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Three-dimensional analysis of shoulder hand-behind-back motion in patients with frozen shoulder. 肩周炎患者肩背-肩背运动的三维分析。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-02-02 DOI: 10.1016/j.jse.2026.01.003
Takafumi Niwa, Noboru Matsumura, Yuki Yoshida, Yoichi Yokoyama, Minoru Yamada, Yoshitake Yamada, Takeo Nagura, Masaya Nakamura, Masahiro Jinzaki

Background: Hand-behind-back (HBB) motion is commonly used to assess shoulder internal rotation; however, it involves multiple joint movements, including scapulothoracic, glenohumeral, and elbow joint motions, thus complicating the interpretation of the HBB position. This study aimed to investigate three-dimensional joint alignment during HBB motion of the bilateral shoulders in patients with frozen shoulder and to identify which joint motions primarily contribute to motion limitation.

Methods: Seventeen patients with unilateral frozen shoulder underwent bilateral shoulder computed tomography (CT) scans in the neutral and HBB positions using an upright multidetector CT. Bone surface models of the thorax, scapula, humerus, and forearm were created to calculate the rotation of the scapulothoracic, glenohumeral, thoracohumeral, and elbow joints. The affected and unaffected sides were compared, and the correlation between the HBB reach level (vertebral level) and the thoracohumeral internal rotation angle was analyzed.

Results: No significant differences in joint rotation were observed between the sides in the neutral position. The affected side demonstrated significantly reduced glenohumeral internal rotation (31° vs. 66°, P < 0.001), abduction (10° vs. 22°, P < 0.001), and elbow flexion (74° vs. 115°, P < 0.001) during HBB motion. The scapulothoracic joint on the affected side had less internal rotation (18° vs. 21°; P = 0.045) and more anterior tilt (24° vs. 19°; P = 0.003). The HBB reach level was negatively correlated with the thoracohumeral internal rotation angle in the unaffected and affected sides (r = -0.518 and r = -0.675, respectively).

Conclusion: This study clarified that limited internal rotation of the glenohumeral joint is the main cause of restricted HBB motion in frozen shoulder, which supports the use of the thumb-to-spinous process as a valid measure of thoracohumeral internal rotation in patients with frozen shoulder.

