Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-114-128
E. V. Kharakterova, A. A. Ivanilova, S. Fetisova, A. Y. Kulpina, O. Kofeynikova, T. Vershinina, T. Pervunina, E. Vasichkina
The Fontan operation is a palliative surgical correction, which is performed on children with congenital heart defects (CHD) in cases when surgical creation of two equally working ventricles is impossible. Today there are about 70,000 patients with Fontan circulation all over the world. Due to improvement of methods in early detection and treatment of CHD, as well as monitoring algorithms, an increasing number of patients with a single ventricle (SV) stay alive until adulthood.However, this group’s mortality is still quite high, despite the constant development of the surgery approach using modern technical equipment and high-tech examination methods. Chronic increase in systemic venous pressure, non-physiological passive pulmonary blood flow and progressive heart failure (HF) with a decreasing cardiac output (CO) gradually lead to complications from other organs and systems. That is why a multidisciplinary approach and development of optimal management tactics are required to follow-up patients with Fontan hemodynamics.Thus, the purpose of our work was to analyze and summarize current data of the management strategy and timely diagnosis complications in patients with Fontan circulation.
{"title":"Patients with Fontan circulation: long-term complications and follow-up strategy","authors":"E. V. Kharakterova, A. A. Ivanilova, S. Fetisova, A. Y. Kulpina, O. Kofeynikova, T. Vershinina, T. Pervunina, E. Vasichkina","doi":"10.18705/2782-3806-2024-4-2-114-128","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-114-128","url":null,"abstract":"The Fontan operation is a palliative surgical correction, which is performed on children with congenital heart defects (CHD) in cases when surgical creation of two equally working ventricles is impossible. Today there are about 70,000 patients with Fontan circulation all over the world. Due to improvement of methods in early detection and treatment of CHD, as well as monitoring algorithms, an increasing number of patients with a single ventricle (SV) stay alive until adulthood.However, this group’s mortality is still quite high, despite the constant development of the surgery approach using modern technical equipment and high-tech examination methods. Chronic increase in systemic venous pressure, non-physiological passive pulmonary blood flow and progressive heart failure (HF) with a decreasing cardiac output (CO) gradually lead to complications from other organs and systems. That is why a multidisciplinary approach and development of optimal management tactics are required to follow-up patients with Fontan hemodynamics.Thus, the purpose of our work was to analyze and summarize current data of the management strategy and timely diagnosis complications in patients with Fontan circulation.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"45 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-180-188
O. V. Kotomina, V. V. Pogodin, Yu. L. Pazgaleva
This article describes a rare clinical case of the development of severe ventricular tachycardia while taking etacizine in a 3-year-8-month-old patient with chronic kidney disease. A clinical case demonstrates the pharmacodynamics and pharmacokinetics of class 1C antiarrhythmic drugs in pediatric patients with kidney pathology.
{"title":"A rare variant of the development of the proarrhythmogenic effect of etacizine in a child with chronic kidney disease (clinical case)","authors":"O. V. Kotomina, V. V. Pogodin, Yu. L. Pazgaleva","doi":"10.18705/2782-3806-2024-4-2-180-188","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-180-188","url":null,"abstract":"This article describes a rare clinical case of the development of severe ventricular tachycardia while taking etacizine in a 3-year-8-month-old patient with chronic kidney disease. A clinical case demonstrates the pharmacodynamics and pharmacokinetics of class 1C antiarrhythmic drugs in pediatric patients with kidney pathology.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"31 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-145-155
E. D. Kessenikh, E. A. Osintseva, M. А. Migunova, M. I. Krivosheina, E. A. Murashko
Metabolomics is the comprehensive analysis of small molecules involved in metabolic pathways that control biochemical processes and functions of cells in the body. Metabolomic studies consist of three major steps: pre-analytical, analytical and post-analytical. The review emphasizes the importance of the pre-analytical stage, which is the journey of a biosample from the patient to the biobank and then to the analytical laboratory. Based on the literature analysis, the review presents the factors that influence the quality of the sample and therefore the quality of the final research result: clinical information collection, biosample selection, biosample collection and processing, and subsequent storage. Proper design of metabolomic studies, quality control of samples from collection to analysis by physicochemical methods provides data that can improve the quality of disease diagnosis, provide a transition to personalized medicine.
