capabilities of neutrophils in case of disease recurrence.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140220262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-29-43
S. M. Sklyar, N. E. Voinov, A. Ulitin, M. Matsko
Relevance. Despite all the treatment glioblastoma recurs as an aggressive and therapy-resistant tumor, and patients quickly die from these neoplasms. The study of glioblastoma recurrence processes and search for prognostic factors of the disease should lead to the improvement of survival rates of patients with this pathology. Purpose of the study. To study the influence of clinical and molecular-genetic factors on the median second recurrence-free period. Materials and methods. Progression-free survival after first recurrence in 34 patients aged 28 to 81 years with recurrent glioblastoma was analyzed. The diagnosis was established according to the WHO 2021 classification of CNS tumors. In each observation we studied such clinical parameters as patient’s age, functional status according to the Karnovsky scale pre- and postoperatively, peculiarities of neuroimaging picture (prevalence of tumor process, localization of recurrence, tumor volume), conducted treatment and molecular-genetic characteristics of the tumor (determination of mRNA expression level of genes: MGMT, VEGF, PDGFRA, β-tubulin III, ERCC-1, TOP2A). Results. Among the clinical and demographic characteristics, the median of the survival was influenced by the patients’ age and functional status after surgery. The median of the survival was more than 2 times higher in the group of patients under 50 years old, compared to patients over 50 years old (18.5 vs 8 weeks). The dependence of the median of the survival on the post- operative functional status (according to the Karnovsky scale) was determined (p = 0.001). The median of the survival in case of a single brain lobe lesion was more than 5 times higher than in case of widespread tumor process, though without statistical reliability (p = 0.09, 21.5 vs 4 weeks). Survival rates were higher when recurrence was localized within 2 cm of the area of removal of the primary neoplasm. After disease progression, the MGMT gene lost its predictive value. Patients with low expression of the TOR2A gene had a higher survival rate than those with medium and high expression (47.5 vs 3 weeks, p = 0.001; 47.5 vs 22.5 weeks, p = 0.06). The median of survival was higher than at high levels at low and medium PDGFRA gene expression levels (29 vs 0 weeks, p = 0.04; 21 vs 0 weeks; p = 0.05, respectively). Maximum survival rates were recorded in the group of patients after total and subtotal removal of tumor recurrence (22 and 18.5 weeks, p = 0.05). Administration of second-line chemotherapy with temozolomide statistically significantly increased the median of the second BRS (p = 0.01). Conclusion. Recurrent glioblastomas are characterized by an extremely aggressive course. Therefore, such prognostic factors as patient age, degree of tumor resection, tumor process prevalence, degree of tumor resection and 2nd line chemotherapy come to the forefront. It should be noted that the MGMT gene loses its predictive value during disease progression, while the TOR2A gene
{"title":"Progression-free survival after first recurrence in patients with glioblastoma.","authors":"S. M. Sklyar, N. E. Voinov, A. Ulitin, M. Matsko","doi":"10.18705/2782-3806-2024-4-1-29-43","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-29-43","url":null,"abstract":"Relevance. Despite all the treatment glioblastoma recurs as an aggressive and therapy-resistant tumor, and patients quickly die from these neoplasms. The study of glioblastoma recurrence processes and search for prognostic factors of the disease should lead to the improvement of survival rates of patients with this pathology. Purpose of the study. To study the influence of clinical and molecular-genetic factors on the median second recurrence-free period. Materials and methods. Progression-free survival after first recurrence in 34 patients aged 28 to 81 years with recurrent glioblastoma was analyzed. The diagnosis was established according to the WHO 2021 classification of CNS tumors. In each observation we studied such clinical parameters as patient’s age, functional status according to the Karnovsky scale pre- and postoperatively, peculiarities of neuroimaging picture (prevalence of tumor process, localization of recurrence, tumor volume), conducted treatment and molecular-genetic characteristics of the tumor (determination of mRNA expression level of genes: MGMT, VEGF, PDGFRA, β-tubulin III, ERCC-1, TOP2A). Results. Among the clinical and demographic characteristics, the median of the survival was influenced by the patients’ age and functional status after surgery. The median of the survival was more than 2 times higher in the group of patients under 50 years old, compared to patients over 50 years old (18.5 vs 8 weeks). The dependence of the median of the survival on the post- operative functional status (according to the Karnovsky scale) was determined (p = 0.001). The median of the survival in case of a single brain lobe lesion was more than 5 times higher than in case of widespread tumor process, though without statistical reliability (p = 0.09, 21.5 vs 4 weeks). Survival rates were higher