Journal of Thoracic and Cardiovascular Surgery最新文献

英文中文

Reply: The evolving role of artificial intelligenge in pediatric cardiovascular surgery: A call for transparency, collaboration, and rigorous validation 回复：人工智能在儿科心血管手术中的作用：呼吁透明度、协作和严格的验证。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.04.005

Rittal Mehta MS, BDS , Justus G. Reitz MD , Yves d’Udekem MD, PhD

引用次数: 0

On the hindered path of evidence in postinfarction mechanical complications: How research can support improved management 关于梗塞后机械并发症的证据受阻：研究如何支持改进的管理。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.06.004

Daniele Ronco MD , Matteo Matteucci MD, PhD , Michele Di Mauro MD, PhD, MStat , Giulio Massimi MD , Marco Gemelli MD , Albert Ariza-Solé MD, PhD , Roberto Lorusso MD, PhD

引用次数: 0

Commentary: Testing the warranty on your BITA graft 评论：测试BITA保修。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.08.010

Craig R. Smith MD

引用次数: 0

Ensuring safety and reliability in ChatGPT-assisted pediatric cardiovascular surgical decision-making 确保chatgpt辅助儿科心血管手术决策的安全性和可靠性。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.02.015

Xiaobin Zhang (Dr), Jiawei Wang (Dr)

引用次数: 0

Reply: Preoperative diabetes duration and long-term outcomes in patients with acute myocardial infarction undergoing coronary artery bypass grafting 回复：接受冠状动脉旁路移植术的急性心肌梗死患者术前糖尿病持续时间与长期预后。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.03.008

Jun Ho Lee MD, PhD, Hee Jung Kim MD, PhD

引用次数: 0

Long-term outcomes of semirigid ring and band annuloplasty in functional mitral regurgitation patients without advanced left ventricular dilation 半刚性环和带状环成形术治疗无晚期左室扩张的功能性二尖瓣返流患者的长期疗效。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.06.023

Preetha Pamidighantam BS , Carol Chen MD , Nabin Shrestha PhD , Holliann Umana MD, JD , Kevin Patterson MD , Justin Fanning MD , Stephane Leung Wai Sang MD, MSc , Edward Murphy MD , Charles Willekes MD , Tomasz Timek MD, PhD

Objective

Our study aims to compare the long-term survival and clinical outcomes of ring and band prostheses for annuloplasty repair of functional mitral regurgitation.

Methods

From March 2005 to November 2017, 160 patients with moderate to severe functional mitral regurgitation underwent undersized annuloplasty using semirigid complete ring (N = 69) or partial band (N = 91) prostheses of the same material and manufacturer. Primary outcomes were long-term survival and clinical outcomes, and secondary outcomes included comparison of postoperative echocardiography data.

Results

Both groups had comparable baseline characteristics, cardiac function, functional mitral regurgitation severity, and perioperative complications. Complete ring and partial band groups experienced equivalent 10-year freedom from cardiovascular mortality (65.2% vs 68.3%, P = .39) and functional mitral regurgitation recurrence (78.5% vs 71.4%, P = .27). At a mean follow-up of 58 ± 46 months, both groups had a parallel increase in ejection fraction (+7% ± 16% vs +5% ± 15%, P = .35) and reduction of left ventricle internal diameter end-diastole (−0.5 ± 0.8 cm vs −0.4 ± 0.9 cm, P = .61). The complete ring group had greater reduction in left ventricle internal diameter end-systole (−0.6 ± 0.9 cm vs −0.2 ± 0.9 cm, P = .007) but higher mean (5.6 ± 3.4 mm Hg vs 5.0 ± 7 mm Hg, P = .025) and peak (16.7 ± 19.4 mm Hg vs 12.9 ± 10.7 mm Hg, P = .048) transvalvular pressure gradients. Mean transvalvular pressure gradient predicted postoperative mortality at 10 years (hazard ratio, 1.19; 95% CI, 1.0037-1.357; P = .013).

Conclusions

Complete ring and partial band annuloplasty for functional mitral regurgitation confer equivalent 10-year survival and mitral regurgitation recurrence. Complete ring repair was associated with increased left ventricle reverse remodeling yet higher long-term valvular gradients.

