Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.08.023
Samad Ashraf BS , Sabeen Nadeem , Wajahat Efridi MD , Feras J. Deek MS , Mubin I. Syed MD
{"title":"Superselective Esophageal Arterial Embolization for the Treatment of a Mallory-Weiss Tear","authors":"Samad Ashraf BS , Sabeen Nadeem , Wajahat Efridi MD , Feras J. Deek MS , Mubin I. Syed MD","doi":"10.1016/j.jvir.2025.08.023","DOIUrl":"10.1016/j.jvir.2025.08.023","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Page 2057"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/S1051-0443(25)00701-8
{"title":"Contents in Brief","authors":"","doi":"10.1016/S1051-0443(25)00701-8","DOIUrl":"10.1016/S1051-0443(25)00701-8","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Page A7"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.09.005
Gretchen M. Foltz MD , Adrienne L. Kisting MS , Katrina L. Falk MS , Edwarda Golden MD , Paul Laeseke MD, PhD , Clifford S. Cho MD , Timothy Ziemlewicz MD , J.Louis Hinshaw MD , Erica Knavel Koepsel MD , Fred T. Lee Jr. MD
Percutaneous thermal ablation (TA) is a first-line treatment option for early-stage hepatocellular carcinoma and certain hepatic metastases in patients who are not surgical candidates based on lesion location or patient factors. The traditional treatment goal for TA is destruction of a targeted tumor with an ablative margin, a goal adapted from the hepatic resection literature. Two new non-TA modalities, histotripsy and nanosecond pulsed electric field, have emerged as treatment options with different mechanisms of action compared with TA. There is nascent evidence to suggest that these new technologies might also provoke an immune response, which could provide additional benefit beyond local tumor control. This study examines the available preclinical evidence and data from early human clinical trials for these new technologies and discusses future requirements to realize a potential new paradigm in ablation treatment.
{"title":"An Emerging Paradigm Shift in Liver Ablation: The Potential for Clinical Impact of Nonthermal Ablation Technologies","authors":"Gretchen M. Foltz MD , Adrienne L. Kisting MS , Katrina L. Falk MS , Edwarda Golden MD , Paul Laeseke MD, PhD , Clifford S. Cho MD , Timothy Ziemlewicz MD , J.Louis Hinshaw MD , Erica Knavel Koepsel MD , Fred T. Lee Jr. MD","doi":"10.1016/j.jvir.2025.09.005","DOIUrl":"10.1016/j.jvir.2025.09.005","url":null,"abstract":"<div><div>Percutaneous thermal ablation (TA) is a first-line treatment option for early-stage hepatocellular carcinoma and certain hepatic metastases in patients who are not surgical candidates based on lesion location or patient factors. The traditional treatment goal for TA is destruction of a targeted tumor with an ablative margin, a goal adapted from the hepatic resection literature. Two new non-TA modalities, histotripsy and nanosecond pulsed electric field, have emerged as treatment options with different mechanisms of action compared with TA. There is nascent evidence to suggest that these new technologies might also provoke an immune response, which could provide additional benefit beyond local tumor control. This study examines the available preclinical evidence and data from early human clinical trials for these new technologies and discusses future requirements to realize a potential new paradigm in ablation treatment.</div></div>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Pages 1868-1875"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.07.018
Sam Meiselman BS , M. Allan Thomas PhD , J. Daniel Giardina MD , Alexander Zheleznyak MS , Daniel L.J. Thorek PhD , Christopher D. Malone MD
Radioembolization, most commonly in the form of transarterial delivery of microspheres embedded or loaded with yttrium-90, has evolved to become a highly effective and versatile treatment modality for both primary and metastatic liver cancers. Refinements in patient selection and dosimetry have advanced this therapy as a frontline choice in many clinical scenarios. Despite this, certain limitations restrain the full potential of this therapy and its application to liver cancer and solid tumors in other organs. Recent preclinical advances in image-guided delivery of cancer therapeutics seek to improve upon the existing platform of radioembolization. These include codelivery of agents that harness untapped tumoricidal sources of radionuclides including nanophotosensitizers, chemotherapeutics, immune adjuvants, and photothermal agents. Alternative radionuclides such as alpha emitters can also be locally delivered using image guidance. This review details some of these preclinical advances.
