Journal of the American Society of Echocardiography最新文献

英文中文

The Effect of Mavacamten on Left Atrial Strain Dynamics in Obstructive Hypertrophic Cardiomyopathy 马伐卡坦对梗阻性肥厚性心肌病左心房应变动力学的影响。

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.09.014

Jaehyun Lim MD, Soongu Kwak MD, Min-Ha Jeong MD, Jae Yeong Cho MD, PhD, ChanSoon Park MD, PhD, Jiesuck Park MD, Hong-Mi Choi MD, Ga Hui Choi MD, Jihoon Kim MD, Jin-Oh Na MD, PhD, Sun Hwa Lee MD, PhD, Mi-Hyang Jung MD, PhD, Hae Ok Jung MD, PhD, Sang-Chol Lee MD, PhD, Hyung-Kwan Kim MD, PhD, Kye Hun Kim MD, PhD, Goo-Yeong Cho MD, PhD

引用次数: 0

Systematizing Diastolic Function Evaluation: From Algorithms to Practical Approach—Are We Finally Reaching Diagnostic Consistency? 系统化舒张功能评估：从算法到实用方法。我们最终达到诊断一致性了吗？

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.09.023

Jorge Eduardo Assef PhD, MD, Gustavo Nishida PhD

引用次数: 0

Implementation of Modified Venous Excess Ultrasound in Clinical Practice 改良的VExUS在临床中的应用。

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.10.002

Yohei Masuda MD, Fumio Otsuka MD, PhD

引用次数: 0

Reply to “Intraoperative Factors Should Be Considered in Assessing the Association between Three-Dimensional Right Ventricular Ejection Fraction and Early Postoperative Outcomes” 回复“在评估3D RVEF与术后早期预后的关系时应考虑术中因素”

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.09.011

Edith L. Posada-Martinez MD, Juan B. Ivey-Miranda MD, PhD

引用次数: 0

Threshold Values of Vena Contracta Area for Grading Secondary Tricuspid Regurgitation and its Association with Outcomes 二次三尖瓣反流分级的收缩静脉面积阈值及其与预后的关系。

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.10.015

Giorgia Benzoni MD , Michele Tomaselli MD, PhD , Noela Radu MD , Alexandra Clement MD , Marco Penso BME , Paolo Springhetti MD , Daniel Ignacio Conforme Torres MD , Tommaso Rinforzi MD , Carlotta Tosi MD , Alexandra Buta MD , Yuka Kawada MD , Denisa Muraru MD, PhD , Luigi P. Badano MD, PhD

Background

Three-dimensional echocardiographic planimetry of vena contracta area (VCA), which avoids geometric assumptions about the regurgitant orifice, has emerged as a promising method for grading secondary tricuspid regurgitation (STR). The aims of this study were to (1) define VCA threshold values to grade the severity of STR using a five-grade system, (2) identify the VCA cutoff value associated with adverse clinical outcomes, and (3) assess the incremental prognostic value of VCA compared with conventional quantitative parameters of tricuspid regurgitation severity.

Methods

Three-dimensional echocardiography was used to obtain VCA from 204 outpatients (mean age, 77 ± 12 years; 44% men) with mild to torrential STR (52% with severe or greater STR) according to current guidelines, and its association with a composite outcome of all-cause death and hospitalization for heart failure was assessed.

Results

The VCA threshold values for STR severity were <0.43 cm² for mild, 0.43 to 0.67 cm² for moderate, 0.68 to 0.88 cm² for severe, 0.89 to 1.26 cm² for massive, and >1.26 cm² for torrential STR. Spline curve analysis identified a VCA threshold of 0.65 cm² as the optimal cutoff associated with an increased risk for experiencing the composite end point. Although not yet severe, patients with VCA > 0.65 cm² experienced an exponential increase in their risk. VCA > 0.65 cm² was associated with a threefold risk increase for the composite end point regardless of effective regurgitant orifice area (EROA; log-rank P = .00068). In multivariate analysis, VCA remained independently associated with the composite end point (adjusted hazard ratio, 1.06; 95% CI, 1.02-1.10; P = .004). Adding VCA to baseline models incorporating clinical and echocardiographic variables, including either EROA or regurgitant volume, significantly improved the prognostic performance of the model (P = .007 and P = .018, respectively).