目的：比较环状和带状假体用于功能性二尖瓣反流（FMR）成形术修复的长期生存率和临床结果。方法：从2005年3月至2017年11月，160例中重度FMR患者采用相同材料和制造商的半刚性完整环（CR， N=69）或部分带（PB， N=91）假体进行小尺寸环成形术。主要结果是长期生存和临床结果，而次要结果包括术后超声心动图数据的比较。结果：两组的基线特征、心功能、FMR严重程度和围手术期并发症具有可比性。CR和PB的10年无CV死亡率（65.2% vs 68.3%， P= 0.39）和FMR复发率（78.5% vs 71.4%， P= 0.27）相同。平均随访58±46个月，两组患者射血分数平行升高（+7±16 vs +5±15%，P= 0.35），左心室舒张末期内径减小（-0.5±0.8 vs -0.4±0.9 cm， P= 0.61）。CR组左心室收缩末期内径（-0.6±0.9 vs -0.2±0.9 cm， P= 0.007）明显降低，但平均（5.6±3.4 vs 5.0±7 mmHg， P= 0.025）和峰值（16.7±19.4 vs 12.9±10.7 mmHg， P= 0.048）跨瓣压力梯度（TPG）明显升高。平均TPG预测术后10年死亡率（HR 1.19[CI 95% (1.0037-1.357)]， P= 0.013）。结论：CR和PB环成形术治疗FMR可获得相当的10年生存率和MR复发率。CR修复与左室反向重构增加和长期瓣膜梯度升高相关。

{"title":"Long-term outcomes of semirigid ring and band annuloplasty in functional mitral regurgitation patients without advanced left ventricular dilation","authors":"Preetha Pamidighantam BS , Carol Chen MD , Nabin Shrestha PhD , Holliann Umana MD, JD , Kevin Patterson MD , Justin Fanning MD , Stephane Leung Wai Sang MD, MSc , Edward Murphy MD , Charles Willekes MD , Tomasz Timek MD, PhD","doi":"10.1016/j.jtcvs.2025.06.023","DOIUrl":"10.1016/j.jtcvs.2025.06.023","url":null,"abstract":"<div><h3>Objective</h3><div>Our study aims to compare the long-term survival and clinical outcomes of ring and band prostheses for annuloplasty repair of functional mitral regurgitation.</div></div><div><h3>Methods</h3><div>From March 2005 to November 2017, 160 patients with moderate to severe functional mitral regurgitation underwent undersized annuloplasty using semirigid complete ring (N = 69) or partial band (N = 91) prostheses of the same material and manufacturer. Primary outcomes were long-term survival and clinical outcomes, and secondary outcomes included comparison of postoperative echocardiography data.</div></div><div><h3>Results</h3><div>Both groups had comparable baseline characteristics, cardiac function, functional mitral regurgitation severity, and perioperative complications. Complete ring and partial band groups experienced equivalent 10-year freedom from cardiovascular mortality (65.2% vs 68.3%, <em>P</em> = .39) and functional mitral regurgitation recurrence (78.5% vs 71.4%, <em>P</em> = .27). At a mean follow-up of 58 ± 46 months, both groups had a parallel increase in ejection fraction (+7% ± 16% vs +5% ± 15%, <em>P</em> = .35) and reduction of left ventricle internal diameter end-diastole (−0.5 ± 0.8 cm vs −0.4 ± 0.9 cm, <em>P</em> = .61). The complete ring group had greater reduction in left ventricle internal diameter end-systole (−0.6 ± 0.9 cm vs −0.2 ± 0.9 cm, <em>P</em> = .007) but higher mean (5.6 ± 3.4 mm Hg vs 5.0 ± 7 mm Hg, <em>P</em> = .025) and peak (16.7 ± 19.4 mm Hg vs 12.9 ± 10.7 mm Hg, <em>P</em> = .048) transvalvular pressure gradients. Mean transvalvular pressure gradient predicted postoperative mortality at 10 years (hazard ratio, 1.19; 95% CI, 1.0037-1.357; <em>P</em> = .013).</div></div><div><h3>Conclusions</h3><div>Complete ring and partial band annuloplasty for functional mitral regurgitation confer equivalent 10-year survival and mitral regurgitation recurrence. Complete ring repair was associated with increased left ventricle reverse remodeling yet higher long-term valvular gradients.</div></div>","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":"171 2","pages":"Pages 374-383.e1"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cold storage solution on warm ischemia-induced myocardial plasma membrane damage and pyroptosis in human hearts from circulatory death donors 低温冷藏对循环死亡供者心脏热缺血引起的心肌质膜损伤和焦亡的影响。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.08.038