{"title":"Design of metabolomic studies: pre-analytical process","authors":"E. D. Kessenikh, E. A. Osintseva, M. А. Migunova, M. I. Krivosheina, E. A. Murashko","doi":"10.18705/2782-3806-2024-4-2-145-155","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-145-155","url":null,"abstract":"Metabolomics is the comprehensive analysis of small molecules involved in metabolic pathways that control biochemical processes and functions of cells in the body. Metabolomic studies consist of three major steps: pre-analytical, analytical and post-analytical. The review emphasizes the importance of the pre-analytical stage, which is the journey of a biosample from the patient to the biobank and then to the analytical laboratory. Based on the literature analysis, the review presents the factors that influence the quality of the sample and therefore the quality of the final research result: clinical information collection, biosample selection, biosample collection and processing, and subsequent storage. Proper design of metabolomic studies, quality control of samples from collection to analysis by physicochemical methods provides data that can improve the quality of disease diagnosis, provide a transition to personalized medicine.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"31 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141357219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-139-145
Yuliya Lutsenko, Yu. G. Abramova, A. B. Matiytsiv
The prevalence of diabetes mellitus (DM) in the population aged 20–79 years has reached more than half a billion people, representing about 10.5 % of the adult population on the planet. The risk of developing diabetic foot ulcers ranges from 19 to 34 % with a recurrence rate of 65 % within 5 years.The aim of the study: to evaluate the efficacy of dressings containing lyophilized collagen solution in the complex treatment of chronic diabetic foot ulcers.Materials and methods. 101 patients with diabetic foot ulcers (degree of foot lesions I–II according to Wagner) were under observation: in I (main) group — 52 patients — we used dressings containing lyophilized collagen solution (Zelenaya Dubrava, ZAO, RF), in II (comparison group) — 49 patients — traditional local treatment. Planimetric indices of the wound surface were measured using the MultiSpec program, and the assessment of treatment efficacy was determined as the ratio of the final area and depth of the wound to the initial values in percent. Results and their discussion. On admission, the wound area in the main group was 4.3 ± 3.7 cm2, whereas in the comparison group it was 4.1 ± 3.6 cm2. The final wound area (by 4-week measurement) decreased to 1.2 ± 1.3 cm2 in group I, whereas it was 2.6 ± 3.5 cm2 in group II. On 8–10 days after removal of purulent-necrotic tissues in the first group clinically there was a significant reduction of finger edema, cytologically there was no microflora in the wound discharge, phagocytosis was completed, whereas in the second group there was an inflammatory reaction (single areas of lysed leukocytes alternated with accumulation of leukocytes up to ¼ in f/v).Conclusions. Cytologically the effectiveness of collagen dressings application in complex treatment of diabetic foot ulcers was proved: by the end of the second week absence of inflammatory reaction and presence of proliferation signs in the majority of 69,4 % of patients. Planimetrically positive dynamics of the wound process was established: reduction of the area by the end of the 4th week in comparison with the initial one by 45,1 ± 33,8 % at traditional methods of treatment and by 79,9 ± 16,4 % at local use of collagen dressings, and depth — 53,1 ± 37,5 % and 76,8 ± 18,6 % respectively.