when recurrence was localized within 2 cm of the area of removal of the primary neoplasm. After disease progression, the MGMT gene lost its predictive value. Patients with low expression of the TOR2A gene had a higher survival rate than those with medium and high expression (47.5 vs 3 weeks, p = 0.001; 47.5 vs 22.5 weeks, p = 0.06). The median of survival was higher than at high levels at low and medium PDGFRA gene expression levels (29 vs 0 weeks, p = 0.04; 21 vs 0 weeks; p = 0.05, respectively). Maximum survival rates were recorded in the group of patients after total and subtotal removal of tumor recurrence (22 and 18.5 weeks, p = 0.05). Administration of second-line chemotherapy with temozolomide statistically significantly increased the median of the second BRS (p = 0.01). Conclusion. Recurrent glioblastomas are characterized by an extremely aggressive course. Therefore, such prognostic factors as patient age, degree of tumor resection, tumor process prevalence, degree of tumor resection and 2nd line chemotherapy come to the forefront. It should be noted that the MGMT gene loses its predictive value during disease progression, while the TOR2A gene ","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140217030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-6-11
I. A. Turchinskaya, L. G. Konstantinova, G. E. Trufanov
The article is dedicated to reviewing the role of radiological diagnosis in “Identifying neonatal pneumonia”. It includes a brief historical and terminological overview, as well as a description of the current state of the issue. The article discusses the clinical importance and feasibility of using radiological diagnostic methods, summarizes existing approaches in the diagnosis and treatment of the most significant nosological forms, and concludes with an overview of the prospects and significance of these methods in the healthcare system.
{"title":"Radiology diagnostics of neonatal pneumonia.","authors":"I. A. Turchinskaya, L. G. Konstantinova, G. E. Trufanov","doi":"10.18705/2782-3806-2024-4-1-6-11","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-6-11","url":null,"abstract":"The article is dedicated to reviewing the role of radiological diagnosis in “Identifying neonatal pneumonia”. It includes a brief historical and terminological overview, as well as a description of the current state of the issue. The article discusses the clinical importance and feasibility of using radiological diagnostic methods, summarizes existing approaches in the diagnosis and treatment of the most significant nosological forms, and concludes with an overview of the prospects and significance of these methods in the healthcare system.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140212708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-19-24
S. R. Sheriev, I. A. Turchinskaya, V. A. Fokin, A. V. Ryzhkov
The article is dedicated to reviewing the role of the 4D FLOW technique in assessing blood flow in the aorta. A brief historical and terminological overview is provided, along with a description of the current state of the issue. The clinical relevance and appropriateness of using this radiological diagnostic method are discussed. The scanning and image post-processing process is summarized. Finally, the prospects and significance of the reviewed technique in healthcare are outlined.
{"title":"4D FLOW in assessing blood flow in aorta.","authors":"S. R. Sheriev, I. A. Turchinskaya, V. A. Fokin, A. V. Ryzhkov","doi":"10.18705/2782-3806-2024-4-1-19-24","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-19-24","url":null,"abstract":"The article is dedicated to reviewing the role of the 4D FLOW technique in assessing blood flow in the aorta. A brief historical and terminological overview is provided, along with a description of the current state of the issue. The clinical relevance and appropriateness of using this radiological diagnostic method are discussed. The scanning and image post-processing process is summarized. Finally, the prospects and significance of the reviewed technique in healthcare are outlined.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140213733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-25-28
N. S. Bayramova
The role of immunological processes in the pathophysiology of colorectal cancer has received a lot of attention lately and has been extensively researched. Immune processes are significantly regulated by cytokines and antimicrobial peptides (AMP). Numerous studies have demonstrated the significance of cytokines in the prognosis and surveillance of malignant oncological illnesses. In group II, the blood serum concentration of Calprotectin was found to be greater in 13 patients (92.0 %) and lower in 1 patient (8.0 %) compared to control limits (χ = 24.27, p < 0.001). The obtained results show that, in comparison to the control group, the concentration of Calprotectin rises statistically consistently by 3.5 times, with a coefficient of integrity of p < 0.001. According to the data, there is a statistically significant rise in Calprotectin concentration (3.5 times higher than in the control group) with a p-value of less than 0.001. The average mathematical density of this indicator is 3.42 ± 0.48 pg/ml, the minimum density is 0.7 pg/ml, and the maximum thickness is 6.1 pg/ml.