Conclusions

VCA obtained from color Doppler three-dimensional echocardiography is a robust parameter to grade STR severity, showing incremental prognostic value in comparison with both EROA and regurgitant volume.

背景：三维超声心动图（3DE）测量收缩静脉（VCA）的平面度，避免了对反流口的几何假设，已经成为一种有前途的分级继发性三尖瓣反流（STR）的方法。本研究旨在：(i)定义VCA阈值，使用五级系统对STR的严重程度进行分级；（ii）确定与不良临床结果相关的VCA临界值；（iii）与TR严重程度的常规定量参数相比，评估VCA的增量预后价值。方法：根据现行指南，我们使用3DE获取204例轻度至重度STR门诊患者（77±12岁，44%男性）（52%≥重度）的VCA，并评估其与全因死亡和心力衰竭住院的综合结局的相关性。结果：STR严重程度的VCA阈值为：轻度为2，中度为0.43 cm2-0.67 cm2，重度为0.68 cm2-0.88 cm2，重度为0.89 cm2-1.26 cm2，重度为>1.26 cm2。样条曲线分析确定VCA阈值为0.65 cm2是与经历复合终点风险增加相关的最佳临界值。虽然还不严重，但VCA患者的风险呈指数增长。无论有效返流孔面积如何，VCA>0.65 cm2与复合终点的风险增加3倍相关（EROA, log-rank p=0.00068）。在多变量分析中，VCA仍然与复合终点独立相关[aHR 1.06 (95% CI 1.02-1.10), p=0.004]。将VCA添加到包含临床和超声心动图变量（包括EROA或RegVol）的基线模型中，可显着改善模型的预后表现（p=0.007和p=0.018）。结论：彩色多普勒3DE获得的VCA是分级STR严重程度的可靠参数，与EROA和RegVol相比，具有增加的预后价值。

{"title":"Threshold Values of Vena Contracta Area for Grading Secondary Tricuspid Regurgitation and its Association with Outcomes","authors":"Giorgia Benzoni MD , Michele Tomaselli MD, PhD , Noela Radu MD , Alexandra Clement MD , Marco Penso BME , Paolo Springhetti MD , Daniel Ignacio Conforme Torres MD , Tommaso Rinforzi MD , Carlotta Tosi MD , Alexandra Buta MD , Yuka Kawada MD , Denisa Muraru MD, PhD , Luigi P. Badano MD, PhD","doi":"10.1016/j.echo.2025.10.015","DOIUrl":"10.1016/j.echo.2025.10.015","url":null,"abstract":"<div><h3>Background</h3><div>Three-dimensional echocardiographic planimetry of vena contracta area (VCA), which avoids geometric assumptions about the regurgitant orifice, has emerged as a promising method for grading secondary tricuspid regurgitation (STR). The aims of this study were to (1) define VCA threshold values to grade the severity of STR using a five-grade system, (2) identify the VCA cutoff value associated with adverse clinical outcomes, and (3) assess the incremental prognostic value of VCA compared with conventional quantitative parameters of tricuspid regurgitation severity.</div></div><div><h3>Methods</h3><div>Three-dimensional echocardiography was used to obtain VCA from 204 outpatients (mean age, 77 ± 12 years; 44% men) with mild to torrential STR (52% with severe or greater STR) according to current guidelines, and its association with a composite outcome of all-cause death and hospitalization for heart failure was assessed.</div></div><div><h3>Results</h3><div>The VCA threshold values for STR severity were <0.43 cm<sup>2</sup> for mild, 0.43 to 0.67 cm<sup>2</sup> for moderate, 0.68 to 0.88 cm<sup>2</sup> for severe, 0.89 to 1.26 cm<sup>2</sup> for massive, and >1.26 cm<sup>2</sup> for torrential STR. Spline curve analysis identified a VCA threshold of 0.65 cm<sup>2</sup> as the optimal cutoff associated with an increased risk for experiencing the composite end point. Although not yet severe, patients with VCA > 0.65 cm<sup>2</sup> experienced an exponential increase in their risk. VCA > 0.65 cm<sup>2</sup> was associated with a threefold risk increase for the composite end point regardless of effective regurgitant orifice area (EROA; log-rank <em>P</em> = .00068). In multivariate analysis, VCA remained independently associated with the composite end point (adjusted hazard ratio, 1.06; 95% CI, 1.02-1.10; <em>P</em> = .004). Adding VCA to baseline models incorporating clinical and echocardiographic variables, including either EROA or regurgitant volume, significantly improved the prognostic performance of the model (<em>P</em> = .007 and <em>P</em> = .018, respectively).</div></div><div><h3>Conclusions</h3><div>VCA obtained from color Doppler three-dimensional echocardiography is a robust parameter to grade STR severity, showing incremental prognostic value in comparison with both EROA and regurgitant volume.</div></div>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"39 2","pages":"Pages 156-166"},"PeriodicalIF":6.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to “Optimizing Clinical Applicability of Left Atrial Strain Index in Patients with Heart Failure with Preserved Ejection Fraction” 回复“优化左房应变指数在保留射血分数心力衰竭患者中的临床适用性”。