背景:手背(HBB)运动通常用于评估肩部内旋;然而,它涉及多个关节运动,包括肩胛骨、肩关节和肘关节运动,因此使HBB位置的解释复杂化。本研究旨在探讨冻结肩患者双侧肩关节HBB运动时的三维关节对齐,并确定哪些关节运动主要导致运动受限。方法:17例单侧肩周炎患者行双侧肩关节CT扫描(CT),采用直立式多探测器CT,在中立位和HBB位进行扫描。建立胸、肩胛骨、肱骨和前臂的骨表面模型,计算肩胛骨、肱骨盂、胸肱骨和肘关节的旋转。比较受累侧与未受累侧,分析HBB到达水平(椎体水平)与胸肱内旋角的相关性。结果:中立位两侧关节旋转无明显差异。患侧表现出HBB运动时肩关节内旋(31°对66°,P < 0.001)、外展(10°对22°,P < 0.001)和肘关节屈曲(74°对115°,P < 0.001)明显减少。患侧肩胸关节内旋较少(18°vs. 21°,P = 0.045),前倾较多(24°vs. 19°,P = 0.003)。HBB到达水平与未患侧和患侧胸肱内旋角呈负相关(r = -0.518, r = -0.675)。结论:本研究明确了肩关节内旋受限是冻结肩关节HBB运动受限的主要原因,这支持了将拇指-棘突作为冻结肩关节患者胸肱内旋的有效测量。
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引用次数: 0
Standard versus the Alternative Center Line Technique for Baseplate Fixation in Reverse Shoulder Arthroplasty: A Comparison of Anterior Shoulder Pain. 标准与替代中心线技术在反向肩关节置换术中用于底板固定:前肩疼痛的比较。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-02-02 DOI: 10.1016/j.jse.2025.12.021
Olawale A Sogbein, Adam A Rizk, Christopher A Colasanti, Pranav Jain, Ben Campbell, Rohan Patil, Jay Levin, Gerald Williams, Surena Namdari
<p><strong>Background: </strong>Reverse total shoulder arthroplasty (rTSA) has increasingly become a reliable intervention to improve function and pain for a variety of indications. Glenoid fixation is critical to the success of rTSA and traditionally the standard anatomic centerline is used allowing for central baseplate fixation. However, in cases of severe bone loss, baseplate fixation along the alternative center line has been described. The baseplate axis is anteverted and inferiorly tilted allowing for fixation into a column of bone where the base of the scapular spine and coracoid meet, thereby prioritizing glenoid fixation. Previous studies have demonstrated no differences in pain, function, or complications when comparing the former technique to standard center line fixation. However, there is concern that excessive anteversion may lead to pain related to anterior soft tissue or bony impingement. Therefore, the objective of this study was to investigate the outcomes of rTSA in cases when the alternative center line was used for baseplate fixation and to specifically assess the incidence of anterior shoulder pain and dysfunction.</p><p><strong>Materials & methods: </strong>This was a single-institution retrospective series of all primary or revision rTSA patients who underwent glenoid baseplate fixation using an alternative center line with a minimum two year follow up. A matched-cohort analysis was performed to compare the standard and alternative center line groups (ratio 2:1) based on indication for surgery, age, and sex. Our primary outcome was anterior shoulder pain using the anterior shoulder pain and dysfunction survey (ASPDS). Secondary outcomes included the American Shoulder and Elbow Surgeons score (ASES), visual analogue pain scale (VAS), Single Assessment Numerical Evaluation (SANE), radiographic outcomes, and complications.</p><p><strong>Results: </strong>A total of 48 patients participated in our matched analysis (16 alternative center line group and 32 in the standard center line group). The mean age of our cohort was 65.4 ±9.3 years of which 28% were males. The average length of follow up was 62.6 ±37 months. Sixty-three and 70% of alternative and matched cases were revisions respectively. At final follow up, anterior shoulder pain and dysfunction was not significantly different between groups (28.1±9.2 vs. 28.2±7.0, p=0.96). Furthermore, ASES, VAS, and SANE scores did not differ significantly between groups postoperatively at final follow up. Three patients in the alternative center line group (18%) developed radiographic evidence of humeral loosening. Four patients developed notching (25%), and one patient had an instability episode (6%). There were no cases of baseplate failure or acromial stress fractures in the alternative center line group. Postoperative reverse shoulder angle (inferior tilt) was significantly larger in patients treated with an alternative center line (-37°±11 vs. -14°±6, p=0.03). In the control grou
背景:反向全肩关节置换术(rTSA)越来越成为一种可靠的干预措施,以改善各种适应症的功能和疼痛。关节盂固定对rTSA的成功至关重要,传统上使用标准解剖中心线允许中央基板固定。然而,在严重骨丢失的情况下,沿替代中心线进行底板固定。钢板轴前倾并向下倾斜,以便在肩胛骨基部和喙骨相交处固定成柱状骨,从而优先固定肩关节。先前的研究表明,将前一种技术与标准中心线固定相比,在疼痛、功能或并发症方面没有差异。然而,过度前倾可能导致与前路软组织或骨撞击相关的疼痛。因此,本研究的目的是研究采用替代中心线进行底板固定时rTSA的结果,并专门评估前肩疼痛和功能障碍的发生率。材料和方法:这是一项单一机构的回顾性研究,所有接受肩关节基板固定的原发性或改进性rTSA患者使用替代中心线进行至少两年的随访。根据手术适应证、年龄和性别,进行配对队列分析,比较标准和替代中心线组(比例2:1)。我们的主要结局是前肩疼痛和功能障碍调查(ASPDS)。次要结果包括美国肩肘外科医生评分(ASES)、视觉模拟疼痛量表(VAS)、单一评估数值评估(SANE)、影像学结果和并发症。结果:共有48例患者参与了我们的匹配分析(替代中心线组16例,标准中心线组32例)。我们队列的平均年龄为65.4±9.3岁,其中28%为男性。平均随访时间为62.6±37个月。替代病例和匹配病例分别有63%和70%进行了修订。最后随访时,两组前肩疼痛和功能障碍无显著差异(28.1±9.2比28.2±7.0,p=0.96)。此外,在最终随访时,两组之间的as、VAS和SANE评分无显著差异。替代中心线组中有3例(18%)出现肱骨松动的影像学证据。4例患者出现切口(25%),1例患者出现不稳定发作(6%)。替代中心线组无基底板失效或肩峰应力性骨折病例。采用替代中心线治疗的患者术后反向肩角(下倾斜)明显更大(-37°±11 vs -14°±6,p=0.03)。在对照组中,有1例患者发生肩峰应力性骨折,1例患者发生底板失效,1例患者出现低级别缺口。结论:对于严重骨丢失的病例,沿备选中心线进行钢板固定是一种合理的选择,并发症发生率低。虽然该技术增加了基底板前倾,但我们的研究并未显示与rTSA后标准中心线技术相比,肩关节前疼痛和功能障碍的增加具有相似的术后结果。
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引用次数: 0
What factors influence outcomes in olecranon fractures in older adults? A cohort study of operative and non-operative management. 哪些因素影响老年人鹰嘴骨折的预后?手术与非手术治疗的队列研究。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-02-02 DOI: 10.1016/j.jse.2026.01.004
Taylor Woolnough, Shaelene Standing, J W Pollock, Wassim Elmasry, Zoe Rubin, Steven R Papp

Background: Olecranon fractures occur more commonly in older individuals. For patients ≥70 years of age, operative management is often considered standard of care, although recent evidence has supported non-operative treatment in frail and/or elderly patients. With evolving treatment indications, more granular evidence is beneficial to guide patient-specific decision making. The aim of this investigation was to explore patient and treatment factors associated with outcomes after displaced, closed olecranon fractures in older individuals.

Methods: This retrospective cohort study with prospective data collection included 113 patients (mean age 81; 81% female) ≥70 years of age with displaced, stable olecranon fractures (Mayo 2A/2B). Patients were treated operatively via precontoured olecranon locking plates (n=68) or tension band wiring (n=6) or non-operatively (n=39) with progressive mobilization. Frailty was quantified using the Clinical Frailty Scale. The primary outcome was Quick Disability of the Arm, Shoulder, Hand (QuickDASH) score. Secondary outcomes included range of motion, PROMIS global health, and complications. Mean time from injury to outcome collection was 16 ± 2 months.

Results: Mean QuickDASH was lower in the operative cohort (mean difference -8.3; 95% CI 0.4 to 16.2; p = 0.021) although the difference was not clinically meaningful (minimal clinically important difference = 15). Subgroup analysis by frailty revealed no differences between operative and non-operative management in the mildly frail and moderate to severely frail subgroups. Linear regression identified frailty was associated with limb-specific disability (β=4.86, p=0.001); age was not a significant predictor when controlling for frailty. In the plate fixation group, engaging the proximal fragment fixation with < 3 screws was associated with proximal fragment escape (β=3.13, SE=0.94, OR=22.9, 95% CI 3.63 to 144.8, p=0.001) independent of fragment size, comminution, and triceps reinforcement. In the non-operative group, increasing immobilization duration was associated with decreased arc of motion (β=-4.1, SE=1.3, R2=0.29, p=0.006).

