Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-22-50-55
S. Y. Bartosh-Zelenaya, V. V. Stepanova, N. E. Pavlova, O. P. Mamaeva, S. G. Sherbak
The purpose of this article is to evaluate the systolic function of the left and right ventricles and measure myocardial Strain in young people (from 18 to 44 years old) with a newly established clinical and laboratory diagnosis of metabolic syndrome (MS) according to the criteria of the International Diabetes Federation (IDF), to identify possible early markers of myocardial dysfunction. All patients underwent standard transthoracic echocardiography (EchoCG) with assessment of systolic function of the left and right ventricles (LV and RV). The work detects early markers of ventricular myocardial dysfunction using speckle tracking 2D and 4D EchoCG, and also investigates the relationship between the main components of MS and echocardiographic parameters. With the help of a comparative analysis, statistical data were revealed on the low global longitudinal strain of the left and right ventricle in 2D and 4D in the main group compared with the control group. In individuals with MS, the mean values of global circular strain (GCS), radial (GRS) strain and global area strain (GAS) of the left ventricle were also significantly lower than the control group. Indicators obesity diseases (body weight and waist circumference) had a negative correlation with the ejection fraction (EF) and parameters of ventricular strain.
{"title":"Systolic function of the left and right ventricles and myocardial strain in young adults with metabolic syndrome","authors":"S. Y. Bartosh-Zelenaya, V. V. Stepanova, N. E. Pavlova, O. P. Mamaeva, S. G. Sherbak","doi":"10.33667/2078-5631-2023-22-50-55","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-22-50-55","url":null,"abstract":"The purpose of this article is to evaluate the systolic function of the left and right ventricles and measure myocardial Strain in young people (from 18 to 44 years old) with a newly established clinical and laboratory diagnosis of metabolic syndrome (MS) according to the criteria of the International Diabetes Federation (IDF), to identify possible early markers of myocardial dysfunction. All patients underwent standard transthoracic echocardiography (EchoCG) with assessment of systolic function of the left and right ventricles (LV and RV). The work detects early markers of ventricular myocardial dysfunction using speckle tracking 2D and 4D EchoCG, and also investigates the relationship between the main components of MS and echocardiographic parameters. With the help of a comparative analysis, statistical data were revealed on the low global longitudinal strain of the left and right ventricle in 2D and 4D in the main group compared with the control group. In individuals with MS, the mean values of global circular strain (GCS), radial (GRS) strain and global area strain (GAS) of the left ventricle were also significantly lower than the control group. Indicators obesity diseases (body weight and waist circumference) had a negative correlation with the ejection fraction (EF) and parameters of ventricular strain.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-24-52-55
S. N. Gres, N. V. Gryazeva
Combined procedures can be performed during one appointment to solve several problems for the patient. However, some treatments should be planned over several consecutive sessions to avoid complications and achieve optimal results. The purpose of our study was the scientific substantiation and development of an algorithm for the complex use of microneedle radiofrequency lifting and injection fillers based on hyaluronic acid in patients with involutive changes in the facial skin, taking into account the data of the pathomorphological research method. The patients were divided into three groups, depending on the treatment methods. In order to assess the effectiveness of therapy, a histological examination was carried out in five patients from each group, and a morphometric assessment was carried out. The histological picture and morphometric assessment of microslides from patients from different study groups indicate that microneedle RF lifting entails scar-type changes, which thins the thickness of the epidermis. However, the use of hyaluronic acid smoothes out these changes and leads to faster tissue restoration. At the same time, in the complex treatment group, better regenerative potential was noted than in the monotherapy groups, which is confirmed by the maximum value of basal epidermocytes per unit length.