{"title":"Identifying Immunological Markers for Bowel Cancer.","authors":"N. S. Bayramova","doi":"10.18705/2782-3806-2024-4-1-25-28","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-25-28","url":null,"abstract":"The role of immunological processes in the pathophysiology of colorectal cancer has received a lot of attention lately and has been extensively researched. Immune processes are significantly regulated by cytokines and antimicrobial peptides (AMP). Numerous studies have demonstrated the significance of cytokines in the prognosis and surveillance of malignant oncological illnesses. In group II, the blood serum concentration of Calprotectin was found to be greater in 13 patients (92.0 %) and lower in 1 patient (8.0 %) compared to control limits (χ = 24.27, p < 0.001). The obtained results show that, in comparison to the control group, the concentration of Calprotectin rises statistically consistently by 3.5 times, with a coefficient of integrity of p < 0.001. According to the data, there is a statistically significant rise in Calprotectin concentration (3.5 times higher than in the control group) with a p-value of less than 0.001. The average mathematical density of this indicator is 3.42 ± 0.48 pg/ml, the minimum density is 0.7 pg/ml, and the maximum thickness is 6.1 pg/ml.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140217016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-68-72
M. S. Nikolaenko, N. Samochernykh
Tumors of the third ventricle are rare and account for 0.6–0.9 % of all pediatric brain tumors. Tumors of the third ventricle are divided into primary tumors, such as choroid plexus papillomas and ependymomas, and secondary tumors, such as craniopharyngiomas, optic nerve gliomas, pineal tumors, and meningiomas. Choroid papilloma is a common tumor, the treatment of which is mainly based on microsurgical resection. Apart from the many treatment options for craniopharyngiomas, microsurgery is the preferred treatment option. Ependymomas also have several treatment options, with microsurgical removal considered the first line of treatment.
{"title":"Tumors of the third ventricle in children (literature review).","authors":"M. S. Nikolaenko, N. Samochernykh","doi":"10.18705/2782-3806-2024-4-1-68-72","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-68-72","url":null,"abstract":"Tumors of the third ventricle are rare and account for 0.6–0.9 % of all pediatric brain tumors. Tumors of the third ventricle are divided into primary tumors, such as choroid plexus papillomas and ependymomas, and secondary tumors, such as craniopharyngiomas, optic nerve gliomas, pineal tumors, and meningiomas. Choroid papilloma is a common tumor, the treatment of which is mainly based on microsurgical resection. Apart from the many treatment options for craniopharyngiomas, microsurgery is the preferred treatment option. Ependymomas also have several treatment options, with microsurgical removal considered the first line of treatment.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140217095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.18705/2782-3806-2024-4-1-44-57
K. K. Kukanov, A. Nechaeva, A. Ulitin, S. M. Sklyar, A. E. Vershinin, M. V. Dikonenko, A. O. Politova, G. V. Papayan, V. Olyushin
Literature review reflects the current status and development status of intraoperative photodynamic therapy in neurooncology and discusses the results of the most important studies on photodynamic therapy (PDT). We searched the Pubmed, EMBASE, Cochrane Library and eLibrary databases for publications published between January 2000 and December 2022. Found 204 publications in foreign sources and 59 publications in domestic editions, dealing with the issues of photodynamic therapy in neurooncology. An analysis of the literature has shown that intraoperative PDT in neurooncology is an important tool that contributes to increasing the radicality of the operation and local control. The basic rationale for the effectiveness of PDT lies in the study of the pathways leading to the complete devitalization of a malignant tumor, the study of the mechanisms of the local and systemic immune response. In addition, subcellular targets in PDT are determined by the properties of photosensitizers (PS). Second generation PSs have already been introduced into clinical practice. The effectiveness of PDT using photoditazine, 5-aminolevulinic acid has been demonstrated. The mechanisms of action and targets of these PS have been established. In Russia, a number of studies have repeatedly shown and proved the clinical effectiveness of PDT in groups of neurooncological patients with glial tumors and secondary metastatic tumors, but so far, the method has not been included in the clinical guidelines for the provision of high-tech neurosurgical care. There is certainly a need for further development of PTD techniques in neurooncology, especially in patients at high risk of recurrence and aggressive CNS tumors.