Conclusion: This study reinforces recent Level I evidence suggesting that operative management of displaced olecranon fractures does not result in superior long-term functional outcomes for the average older patient. Frailty, rather than chronological age, is a primary driver of limb-related disability. Early mobilization is a low-risk alternative to operative management. When surgery is pursued to achieve faster recovery or improved early elbow extension, surgeons should ensure robust proximal fragment fixation with at least three screws to minimize the risk of failure.

背景:鹰嘴骨折更常见于老年人。对于≥70岁的患者,手术治疗通常被认为是标准的护理,尽管最近的证据支持非手术治疗体弱和/或老年患者。随着治疗适应症的发展,更细粒度的证据有助于指导患者的具体决策。本研究的目的是探讨与老年人移位闭合性鹰嘴骨折后预后相关的患者和治疗因素。方法:本回顾性队列研究纳入113例年龄≥70岁的鹰嘴移位、稳定骨折患者(平均年龄81岁,81%为女性)(Mayo 2A/2B)。患者通过预轮廓鹰嘴锁定钢板(n=68)或张力带钢丝(n=6)或非手术(n=39)进行渐进式活动治疗。使用临床虚弱量表对虚弱进行量化。主要终点是手臂、肩膀、手的快速残疾(QuickDASH)评分。次要结局包括活动范围、PROMIS整体健康和并发症。从损伤到结果收集的平均时间为16±2个月。结果:手术组的平均QuickDASH较低(平均差值为-8.3;95% CI为0.4 ~ 16.2;p = 0.021),但差异无临床意义(最小临床重要差异= 15)。虚弱亚组分析显示,在轻度虚弱和中度至重度虚弱亚组中,手术和非手术治疗没有差异。线性回归发现虚弱与肢体特异性残疾相关(β=4.86, p=0.001);当控制虚弱时,年龄不是一个显著的预测因子。在钢板固定组中,使用< 3颗螺钉固定近端碎片与近端碎片逃逸相关(β=3.13, SE=0.94, OR=22.9, 95% CI 3.63至144.8,p=0.001),与碎片大小、粉碎程度和肱三头肌加固无关。在非手术组,增加固定时间与运动弧度降低相关(β=-4.1, SE=1.3, R2=0.29, p=0.006)。结论:这项研究强化了最近的I级证据,表明手术治疗移位的鹰嘴骨折对普通老年患者来说并不能带来更好的长期功能结果。身体虚弱,而不是实际年龄,是肢体相关残疾的主要驱动因素。早期动员是手术治疗的低风险替代方法。当进行手术以获得更快的恢复或改善早期肘关节伸展时,外科医生应确保近端碎片固定至少三枚螺钉,以尽量减少失败的风险。
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引用次数: 0
Association of Preoperative Testosterone Replacement Therapy with Postoperative Complications Following Rotator Cuff Repair. 术前睾酮替代治疗与肩袖修复术后并发症的关系。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-30 DOI: 10.1016/j.jse.2025.12.013
Jad Lawand, Alireza Mirahmadi, Alejandro M Holle, Romir P Parmar, Tristan Elias, Jeremy Somerson, Brian Hill, Adam Khan, John Horneff, Joseph Abboud

Background: Rotator cuff repair (RCR) is increasingly performed due to advancements in surgical techniques and an aging population. While generally successful, complications like re-tear, stiffness, infection, and thromboembolic events remain concerns. The rising use of testosterone replacement therapy (TRT) in middle-aged and older men raises questions about its impact on surgical outcomes, as its effect on RCR complications remains unclear.

Methods: A retrospective cohort study was conducted using the PearlDiver Database. Patients who underwent arthroscopic RCR between January 2010 and April 2023 were identified using Current Procedural Terminology (CPT) code 29827. Those with at least two years of continuous follow-up were included, while patients under 21 or with unknown procedural laterality were excluded. Patients were categorized into two cohorts: those who received TRT within three months preoperatively and a control group who did not. Propensity score matching (1:1, caliper = 0.001) was performed to control for age, gender, Charlson Comorbidity Index, obesity, tobacco use, and hypogonadism. The primary outcomes included 2-year postoperative complications and reoperations. Secondary outcomes included 90-day major medical complications such as surgical site infection (SSI), pneumonia, pulmonary embolism, deep vein thrombosis, urinary tract infection, wound dehiscence, sepsis, acute kidney injury, and readmissions. Statistical analyses were performed using chi-square tests, and odds ratios with 95% confidence intervals were calculated.

Results: A total of 8,241 TRT users and 673,982 control patients were identified before matching. After propensity score matching, 5,109 patients remained in each cohort with no significant baseline differences. No significant differences were observed in 90-day postoperative complications, including SSI (0.5% vs. 0.4%, p = 0.64), pneumonia (0.6% vs. 0.5%, p = 0.79), sepsis (0.4% vs. 0.3%, p = 0.51), acute kidney injury (0.7% vs. 0.5%, p = 0.18), or readmissions (1.2% vs. 1.0%, p = 0.29). Similarly, no significant differences were found in pulmonary embolism or deep vein thrombosis. Over the two-year follow-up, TRT use was associated with a higher incidence of total shoulder arthroplasty (TSA) (0.7% vs. 0.4%, p = 0.037) but a lower incidence of lysis of adhesions (0.5% vs. 0.9%, p = 0.032). No significant differences were observed in revision RCR rates (2.6% vs. 2.3%, p = 0.41).