{"title":"Combined use of microneedle radiofrequency lifting and injectable fillers based on hyaluronic acid in treatment of involutive changes in facial skin","authors":"S. N. Gres, N. V. Gryazeva","doi":"10.33667/2078-5631-2023-24-52-55","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-24-52-55","url":null,"abstract":"Combined procedures can be performed during one appointment to solve several problems for the patient. However, some treatments should be planned over several consecutive sessions to avoid complications and achieve optimal results. The purpose of our study was the scientific substantiation and development of an algorithm for the complex use of microneedle radiofrequency lifting and injection fillers based on hyaluronic acid in patients with involutive changes in the facial skin, taking into account the data of the pathomorphological research method. The patients were divided into three groups, depending on the treatment methods. In order to assess the effectiveness of therapy, a histological examination was carried out in five patients from each group, and a morphometric assessment was carried out. The histological picture and morphometric assessment of microslides from patients from different study groups indicate that microneedle RF lifting entails scar-type changes, which thins the thickness of the epidermis. However, the use of hyaluronic acid smoothes out these changes and leads to faster tissue restoration. At the same time, in the complex treatment group, better regenerative potential was noted than in the monotherapy groups, which is confirmed by the maximum value of basal epidermocytes per unit length.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"362 15","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135393236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-24-20-26
I. O. Smirnova, K. D. Khazhomiya, P. D. Ptashnikova, O. N. Smirnova
Currently, the microbial community of the skin is considered as a dynamic functional system that develops synergistically with the body in general and the skin in particular, participates in the regulation and implementation of its functions, contributes to skin aging and the pathogenesis of chronic inflammatory dermatoses. Understanding the contribution of skin dysbiosis to skin aging and the pathogenesis of chronic dermatoses has provided the basis for the development of strategies aimed at correcting the skin microbiota, or bacteriotherapy. The latter includes the use of allogeneic or autologous living bacteria, as well as inactivated microorganisms, components of their cell wall, signaling molecules and metabolites. The latter are included in products for external use, including dermatocosmetics. Among the bacteria that are considered as potential sources of active ingredients for cosmetics, lactic acid bacteria deserve special attention. Not only are they members of the normal microbiota of the skin and gastrointestinal tract and produce antimicrobial compounds such as organic acids and bacteriocins, but they are also widely used as probiotics. The article discusses the importance of the skin microbiota for the implementation of its functions normally, including in the age aspect, as well as the prospects for using methods of bacteriotherapy with products for external use containing inactivated Lactobacillus, Lactococcus, Bifidobacterium and the prebiotics inulin and trehalose, using the example of atopic dermatitis and age-related skin changes.
{"title":"Skin microbiome and possibilities of bacteriotherapy (on example of skin aging and atopic dermatitis)","authors":"I. O. Smirnova, K. D. Khazhomiya, P. D. Ptashnikova, O. N. Smirnova","doi":"10.33667/2078-5631-2023-24-20-26","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-24-20-26","url":null,"abstract":"Currently, the microbial community of the skin is considered as a dynamic functional system that develops synergistically with the body in general and the skin in particular, participates in the regulation and implementation of its functions, contributes to skin aging and the pathogenesis of chronic inflammatory dermatoses. Understanding the contribution of skin dysbiosis to skin aging and the pathogenesis of chronic dermatoses has provided the basis for the development of strategies aimed at correcting the skin microbiota, or bacteriotherapy. The latter includes the use of allogeneic or autologous living bacteria, as well as inactivated microorganisms, components of their cell wall, signaling molecules and metabolites. The latter are included in products for external use, including dermatocosmetics. Among the bacteria that are considered as potential sources of active ingredients for cosmetics, lactic acid bacteria deserve special attention. Not only are they members of the normal microbiota of the skin and gastrointestinal tract and produce antimicrobial compounds such as organic acids and bacteriocins, but they are also widely used as probiotics. The article discusses the importance of the skin microbiota for the implementation of its functions normally, including in the age aspect, as well as the prospects for using methods of bacteriotherapy with products for external use containing inactivated Lactobacillus, Lactococcus, Bifidobacterium and the prebiotics inulin and trehalose, using the example of atopic dermatitis and age-related skin changes.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"362 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135393237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-26-41-45
O. T. Bogova, A. V. Sviridenko, S. S. Puzin, A. S. Markova, S. N. Puzin
In this study, spectral parameters in patients with various forms of atrial fibrillation and the effect of the class III antiarrhythmic drug amiodarone on these parameters were studied. The use of spectral analysis of heart rate variability (hereinafter referred to as HRV) when choosing a drug for the treatment of arrhythmia and arterial hypertension is becoming increasingly widespread in experimental and clinical practice. This method, thanks to the mathematical analysis of the time and frequency characteristics of heart rate variability, allows you to get an idea of slow oscillatory processes that constantly exist in the body and have the properties of autowaves. The use of this method gives an idea of the role of various departments of the autonomic nervous system (sympathetic and parasympathetic), as well as the implementation of humoral mechanisms in the implementation of the chronotropic function of the heart.