{"title":"Achievements and prospects for further development of photodynamic therapy technology in the treatment of cerebral tumors","authors":"K. K. Kukanov, A. Nechaeva, A. Ulitin, S. M. Sklyar, A. E. Vershinin, M. V. Dikonenko, A. O. Politova, G. V. Papayan, V. Olyushin","doi":"10.18705/2782-3806-2024-4-1-44-57","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-1-44-57","url":null,"abstract":"Literature review reflects the current status and development status of intraoperative photodynamic therapy in neurooncology and discusses the results of the most important studies on photodynamic therapy (PDT). We searched the Pubmed, EMBASE, Cochrane Library and eLibrary databases for publications published between January 2000 and December 2022. Found 204 publications in foreign sources and 59 publications in domestic editions, dealing with the issues of photodynamic therapy in neurooncology. An analysis of the literature has shown that intraoperative PDT in neurooncology is an important tool that contributes to increasing the radicality of the operation and local control. The basic rationale for the effectiveness of PDT lies in the study of the pathways leading to the complete devitalization of a malignant tumor, the study of the mechanisms of the local and systemic immune response. In addition, subcellular targets in PDT are determined by the properties of photosensitizers (PS). Second generation PSs have already been introduced into clinical practice. The effectiveness of PDT using photoditazine, 5-aminolevulinic acid has been demonstrated. The mechanisms of action and targets of these PS have been established. In Russia, a number of studies have repeatedly shown and proved the clinical effectiveness of PDT in groups of neurooncological patients with glial tumors and secondary metastatic tumors, but so far, the method has not been included in the clinical guidelines for the provision of high-tech neurosurgical care. There is certainly a need for further development of PTD techniques in neurooncology, especially in patients at high risk of recurrence and aggressive CNS tumors.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140214465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.18705/2782-3806-2023-3-4-96-105
P. D. Puzdriak, V. V. Shlomin, E. F. Rzaev, K. V. Zhdanovich, M. A. Shatil, M. A. Voskresensky, P. B. Bondarenko
The paper demonstrates a clinical case of open surgical re-interventional on the abdominal aorta 8 years later after primary aortofemoral bypass through the right and left retroperitoneal accesses. Severe ischemic damage to the tissues of both lower extremities required repeated vascular reconstruction. The tactics of repeated retroperitoneal intervention on the aorta was chosen, while the access could be expanded to thoracophrenolumbotomy. Due to the pronounced cicatricial process in the retroperitoneal space and intraoperative damage to the ureter, the branches of the prosthesis were performed in an atypical manner.
{"title":"Case of successful surgical treatment of the aorto-bifemoral re-occlusion with both lower limbs dry gangrene formation","authors":"P. D. Puzdriak, V. V. Shlomin, E. F. Rzaev, K. V. Zhdanovich, M. A. Shatil, M. A. Voskresensky, P. B. Bondarenko","doi":"10.18705/2782-3806-2023-3-4-96-105","DOIUrl":"https://doi.org/10.18705/2782-3806-2023-3-4-96-105","url":null,"abstract":"The paper demonstrates a clinical case of open surgical re-interventional on the abdominal aorta 8 years later after primary aortofemoral bypass through the right and left retroperitoneal accesses. Severe ischemic damage to the tissues of both lower extremities required repeated vascular reconstruction. The tactics of repeated retroperitoneal intervention on the aorta was chosen, while the access could be expanded to thoracophrenolumbotomy. Due to the pronounced cicatricial process in the retroperitoneal space and intraoperative damage to the ureter, the branches of the prosthesis were performed in an atypical manner.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"334 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136061207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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