Conclusion: Preoperative TRT use was not linked to increased short-term complications after arthroscopic RCR. Over two years, TRT was associated with higher rates of TSA but lower rates of lysis of adhesions, with no difference in revision RCR.

背景:由于手术技术的进步和人口老龄化,肩袖修复(RCR)越来越多地被应用。虽然总体上是成功的,但诸如再撕裂、僵硬、感染和血栓栓塞事件等并发症仍然值得关注。睾酮替代疗法(TRT)在中老年男性中的应用越来越多,由于其对RCR并发症的影响尚不清楚,因此对手术结果的影响提出了疑问。方法:采用PearlDiver数据库进行回顾性队列研究。2010年1月至2023年4月期间接受关节镜RCR的患者使用现行程序术语(CPT)代码29827进行鉴定。那些至少连续随访两年的患者被纳入,而21岁以下或手术侧性不明的患者被排除在外。患者被分为两组:术前三个月内接受TRT治疗的患者和未接受TRT治疗的对照组。采用倾向评分匹配(1:1,卡尺= 0.001)来控制年龄、性别、Charlson合并症指数、肥胖、吸烟和性腺功能减退。主要结局包括术后2年并发症和再手术。次要结局包括90天的主要医疗并发症,如手术部位感染(SSI)、肺炎、肺栓塞、深静脉血栓形成、尿路感染、伤口裂开、败血症、急性肾损伤和再入院。采用卡方检验进行统计分析,并计算95%置信区间的比值比。结果:匹配前共确定了8241例TRT使用者和673982例对照患者。在倾向评分匹配后,每个队列中仍有5109例患者,没有显著的基线差异。术后90天并发症无显著差异,包括SSI (0.5% vs. 0.4%, p = 0.64)、肺炎(0.6% vs. 0.5%, p = 0.79)、败血症(0.4% vs. 0.3%, p = 0.51)、急性肾损伤(0.7% vs. 0.5%, p = 0.18)或再入院(1.2% vs. 1.0%, p = 0.29)。同样,肺栓塞和深静脉血栓也无显著差异。在两年的随访中,TRT的使用与较高的全肩关节置换术(TSA)发生率相关(0.7% vs. 0.4%, p = 0.037),但粘连溶解的发生率较低(0.5% vs. 0.9%, p = 0.032)。修正RCR率无显著差异(2.6% vs. 2.3%, p = 0.41)。结论:术前使用TRT与关节镜RCR术后短期并发症的增加无关。在两年多的时间里,TRT与较高的TSA发生率相关,但与较低的粘连溶解率相关,修正RCR没有差异。
{"title":"Association of Preoperative Testosterone Replacement Therapy with Postoperative Complications Following Rotator Cuff Repair.","authors":"Jad Lawand, Alireza Mirahmadi, Alejandro M Holle, Romir P Parmar, Tristan Elias, Jeremy Somerson, Brian Hill, Adam Khan, John Horneff, Joseph Abboud","doi":"10.1016/j.jse.2025.12.013","DOIUrl":"https://doi.org/10.1016/j.jse.2025.12.013","url":null,"abstract":"<p><strong>Background: </strong>Rotator cuff repair (RCR) is increasingly performed due to advancements in surgical techniques and an aging population. While generally successful, complications like re-tear, stiffness, infection, and thromboembolic events remain concerns. The rising use of testosterone replacement therapy (TRT) in middle-aged and older men raises questions about its impact on surgical outcomes, as its effect on RCR complications remains unclear.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the PearlDiver Database. Patients who underwent arthroscopic RCR between January 2010 and April 2023 were identified using Current Procedural Terminology (CPT) code 29827. Those with at least two years of continuous follow-up were included, while patients under 21 or with unknown procedural laterality were excluded. Patients were categorized into two cohorts: those who received TRT within three months preoperatively and a control group who did not. Propensity score matching (1:1, caliper = 0.001) was performed to control for age, gender, Charlson Comorbidity Index, obesity, tobacco use, and hypogonadism. The primary outcomes included 2-year postoperative complications and reoperations. Secondary outcomes included 90-day major medical complications such as surgical site infection (SSI), pneumonia, pulmonary embolism, deep vein thrombosis, urinary tract infection, wound dehiscence, sepsis, acute kidney injury, and readmissions. Statistical analyses were performed using chi-square tests, and odds ratios with 95% confidence intervals were calculated.</p><p><strong>Results: </strong>A total of 8,241 TRT users and 673,982 control patients were identified before matching. After propensity score matching, 5,109 patients remained in each cohort with no significant baseline differences. No significant differences were observed in 90-day postoperative complications, including SSI (0.5% vs. 0.4%, p = 0.64), pneumonia (0.6% vs. 0.5%, p = 0.79), sepsis (0.4% vs. 0.3%, p = 0.51), acute kidney injury (0.7% vs. 0.5%, p = 0.18), or readmissions (1.2% vs. 1.0%, p = 0.29). Similarly, no significant differences were found in pulmonary embolism or deep vein thrombosis. Over the two-year follow-up, TRT use was associated with a higher incidence of total shoulder arthroplasty (TSA) (0.7% vs. 0.4%, p = 0.037) but a lower incidence of lysis of adhesions (0.5% vs. 0.9%, p = 0.032). No significant differences were observed in revision RCR rates (2.6% vs. 2.3%, p = 0.41).</p><p><strong>Conclusion: </strong>Preoperative TRT use was not linked to increased short-term complications after arthroscopic RCR. Over two years, TRT was associated with higher rates of TSA but lower rates of lysis of adhesions, with no difference in revision RCR.</p>","PeriodicalId":50051,"journal":{"name":"Journal of Shoulder and Elbow Surgery","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLP-1 Receptor Agonist Therapy Is Not Associated with Adverse Events Following Shoulder Surgery: A Systematic Review and Meta-Analysis. GLP-1受体激动剂治疗与肩关节手术后不良事件无关:一项系统回顾和荟萃分析
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-29 DOI: 10.1016/j.jse.2025.12.005
Logan D Moews, Kyle N Kunze, Napatpong Thamrongskulsiri, Tomas F Vega, Jacob T Morgan, Tanner Nishioka, Jorge Chahla, Nikhil N Verma