{"title":"The effect of amiodarone on the spectral parameters of heart rate variability in patients with various forms of atrial fibrillation","authors":"O. T. Bogova, A. V. Sviridenko, S. S. Puzin, A. S. Markova, S. N. Puzin","doi":"10.33667/2078-5631-2023-26-41-45","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-26-41-45","url":null,"abstract":"In this study, spectral parameters in patients with various forms of atrial fibrillation and the effect of the class III antiarrhythmic drug amiodarone on these parameters were studied. The use of spectral analysis of heart rate variability (hereinafter referred to as HRV) when choosing a drug for the treatment of arrhythmia and arterial hypertension is becoming increasingly widespread in experimental and clinical practice. This method, thanks to the mathematical analysis of the time and frequency characteristics of heart rate variability, allows you to get an idea of slow oscillatory processes that constantly exist in the body and have the properties of autowaves. The use of this method gives an idea of the role of various departments of the autonomic nervous system (sympathetic and parasympathetic), as well as the implementation of humoral mechanisms in the implementation of the chronotropic function of the heart.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"19 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135390190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-26-13-20
N. V. Baryshnikova
This article discusses the relevance and prospects of using metabiotics and targeted metabiotics in the complex therapy of acute respiratory diseases. The metabiotics (postbiotics) include bacterial metabolites and/or signaling molecules with a known chemical structure that optimize the composition and functions of the indigenous microbiota, including improving human immunity and metabolism. Bacterial metabolites of Bacillus subtilis SA44 and Lactobacillus rhamnosus CRL1505 strains demonstrate high efficiency in the treatment of patients with respiratory diseases. It is important to use targeted metabiotics, i.e. metabiotics that contribute to the restoration and maintenance of the microbiota of the respiratory organs and human immunity. Targeted metabiotics, as a rule, contain not only bacterial metabolites, but also additional substances with positive effects aimed at optimizing the functioning of a particular organ or system. An example of a targeted metabiotic for the treatment of acute respiratory diseases is a three-component Biocomplete® Bronchobiotic complex, which includes inactivated bacteria of the species Lactobacillus rhamnosus CRL1505 (the metabiotic, is an antagonist of opportunistic and pathogenic microorganisms, promotes immunity), inulin (the prebiotic, serves as nutrition for the indigenous flora) and thyme extract (has expectorant, anti-inflammatory and bactericidal, antioxidant effect).
{"title":"The effectiveness of metabiotics in the treatment of acute respiratory diseases","authors":"N. V. Baryshnikova","doi":"10.33667/2078-5631-2023-26-13-20","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-26-13-20","url":null,"abstract":"This article discusses the relevance and prospects of using metabiotics and targeted metabiotics in the complex therapy of acute respiratory diseases. The metabiotics (postbiotics) include bacterial metabolites and/or signaling molecules with a known chemical structure that optimize the composition and functions of the indigenous microbiota, including improving human immunity and metabolism. Bacterial metabolites of Bacillus subtilis SA44 and Lactobacillus rhamnosus CRL1505 strains demonstrate high efficiency in the treatment of patients with respiratory diseases. It is important to use targeted metabiotics, i.e. metabiotics that contribute to the restoration and maintenance of the microbiota of the respiratory organs and human immunity. Targeted metabiotics, as a rule, contain not only bacterial metabolites, but also additional substances with positive effects aimed at optimizing the functioning of a particular organ or system. An example of a targeted metabiotic for the treatment of acute respiratory diseases is a three-component Biocomplete® Bronchobiotic complex, which includes inactivated bacteria of the species Lactobacillus rhamnosus CRL1505 (the metabiotic, is an antagonist of opportunistic and pathogenic microorganisms, promotes immunity), inulin (the prebiotic, serves as nutrition for the indigenous flora) and thyme extract (has expectorant, anti-inflammatory and bactericidal, antioxidant effect).","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"4 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135390193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-22-63-67
M. A. Podolskaya, Yu. E. Teregulov
One of the world’s leading physiologists of the late 19th — the first third of the 20th centuries, Doctor of Medicine, Professor, Head of the Department of Physiology of Kazan University, Lenin Prize winner, Honored Scientist of the RSFSR Alexander Filippovich Samoilov (1867, Odessa — 1930, Kazan) is known as one of the creators of the theory and practice of electrocardiography, introduction of this method into the clinic. In 1924, A. F. Samoilov proved the chemical nature of the transition of excitation from a nerve to a muscle. Many fundamental works of the scientist are devoted to spinal and central nervous mechanisms. As a student and follower of I. M. Sechenov, A. F. Samoilov proceeded to formulate the principles of systematic organization of functions in animals and humans based on the material of his works. The scientists studied the systems of coding characters in the notation of notes. On the example of the circular rhythm of muscle excitation described by him in 1929, A. F. Samoilov anticipated the model of an automatic self-regulating system and systemic social circular interaction.