{"title":"The role of collagen dressings in the complex treatment of diabetic foot ulcers","authors":"Yuliya Lutsenko, Yu. G. Abramova, A. B. Matiytsiv","doi":"10.18705/2782-3806-2024-4-2-139-145","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-139-145","url":null,"abstract":"The prevalence of diabetes mellitus (DM) in the population aged 20–79 years has reached more than half a billion people, representing about 10.5 % of the adult population on the planet. The risk of developing diabetic foot ulcers ranges from 19 to 34 % with a recurrence rate of 65 % within 5 years.The aim of the study: to evaluate the efficacy of dressings containing lyophilized collagen solution in the complex treatment of chronic diabetic foot ulcers.Materials and methods. 101 patients with diabetic foot ulcers (degree of foot lesions I–II according to Wagner) were under observation: in I (main) group — 52 patients — we used dressings containing lyophilized collagen solution (Zelenaya Dubrava, ZAO, RF), in II (comparison group) — 49 patients — traditional local treatment. Planimetric indices of the wound surface were measured using the MultiSpec program, and the assessment of treatment efficacy was determined as the ratio of the final area and depth of the wound to the initial values in percent. Results and their discussion. On admission, the wound area in the main group was 4.3 ± 3.7 cm2, whereas in the comparison group it was 4.1 ± 3.6 cm2. The final wound area (by 4-week measurement) decreased to 1.2 ± 1.3 cm2 in group I, whereas it was 2.6 ± 3.5 cm2 in group II. On 8–10 days after removal of purulent-necrotic tissues in the first group clinically there was a significant reduction of finger edema, cytologically there was no microflora in the wound discharge, phagocytosis was completed, whereas in the second group there was an inflammatory reaction (single areas of lysed leukocytes alternated with accumulation of leukocytes up to ¼ in f/v).Conclusions. Cytologically the effectiveness of collagen dressings application in complex treatment of diabetic foot ulcers was proved: by the end of the second week absence of inflammatory reaction and presence of proliferation signs in the majority of 69,4 % of patients. Planimetrically positive dynamics of the wound process was established: reduction of the area by the end of the 4th week in comparison with the initial one by 45,1 ± 33,8 % at traditional methods of treatment and by 79,9 ± 16,4 % at local use of collagen dressings, and depth — 53,1 ± 37,5 % and 76,8 ± 18,6 % respectively.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"22 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141357471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-87-95
A. V. Savelyeva, Y. Zhilenkova, M. A. Simakova, O. V. Sirotkina
Cancer patients are at increased risk of venous thromboembolic complications (VTE), which are the second leading cause of death in these patients. Moreover, the maximum incidence of VTE occurs in tumors of the central nervous system [1]. Research is being conducted to identify laboratory biomarkers of increased risk of VTE, but to date data on their role are ambiguous. Patients with a mutation in the isocitrate dehydrogenase (IDH) gene are at lower risk of VTE, and the IDH mutation is associated with suppression of the production of tissue factor (TF) and podoplanin, the most studied molecules responsible for the occurrence of thromboembolic complications [2]. The main specific markers of VTE are based on immunohistochemical methods, which are possible only with histological examination of the tumor material. Therefore, it is important to find noninvasive biomarkers that could be used to assess the risk of venous thromboembolic complications. In this review, we will focus on highlighting the accumulated knowledge on this theme.
{"title":"Molecular mechanisms of thrombotic complications in glial tumors","authors":"A. V. Savelyeva, Y. Zhilenkova, M. A. Simakova, O. V. Sirotkina","doi":"10.18705/2782-3806-2024-4-2-87-95","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-87-95","url":null,"abstract":"Cancer patients are at increased risk of venous thromboembolic complications (VTE), which are the second leading cause of death in these patients. Moreover, the maximum incidence of VTE occurs in tumors of the central nervous system [1]. Research is being conducted to identify laboratory biomarkers of increased risk of VTE, but to date data on their role are ambiguous. Patients with a mutation in the isocitrate dehydrogenase (IDH) gene are at lower risk of VTE, and the IDH mutation is associated with suppression of the production of tissue factor (TF) and podoplanin, the most studied molecules responsible for the occurrence of thromboembolic complications [2]. The main specific markers of VTE are based on immunohistochemical methods, which are possible only with histological examination of the tumor material. Therefore, it is important to find noninvasive biomarkers that could be used to assess the risk of venous thromboembolic complications. In this review, we will focus on highlighting the accumulated knowledge on this theme.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"2 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-156-169
N. V. Muliarova, A. Smirnova, S. Lapaeva, Y. Toshina, Y. Dinikina
Background. Despite the successes achieved in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), overcoming the toxicity of standard chemotherapy regimens and the treatment of relapsed/refractory (r/r) forms of the disease remains relevant. The most promising option is to use immunotherapy (IT), including a monoclonal antibody blinatumomab (BM). The purpose of the study. To analyze indications of using, as well as efficacy and tolerability of BM in children with V-ALL. Materials and methods. From April 2016 to January 2024 a retrospective assessment of using of BM in children with B-ALL in the chemotherapy department of oncohematological diseases and TCM for children in Almazov National Medical Research Centre was performed. Results. The study included 53 patients, including 28 (53 %) girls and 25 (47 %) boys with median age of 7,7 (2,08–19,8) years. Indications for using of BM were as follows: (1) consolidation of remission (CR) with primary ALL (n = 17, 32 %); (2) persistence of minimal residual disease (MRD) (n = 23, 43 %) after completion of chemotherapy (CT) induction or before the stage of allogeneic haematopoietic stem cell transplantation (alloHSCT); (3) replacement of the standard CR due to the previous toxicity of СT or other contraindications to its implementation (n = 12, 23 %); (4) salvage therapy for r/r ALL (n = 1, 1,9 %). The status of MRD-negative remission after the 1st course of IT was achieved in 89 % of cases. Therapy using BM in a patient with the r/r ALL and total blast infiltration of the bone marrow was effective and facilitated reducing the tumor population to 7,2% by day 15 of therapy, however, there was a fatal outcome due to development and progression of preexisted severe infection. The most common variants of grade III–IV toxicity were leuko-/neutropenia (28 %) and neurotoxicity (3,7 %). BM dose reduction for the purpose of relieving toxicity was required in 19 % of patients, while the median days of therapy with dose reduction was 4. Corticosteroids were used for this purpose in 11 % of cases, antibacterial therapy — in 13 %. At the time of results evalution, there were no relapses of the disease in the study group. The article analyzes the international experience of using BM in patients with B-ALL.Conclusion. Our experience and the presented literature data demonstrate a reasonable expansion of indications for using of BM in children with B-ALL with high efficacy and satisfactory toxicity profile.