Background: Glucagon-like peptide-1 agonists (GLP-1s) are increasingly prescribed for type 2 diabetes mellitus (T2DM) and obesity, with over 12% of the United States population reported to being using this medication. While GLP-1s have been associated with reduced complication rates in total hip and knee arthroplasty populations, their association with outcomes after shoulder surgery remains unclear. The purpose of the current study was to perform a systematic review and meta-analysis of studies comparing adverse events between GLP-1 users and non-users following shoulder surgery.

Methods: A PRISMA-compliant literature search of PubMed, Embase, and Scopus was performed in August 2025. Comparative studies (Level of Evidence I-III) assessing postoperative adverse events in GLP-1 and non-GLP-1 users undergoing total shoulder arthroplasty (TSA) or shoulder arthroscopic procedures were included. Data pertaining to 90-day and 2-year complication rates were extracted. Random effects meta-analyses were conducted independently for TSA studies and pooled odds ratios with confidence estimates were quantified. Outcomes of studies examining arthroscopic procedures were described narratively given limited data.

Results: Six studies encompassing outcomes of 43,415 patients were included. Four (66.7%) studies evaluated TSA, while one evaluated arthroscopic RCR and one manipulation under anesthesia/capsular release for adhesive capsulitis (AC). The overall pooled 90-day complication rate following TSA was 18.1% for GLP-1 users and 15.9% for non-users (OR 0.86, 95% CI 0.36-2.07, p=0.74). The overall pooled 2-year complication rate following TSA was 3.8% in the GLP-1 group and 3.7% in the non-GLP-1 group (OR 1.24, 95% CI 0.73-2.00, P = 0.42). The RCR and AC studies reported significantly lower 90-day complication rates for GLP-1 users (11.0% vs. 27.4%) and (2.5% vs. 4.8%), respectively. A lower re-tear rate was observed in GLP-1 users compared with non-users by two-years postoperatively (12.5% vs. 18.3%).

Conclusion: GLP-1 agonist use is not significantly associated with 90-day or two-year adverse events following TSA. Based on this data, GLP-1 agonist use should not be a contraindication for proceeding with TSA. Lower complication rates were observed in both studies concerning arthroscopic intervention for non-arthritic shoulder conditions.

背景:胰高血糖素样肽-1激动剂(glp -1)越来越多地被用于治疗2型糖尿病(T2DM)和肥胖症,据报道超过12%的美国人正在使用这种药物。虽然glp -1与全髋关节和膝关节置换术患者并发症发生率降低有关,但其与肩关节手术后预后的关系尚不清楚。本研究的目的是对比较肩关节手术后GLP-1使用者和非使用者不良事件的研究进行系统回顾和荟萃分析。方法:于2025年8月在PubMed、Embase和Scopus中检索符合prisma标准的文献。评估GLP-1和非GLP-1使用者接受全肩关节置换术(TSA)或肩关节镜手术后不良事件的比较研究(证据水平为I-III)被纳入。提取有关90天和2年并发症发生率的数据。随机效应荟萃分析对TSA研究进行了独立分析,并量化了合并优势比和置信度估计。检查关节镜手术的研究结果在有限的数据下被叙述。结果:纳入6项研究,共纳入43,415例患者。4项(66.7%)研究评估TSA, 1项研究评估关节镜下RCR, 1项研究评估麻醉/囊膜释放下治疗粘连性囊炎(AC)。GLP-1使用者TSA后90天总并发症发生率为18.1%,非GLP-1使用者为15.9% (OR 0.86, 95% CI 0.36-2.07, p=0.74)。GLP-1组TSA术后2年总并发症发生率为3.8%,非GLP-1组为3.7% (OR 1.24, 95% CI 0.73-2.00, P = 0.42)。RCR和AC研究报告GLP-1使用者90天并发症发生率显著降低(分别为11.0%对27.4%和2.5%对4.8%)。术后2年,GLP-1使用者的再撕裂率较非GLP-1使用者低(12.5%对18.3%)。结论:GLP-1激动剂的使用与TSA后90天或2年的不良事件无显著相关性。基于这些数据,GLP-1激动剂的使用不应该是进行TSA的禁忌症。两项关于关节镜干预治疗非关节炎肩关节疾病的研究均观察到较低的并发症发生率。
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引用次数: 0
Vertical Incomplete Humerotomy (VIH) with Suture Loop Cerclages for Humeral Stem Extraction and Reimplantation in Revision of Shoulder Arthroplasty. 垂直不完全肱骨切开术(VIH)与缝合环环环在肩关节置换术翻修中的肱骨柄提取和再植。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-27 DOI: 10.1016/j.jse.2025.12.009
Juan-David Lacouture, Ethan Harlow, Manon Biegun, Pascal Boileau

Background: Extraction of well-fixed humeral implants during revision shoulder arthroplasty is difficult and prone to complications, especially humeral fracture (up to 12% in anatomical stem revision and 30% in reversed stem revision). To prevent this complication, we perform a Vertical Incomplete Humerotomy (VIH) and use cerclages with suture loops and Nice Knots for fixation.

