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Commentary: Utilizing donation after circulatory death donors for patients supported on left ventricular assist devices: Is it safe? 评论:对使用左心室辅助装置的患者使用循环死亡后捐献者:是否安全?
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-02 DOI: 10.1016/j.jtcvs.2024.09.045
Valluvan Jeevanandam
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引用次数: 0
Initial balloon versus surgical valvuloplasty in children with isolated congenital aortic stenosis: Influence on timing of aortic valve replacement. 孤立性先天性主动脉瓣狭窄患儿的初始球囊与手术瓣膜成形术:对主动脉瓣置换时机的影响。
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-02 DOI: 10.1016/j.jtcvs.2024.09.043
Michael O Murphy, Jared P Beller, Jordan P Bloom, Claudia Montanaro, Andreas Hoschtitzky, Darryl Shore, Carles Bautista, Alain Fraisse

Objective: To evaluate the influence of initial intervention on the long-term outcomes in congenital aortic stenosis.

Methods: Two hundred forty-three children underwent initial intervention between 1997 and 2022, by surgical valvuloplasty in 92 (32% neonates, 36% infants) and balloon valvuloplasty in 151 (27% neonates, 30% infants). Twenty-eight patients (11.5%) had associated mitral valve stenosis. Competing risk analysis for death, alive after initial intervention, or alive after aortic valve replacement (AVR) was performed and factors influencing survival or AVR examined.

Results: There were 9 early deaths (3.7%). During a median follow-up of 13.5 years (range, 1.5-26.7), 98 patients had reintervention on the aortic valve (40.3%), whereas 145 had AVR (59.6%) at a median age of 14.0 years (interquartile range, 9.0-17.0), which was by Ross procedure in 130 (89.6%). Of the 12 late deaths, 3 were perioperative and 9 occurred as outpatients. There were no perioperative or late deaths after AVR. AVR occurred earlier in patients who had initial balloon (12.0 years [interquartile range, 5.0-14.5]) rather than surgical (18.5 years [interquartile range, 15.5-21.5]) valvuloplasty (P < .05). Actuarial survival in the cohort was 91.3% at 25 years, with no difference between the 2 initial interventions. Critical aortic stenosis, mitral stenosis, and initial intervention as a neonate were independent risk factors for worse survival.

Conclusions: We demonstrate excellent early and late survival in patients with congenital aortic stenosis after initial balloon or surgical valvuloplasty. Whilst children who had balloon valvuloplasty had AVR earlier than those who had initial surgical valvuloplasty, patient factors had a greater influence on survival than choice of initial intervention.