Shiyi Li MD , Katherine V. Nordick MD , Abdussalam E. Elsenousi MD , Adel M. Hassan MS , Ronald A. Shaju MS , Rishav Bhattacharya BS , Syed B. Peer MD , Abhinav Rajkumar MS , Shivam Banerjee BS , Randall P. Kirby MS , Camila Hochman-Mendez PhD , Todd K. Rosengart MD, MBA, FACS , Kenneth K. Liao MD, PhD, FACS , Nandan K. Mondal MS, MPhil, PhD

Objective

Celsior solution (CS) (IGL Group) is used for cold preservation of hearts from brain death donors but not for those from circulatory death donors (DCD). Plasma membrane repair proteins are crucial for maintaining myocardial integrity during ischemia. We compared the effects of CS cold preservation with normal saline (NS) on myocardial membrane disruption and pyroptosis in human DCD hearts, with varying warm ischemia times (WIT) and cold storage durations.

Methods

Twenty-four human DCD hearts (WIT ≤30 minutes [n = 12] and WIT >30 minutes [n = 12]) were procured and divided into 4 groups based on preservation solutions and WIT (n = 6 per group): NS + WIT ≤30 minutes, CS + WIT ≤30 minutes, NS + WIT >30 minutes, and CS + WIT >30 minutes. All hearts received del Nido cardioplegia before cold storage in CS (n = 12) or NS (n = 12) for 6 hours. Left ventricle biopsies were performed at 0, 2, 4, and 6 hours to assess myocardial membrane proteins (annexin A1, dysferlin, and mitsugumin 53), calcium levels, pyroptotic proteins (NACHT, LRR, and PYD domains-containing protein 3 and gasdermin D, N-terminal fragment), edema, and injury scores.

Results

Before cold storage, DCD hearts with a WIT >30 minutes showed impaired membrane integrity, increased pyroptosis, calcium overload, significant edema, and injury. After cold storage, neither normal saline nor CS improved myocardial integrity in hearts with a WIT >30 minutes. However, cold CS storage did help preserve myocardial membrane integrity and reduce pyroptosis, edema, and injury for up to 4 hours in hearts with a WIT of 30 minutes or less.

Conclusions

CS effectively preserves DCD hearts with WIT ≤30 minutes for up to 4 hours, highlighting its potential in optimizing DCD heart preservation.

目的：冻干液（CS）用于脑死亡供者的心脏冷保存，但不适用于循环死亡供者的心脏冷保存。质膜修复蛋白在缺血时维持心肌完整性至关重要。我们比较了CS冷保存与生理盐水（NS）在不同热缺血时间（WIT）和冷保存时间下对人DCD心脏心肌膜破坏和焦亡的影响。方法：取24颗人DCD心脏（WIT≤30,n=12, WIT bbb30, n=12），根据保存溶液和WIT分为4组（n=6/组）：(i) NS+WIT≤30分钟（min），（ii） CS+WIT≤30分钟，（iii） NS+WIT>30分钟，（iv） CS+WIT>30分钟。所有心脏在冷藏前均接受del Nido心脏骤停，对照组（n=12）或对照组（n=12）保存6小时。在0、2、4和6小时进行左心室活检，以评估心肌膜蛋白（膜联蛋白A1、Dysferlin和MG53）、钙水平、焦亡蛋白（NLRP3、GSDMD-NT）、水肿和损伤评分。结果：在冷藏前，体外循环30分钟的DCD心脏表现出膜完整性受损、焦亡增加、钙超载、明显水肿和损伤。冷藏后，生理盐水和低温均不能改善心肌完整性。然而，低温低温储存确实有助于保持心肌膜的完整性，减少心肌坏死、水肿和损伤，并在心肌缺血30分钟或更短时间内保存长达4小时。结论：Celsior可有效保存WIT≤30 min的DCD心脏长达4小时，突出了其优化DCD心脏保存的潜力。

