Purpose: To evaluate the characteristics and effectiveness of embolization for hemoptysis due to pulmonary aspergillosis and analyze the risk factors for recurrence.
Materials and methods: This retrospective cohort study evaluated 158 consecutive patients, including 117 males and 41 females with a median age of 60 years (range,18-84 years), who underwent transarterial embolization (TAE) for aspergillosis-related hemoptysis. The rate of absence of recurrent hemoptysis was calculated via Kaplan-Meier analysis, with univariate and multivariate Cox regression to analyze the risk factors for recurrence.
Results: Among patients with aspergillosis-related hemoptysis in this cohort, 77% had comorbid bronchiectasis. TAE achieved a 93% clinical success rate, with postprocedural chest pain and fever constituting the predominant adverse events. The rates of absence of recurrent hemoptysis at 1, 3, 6, 12, 24, and 36 months after TAE were 93%, 82%, 77%, 69%, 58%, and 57%, respectively. Multivariate Cox analysis identified pulmonary cavities (P = .006), bronchiectasis (P = .027), and embolization-required inferior phrenic artery (IPA) (P = .026) as independent predictors of recurrence.
Conclusions: TAE is safe and effective in treating aspergillosis-related hemoptysis. IPA that required embolization independently predicted recurrence of hemoptysis, and nonvascular predictors of recurrent hemoptysis were pulmonary cavity and bronchiectasis.
Purpose: This study aims to assess the effectiveness of nitinol-constrained balloon (NCB; Chocolate, Medtronic) percutaneous transluminal angioplasty (PTA) for treating DISFORM III post-angioplasty dissections in chronic total occlusions (CTO) of the femoro-popliteal segment.
Materials and methods: The CHOCO-STAB study was conducted from February 2019 to February 2022. It included patients with peripheral artery disease (PAD) affected by chronic limb-threatening ischemia (CLTI). This study specifically included patients with DISFORM III post-angioplasty dissections who were treated using NCB angioplasty after initial PTA. The main outcomes assessed in this study were technical success and the occurrence of major adverse events (MAE).
Results: This study included 68 patients with a mean age of 72 years (SD: 10), of whom 39% were diabetic. The initially treated CTOs had a mean length of 10.32 mm (IQR: 5-15; SD: 5), with moderate or severe calcification in 28%. Forty-seven (69%) patients received initial treatment with drug-coated balloons (DCB). NCB angioplasty was feasible in all patients, achieving technical success in 62 (91%). Stent placement was required in the remaining 6 (9%) cases. Three-year estimated overall survival was 98.5%, primary patency was 88.2%, freedom from major amputation was 94.1%, and freedom from clinical TLR was 94.1%.
Conclusions: Post-angioplasty dissections represent a relevant adverse event that necessitates scaffolding in moderate and severe grades. The CHOCO-STAB study demonstrated the safety and potential of NCB angioplasty to reduce stent placement in patients treated with DCB and POBA who present post-angioplasty dissections.
Purpose: To evaluate the safety and feasibility of treating pancreatic tumors in an Oncopig tumor model, using bumetanide (BU)/ethiodized oil emulsion.
Materials and methods: Pancreatic tumors were induced in 18 transgenic Oncopigs with inducible p53 and Kras mutations. Sixteen pigs developed tumor and were treated with intra-arterial (IA) injection of BU/ethiodized oil emulsion (n = 6) (mean injected volume, 1.8 mL of 2.9 mL of ethiodized oil + 2.10 mL [0.44 mg, 0.02 mg/kg] of BU), IA injection of ethiodized oil (n = 3), and systemic intravenous gemcitabine (n = 2). Five pigs did not receive any treatment (control). Laboratory evaluation and contrast-enhanced computed tomography (CT) scan was obtained on Days 0, 7, and 14. Necropsy was performed on Day 14. Treatment was evaluated by tumor size change, radiographic response per Response Evaluation Criteria in Solid Tumors 1.1 at Day 14, and degree of tumor necrosis on histopathological examination. One-way analysis of variance and the Tukey-Kramer post hoc test were used.
Results: Median tumor diameter before treatment was 1.5 cm (interquartile range [IQR], 1.1-3.1 cm). No significant increase in the posttreatment serum lipase levels was detected in the BU/ethiodized oil group (P > .05). No clinical, radiographic, or histopathological evidence of pancreatitis was detected. Tumor size in the BU/ethiodized oil group decreased by a median of 10.3% (6.7%-13.6%, P < .05). The control group had an increase in median (IQR) tumor size by 45% (32.8%-61.4%, P < .05). The median tumor size change was significantly different between the BU/ethiodized oil and control groups (P = .01). Mean degree of necrosis was less than 10% in the treated groups (P > .05).
Conclusions: IA injection of BU/ethiodized oil emulsion is safe and feasible in treating pancreatic tumor in a transgenic porcine model.