{"title":"A.F. Samoilov: from synapse to systemic organization of functions","authors":"M. A. Podolskaya, Yu. E. Teregulov","doi":"10.33667/2078-5631-2023-22-63-67","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-22-63-67","url":null,"abstract":"One of the world’s leading physiologists of the late 19th — the first third of the 20th centuries, Doctor of Medicine, Professor, Head of the Department of Physiology of Kazan University, Lenin Prize winner, Honored Scientist of the RSFSR Alexander Filippovich Samoilov (1867, Odessa — 1930, Kazan) is known as one of the creators of the theory and practice of electrocardiography, introduction of this method into the clinic. In 1924, A. F. Samoilov proved the chemical nature of the transition of excitation from a nerve to a muscle. Many fundamental works of the scientist are devoted to spinal and central nervous mechanisms. As a student and follower of I. M. Sechenov, A. F. Samoilov proceeded to formulate the principles of systematic organization of functions in animals and humans based on the material of his works. The scientists studied the systems of coding characters in the notation of notes. On the example of the circular rhythm of muscle excitation described by him in 1929, A. F. Samoilov anticipated the model of an automatic self-regulating system and systemic social circular interaction.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"31 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135390681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-24-56-60
L. S. Kruglova, N. V. Gryazeva, E. D. Verbovaya
In acne, a microbial imbalance compared to a normal distribution in healthy tissues is thought to be involved in the pathophysiology of inflammatory acne. Extended metagenomic sequencing has shown that the skin microbiota of acne patients differs from the microbiota of people without acne at the level of a virulent-specific lineage. Acquired DNA sequences and bacterial immune elements may be involved in the virulence of C. acnes strains. Acne-associated strains produce significantly higher levels of pro-inflammatory metabolites, porphyrins, which generate reactive oxygen species and induce inflammation in keratinocytes. In light of these data, restoration of the skin microbiome in acne is one of the main goals of therapy. Specialized cosmetics that allow restoring skin microbiocenosis is a pathogenetically substantiated option for the complex treatment of patients with acne. To solve this problem, the scientists of the laboratory of La Roche-Posay have created an innovative range of products EFFACLAR H ISO-BIOME. The products effectively reduce all side effects caused by the use of topical and systemic drugs, and also normalize the skin microbiome by activating the growth of commensal microorganisms.
在痤疮中，与健康组织中的正态分布相比，微生物失衡被认为参与了炎症性痤疮的病理生理。扩展宏基因组测序显示，痤疮患者的皮肤微生物群不同于没有痤疮的人在毒力特异性谱系水平上的微生物群。获得的DNA序列和细菌免疫元件可能与痤疮C.菌株的毒力有关。痤疮相关菌株产生显著更高水平的促炎代谢产物卟啉，卟啉产生活性氧并诱导角化细胞炎症。根据这些数据，痤疮皮肤微生物群的恢复是治疗的主要目标之一。专门的化妆品，允许恢复皮肤微生物斑疹是一个病理证实的选择，复杂的治疗痤疮患者。为了解决这个问题，罗氏葆赛实验室的科学家们创造了一系列创新的EFFACLAR H ISO-BIOME产品。该产品有效减少了使用局部和全身药物引起的所有副作用，并通过激活共生微生物的生长使皮肤微生物群正常化。
{"title":"Skin microbiome in acne and role of dermatocosmetics in complex treatment (literature review)","authors":"L. S. Kruglova, N. V. Gryazeva, E. D. Verbovaya","doi":"10.33667/2078-5631-2023-24-56-60","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-24-56-60","url":null,"abstract":"In acne, a microbial imbalance compared to a normal distribution in healthy tissues is thought to be involved in the pathophysiology of inflammatory acne. Extended metagenomic sequencing has shown that the skin microbiota of acne patients differs from the microbiota of people without acne at the level of a virulent-specific lineage. Acquired DNA sequences and bacterial immune elements may be involved in the virulence of C. acnes strains. Acne-associated strains produce significantly higher levels of pro-inflammatory metabolites, porphyrins, which generate reactive oxygen species and induce inflammation in keratinocytes. In light of these data, restoration of the skin microbiome in acne is one of the main goals of therapy. Specialized cosmetics that allow restoring skin microbiocenosis is a pathogenetically substantiated option for the complex treatment of patients with acne. To solve this problem, the scientists of the laboratory of La Roche-Posay have created an innovative range of products EFFACLAR H ISO-BIOME. The products effectively reduce all side effects caused by the use of topical and systemic drugs, and also normalize the skin microbiome by activating the growth of commensal microorganisms.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"362 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135393235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-24-41-46