{"title":"Advances in Radioembolization for Liver Cancer","authors":"Sam Meiselman BS , M. Allan Thomas PhD , J. Daniel Giardina MD , Alexander Zheleznyak MS , Daniel L.J. Thorek PhD , Christopher D. Malone MD","doi":"10.1016/j.jvir.2025.07.018","DOIUrl":"10.1016/j.jvir.2025.07.018","url":null,"abstract":"<div><div>Radioembolization, most commonly in the form of transarterial delivery of microspheres embedded or loaded with yttrium-90, has evolved to become a highly effective and versatile treatment modality for both primary and metastatic liver cancers. Refinements in patient selection and dosimetry have advanced this therapy as a frontline choice in many clinical scenarios. Despite this, certain limitations restrain the full potential of this therapy and its application to liver cancer and solid tumors in other organs. Recent preclinical advances in image-guided delivery of cancer therapeutics seek to improve upon the existing platform of radioembolization. These include codelivery of agents that harness untapped tumoricidal sources of radionuclides including nanophotosensitizers, chemotherapeutics, immune adjuvants, and photothermal agents. Alternative radionuclides such as alpha emitters can also be locally delivered using image guidance. This review details some of these preclinical advances.</div></div>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Pages 1876-1881"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.07.004
Erik N.K. Cressman MD, PhD , Monika Raj PhD , Erin H. Seeley PhD , Natalie W. Fowlkes DVM, PhD , Peiman Habibollahi MD
Transcatheter embolotherapies have undergone tremendous evolution and development since the initial reports 5 decades ago. Imaging has likewise advanced with the advent and refinement of computed tomography (CT) and magnetic resonance (MR) imaging. Despite these technical improvements, viable tumor is found in the majority of embolotherapy treated tumors examined under the microscope. Thermoembolization is a novel approach under development that uses in vivo chemistry to address this problem. Relying on basic chemical principles of reactivity, exciting possibilities are emerging for more effective treatments. Furthermore, the serendipitous discovery of unexpected chemical reactions has pointed to a new area of investigation. The authors introduce a unique paradigm, expanding targeted, image-guided in vivo chemistry beyond initial destructive interventions to nondestructive ones, particularly protein modifications. An entirely new world of opportunities is opening for collaboration between interventional radiologists, chemists, and molecular biologists.
{"title":"Recent Developments and Future Directions in Image-Guided Chemistry","authors":"Erik N.K. Cressman MD, PhD , Monika Raj PhD , Erin H. Seeley PhD , Natalie W. Fowlkes DVM, PhD , Peiman Habibollahi MD","doi":"10.1016/j.jvir.2025.07.004","DOIUrl":"10.1016/j.jvir.2025.07.004","url":null,"abstract":"<div><div>Transcatheter embolotherapies have undergone tremendous evolution and development since the initial reports 5 decades ago. Imaging has likewise advanced with the advent and refinement of computed tomography (CT) and magnetic resonance (MR) imaging. Despite these technical improvements, viable tumor is found in the majority of embolotherapy treated tumors examined under the microscope. Thermoembolization is a novel approach under development that uses in vivo chemistry to address this problem. Relying on basic chemical principles of reactivity, exciting possibilities are emerging for more effective treatments. Furthermore, the serendipitous discovery of unexpected chemical reactions has pointed to a new area of investigation. The authors introduce a unique paradigm, expanding targeted, image-guided in vivo chemistry beyond initial destructive interventions to nondestructive ones, particularly protein modifications. An entirely new world of opportunities is opening for collaboration between interventional radiologists, chemists, and molecular biologists.</div></div>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Pages 1894-1898"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.09.020
Arun Kamireddy MBBS, Mohammad Mirza Aghazadeh Attari MD, MPH, Dara L. Kraitchman VMD, PhD, Clifford R. Weiss MD
Obesity affects over 40% of adults in the United States and is associated with major comorbidities, including type 2 diabetes, cardiovascular disease, and mental health disorders. While lifestyle modification and bariatric surgery remain foundational treatments, limitations such as access, cost, and procedural risk have driven interest in minimally invasive, image-guided alternatives. This review highlights recent advances in interventional radiology–based strategies for obesity management, with a focus on bariatric artery embolization (BAE), bariatric arterial radioembolization (BARE), and MRI-guided vagal cryoablation. These techniques act peripherally, modulating appetite via ghrelin suppression, vagal input, or local metabolic effects, and may offer synergistic benefits when combined with centrally acting anti-obesity medications (AOMs), enhancing weight loss durability while reducing medication burden. Additionally, image-guided procedures may serve as rapid, organ-sparing strategies for preoperative optimization in patients requiring time-sensitive surgeries such as joint replacement or organ transplantation, where even modest weight loss improves eligibility and perioperative outcomes. Together, these modalities represent a shift toward multimodal, personalized obesity care. As pharmacologic therapies continue to evolve, integrating image-guided interventions into multidisciplinary care pathways may expand treatment options and improve outcomes for patients with obesity.