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.10.016

Aileen Paula Chua MD, Nina Ajmone Marsan MD, PhD

引用次数: 0

Information for Readers 读者资讯

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/S0894-7317(26)00005-2

引用次数: 0

Diagnosing Mitral Annular Disjunction in Patients ≤21 Years in a Large Pediatric and Congenital Echocardiographic Laboratory 在大型儿科和先天性超声心动图实验室诊断≤21岁患者的二尖瓣环分离

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.10.008

Derek M. Norton MD, Alejandra Iturralde Chavez MD, Ricardo H. Pignatelli MD, Lance W. Patterson BS, Christina Y. Miyake MD, MS, MPH, Tam T. Doan MD

引用次数: 0

Influence of Microbubble Properties and Carrier Frequency on Ultrasound Cavitation-Induced Flow Augmentation 微泡特性和载流子频率对超声空化增流的影响。

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.09.004

J.Todd Belcik BS, ACS, RDCS , Aris Xie MS , Yue Qie MD , David Giraud PhD , Ruei-Jen Abraham-Fen PhD , Onur Varli MD , Jeffry Powers PhD , Jonathan R. Lindner MD

Background

Cavitation of microbubble (MB) contrast agents produces shear-mediated vasodilation and an increase in tissue perfusion. These effects are mediated through endothelial and erythrocyte shear-sensitive pathways. Our aim was to determine whether augmentation of tissue perfusion produced by cavitation is influenced by the deformability of MBs, MB charge-mediated interaction with vascular cells, or ultrasound (US) frequency, which affects MB resonance.

Methods

In mice, highly deformable lipid-stabilized decafluorobutane MBs with neutral or cationic charge, as well as less-deformable MBs (Sonazoid), were administered intravenously during proximal hind limb US (1.3 MHz, mechanical index = 1.3) for 10 minutes. In separate experiments, high-frequency US (7.0 MHz) was compared to low-frequency US. Conditional variables were compared using quantitative contrast-enhanced US perfusion imaging, and bioluminescence assays of shear-mediated adenosine triphosphate release. Beam spatial characteristics and passive cavitation detection response for each MB agent were assessed by calibrated hydrophone.

Results

Passive cavitation detection confirmed intended differences in MB deformability. Cavitation at 1.3 MHz increased perfusion in the US-exposed limb by 6- to 8-fold for highly deformable MBs. There were no differences according to MB charge despite evidence for interaction with vascular endothelial cells on intravital microscopy. Cavitation-mediated flow augmentation was lower (4-fold) for less-deformable MBs (P < .05 vs other agents). Flow augmentation was attributable to increases in microvascular flux rate (β-value). Despite producing less flow augmentation, cavitation with the less-deformable MBs produced equivalent endothelial adenosine triphosphate release. Using high-frequency US for cavitation resulted in a 60% to 70% loss of flow augmentation response.

Conclusions

Factors that affect MB resonance such as US frequency and MB deformability influence the degree of flow augmentation achieved by MB cavitation. Alteration of MB charge that enhances interaction with the endothelial cells does not influence cavitation-mediated flow augmentation.

