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The Effect of Mavacamten on Left Atrial Strain Dynamics in Obstructive Hypertrophic Cardiomyopathy 马伐卡坦对梗阻性肥厚性心肌病左心房应变动力学的影响。
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-09-25 DOI: 10.1016/j.echo.2025.09.014
Jaehyun Lim MD, Soongu Kwak MD, Min-Ha Jeong MD, Jae Yeong Cho MD, PhD, ChanSoon Park MD, PhD, Jiesuck Park MD, Hong-Mi Choi MD, Ga Hui Choi MD, Jihoon Kim MD, Jin-Oh Na MD, PhD, Sun Hwa Lee MD, PhD, Mi-Hyang Jung MD, PhD, Hae Ok Jung MD, PhD, Sang-Chol Lee MD, PhD, Hyung-Kwan Kim MD, PhD, Kye Hun Kim MD, PhD, Goo-Yeong Cho MD, PhD
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引用次数: 0
Implementation of Modified Venous Excess Ultrasound in Clinical Practice 改良的VExUS在临床中的应用。
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-10-10 DOI: 10.1016/j.echo.2025.10.002
Yohei Masuda MD, Fumio Otsuka MD, PhD
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引用次数: 0
Reply to “Optimizing Clinical Applicability of Left Atrial Strain Index in Patients with Heart Failure with Preserved Ejection Fraction” 回复“优化左房应变指数在保留射血分数心力衰竭患者中的临床适用性”。
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-10-31 DOI: 10.1016/j.echo.2025.10.016
Aileen Paula Chua MD, Nina Ajmone Marsan MD, PhD
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引用次数: 0
Threshold Values of Vena Contracta Area for Grading Secondary Tricuspid Regurgitation and its Association with Outcomes 二次三尖瓣反流分级的收缩静脉面积阈值及其与预后的关系。
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-10-31 DOI: 10.1016/j.echo.2025.10.015
Giorgia Benzoni MD , Michele Tomaselli MD, PhD , Noela Radu MD , Alexandra Clement MD , Marco Penso BME , Paolo Springhetti MD , Daniel Ignacio Conforme Torres MD , Tommaso Rinforzi MD , Carlotta Tosi MD , Alexandra Buta MD , Yuka Kawada MD , Denisa Muraru MD, PhD , Luigi P. Badano MD, PhD

Background

Three-dimensional echocardiographic planimetry of vena contracta area (VCA), which avoids geometric assumptions about the regurgitant orifice, has emerged as a promising method for grading secondary tricuspid regurgitation (STR). The aims of this study were to (1) define VCA threshold values to grade the severity of STR using a five-grade system, (2) identify the VCA cutoff value associated with adverse clinical outcomes, and (3) assess the incremental prognostic value of VCA compared with conventional quantitative parameters of tricuspid regurgitation severity.

Methods

Three-dimensional echocardiography was used to obtain VCA from 204 outpatients (mean age, 77 ± 12 years; 44% men) with mild to torrential STR (52% with severe or greater STR) according to current guidelines, and its association with a composite outcome of all-cause death and hospitalization for heart failure was assessed.

Results

The VCA threshold values for STR severity were <0.43 cm2 for mild, 0.43 to 0.67 cm2 for moderate, 0.68 to 0.88 cm2 for severe, 0.89 to 1.26 cm2 for massive, and >1.26 cm2 for torrential STR. Spline curve analysis identified a VCA threshold of 0.65 cm2 as the optimal cutoff associated with an increased risk for experiencing the composite end point. Although not yet severe, patients with VCA > 0.65 cm2 experienced an exponential increase in their risk. VCA > 0.65 cm2 was associated with a threefold risk increase for the composite end point regardless of effective regurgitant orifice area (EROA; log-rank P = .00068). In multivariate analysis, VCA remained independently associated with the composite end point (adjusted hazard ratio, 1.06; 95% CI, 1.02-1.10; P = .004). Adding VCA to baseline models incorporating clinical and echocardiographic variables, including either EROA or regurgitant volume, significantly improved the prognostic performance of the model (P = .007 and P = .018, respectively).