{"title":"Image-Guided Approaches for Management of Obesity in Interventional Radiology","authors":"Arun Kamireddy MBBS, Mohammad Mirza Aghazadeh Attari MD, MPH, Dara L. Kraitchman VMD, PhD, Clifford R. Weiss MD","doi":"10.1016/j.jvir.2025.09.020","DOIUrl":"10.1016/j.jvir.2025.09.020","url":null,"abstract":"<div><div>Obesity affects over 40% of adults in the United States and is associated with major comorbidities, including type 2 diabetes, cardiovascular disease, and mental health disorders. While lifestyle modification and bariatric surgery remain foundational treatments, limitations such as access, cost, and procedural risk have driven interest in minimally invasive, image-guided alternatives. This review highlights recent advances in interventional radiology–based strategies for obesity management, with a focus on bariatric artery embolization (BAE), bariatric arterial radioembolization (BARE), and MRI-guided vagal cryoablation. These techniques act peripherally, modulating appetite via ghrelin suppression, vagal input, or local metabolic effects, and may offer synergistic benefits when combined with centrally acting anti-obesity medications (AOMs), enhancing weight loss durability while reducing medication burden. Additionally, image-guided procedures may serve as rapid, organ-sparing strategies for preoperative optimization in patients requiring time-sensitive surgeries such as joint replacement or organ transplantation, where even modest weight loss improves eligibility and perioperative outcomes. Together, these modalities represent a shift toward multimodal, personalized obesity care. As pharmacologic therapies continue to evolve, integrating image-guided interventions into multidisciplinary care pathways may expand treatment options and improve outcomes for patients with obesity.</div></div>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Pages 1912-1916"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.09.009
Maxwell E. Cooper MD , Rahul A. Sheth MD
Intratumoral injection of immunotherapy enables direct delivery into the tumor microenvironment with a wide array of therapeutics, including immune check point inhibitors, oncolytic viruses, and chimeric antigen receptor T cell therapy. Intratumoral immunotherapy had been demonstrated to increase tumor cell lysis, local and distant antigen presentation, immune cell activation and infiltration of the tumor, and systemic immune activation leading to abscopal effects. Despite limited clinical translation over the past 10 years, image-guided intratumoral immunotherapy has been demonstrated to be safe with many advantages over systemic therapy. The landscape of intratumoral immunotherapy is poised to expand substantially with multiple therapies pending approval based on compelling clinical trial data. Interventional radiologists have an opportunity to play an active role in intratumoral immunotherapy programs, specifically with developing protocols, procedural techniques, devices, and drug delivery materials to overcome limitations that have precluded clinical translation.