目的:评估初始干预对先天性主动脉瓣狭窄长期预后的影响:方法:1997 年至 2022 年间,243 名儿童接受了初始干预,其中 92 人(32% 为新生儿,36% 为婴儿)接受了手术瓣膜成形术,151 人(27% 为新生儿,30% 为婴儿)接受了球囊瓣膜成形术。28名患者(11.5%)伴有二尖瓣狭窄。对死亡、初始干预后存活或反向瓣膜置换术后存活进行了竞争风险分析,并对影响存活或反向瓣膜置换术的因素进行了研究:结果:共有九例早期死亡(3.7%)。在中位 13.5 年(范围:1.5-26.7 年)的随访期间,98 名患者(40.3%)接受了主动脉瓣的再次介入治疗,145 名患者(59.6%)在中位 14.0 岁(IQR:9.0-17.0)时接受了 AVR,其中 130 名患者(89.6%)接受了 Ross 手术。12例逾期死亡中,3例为围手术期死亡,9例为门诊患者死亡。房室重建术后没有围手术期死亡或逾期死亡。最初接受球囊瓣膜成形术[12.0 年(IQR:5.0-14.5)]而非手术瓣膜成形术[18.5 年(IQR:15.5-21.5)]的患者进行 AVR 的时间较早:我们的研究表明,先天性主动脉瓣狭窄患者在初次接受球囊或手术瓣膜成形术后的早期和晚期存活率都很高。虽然接受球囊瓣膜成形术的患儿比最初接受手术瓣膜成形术的患儿更早进行主动脉瓣置换术,但患者因素对存活率的影响比选择最初的干预措施更大。
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引用次数: 0
Surgical redo mitral replacement compared with transcatheter valve-in-valve in the mitral position. 二尖瓣位置手术重做二尖瓣置换术与经导管瓣膜置入术的比较
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-02 DOI: 10.1016/j.jtcvs.2024.09.048
Pedro Cepas-Guillén, Dimitri Kalavrouziotis, Eric Dumont, Jean Porterie, Jean-Michel Paradis, Josep Rodés-Cabau, Siamak Mohammadi
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引用次数: 0
Commentator Discussion: Diversity presentations at cardiothoracic surgery meetings: Opportunity to align our actions with our values. 评论员讨论:在心胸外科会议上介绍多样性:使我们的行动与价值观保持一致的机会。
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-02 DOI: 10.1016/j.jtcvs.2024.09.011
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引用次数: 0
Commentator Discussion: A novel hybrid prosthesis for open repair of acute DeBakey type I dissection with malperfusion: Early results from the Prospective, Single Arm, Multi-center Clinical Investigation to Evaluate the Safety and Effectiveness of AMDS in the Treatment of acute DeBakey Type I Dissection trial. 评论员讨论:一种新型混合假体用于急性DeBakey I型夹层伴灌注不良的开放式修复:评估 AMDS 治疗急性 DeBakey I 型夹层安全性和有效性的前瞻性、单臂、多中心临床研究》试验的早期结果。
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-30 DOI: 10.1016/j.jtcvs.2024.08.043
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引用次数: 0
Outcomes of single-lung retransplantation after double-lung transplantation. 双肺移植后的单肺再移植结果
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-30 DOI: 10.1016/j.jtcvs.2024.09.039
Victoria Yin, John C S Rodman, Scott M Atay, Sean C Wightman, Graeme M Rosenberg, Brooks V Udelsman, Sivagini Ganesh, Peter Chung, Anthony W Kim, Takashi Harano

Objective: To compare outcomes of single-lung retransplantation (SLRTx) and double-lung retransplantation (DLRTx) after an initial double-lung transplantation.

Methods: The Organ Procurement and Transplantation Network/United Network for Organ Sharing database between May 2005 and December 2022 was retrospectively analyzed. Multiorgan transplantations, repeated retransplantations, and lung retransplantations when the status of the initial transplantation was unknown were excluded.

Results: A total of 891 patients were included in the analysis, included 698 (78.3%) with DLRTx and 193 (21.7%) with SLRTx. The mean lung allocation score was higher in the DLRTx group (59.6 ± 20.7 vs 55.1 ± 19.3; P = .007). The use of extracorporeal membrane oxygenation (ECMO) bridge to lung transplantation was similar in the 2 groups (P = .125), as was waitlist time (P = .610). The need for mechanical ventilation (54.6% vs 35.8%; P = .005) and ECMO (17.9% vs 9.0%; P = .069) at 72 hours post-transplantation was greater in the DLRTx group. However, median post-transplantation hospital stay (21.5 [interquartile range (IQR), 12-35] days versus 20 [IQR, 12-35] days; P = .119) and in-hospital mortality (10.9% [n = 76/698] vs 12.4% [n = 24/193]; P = .547) were comparable in the 2 groups. Long-term survival was significantly better in the DLRTx group (P < .001, log-rank test). In the propensity score-weighted multivariable model, the DLRTx group had 28% lower risk of mortality at any point during follow-up compared to the SLRTx group (hazard ratio, 0.72; 95% confidence interval, 0.57-0.91; P = .006).

Conclusions: The less invasiveness of single-lung transplantation in the retransplantation setting has minimal short-term benefit and is associated with significantly worse long-term survival. Double-lung retransplantation should remain the standard for lung retransplantation after initial double-lung transplantation.