L. S. Kruglova, N. O. Pereverzina
Published research results indicate the high effectiveness of sertaconazole in the treatment of mycoses of the skin. According to a number of studies, it is superior to other antifungal agents in terms of cure rate and speed of action, and also has anti-inflammatory and antipruritic activity. Material and methods. The aim of the observational study was to evaluate the effectiveness of Zalain cream (sertaconazole 2%) in patients with mycosis of the smooth skin of the groin area. We observed 21 patients (13 men and 8 women) aged from 37 to 72 years with a verified diagnosis of mycosis of smooth skin, confirmed by microscopic and cultural methods. In patients, during a cultural study, a mixed fungal-bacterial infection was isolated in various combinations: 14 (66.7%) – Trichophyton rubrum and Staphylococcus, 7 (33.3%) – Candida albicans and Staphylococcus. Of the concomitant pathologies, the following diseases were most often diagnosed: hypertension (52.4%), obesity (BMI > 30) (47.6%), type 2 diabetes mellitus (42.9%), gastrointestinal diseases (23.8%), diseases of the hepatobiliary system (19.1%). The effectiveness was assessed taking into account the VAS index (erythema, infiltration, desquamation, cracks, itching, burning) and special methods (microscopic and cultural) of the study at control points B1 (before therapy) and B2 (after 4 weeks of therapy). Long-term results of observations (disease relapse) were assessed after 6 months. Results. The total VAS at control point B 2 decreased by 94.9% (p < 0.01). After therapy (4 weeks), in 18 (85.7%) patients, pathogenic fungi (Trichophyton rubrum, Trichophyton mentagrophytes var. interdigitale) were not sown during cultural examination. Patients with no laboratory cure were recommended to continue therapy with sertaconazole for 2–4 weeks until complete eradication of pathogenic fungi. Long-term results of observations (6 months) showed relapse of the disease in 28.6% of patients with concomitant metabolic syndrome and type 2 diabetes mellitus. Also, among patients with relapses, males predominated – 66.7%. Conclusions. Sertaconazole has a wide spectrum of antimycotic activity, which makes it possible to quickly achieve clinical and mycological recovery in patients with mycosis of smooth skin in the groin area.
{"title":"Efficacy of topical forms of sertaconazole in treatment of mycoses of skin","authors":"L. S. Kruglova, N. O. Pereverzina","doi":"10.33667/2078-5631-2023-24-41-46","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-24-41-46","url":null,"abstract":"Published research results indicate the high effectiveness of sertaconazole in the treatment of mycoses of the skin. According to a number of studies, it is superior to other antifungal agents in terms of cure rate and speed of action, and also has anti-inflammatory and antipruritic activity. Material and methods. The aim of the observational study was to evaluate the effectiveness of Zalain cream (sertaconazole 2%) in patients with mycosis of the smooth skin of the groin area. We observed 21 patients (13 men and 8 women) aged from 37 to 72 years with a verified diagnosis of mycosis of smooth skin, confirmed by microscopic and cultural methods. In patients, during a cultural study, a mixed fungal-bacterial infection was isolated in various combinations: 14 (66.7%) – Trichophyton rubrum and Staphylococcus, 7 (33.3%) – Candida albicans and Staphylococcus. Of the concomitant pathologies, the following diseases were most often diagnosed: hypertension (52.4%), obesity (BMI > 30) (47.6%), type 2 diabetes mellitus (42.9%), gastrointestinal diseases (23.8%), diseases of the hepatobiliary system (19.1%). The effectiveness was assessed taking into account the VAS index (erythema, infiltration, desquamation, cracks, itching, burning) and special methods (microscopic and cultural) of the study at control points B1 (before therapy) and B2 (after 4 weeks of therapy). Long-term results of observations (disease relapse) were assessed after 6 months. Results. The total VAS at control point B 2 decreased by 94.9% (p < 0.01). After therapy (4 weeks), in 18 (85.7%) patients, pathogenic fungi (Trichophyton rubrum, Trichophyton mentagrophytes var. interdigitale) were not sown during cultural examination. Patients with no laboratory cure were recommended to continue therapy with sertaconazole for 2–4 weeks until complete eradication of pathogenic fungi. Long-term results of observations (6 months) showed relapse of the disease in 28.6% of patients with concomitant metabolic syndrome and type 2 diabetes mellitus. Also, among patients with relapses, males predominated – 66.7%. Conclusions. Sertaconazole has a wide spectrum of antimycotic activity, which makes it possible to quickly achieve clinical and mycological recovery in patients with mycosis of smooth skin in the groin area.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"362 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135393238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-26-7-12