{"title":"Biological Rationale and Advantages of Image-Guided Immunotherapy","authors":"Maxwell E. Cooper MD , Rahul A. Sheth MD","doi":"10.1016/j.jvir.2025.09.009","DOIUrl":"10.1016/j.jvir.2025.09.009","url":null,"abstract":"<div><div>Intratumoral injection of immunotherapy enables direct delivery into the tumor microenvironment with a wide array of therapeutics, including immune check point inhibitors, oncolytic viruses, and chimeric antigen receptor T cell therapy. Intratumoral immunotherapy had been demonstrated to increase tumor cell lysis, local and distant antigen presentation, immune cell activation and infiltration of the tumor, and systemic immune activation leading to abscopal effects. Despite limited clinical translation over the past 10 years, image-guided intratumoral immunotherapy has been demonstrated to be safe with many advantages over systemic therapy. The landscape of intratumoral immunotherapy is poised to expand substantially with multiple therapies pending approval based on compelling clinical trial data. Interventional radiologists have an opportunity to play an active role in intratumoral immunotherapy programs, specifically with developing protocols, procedural techniques, devices, and drug delivery materials to overcome limitations that have precluded clinical translation.</div></div>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Pages 1839-1845"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.09.013
{"title":"Crossword Puzzle","authors":"","doi":"10.1016/j.jvir.2025.09.013","DOIUrl":"10.1016/j.jvir.2025.09.013","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Page 2056"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.09.018
Juhyun Oh PhD , Lena Bauer BS , Sierra A. Walker PhD , Ralph Weissleder MD, PhD , Shams Iqbal MD
Image-guided core biopsies and fine needle aspirations (FNAs) are routinely performed by interventional radiology (IR) practitioners for a large variety of indications. However, such tissue sampling can be nondiagnostic in up to 20% of cases. The reasons are varied but include technical shortcomings that could ultimately be solved with new technologies. In this article, the authors highlight emerging multiplexed analytical technologies designed to enhance the information content and detection sensitivity from biopsies and FNAs. These technologies have much to offer not only in deciphering cellular heterogeneity and comprehensive immune cell profiling but also in advancing personalized clinical care and in developing improved therapeutics. As these multiplexed tissue sampling technologies continue to evolve, they are expected to become more relevant in IR practices of the future.
{"title":"Next-Generation Approaches to Improve the Information Content of Interventional Radiology Biopsies","authors":"Juhyun Oh PhD , Lena Bauer BS , Sierra A. Walker PhD , Ralph Weissleder MD, PhD , Shams Iqbal MD","doi":"10.1016/j.jvir.2025.09.018","DOIUrl":"10.1016/j.jvir.2025.09.018","url":null,"abstract":"<div><div>Image-guided core biopsies and fine needle aspirations (FNAs) are routinely performed by interventional radiology (IR) practitioners for a large variety of indications. However, such tissue sampling can be nondiagnostic in up to 20% of cases. The reasons are varied but include technical shortcomings that could ultimately be solved with new technologies. In this article, the authors highlight emerging multiplexed analytical technologies designed to enhance the information content and detection sensitivity from biopsies and FNAs. These technologies have much to offer not only in deciphering cellular heterogeneity and comprehensive immune cell profiling but also in advancing personalized clinical care and in developing improved therapeutics. As these multiplexed tissue sampling technologies continue to evolve, they are expected to become more relevant in IR practices of the future.</div></div>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Pages 1856-1861.e1"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.jvir.2025.09.036
Ron C. Gaba MD, MS , Vishnu Chandra MD , Rebecca Le MD , Mohammad Mirza-Agazadeh-Attari MD , Anne Sailer MD , Avik Som MD, PhD , Daniel Y. Sze MD, PhD
{"title":"Future Horizons in Interventional Radiology","authors":"Ron C. Gaba MD, MS , Vishnu Chandra MD , Rebecca Le MD , Mohammad Mirza-Agazadeh-Attari MD , Anne Sailer MD , Avik Som MD, PhD , Daniel Y. Sze MD, PhD","doi":"10.1016/j.jvir.2025.09.036","DOIUrl":"10.1016/j.jvir.2025.09.036","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":"36 12","pages":"Page 1825"},"PeriodicalIF":2.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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