研究目的本研究旨在比较初次双肺移植后进行单肺再移植(SLRTx)和双肺再移植(DLRTx)的结果:方法:对2005年5月至2022年12月期间的器官获取与移植网络/器官共享联合网络数据库进行了回顾性分析。方法:对2005年5月至2022年12月期间的器官获取与移植网络/器官共享联合网络数据库进行了回顾性分析,排除了多器官移植、重复再移植以及初次移植状况不明的肺再移植:分析共纳入891例患者:698例(78.3%)为DLRTx,193例(21.7%)为SLRTx。DLRTx患者的平均肺分配评分更高(59.6±20.7 vs 55.1±19.3,P = 0.007)。体外膜肺氧合(ECMO)桥接肺移植的使用情况在各组之间相似(P=0.125),等待时间也相似(P=0.610)。DLRTx组在移植后72小时内需要机械通气(54.6% vs 35.8%,p=0.005)和ECMO(17.9% vs 9.0%,p=0.069)的频率更高。然而,移植后中位住院时间(21.5 [IQR 12-35] vs 20 天 [IQR12-35],p=0.119)和院内死亡率(10.9% [76/698] vs 12.4% [24/193],p=0.547)在两组之间不相上下。DLRTx组的长期生存率明显更高(对数秩检验 p < 0.001)。在倾向分数加权多变量模型中,DLRTx与SLRTx相比,在随访期间任何时间点的死亡风险均低28%(HR:0.72,95%置信区间:0.57-0.91,P=0.006):结论:在再移植情况下,单肺移植的创面较小,短期获益甚微,但长期生存率却明显较低。双肺再移植仍应是初次双肺移植后进行肺再移植的标准。
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引用次数: 0
Gender, race, and ethnicity in lung cancer clinical trial participation: Analysis of 253,845 patients from 2002 to 2021. 肺癌临床试验参与中的性别、种族和民族:2002-2021年253,845名患者的分析。
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-29 DOI: 10.1016/j.jtcvs.2024.09.040
Meghamsh Kanuparthy, Srikur Kanuparthy, Dwight D Harris, Mark Broadwin, Christopher Stone, Abbas E Abbas, Frank W Sellke

Background: Lung cancer remains the greatest cause of cancer-related death, and multiple large studies have identified persistent racial disparities in lung cancer outcomes. In this study, we used public recording of lung cancer data on clinicaltrials.gov to sample age, gender, racial, and ethnic characteristics of participants in lung cancer clinical trials.

Methods: ClinicalTrials.gov, a US federal government repository of clinical trials, was queried for the term "lung cancer" and several related terms. A list of all studies matching these criteria was generated, and information regarding age, gender, ethnicity, and racial breakdown of participants was analyzed. Studies that did not report results to ClinicalTrials.gov or had at least one non-US site were excluded. Hypothesis testing was performed with the Student t test and χ2 test. Trends were analyzed using Spearman testing in Python (VSCode).

Results: Rates of minority (ie, nonwhite) and female participation in US lung cancer clinical trials have increased significantly (P < .01) over the 20-year period from 2002 to 2021 but still do not represent parity with lung cancer incidence. Subset analysis by intervention offered did not show any significant differences in race, gender, or ethnic participation between studies that offered surgical intervention and those involving noninvasive interventions. National Institutes of Health-funded studies do not appear to have recruited any Hispanic participants, as assessed by reporting on ClinicalTrials.gov. The rates of race and ethnicity reporting also increased significantly over the study period.

Conclusions: Our data demonstrate that there are persistent but improving racial and ethnic disparities in lung cancer clinical trials. Limitations of this study include poor reporting of results on clinicaltrials.gov. These findings demonstrate significant progress in the recruitment of minority participation, but also identify a significant role for policy changes to align participation with lung cancer incidence.