{"title":"Effect of cold storage solution on warm ischemia-induced myocardial plasma membrane damage and pyroptosis in human hearts from circulatory death donors","authors":"Shiyi Li MD , Katherine V. Nordick MD , Abdussalam E. Elsenousi MD , Adel M. Hassan MS , Ronald A. Shaju MS , Rishav Bhattacharya BS , Syed B. Peer MD , Abhinav Rajkumar MS , Shivam Banerjee BS , Randall P. Kirby MS , Camila Hochman-Mendez PhD , Todd K. Rosengart MD, MBA, FACS , Kenneth K. Liao MD, PhD, FACS , Nandan K. Mondal MS, MPhil, PhD","doi":"10.1016/j.jtcvs.2025.08.038","DOIUrl":"10.1016/j.jtcvs.2025.08.038","url":null,"abstract":"<div><h3>Objective</h3><div>Celsior solution (CS) (IGL Group) is used for cold preservation of hearts from brain death donors but not for those from circulatory death donors (DCD). Plasma membrane repair proteins are crucial for maintaining myocardial integrity during ischemia. We compared the effects of CS cold preservation with normal saline (NS) on myocardial membrane disruption and pyroptosis in human DCD hearts, with varying warm ischemia times (WIT) and cold storage durations.</div></div><div><h3>Methods</h3><div>Twenty-four human DCD hearts (WIT ≤30 minutes [n = 12] and WIT >30 minutes [n = 12]) were procured and divided into 4 groups based on preservation solutions and WIT (n = 6 per group): NS + WIT ≤30 minutes, CS + WIT ≤30 minutes, NS + WIT >30 minutes, and CS + WIT >30 minutes. All hearts received del Nido cardioplegia before cold storage in CS (n = 12) or NS (n = 12) for 6 hours. Left ventricle biopsies were performed at 0, 2, 4, and 6 hours to assess myocardial membrane proteins (annexin A1, dysferlin, and mitsugumin 53), calcium levels, pyroptotic proteins (NACHT, LRR, and PYD domains-containing protein 3 and gasdermin D, N-terminal fragment), edema, and injury scores.</div></div><div><h3>Results</h3><div>Before cold storage, DCD hearts with a WIT >30 minutes showed impaired membrane integrity, increased pyroptosis, calcium overload, significant edema, and injury. After cold storage, neither normal saline nor CS improved myocardial integrity in hearts with a WIT >30 minutes. However, cold CS storage did help preserve myocardial membrane integrity and reduce pyroptosis, edema, and injury for up to 4 hours in hearts with a WIT of 30 minutes or less.</div></div><div><h3>Conclusions</h3><div>CS effectively preserves DCD hearts with WIT ≤30 minutes for up to 4 hours, highlighting its potential in optimizing DCD heart preservation.</div></div>","PeriodicalId":49975,"journal":{"name":"Journal of Thoracic and Cardiovascular Surgery","volume":"171 2","pages":"Pages 439-453.e1"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatility of the right atrial wall for tricuspid valve repair in children with Ebstein anomaly Ebstein畸形儿童三尖瓣修复右房壁的多功能性。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.11.011

Igor E. Konstantinov MD, PhD, FRACS , Bakhytzhan Nurkeyev MD, PhD , Erbol Aldabergenov MD , Elmira Kuandykova MD , Bauyrzhan Tuyakbayev MD , Assel Kabakanova MD , Amangeldy Kerimkulov MD , Zhanibek Z. Ashirov MD , Aidos Erpashov MD , Abay K. Baigenzhin MD, PhD

引用次数: 0

Commentary: Functional mitral regurgitation: An entity with more questions than answers 评论：功能性二尖瓣反流：一个问题多于答案的实体。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.07.003

Ali Hage MD, Eugene A. Grossi MD

引用次数: 0

Commentary: If at first you don't succeed 评论：如果一开始你没有成功。

IF 4.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery

Pub Date : 2026-02-01 DOI: 10.1016/j.jtcvs.2025.08.006

Stephanie L. Mick MD

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Journal of Thoracic and Cardiovascular Surgery

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