L. D. Khidirova, A. A. Starichkova, V. L. Lukinov
Introduction . Currently, psychopathological symptoms are noted in a third of patients with COVID-19, according to published systematic reviews. Aim. To study psychocognitive function in comorbid patients depending on the coronavirus infection caused by SARS-CoV-2. Material and methods . The observational analytical cohort study included 223 patients with AF and comorbidity (ischemic heart disease, arterial hypertension, obesity, type 2 diabetes mellitus) aged 60–74 years, who were divided into 2 groups: 1st – 123 patients without COVID –19 and 2nd – 110 patients with a history of COVID-19 and the presence of PCS. The group of patients with a history of COVID-19 was retrospectively divided into 2 groups depending on the intake of sulodexide; patients in the subgroups were comparable. The work assessed psychological disorders (anxiety and depression) and cognitive status using specialized scales «HADS» and «SPMSQ». Results. In patients with COVID-19, compared with patients from group 1, there is a more pronounced depressive syndrome (p<0.001); subclinical depression in 26% of patients (p<0.001) and the absence of the latter in group 1; clinically pronounced depression was found in 15% (p=0.007). At the same time, the severity of subclinical symptoms of anxiety syndrome was noted in patients without COVID-19, and clinically significant anxiety was more often observed in recovered patients, although statistical significance was not achieved. When assessing cognitive function, it was found that moderate dysfunction was observed in patients with COVID-19 significantly more often (p=0.001). In the sulodexide group, only mild cognitive dysfunction was detected (14%), and the majority of patients taking sulodexide had no cognitive dysfunction. Conclusion . Thus, in comorbid elderly patients in the post-COVID period, an increase in the number of people with psychocognitive disorders was noted. In this regard, long-term follow-up of patients who have undergone COVID-19 is necessary, both for the dynamic assessment of underlying diseases and the analysis of psychocognitive status. In addition, it should be noted that the drug sulodexide, consisting of a heparin-like fraction and dermatan sulfate, has many pharmacodynamic (anti-inflammatory, angioprotective, anticoagulant, antifibrotic) and pharmacokinetic advantages (safety, the possibility of oral administration) can effectively prevent the development of cognitive dysfunction, which requires even further in-depth research.
{"title":"Psychocognitive dysfunction in comorbid patients in the post-COVID period","authors":"L. D. Khidirova, A. A. Starichkova, V. L. Lukinov","doi":"10.33667/2078-5631-2023-26-7-12","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-26-7-12","url":null,"abstract":"Introduction . Currently, psychopathological symptoms are noted in a third of patients with COVID-19, according to published systematic reviews. Aim. To study psychocognitive function in comorbid patients depending on the coronavirus infection caused by SARS-CoV-2. Material and methods . The observational analytical cohort study included 223 patients with AF and comorbidity (ischemic heart disease, arterial hypertension, obesity, type 2 diabetes mellitus) aged 60–74 years, who were divided into 2 groups: 1st – 123 patients without COVID –19 and 2nd – 110 patients with a history of COVID-19 and the presence of PCS. The group of patients with a history of COVID-19 was retrospectively divided into 2 groups depending on the intake of sulodexide; patients in the subgroups were comparable. The work assessed psychological disorders (anxiety and depression) and cognitive status using specialized scales «HADS» and «SPMSQ». Results. In patients with COVID-19, compared with patients from group 1, there is a more pronounced depressive syndrome (p<0.001); subclinical depression in 26% of patients (p<0.001) and the absence of the latter in group 1; clinically pronounced depression was found in 15% (p=0.007). At the same time, the severity of subclinical symptoms of anxiety syndrome was noted in patients without COVID-19, and clinically significant anxiety was more often observed in recovered patients, although statistical significance was not achieved. When assessing cognitive function, it was found that moderate dysfunction was observed in