目的:肺癌仍然是癌症相关死亡的最大原因,多项大型研究发现肺癌结果中持续存在种族差异。在本研究中,我们利用临床试验网(clinicaltrials.gov)上公开记录的肺癌数据,对肺癌临床试验参与者的年龄、性别、种族和民族特征进行抽样调查:我们在 Clinicaltrials.gov 这个美国联邦政府的临床试验资料库中查询了 "肺癌 "和其他几个相关术语。我们生成了一份符合这些标准的所有研究清单,并对参与者的年龄、性别、民族和种族分类信息进行了分析。未向 clinicaltrials.gov 报告结果或至少有一个研究地点不在美国的研究被排除在外。假设检验采用学生 T 检验和卡方检验。用 Python(VS Code,Microsoft,Redmond,WA 2023)中的斯皮尔曼检验对趋势进行了分析。 结果:少数族裔(非白人)和女性参与美国肺癌临床试验的比率有了显著增加(p结论:我们的数据表明,肺癌临床试验中的种族和民族差异持续存在,但在不断改善。本研究的局限性包括clinicaltrials.gov上的结果报告较少。这些研究结果表明,在招募少数族裔参与方面取得了重大进展,但同时也指出了政策改革的重要作用,即根据肺癌发病率调整参与情况。
{"title":"Gender, race, and ethnicity in lung cancer clinical trial participation: Analysis of 253,845 patients from 2002 to 2021.","authors":"Meghamsh Kanuparthy, Srikur Kanuparthy, Dwight D Harris, Mark Broadwin, Christopher Stone, Abbas E Abbas, Frank W Sellke","doi":"10.1016/j.jtcvs.2024.09.040","DOIUrl":"10.1016/j.jtcvs.2024.09.040","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer remains the greatest cause of cancer-related death, and multiple large studies have identified persistent racial disparities in lung cancer outcomes. In this study, we used public recording of lung cancer data on clinicaltrials.gov to sample age, gender, racial, and ethnic characteristics of participants in lung cancer clinical trials.</p><p><strong>Methods: </strong>ClinicalTrials.gov, a US federal government repository of clinical trials, was queried for the term \"lung cancer\" and several related terms. A list of all studies matching these criteria was generated, and information regarding age, gender, ethnicity, and racial breakdown of participants was analyzed. Studies that did not report results to ClinicalTrials.gov or had at least one non-US site were excluded. Hypothesis testing was performed with the Student t test and χ<sup>2</sup> test. Trends were analyzed using Spearman testing in Python (VSCode).</p><p><strong>Results: </strong>Rates of minority (ie, nonwhite) and female participation in US lung cancer clinical trials have increased significantly (P < .01) over the 20-year period from 2002 to 2021 but still do not represent parity with lung cancer incidence. Subset analysis by intervention offered did not show any significant differences in race, gender, or ethnic participation between studies that offered surgical intervention and those involving noninvasive interventions. National Institutes of Health-funded studies do not appear to have recruited any Hispanic participants, as assessed by reporting on ClinicalTrials.gov. The rates of race and ethnicity reporting also increased significantly over the study period.</p><p><strong>Conclusions: </strong>Our data demonstrate that there are persistent but improving racial and ethnic disparities in lung cancer clinical trials. Limitations of this study include poor reporting of results on clinicaltrials.gov. These findings demonstrate significant progress in the recruitment of minority participation, but also identify a significant role for policy changes to align participation with lung cancer incidence.</p>","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: Many roads lead to a competent aortic valve after valve-sparing root replacement. 评论:保瓣根部置换术后,通往合格主动脉瓣的道路有很多。
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-28 DOI: 10.1016/j.jtcvs.2024.09.041
Christopher Lau, Leonard N Girardi
{"title":"Commentary: Many roads lead to a competent aortic valve after valve-sparing root replacement.","authors":"Christopher Lau, Leonard N Girardi","doi":"10.1016/j.jtcvs.2024.09.041","DOIUrl":"10.1016/j.jtcvs.2024.09.041","url":null,"abstract":"","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentator Discussion: AATS Quality Gateway: A surgeon case study of its application in adult cardiac surgery for quality assurance. 评论员讨论:AATS 质量网关:外科医生在成人心脏手术质量保证中的应用案例研究。
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-27 DOI: 10.1016/j.jtcvs.2024.08.041
{"title":"Commentator Discussion: AATS Quality Gateway: A surgeon case study of its application in adult cardiac surgery for quality assurance.","authors":"","doi":"10.1016/j.jtcvs.2024.08.041","DOIUrl":"https://doi.org/10.1016/j.jtcvs.2024.08.041","url":null,"abstract":"","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentator Discussion: Expanded polytetrafluoroethylene mesh in chest wall reconstruction: A 27-year experience. 评论员讨论:胸壁重建中的膨体聚四氟乙烯网片:27 年的经验。
IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-27 DOI: 10.1016/j.jtcvs.2024.08.003
{"title":"Commentator Discussion: Expanded polytetrafluoroethylene mesh in chest wall reconstruction: A 27-year experience.","authors":"","doi":"10.1016/j.jtcvs.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.jtcvs.2024.08.003","url":null,"abstract":"","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Thoracic and Cardiovascular Surgery
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