背景：微泡造影剂的空化产生剪切介导的血管扩张和组织灌注的增加。这些作用是通过内皮细胞和红细胞剪切敏感途径介导的。我们的目的是确定空化产生的组织灌注增强是否受到MB的可变形性、MB电荷介导的与血管细胞的相互作用或影响MB共振的超声频率的影响。方法：在小鼠后肢近端超声（1.3 MHz，力学指数1.3）期间，静脉注射高变形脂质稳定的带中性或阳离子电荷的十氟丁烷mb和低变形mb（索那唑）10分钟。在单独的实验中，将高频US （7.0 MHz）与低频US进行比较。使用定量对比增强超声灌注成像比较条件变量，以及剪切介导的ATP释放的生物发光测定。通过标定的水听器评估了每种MB试剂的波束空间特性和被动空化探测（PCD）响应。结果：PCD证实了MB变形性的预期差异。对于高度变形的mb， 1.3 MHz空化使超声暴露肢体的灌注增加6-8倍。尽管在活体显微镜下有与血管内皮细胞相互作用的证据，但根据MB电荷没有差异。结论：超声频率、MB可变形性等影响MB共振的因素会影响MB空化增强流量的程度。MB电荷的改变增强了与内皮细胞的相互作用，但不影响空化介导的血流增强。

{"title":"Influence of Microbubble Properties and Carrier Frequency on Ultrasound Cavitation-Induced Flow Augmentation","authors":"J.Todd Belcik BS, ACS, RDCS , Aris Xie MS , Yue Qie MD , David Giraud PhD , Ruei-Jen Abraham-Fen PhD , Onur Varli MD , Jeffry Powers PhD , Jonathan R. Lindner MD","doi":"10.1016/j.echo.2025.09.004","DOIUrl":"10.1016/j.echo.2025.09.004","url":null,"abstract":"<div><h3>Background</h3><div>Cavitation of microbubble (MB) contrast agents produces shear-mediated vasodilation and an increase in tissue perfusion. These effects are mediated through endothelial and erythrocyte shear-sensitive pathways. Our aim was to determine whether augmentation of tissue perfusion produced by cavitation is influenced by the deformability of MBs, MB charge-mediated interaction with vascular cells, or ultrasound (US) frequency, which affects MB resonance.</div></div><div><h3>Methods</h3><div>In mice, highly deformable lipid-stabilized decafluorobutane MBs with neutral or cationic charge, as well as less-deformable MBs (Sonazoid), were administered intravenously during proximal hind limb US (1.3 MHz, mechanical index = 1.3) for 10 minutes. In separate experiments, high-frequency US (7.0 MHz) was compared to low-frequency US. Conditional variables were compared using quantitative contrast-enhanced US perfusion imaging, and bioluminescence assays of shear-mediated adenosine triphosphate release. Beam spatial characteristics and passive cavitation detection response for each MB agent were assessed by calibrated hydrophone.</div></div><div><h3>Results</h3><div>Passive cavitation detection confirmed intended differences in MB deformability. Cavitation at 1.3 MHz increased perfusion in the US-exposed limb by 6- to 8-fold for highly deformable MBs. There were no differences according to MB charge despite evidence for interaction with vascular endothelial cells on intravital microscopy. Cavitation-mediated flow augmentation was lower (4-fold) for less-deformable MBs (<em>P</em> < .05 vs other agents). Flow augmentation was attributable to increases in microvascular flux rate (β-value). Despite producing less flow augmentation, cavitation with the less-deformable MBs produced equivalent endothelial adenosine triphosphate release. Using high-frequency US for cavitation resulted in a 60% to 70% loss of flow augmentation response.</div></div><div><h3>Conclusions</h3><div>Factors that affect MB resonance such as US frequency and MB deformability influence the degree of flow augmentation achieved by MB cavitation. Alteration of MB charge that enhances interaction with the endothelial cells does not influence cavitation-mediated flow augmentation.</div></div>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"39 2","pages":"Pages 179-187"},"PeriodicalIF":6.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative Factors Should Be Considered in Assessing the Association between Three-Dimensional Right Ventricular Ejection Fraction and Early Postoperative Outcomes 在评估3D RV EF与术后早期预后之间的关系时应考虑术中因素。

IF 6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of the American Society of Echocardiography

Pub Date : 2026-02-01 DOI: 10.1016/j.echo.2025.08.029

Aibek E. Mirrakhimov MD

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Journal of the American Society of Echocardiography

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