{"title":"Blinatumomab in pediatric acute lymphoblastic leukemia: one center experience","authors":"N. V. Muliarova, A. Smirnova, S. Lapaeva, Y. Toshina, Y. Dinikina","doi":"10.18705/2782-3806-2024-4-2-156-169","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-156-169","url":null,"abstract":"Background. Despite the successes achieved in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), overcoming the toxicity of standard chemotherapy regimens and the treatment of relapsed/refractory (r/r) forms of the disease remains relevant. The most promising option is to use immunotherapy (IT), including a monoclonal antibody blinatumomab (BM). The purpose of the study. To analyze indications of using, as well as efficacy and tolerability of BM in children with V-ALL. Materials and methods. From April 2016 to January 2024 a retrospective assessment of using of BM in children with B-ALL in the chemotherapy department of oncohematological diseases and TCM for children in Almazov National Medical Research Centre was performed. Results. The study included 53 patients, including 28 (53 %) girls and 25 (47 %) boys with median age of 7,7 (2,08–19,8) years. Indications for using of BM were as follows: (1) consolidation of remission (CR) with primary ALL (n = 17, 32 %); (2) persistence of minimal residual disease (MRD) (n = 23, 43 %) after completion of chemotherapy (CT) induction or before the stage of allogeneic haematopoietic stem cell transplantation (alloHSCT); (3) replacement of the standard CR due to the previous toxicity of СT or other contraindications to its implementation (n = 12, 23 %); (4) salvage therapy for r/r ALL (n = 1, 1,9 %). The status of MRD-negative remission after the 1st course of IT was achieved in 89 % of cases. Therapy using BM in a patient with the r/r ALL and total blast infiltration of the bone marrow was effective and facilitated reducing the tumor population to 7,2% by day 15 of therapy, however, there was a fatal outcome due to development and progression of preexisted severe infection. The most common variants of grade III–IV toxicity were leuko-/neutropenia (28 %) and neurotoxicity (3,7 %). BM dose reduction for the purpose of relieving toxicity was required in 19 % of patients, while the median days of therapy with dose reduction was 4. Corticosteroids were used for this purpose in 11 % of cases, antibacterial therapy — in 13 %. At the time of results evalution, there were no relapses of the disease in the study group. The article analyzes the international experience of using BM in patients with B-ALL.Conclusion. Our experience and the presented literature data demonstrate a reasonable expansion of indications for using of BM in children with B-ALL with high efficacy and satisfactory toxicity profile.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"63 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141358464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-106-113
V. V. Ushanov, K. K. Kukanov, A. A. Paltsev, A. S. Tsyndyaykina, N. A. Zayachkovsky, M. V. Pryanikov, Yu. M. Zabrodskaya
Background. Meningiomas are common tumors of the central nervous system, most of which are benign. Anaplastic and atypical meningiomas, which together account for 25 % of all meningiomas, have a high recurrence rate even after gross total resection and radiotherapy, which determines a significantly worse prognosis. The mechanisms of recurrence remain poorly understood.Purpose. To assess the significance of arachnoid granulations in the recurrence of meningiomas; to present our own clinical case; to make the review of the literature on this topic.Materials and methods. We searched for publications in the Pubmed, EMBASE, Cohrane Library, and eLibrary databases published between the beginning of database management to February 2023 on the issue of the role of arachnoid granulation in meningioma reccurence. The materials of the desease history and results of histological examination of 71-year-old with intracranial meningioma who were treated in Almazov National Medical Research Center are used in this work.Results. The clinical case of intracranial meningioma surgery is described. Histological examination of the tumor revealed papillary meningioma, grade 3. Tumor growth of meningioma was found in the granulations of the arachnoid. According to the review the clinical case shows the importance of the arachnoid granulations in determining the clinical management for this group of patients.Conclusion. The presented clinical case and analysis of literature data demonstrates the importance of considering the structure of arachnoid granulations in patients with intracranial meningiomas, especially in the recurrent type of the disease. The role of granulations of the arachnoid membrane is currently “forgotten”, but the study of these important structures within the boundaries of the tumor field can provide new information and mechanisms of oncogenesis, malignancy, and recurrence of meningiomas, which may serve as the basis for inclusion in the standards for making a final pathomorphological diagnosis in this groups of patients.