patients with COVID-19 significantly more often (p=0.001). In the sulodexide group, only mild cognitive dysfunction was detected (14%), and the majority of patients taking sulodexide had no cognitive dysfunction. Conclusion . Thus, in comorbid elderly patients in the post-COVID period, an increase in the number of people with psychocognitive disorders was noted. In this regard, long-term follow-up of patients who have undergone COVID-19 is necessary, both for the dynamic assessment of underlying diseases and the analysis of psychocognitive status. In addition, it should be noted that the drug sulodexide, consisting of a heparin-like fraction and dermatan sulfate, has many pharmacodynamic (anti-inflammatory, angioprotective, anticoagulant, antifibrotic) and pharmacokinetic advantages (safety, the possibility of oral administration) can effectively prevent the development of cognitive dysfunction, which requires even further in-depth research.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"8 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135390969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.33667/2078-5631-2023-24-28-35
I. S. Vladimirova, L. S. Kruglova, O. V. Sviridov, M. A. Samushiya
Psoriasis is a chronic immune-mediated systemic disease that is closely associated with comorbid depression and anxiety disorders. Today, a new direction of therapy is represented by biological therapy. One of the effective and safe drugs is the IL‑23 inhibitor guselkumab. Purpose of the study. To study the effectiveness of therapy with the interleukin‑23 inhibitor (guselkumab) and the dynamics of indicators of symptoms of anxiety and depression in patients with moderate and severe psoriasis. Material and methods. A retrospective study of 25 patients diagnosed with widespread vulgar psoriasis was conducted. Initial indicators were assessed using the PASI, BSA, sPGA, DLQI, and VAS (itching scale) indices. Anxiety and depression scores were assessed using the HADS and GAD‑7 scales. All patients received treatment with guselkumab according to the standard regimen. The effectiveness of therapy was assessed by the dynamics of PASI, BSA, sPGA, DLQI, VAS, HADS, GAD‑7 indicators after 12 weeks of therapy with the interleukin‑23 inhibitor (guselkumab). Results. Biological therapy with guselkumab resulted in significant reductions in all parameters at 12 weeks for each patient (p < 0.0001). Only improvement in PASI was significantly correlated with lower depression and anxiety scores (p < 0.0050), whereas decrease in DLQI was not (p > 0.9550). Conclusions. Biological therapy with the interleukin‑23 inhibitor guselkumab is highly effective in both reducing disease severity and alleviating symptoms of depression and anxiety in psoriasis.
{"title":"Efficacy of treatment of patients with psoriasis with anxiety and depression with interleukin‑23 inhibitor guselkumab","authors":"I. S. Vladimirova, L. S. Kruglova, O. V. Sviridov, M. A. Samushiya","doi":"10.33667/2078-5631-2023-24-28-35","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-24-28-35","url":null,"abstract":"Psoriasis is a chronic immune-mediated systemic disease that is closely associated with comorbid depression and anxiety disorders. Today, a new direction of therapy is represented by biological therapy. One of the effective and safe drugs is the IL‑23 inhibitor guselkumab. Purpose of the study. To study the effectiveness of therapy with the interleukin‑23 inhibitor (guselkumab) and the dynamics of indicators of symptoms of anxiety and depression in patients with moderate and severe psoriasis. Material and methods. A retrospective study of 25 patients diagnosed with widespread vulgar psoriasis was conducted. Initial indicators were assessed using the PASI, BSA, sPGA, DLQI, and VAS (itching scale) indices. Anxiety and depression scores were assessed using the HADS and GAD‑7 scales. All patients received treatment with guselkumab according to the standard regimen. The effectiveness of therapy was assessed by the dynamics of PASI, BSA, sPGA, DLQI, VAS, HADS, GAD‑7 indicators after 12 weeks of therapy with the interleukin‑23 inhibitor (guselkumab). Results. Biological therapy with guselkumab resulted in significant reductions in all parameters at 12 weeks for each patient (p < 0.0001). Only improvement in PASI was significantly correlated with lower depression and anxiety scores (p < 0.0050), whereas decrease in DLQI was not (p > 0.9550). Conclusions. Biological therapy with the interleukin‑23 inhibitor guselkumab is highly effective in both reducing disease severity and alleviating symptoms of depression and anxiety in psoriasis.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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