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Study of Pentoxifylline Chemical Stability from Modified Release Tablets with Hydrophilic Mould 亲水发酵剂对己酮茶碱缓释片化学稳定性的研究
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2008-11-08 DOI: 10.1109/CANS.2008.35
E. Mircia, S. Imre, E. Sipos, V. Avrigeanu, A. Popovici, G. Hancu
Thermal and chemical stability of pentoxifylline from modified release tablets were studied. This experimental study observed the influence of temperature and humidity on the stability of pentoxifylline from the proposed formulations. The paper describes the HPLC determination of pentoxifylline from new controlled release tablets with hydrophilic matrix (HPMC, HPC, HEC). A C18 column with a mobile phase containing water : acetonitrile 70:30 (V/V) and UV detection at 280 nm was used. The "in vitro" dissolution test was carried out regarding the officinal stipulations of USP; the machine nr.2 was used (with paddles); as dissolution environment 1000 ml water, a constant temperature of 37 plusmn 0.5degC was kept. In all experiences, the rotation speed was 50 rpm. The studied tablets were kept in the stability chamber at a temperature of 40 plusmn 2degC and a relative humidity of 75 plusmn 5%. At different time intervals (a month, three months, six months), samples were prelevated to accomplish the dissolution test and the quantitative determination of pentoxifylline. From the evaluation of the experimental results, we observed the stability of pentoxifylline from all the prepared tablets.
研究了己酮茶碱改性缓释片的热稳定性和化学稳定性。本实验研究观察了温度和湿度对己酮茶碱配方稳定性的影响。采用高效液相色谱法测定亲水基质新型控释片(HPMC、HPC、HEC)中己酮茶碱的含量。色谱柱为C18,流动相为水:乙腈70:30 (V/V),紫外检测波长为280 nm。按照美国药典的药用规定进行了“体外”溶出度试验;使用机器nr.2(带桨);溶解环境为1000 ml水,恒温37±0.5℃。在所有的实验中,转速都是每分钟50转。所研究的片剂在稳定室中保存,温度为40±2℃,相对湿度为75±5%。在不同的时间间隔(1个月、3个月、6个月)预提样品,完成溶出度试验和己酮茶碱的定量测定。通过对实验结果的评价,观察了各制剂中己酮茶碱的稳定性。
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引用次数: 1
Clustering Based on Context Similarity 基于上下文相似度的聚类
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2008-11-08 DOI: 10.1109/CANS.2008.26
L. Kovács, T. Repasi, E. Baksa-Varga, P. Barabas
The discovery of word categories is an important step in statistical grammar induction systems. Word categories can be considered as clusters containing words with similar grammatical or semantic behavior. Having a metric space of words, the clustering algorithm will place similar words into the same cluster, whereas dissimilar ones are clustered into different groups. In this paper we propose an approximate word clustering method based on context similarity. The context of a word is defined here as the set of sentences containing the word. The similarity of two words is measured with the similarity of the corresponding context sets. For the calculation of the context-based distance of two words, a hierarchical agglomerative clustering algorithm has been developed, and is presented here.
词类的发现是统计语法归纳系统的一个重要步骤。词类可以被认为是包含具有相似语法或语义行为的词的聚类。有了单词的度量空间,聚类算法将相似的单词放在同一个聚类中,而不相似的单词聚类到不同的组中。本文提出了一种基于上下文相似度的近似聚类方法。一个词的上下文在这里被定义为包含这个词的一组句子。两个词的相似度是用对应上下文集的相似度来衡量的。为了计算基于上下文的两个词的距离,本文提出了一种分层聚类算法。
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引用次数: 3
Some Improvements of t-Cherry Junction Trees t型樱桃结树的若干改良
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2008-11-08 DOI: 10.1109/CANS.2008.22
E. Kovács, T. Szántai
One of the important areas of machine learning is the development and use of probabilistic models for classification and prediction. In our earlier work we introduced a special kind of junction tree, based on a hypergraph structure called t-cherry tree and on some information theoretical concepts. In this paper we present a possibility for the improvement of these junction trees, by ldquocutting and refittingrdquo of the junction treepsilas branches. Both theoretical and experimental results demonstrate the improvement of the junction tree obtained after ldquobranch cutting and refittingrdquo.
机器学习的一个重要领域是开发和使用概率模型进行分类和预测。在我们早期的工作中,我们介绍了一种特殊的连接树,它基于一种叫做t-cherry树的超图结构和一些信息理论概念。在本文中,我们提出了一种改进这些连接树的可能性,即通过对连接树的分支进行剪切和改造。理论和实验结果均表明,该方法改进了ldo分支切割和改造后得到的连接树。
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引用次数: 0
Risk Aversion through Fuzzy Numbers 通过模糊数字进行风险规避
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2008-11-08 DOI: 10.1109/CANS.2008.27
I. Georgescu
This paper is concerned with an approach of risk aversion by possibility theory. We introduce and study new possibilistic risk indicators. The main notions are the possibilistic risk premium and the possibilistic relative risk premium associated with a fuzzy number and a utility function. We also give formulae for computing them. They extend to possibility theory the classic notions of risk premium and relative risk premium. We show by an example how the main possibilistic risk indicators are computed using trapezoidal fuzzy numbers.