Purpose: To describe the VIH technique with suture cerclage fixation, report the perioperative complications, and evaluate the radiological and clinical results outcomes.

Methods: We performed a retrospective monocentric study of consecutive patients who underwent revision shoulder arthroplasty with a VIH at a single institution (2007-2022). A straight longitudinal humeral osteotomy was created posterior and parallel to the bicipital groove. This allows for extraction of the humeral stem and cement mantle. Osteotomy closure was performed with 2 to 6 cerclages with suture loops (Nice Loop, Tornier-Stryker, Kalamazoo, MI, USA) and a non-sliding knot ("Nice knot"). The primary outcome was assessment of intraoperative and postoperative complications. The secondary outcome was osteotomy healing at 6 months and clinical results at two years.

Results: A cohort of 47 patients (mean age of 67.34 years, range 33-86) with a mean follow-up was 37.9 months who underwent revision shoulder with VIH were analyzed. There were 21 Hemiarthroplasty (HA), 11 Total Shoulder Arthroplasty (TSA) and 15 Reversed Shoulder Arthroplasty (RSA). There were 5 revisions to TSA, 26 revisions to RSA, 3 humeral stem revision and 13 revisions to spacers secondary to periprosthetic joint infection (PJI). One intraoperative humeral fracture occurred during stem removal. No postoperative complication related to the humerotomy occurred and no patients required surgical revision secondary to the humerotomy. Primary osteotomy healing and callus formation were evident in all cases by 6 months. In 12 cases of PJI, a second stage revision was performed, there were 3 reinterventions (2 instability and 1 infection). At the last follow-up, 82% of patients were satisfied after the intervention; the mean Subjective Shoulder Value (SSV) was 58%, and the VAS score was 3.4/10.

Conclusion: (1) VIH facilitates extraction of well-fixed cemented or uncemented humeral components and prevents iatrogenic humeral fractures in revision shoulder arthroplasty, and (2) Suture fixation, using suture loops (Nice Loop; Tornier-Stryker, Kalamazoo, MI, USA) and a non-sliding knot ("Nice knot"), provides constant bone healing and is an alternative to wire for cerclage fixation of humerotomy.

背景:在翻修肩关节置换术中取出固定良好的肱骨假体是困难的,并且容易发生并发症,特别是肱骨骨折(在解剖柄翻修中高达12%,在反向柄翻修中高达30%)。为了防止这种并发症,我们进行了垂直不完全肱骨切开术(VIH),并使用带缝线环和尼斯结的环扣进行固定。目的:描述缝合环扎固定VIH技术,报告围手术期并发症,评价影像学和临床结果。方法:我们进行了一项回顾性单中心研究,对在单一机构(2007-2022)连续接受肩关节翻修置换术的VIH患者进行了研究。在后侧平行于肱二头沟行肱骨纵向直截骨术。这样可以取出肱骨干和水泥套。截骨闭合采用2 - 6个带缝合环的环扣(Nice Loop, Tornier-Stryker, Kalamazoo, MI, USA)和一个非滑动结(“Nice结”)。主要结果是术中和术后并发症的评估。次要结果是6个月时截骨愈合和2年时的临床结果。结果:对47例(平均年龄67.34岁,范围33-86岁)接受肩关节翻修合并VIH的患者进行了队列分析,平均随访时间为37.9个月。全肩关节置换术(TSA) 11例,反肩关节置换术(RSA) 15例。TSA翻修5次,RSA翻修26次,肱骨杆翻修3次,假体周围关节感染(PJI)继发间隔器翻修13次。术中发生一例肱骨骨折。术后无肱骨切开术相关并发症发生,无患者需要肱骨切开术后再行手术翻修。6个月时,所有病例均有明显的截骨愈合和骨痂形成。在12例PJI中,进行了第二阶段翻修,有3例再次干预(2例不稳定,1例感染)。最后一次随访时,82%的患者对干预后满意;平均主观肩值(SSV)为58%,VAS评分为3.4/10。结论:(1)VIH有助于取出固定良好的骨水泥或非骨水泥肱骨假体,并在肩关节置换术中防止医源性肱骨骨折;(2)缝合固定,使用缝合环(Nice Loop; Tornier-Stryker, Kalamazoo, MI, USA)和非滑动结(“Nice结”),提供持续的骨愈合,是肱骨切开术中钢丝环扎固定的替代选择。
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引用次数: 0
Pectoralis Minor Tenotomy in the Treatment of Painful Shoulder Syndromes associated with Scapular Dyskinesis. 胸小肌肌腱切断术治疗肩胛骨运动障碍相关肩痛综合征。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-23 DOI: 10.1016/j.jse.2025.12.012
Philippe Collin, Laurent Baverel, Donald Tedah, Céline Daniel, Alexandre Lädermann

Background: Scapular dyskinesis is an alteration in scapular position and movement that disrupts glenohumeral kinematics. Among its causes, pectoralis minor retraction induces scapular protraction and internal rotation, altering shoulder biomechanics. Often asymptomatic, scapular dyskinesis may also cause pain and reduced joint mobility, compromising function. Initial management relies on targeted rehabilitation, which generally ensures recovery. However, when conservative treatment fails, surgery may be considered. This study evaluates the clinical outcomes of arthroscopic pectoralis minor tenotomy in patients with painful shoulder and scapular dyskinesis due to pectoralis minor retraction.