{"title":"Рathomorphological features of recurrent meningiomas","authors":"V. V. Ushanov, K. K. Kukanov, A. A. Paltsev, A. S. Tsyndyaykina, N. A. Zayachkovsky, M. V. Pryanikov, Yu. M. Zabrodskaya","doi":"10.18705/2782-3806-2024-4-2-106-113","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-106-113","url":null,"abstract":"Background. Meningiomas are common tumors of the central nervous system, most of which are benign. Anaplastic and atypical meningiomas, which together account for 25 % of all meningiomas, have a high recurrence rate even after gross total resection and radiotherapy, which determines a significantly worse prognosis. The mechanisms of recurrence remain poorly understood.Purpose. To assess the significance of arachnoid granulations in the recurrence of meningiomas; to present our own clinical case; to make the review of the literature on this topic.Materials and methods. We searched for publications in the Pubmed, EMBASE, Cohrane Library, and eLibrary databases published between the beginning of database management to February 2023 on the issue of the role of arachnoid granulation in meningioma reccurence. The materials of the desease history and results of histological examination of 71-year-old with intracranial meningioma who were treated in Almazov National Medical Research Center are used in this work.Results. The clinical case of intracranial meningioma surgery is described. Histological examination of the tumor revealed papillary meningioma, grade 3. Tumor growth of meningioma was found in the granulations of the arachnoid. According to the review the clinical case shows the importance of the arachnoid granulations in determining the clinical management for this group of patients.Conclusion. The presented clinical case and analysis of literature data demonstrates the importance of considering the structure of arachnoid granulations in patients with intracranial meningiomas, especially in the recurrent type of the disease. The role of granulations of the arachnoid membrane is currently “forgotten”, but the study of these important structures within the boundaries of the tumor field can provide new information and mechanisms of oncogenesis, malignancy, and recurrence of meningiomas, which may serve as the basis for inclusion in the standards for making a final pathomorphological diagnosis in this groups of patients.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"7 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-78-86
E. V. Fedorov, O. O. Shmeleva, A. V. Stepanenko, A. V. Kim
The article presents the results of a study of the dynamics of the development of persistent hydrocephalus in children after surgical removal of a tumor of the posterior cranial fossa in the early and late postoperative period. The analysis of the incidence of neuropsychological syndromes: cerebellar cognitive-affective syndrome and cerebellar mutism syndrome in children of this group was carried out. Retrospective analysis included 30 patients under 18 years of age with a diagnosis tumor of the posterior cranial fossa complicated by occlusive hydrocephalus. All patients were operated on in the conditions of the Department of Neurosurgery for Children No. 7 of the Almazov National Medical Research Centre. As a result of the study, the risk groups for maintaining hydrocephalus after removal of the tumor of the posterior cranial fossa were determined, and the frequency of occurrence of neuropsychological syndromes in the postoperative period was determined.