Conclusions

VCA obtained from color Doppler three-dimensional echocardiography is a robust parameter to grade STR severity, showing incremental prognostic value in comparison with both EROA and regurgitant volume.
背景:三维超声心动图(3DE)测量收缩静脉(VCA)的平面度,避免了对反流口的几何假设,已经成为一种有前途的分级继发性三尖瓣反流(STR)的方法。本研究旨在:(i)定义VCA阈值,使用五级系统对STR的严重程度进行分级;(ii)确定与不良临床结果相关的VCA临界值;(iii)与TR严重程度的常规定量参数相比,评估VCA的增量预后价值。方法:根据现行指南,我们使用3DE获取204例轻度至重度STR门诊患者(77±12岁,44%男性)(52%≥重度)的VCA,并评估其与全因死亡和心力衰竭住院的综合结局的相关性。结果:STR严重程度的VCA阈值为:轻度为2,中度为0.43 cm2-0.67 cm2,重度为0.68 cm2-0.88 cm2,重度为0.89 cm2-1.26 cm2,重度为>1.26 cm2。样条曲线分析确定VCA阈值为0.65 cm2是与经历复合终点风险增加相关的最佳临界值。虽然还不严重,但VCA患者的风险呈指数增长。无论有效返流孔面积如何,VCA>0.65 cm2与复合终点的风险增加3倍相关(EROA, log-rank p=0.00068)。在多变量分析中,VCA仍然与复合终点独立相关[aHR 1.06 (95% CI 1.02-1.10), p=0.004]。将VCA添加到包含临床和超声心动图变量(包括EROA或RegVol)的基线模型中,可显着改善模型的预后表现(p=0.007和p=0.018)。结论:彩色多普勒3DE获得的VCA是分级STR严重程度的可靠参数,与EROA和RegVol相比,具有增加的预后价值。
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引用次数: 0
Reply to “Intraoperative Factors Should Be Considered in Assessing the Association between Three-Dimensional Right Ventricular Ejection Fraction and Early Postoperative Outcomes” 回复“在评估3D RVEF与术后早期预后的关系时应考虑术中因素”
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-09-24 DOI: 10.1016/j.echo.2025.09.011
Edith L. Posada-Martinez MD, Juan B. Ivey-Miranda MD, PhD
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引用次数: 0
Information for Readers 读者资讯
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2026-02-03 DOI: 10.1016/S0894-7317(26)00005-2
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引用次数: 0
Optimizing Clinical Applicability of Left Atrial Strain Index in Patients with Heart Failure with Preserved Ejection Fraction 优化左心房应变指数在保留射血分数心力衰竭患者中的临床适用性。
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-09-30 DOI: 10.1016/j.echo.2025.08.030
Chuanwei Zhao MS
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引用次数: 0
Performance of Early Fetal Echocardiography: An Expert Statement from the Fetal Heart Society 早期胎儿超声心动图的表现:胎儿心脏学会的专家声明。
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-10-11 DOI: 10.1016/j.echo.2025.09.020
Miwa K. Geiger MD , Angela McBrien MB BCh, MD , Lisa K. Hornberger MD , Anita J. Moon-Grady MD , Nitin Madan MD , Julene S. Carvalho MD, PhD , Liat Gindes MD , Leila Rittey MBChB, MSc , Joyce T. Johnson MD, MSCI , Mary T. Donofrio MD , Sheetal Patel MD
Congenital heart defects (CHDs) are the most common lethal congenital anomalies. Fetal echocardiography is the mainstay for the diagnosis and subsequent serial assessment of fetal cardiovascular disease. Ideal timing for fetal echocardiography has traditionally been cited as between 18 and 22 weeks of gestation, although many centers now offer evaluations at 16 weeks of gestation and onward. Improved ultrasound resolution and a better understanding of early fetal cardiac development have enabled experienced specialists to diagnose major CHD as early as 11 to 15 weeks of gestation. An earlier diagnosis of CHD