Methods: A retrospective monocentric study included patients operated on between 2020 and 2024 for painful shoulder syndrome associated with scapular dyskinesis secondary to excessive pectoralis minor tension. Patients undergoing concomitant or subsequent surgery on the same shoulder were excluded. We conducted a longitudinal intra-subject study comparing pre- and postoperative outcomes. Patients were assessed preoperatively and at their last follow-up for active range of motion, pain (VAS), Constant score, and Simple Shoulder Value (SSV). Complications were recorded.

Results: Thirty-seven patients met the entry criteria and were enrolled in the study with a mean follow-up 19.9 months (range, 6 to 44). All patients were women (mean age 43.8), with 49% reporting trauma and 57% practicing sports. Among the 37 patients, information on preoperative corticosteroid injections was missing for 2 patients. Of the remaining 35, 34 (97%) received at least one injection. Functional scores and pain improved significantly postoperatively. The Constant score increased from 55.3 to 73.27 (p < 0.001), the VAS decreased from 7.51 to 2.62 (p < 0.001), and the SSV rose from 46.75 to 74.73 (p < 0.001). Active elevation improved significantly from 128.38 degrees to 143.9 degrees (p = 0.013), while external and internal rotations showed no significant difference. Four cases of adhesive capsulitis were reported; three resolved with rehabilitation, while one patient retained stiffness in elevation at last follow-up.

Conclusion: When conservative treatment fails, arthroscopic tenotomy is an effective surgical option for patients with painful shoulder and scapular dyskinesis due to pectoralis minor contracture. This study demonstrates significant improvement in functional scores, pain, and anterior elevation range, while external and internal rotations remain unchanged. However, randomized studies with longer follow-up are needed to confirm result durability.

背景:肩胛骨运动障碍是肩胛骨位置和运动的改变,破坏了肩胛骨的运动学。在其原因中,胸小肌收缩引起肩胛骨拉伸和内旋,改变了肩部的生物力学。通常无症状,肩胛骨运动障碍也可引起疼痛和关节活动减少,损害功能。最初的管理依赖于有针对性的康复,这通常能确保康复。然而,当保守治疗失败时,可以考虑手术治疗。本研究评估了关节镜下胸小肌肌腱切断术治疗因胸小肌收缩引起的肩痛和肩胛骨运动障碍患者的临床结果。方法:回顾性单中心研究纳入了2020年至2024年间因胸小肌过度紧张继发的肩胛骨运动障碍相关肩痛综合征手术的患者。在同一肩部同时或随后接受手术的患者被排除在外。我们进行了一项纵向受试者研究,比较了术前和术后的结果。术前和最后随访时评估患者的活动范围、疼痛(VAS)、恒定评分和简单肩值(SSV)。记录并发症。结果:37例患者符合入组标准,平均随访时间为19.9个月(6 ~ 44个月)。所有患者均为女性(平均年龄43.8岁),其中49%报告创伤,57%从事体育运动。37例患者中,2例患者术前皮质类固醇注射信息缺失。在其余35人中,34人(97%)至少接受了一次注射。术后功能评分和疼痛明显改善。Constant评分从55.3上升到73.27 (p < 0.001), VAS评分从7.51下降到2.62 (p < 0.001), SSV评分从46.75上升到74.73 (p < 0.001)。主动仰角由128.38°提高到143.9°(p = 0.013),而内、外旋转无显著差异。报告粘连性囊炎4例;3例患者康复,1例患者在最后随访时仍保持抬高僵硬。结论:当保守治疗失败时,关节镜下肌腱切断术是治疗胸小肌挛缩引起的肩痛和肩胛骨运动障碍的有效手术选择。该研究表明,在外旋和内旋保持不变的情况下,功能评分、疼痛和前仰角范围均有显著改善。然而,需要更长随访时间的随机研究来证实结果的持久性。
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引用次数: 0
Characterizing Clinical and Non-Clinical Factors in Extremely Negative Online Reviews of Orthopedic Shoulder Surgeons. 骨科肩关节外科医生在线负面评价的临床和非临床因素特征分析
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-22 DOI: 10.1016/j.jse.2025.12.018
Joseph C Brinkman, Evan H Richman, Zachary G LeBaron, Ben R Paul, Boaz Goldberg, John M Tokish, Eric C McCarty

Background: Online physician review websites are being increasingly utilized by patients when choosing their surgeon. Although most reviews are positive, extremely negative reviews can significantly compromise a physician's online reputation. The purpose of this study was to analyze factors that contribute to negative reviews for orthopedic shoulder surgeons.

Methods: One hundred orthopedic shoulder surgeons were randomly selected from the "find a doctor" tool on the American Shoulder and Elbow Surgeons (ASES) website. A search was performed for all reviews listed under the selected surgeons on the following sources: Google Reviews, Healthgrades, Vitals, and Yelp. For each website, a surgeon's average rating, total number of reviews, and number of 1-star reviews was recorded. One-star reviews with comments were then reviewed to categorize the complaint(s), determine whether they referenced a clinical or non-clinical issue, and determine whether the complaint referenced a surgical or non-surgical episode of care. Categorical variables were analyzed using a chi-square test.

Results: A total of 7616 reviews were analyzed and 722 (9.5%) were identified as one-star. After application or exclusion criteria, 329 single-star reviews with 837 total complaints were included for analysis. Of the 329 single-star reviews, 237 (72.0%) were from non-surgical patients and 92 (28.0%) were from surgically treated patients. Non-surgical patients had a significantly higher rate of total complaints per each review than surgical patients (1.76 vs. 0.78, p=0.034). The most common complaints were regarding bedside manner (160 complaints), insufficient time with the provider (82 complaints), uncontrolled pain (73 complaints), and rude staff (72 complaints). Poor surgical outcomes were noted in terms of complication (66 complaints), reoperation (26 complaints) and readmissions (2 complaints).