{"title":"Features of the course of hydrocephalus in children after removal of a tumor of the posterior cranial fossa in the near and long term","authors":"E. V. Fedorov, O. O. Shmeleva, A. V. Stepanenko, A. V. Kim","doi":"10.18705/2782-3806-2024-4-2-78-86","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-78-86","url":null,"abstract":"The article presents the results of a study of the dynamics of the development of persistent hydrocephalus in children after surgical removal of a tumor of the posterior cranial fossa in the early and late postoperative period. The analysis of the incidence of neuropsychological syndromes: cerebellar cognitive-affective syndrome and cerebellar mutism syndrome in children of this group was carried out. Retrospective analysis included 30 patients under 18 years of age with a diagnosis tumor of the posterior cranial fossa complicated by occlusive hydrocephalus. All patients were operated on in the conditions of the Department of Neurosurgery for Children No. 7 of the Almazov National Medical Research Centre. As a result of the study, the risk groups for maintaining hydrocephalus after removal of the tumor of the posterior cranial fossa were determined, and the frequency of occurrence of neuropsychological syndromes in the postoperative period was determined.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"4 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2-170-179
S. A. Dreshina, S. N. Yanishevskiy
Stroke is one of the leading causes of mortality and disability in the world, which is why it is considered a key medical and social problem of modern medicine. According to international multicenter studies, ischemic stroke is the most frequent type of this condition. According to research, the pathogenetic subtype of ischemic stroke cannot be identified in a third of cases. Based on the TOAST classification, cryptogenic stroke requires exclusion of criteria for other pathogenetic subtypes. However, in clinical practice, the reasons for making this diagnosis are as follows: incomplete examination of the patient, negative test results, and identification of two or more causes. The high incidence and risk of recurrent ischemic events determines the need for a thorough diagnostic search in order to exclude rare causes and conduct reasonable secondary prophylaxis.
{"title":"Rare causes of cryptogenic stroke","authors":"S. A. Dreshina, S. N. Yanishevskiy","doi":"10.18705/2782-3806-2024-4-2-170-179","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2-170-179","url":null,"abstract":"Stroke is one of the leading causes of mortality and disability in the world, which is why it is considered a key medical and social problem of modern medicine. According to international multicenter studies, ischemic stroke is the most frequent type of this condition. According to research, the pathogenetic subtype of ischemic stroke cannot be identified in a third of cases. Based on the TOAST classification, cryptogenic stroke requires exclusion of criteria for other pathogenetic subtypes. However, in clinical practice, the reasons for making this diagnosis are as follows: incomplete examination of the patient, negative test results, and identification of two or more causes. The high incidence and risk of recurrent ischemic events determines the need for a thorough diagnostic search in order to exclude rare causes and conduct reasonable secondary prophylaxis.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"37 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.18705/2782-3806-2024-4-2129-138
L. I. Trushina, S. R. Sheriev, Ya. A. Filin, G. E. Trufanov, A. Efimtsev
Ischemic stroke is one of the leading causes of morbidity and mortality worldwide, resulting in significant social and economic consequences for the healthcare system. Moreover, ischemic stroke has a devastating psycho-emotional impact on both the patient and their family, causing anxiety and depressive disorders. To reduce the severity of neurological deficit, increase the percentage of patients returning to their previous level of social and daily activity, and decrease the rates of disability after a cerebrovascular catastrophe, it is necessary to provide the full spectrum of therapeutic and diagnostic assistance in the shortest possible time. Developing neuroimaging techniques help to timely and accurately diagnose cerebral stroke, differentiate ischemic damage from hemorrhagic, and also establish the time of onset of acute cerebrovascular accident.
{"title":"Modern methods of neuroimaging in the diagnosis of acute ischemic stroke","authors":"L. I. Trushina, S. R. Sheriev, Ya. A. Filin, G. E. Trufanov, A. Efimtsev","doi":"10.18705/2782-3806-2024-4-2129-138","DOIUrl":"https://doi.org/10.18705/2782-3806-2024-4-2129-138","url":null,"abstract":"Ischemic stroke is one of the leading causes of morbidity and mortality worldwide, resulting in significant social and economic consequences for the healthcare system. Moreover, ischemic stroke has a devastating psycho-emotional impact on both the patient and their family, causing anxiety and depressive disorders. To reduce the severity of neurological deficit, increase the percentage of patients returning to their previous level of social and daily activity, and decrease the rates of disability after a cerebrovascular catastrophe, it is necessary to provide the full spectrum of therapeutic and diagnostic assistance in the shortest possible time. Developing neuroimaging techniques help to timely and accurately diagnose cerebral stroke, differentiate ischemic damage from hemorrhagic, and also establish the time of onset of acute cerebrovascular accident.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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