allows families to make time-sensitive decisions regarding the continuation of pregnancy while also providing time for additional prenatal testing and thoughtful perinatal planning. Reassuring early fetal echocardiography (eFE) can reduce anxiety in families with elevated risk for fetal CHD, such as those with a prior fetus or child with CHD. Given the benefits of early detection, the American Society of Echocardiography's 2023 Guidelines and Recommendations for Performance of the Fetal Echocardiogram included a section on eFE, which reviewed suggested elements, benefits, and limitations. However, there are challenges regarding the technical aspects of imaging a smaller heart as well as prognosticating during the late first and early second trimester. Most pediatric cardiologists have not had specific training in these skills and, therefore, often do not offer fetal echocardiography before 16 weeks of gestation. To overcome these challenges, the Program Leaders' Committee of the Fetal Heart Society developed this document, in which we review potential indications, propose an imaging protocol for early transabdominal and adjunct transvaginal (or endovaginal) fetal echocardiography, discuss unique findings in early gestation fetal heart morphology and hemodynamics, consider limitations, and discuss important aspects of patient counseling for eFE.
先天性心脏缺陷(CHD)是最常见的致死性先天性异常。胎儿超声心动图是胎儿心血管疾病诊断和后续系列评估的主要手段。传统上,胎儿超声心动图的理想时机是在妊娠18-22周之间,尽管许多中心现在提供妊娠16周及以后的评估。超声分辨率的提高和对早期胎儿心脏发育的更好了解使经验丰富的专家能够在妊娠11-15周诊断出主要的冠心病。早期诊断出冠心病可以让家庭在决定是否继续妊娠时及时做出决定,同时也为额外的产前检查和周到的围产期计划提供时间。让人放心的早期胎儿超声心动图(eFE)可以减少胎儿冠心病风险高的家庭的焦虑,例如那些先前有胎儿或儿童患有冠心病的家庭。鉴于早期发现的好处,美国超声心动图学会的2023年胎儿超声心动图性能指南和建议包括eFE部分,其中回顾了建议的要素、益处和局限性。然而,在成像小心脏的技术方面以及在第一晚期和第二早期妊娠期间的预后方面存在挑战。大多数儿科心脏病专家没有接受过这些技能的专门培训,因此,通常在妊娠16周之前不提供胎儿超声心动图检查。为了克服这些挑战,胎儿心脏学会项目领导委员会制定了本文件,其中我们回顾了潜在的适应症,提出了早期经腹和辅助经阴道(或阴道内)胎儿超声心动图的成像方案,讨论了妊娠早期胎儿心脏形态学和血流动力学的独特发现,考虑局限性,并讨论了eFE患者咨询的重要方面。正常和异常eFE的图片和视频均包含在附录/补充媒体中。
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引用次数: 0
Intraoperative Factors Should Be Considered in Assessing the Association between Three-Dimensional Right Ventricular Ejection Fraction and Early Postoperative Outcomes 在评估3D RV EF与术后早期预后之间的关系时应考虑术中因素。
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-09-24 DOI: 10.1016/j.echo.2025.08.029
Aibek E. Mirrakhimov MD
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引用次数: 0
Diagnosing Mitral Annular Disjunction in Patients ≤21 Years in a Large Pediatric and Congenital Echocardiographic Laboratory 在大型儿科和先天性超声心动图实验室诊断≤21岁患者的二尖瓣环分离
IF 6 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-02-01 Epub Date: 2025-10-25 DOI: 10.1016/j.echo.2025.10.008
Derek M. Norton MD, Alejandra Iturralde Chavez MD, Ricardo H. Pignatelli MD, Lance W. Patterson BS, Christina Y. Miyake MD, MS, MPH, Tam T. Doan MD
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Journal of the American Society of Echocardiography
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