本文用可能性理论研究风险规避的方法。我们引入和研究新的可能性风险指标。主要概念是与模糊数和效用函数相关的可能性风险溢价和可能性相对风险溢价。我们也给出了计算它们的公式。他们将风险溢价和相对风险溢价的经典概念扩展到可能性理论中。通过实例说明了如何利用梯形模糊数计算主要可能性风险指标。
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引用次数: 0
A New Approach for Detecting Intrusions Using Jordan/Elman Neural Networks 基于Jordan/Elman神经网络的入侵检测新方法
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2008-11-08 DOI: 10.1109/CANS.2008.15
H. Karimi, M. A. Montazeri, M. D. Jazi
Intrusion detection system (IDS) is an effective tool that can help to prevent unauthorized access to network resources. A good intrusion detection system should have higher detection rate and lower false positive. A new classification system using Jordan/Elman (J/L) neural network for ID is proposed to detect intrusions from normal connections with satisfactory detection rate and false positive. Experiments and evaluations were performed with the KDD Cup 99 intrusion detection database. This system yields the same performance level or better as compared to other existing systems. Comparison with other approach based on different evaluation parameters showed that proposed approach has noticeable performance with detection rate 99.594% and false positive 0.406% and can classify the network connections with satisfactory performance.
入侵检测系统(IDS)是防止非法访问网络资源的有效工具。一个好的入侵检测系统应该具有较高的检测率和较低的误报率。提出了一种利用Jordan/Elman (J/L)神经网络对ID进行分类的新方法,该方法可以检测正常连接的入侵,检测率令人满意,且没有出现误报。利用KDD Cup 99入侵检测数据库进行了实验和评估。与其他现有系统相比,该系统产生相同或更好的性能水平。与其他基于不同评价参数的方法进行比较,结果表明,该方法具有显著的性能,检测率为99.594%,误报率为0.406%,能够对网络连接进行分类,并取得满意的分类效果。
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引用次数: 1
Semantic Web-Based Knowledge Management in Distributed Systems 分布式系统中基于语义的知识管理
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2008-11-08 DOI: 10.1109/CANS.2008.9
S. Buraga
A study regarding the use of the semantic Web technologies within complex systems-distributed file systems, grid platforms and wiki-like applications-is presented from the perspective of the knowledge management, especially the modeling of the implicated resources. Several case studies are described, involving the use of actual semantic Web model, languages, and technologies-including microformats and ontologies-to express knowledge in the context of the distributed systems.
从知识管理的角度研究了语义Web技术在复杂系统(分布式文件系统、网格平台和类维基应用程序)中的应用,特别是涉及资源的建模。本文描述了几个案例研究,涉及使用实际的语义Web模型、语言和技术(包括微格式和本体)在分布式系统的上下文中表达知识。
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引用次数: 1
Modeling of Social Transitions Using Intelligent Systems 使用智能系统的社会转型建模
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2008-10-11 DOI: 10.1109/CANS.2008.8
H. Owladeghaffari, W. Pedrycz, M. Sharifzadeh
In this study, we reproduce two new hybrid intelligent systems, involve three prominent intelligent computing and approximate reasoning methods: Self Organizing feature Map (SOM), Neuro-Fuzzy Inference System and Rough Set Theory (RST), called SONFIS and SORST. We show how our algorithms can be construed as a linkage of government-society (or any other similar systems) interactions, where government catches various states of behaviors: ldquosolid (absolute) or flexiblerdquo. So, transition of society, by changing of connectivity parameters (noise) from order to disorder is inferred.
在这项研究中,我们重现了两个新的混合智能系统,涉及三种著名的智能计算和近似推理方法:自组织特征映射(SOM),神经模糊推理系统和粗糙集理论(RST),称为SONFIS和SORST。我们展示了如何将我们的算法解释为政府-社会(或任何其他类似系统)相互作用的联系,其中政府捕获各种行为状态:不稳定(绝对)或灵活状态。因此,通过连接参数(噪声)从有序到无序的变化,可以推断出社会的过渡。
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引用次数: 1
Two distinct methods for integration of active differential and active roll control systems 主动差速器和主动横摇控制系统集成的两种不同方法
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2006-07-24 DOI: 10.1504/IJVD.2006.010437
F. Assadian, N. Aneke
The development and application of mechatronic sub-systems has dramatically increased in the automobile industry during recent years. The implementation of these sub-systems, aboard vehicles, has resulted in an increase in vehicle performance and stability. However, until recently, these sub-systems have been developed for specific objectives without considering the dynamic coupling between these systems. Hence, their potential has not been fully exploited. In this paper, the coupling effect of the active differential and the active roll control systems on the lateral and the yaw rate dynamics of a vehicle are demonstrated by deriving a simple linearised model. Then, two distinct control strategies are proposed for illustrating the benefits of integrating the aforementioned systems. The first control method is based on direct use of an optimisation method for computing optimal mapping of the requested vehicle body forces to the actuator inputs. The second method utilises a MIMO model based control methodology. The advantages and the drawbacks of each control strategy are discussed and the simulation results are presented.
近年来,汽车工业中机电子系统的发展和应用得到了迅猛的发展。在车辆上安装这些子系统,提高了车辆的性能和稳定性。然而,直到最近,这些子系统都是为特定的目标而开发的,没有考虑这些系统之间的动态耦合。因此,它们的潜力没有得到充分利用。本文通过推导一个简单的线性化模型,证明了主动差速器和主动侧滚控制系统对车辆横向和横摆角速度动力学的耦合效应。然后,提出了两种不同的控制策略来说明集成上述系统的好处。第一种控制方法基于直接使用优化方法来计算所请求的车身力到执行器输入的最佳映射。第二种方法利用基于MIMO模型的控制方法。讨论了各种控制策略的优缺点,并给出了仿真结果。
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引用次数: 3
Toward an Enlargement of the Role of Natural Languages in Information Processing, Decision and Control 论自然语言在信息处理、决策和控制中的作用
IF 2.1 3区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Pub Date : 2000-01-01 DOI: 10.1007/978-3-7908-1844-4_14
L. Zadeh
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引用次数: 3
期刊
Journal of Systems Science & Complexity
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