Conclusion: For orthopedic shoulder surgeons, the most common complaints are non-clinical and include poor bedside manner, wait time, and insufficient time with the provider. Relatively few negative reviews referenced objective measures of healthcare quality such as complications or surgical outcomes. These results provide a deeper understanding of the reasons for patient dissatisfaction in shoulder surgery, which can be considered when striving to maintain a favorable online reputation.

背景:患者在选择外科医生时越来越多地使用在线医生评论网站。虽然大多数评论都是正面的,但极度负面的评论会严重损害医生的在线声誉。本研究的目的是分析导致骨科肩关节手术负面评价的因素。方法:从美国肩关节外科医生网站的“找医生”工具中随机抽取100名骨科肩关节外科医生。对选定外科医生下列出的所有评论进行搜索,这些评论来自以下来源:谷歌评论、Healthgrades、vital和Yelp。对于每个网站,记录了外科医生的平均评分、评论总数和一星评论数量。然后对带有评论的一星评论进行审查,以对投诉进行分类,确定它们是否涉及临床或非临床问题,并确定投诉是否涉及手术或非手术治疗。分类变量分析采用卡方检验。结果:共分析了7616条评论,其中722条(9.5%)被评为一星。经过申请或排除标准,329条单星评论和837条投诉被纳入分析。在329篇单星评价中,237篇(72.0%)来自非手术患者,92篇(28.0%)来自手术患者。非手术患者每次复查的总抱怨率明显高于手术患者(1.76比0.78,p=0.034)。最常见的投诉是床边态度(160项投诉)、与医生相处时间不够(82项投诉)、无法控制的疼痛(73项投诉)和粗鲁的工作人员(72项投诉)。在并发症(66例)、再手术(26例)和再入院(2例)方面,手术结果较差。结论:肩关节矫形外科医生最常见的投诉是非临床的,包括不良的床边态度、等待时间和与医生的时间不足。相对较少的负面评论涉及医疗质量的客观指标,如并发症或手术结果。这些结果为患者对肩部手术不满意的原因提供了更深入的了解,在努力保持良好的网络声誉时可以考虑这些原因。
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引用次数: 0
Primary Osteoarthritis of the Sternoclavicular Joint: Surgical Management Using the Sternal Docking Technique. 胸锁关节原发性骨关节炎:胸骨对接技术的外科治疗。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-22 DOI: 10.1016/j.jse.2025.12.011
Amanda S Vazquez-Lloret, Leilani Garayua-Cruz, Michael D Baird, Kristin E Yu, Farah Selman, Joaquin Sanchez-Sotelo

Background: Dislocation of the sternoclavicular joint (SCJ) is the most common SCJ condition reported to be managed surgically. However, primary SCJ osteoarthritis is substantially more common. There are few reports in the literature on the outcome of surgical management of primary SCJ osteoarthritis. We have successfully adopted sternal docking allograft reconstruction for SCJ instability and have now expanded the technique to patients with primary SCJ osteoarthritis. This is our first report on the outcome of the sternal docking technique specifically for patients with primary SCJ osteoarthritis.

Methods: Between 2012 and 2023, one fellowship trained shoulder surgeon consecutively performed surgical resection of the medial end of the clavicle and semitendinosus allograft ligament reconstruction using the sternal docking technique in 29 patients with SCJ osteoarthritis. Seven patients were lost to follow-up (one declined participation, and six could not be contacted). The remaining 22 patients form the study cohort. There were 17 females and 5 males with a mean age of 49 ± 11 years at the time of surgery (range, 32-71 years). Their electronic medical records were reviewed to collect demographics, pain using a Visual Analog Scale (VAS), complications and reoperations. Patients were also contacted at most recent follow-up to record VAS for pain, subjective shoulder value (SSV) and American Shoulder and Elbow Surgeons (ASES) shoulder score. The procedure was considered successful when patients experienced pain relief and did not develop any complications or required reoperation. The mean length of follow-up was 4 ± 3 (range, 1-12) years.

Results: SCJ reconstruction was associated with significantly improved pain relief and overall shoulder function. Preoperatively, the mean VAS was 6 ± 1.5 (range, 4-9) points. At the most recent follow-up, the mean pain score was 0.5 ± 1.5 (range, 0-6) points, with median scores of 90 (IRQ 60-98) for SSV and 80 (IQR 70-81) points for ASES. 21 of 22 patients reported high satisfaction rates with their postoperative outcomes, with one patient endorsing partial satisfaction due to limited shoulder range of motion. Persistent peri-incisional numbness was reported by one patient. There were no re-operations at the time of the most recent follow-up.

Conclusion: Medial clavicle resection and ligament reconstruction seems to be associated with good overall outcomes, a high degree of patient satisfaction, and a low reoperation rate in patients with primary SCJ OA.

背景:胸锁关节脱位(SCJ)是最常见的经手术治疗的SCJ疾病。然而,原发性SCJ骨关节炎更为常见。文献中很少有关于原发性SCJ骨关节炎手术治疗结果的报道。我们已经成功地采用胸骨对接异体移植重建治疗SCJ不稳定,现在已经将该技术扩展到原发性SCJ骨关节炎患者。这是我们首次报道胸骨对接技术专门用于原发性SCJ骨关节炎患者的结果。方法:2012年至2023年,1名培训过的肩关节外科医生连续对29例SCJ骨关节炎患者行锁骨内侧端切除术和胸骨对接技术重建同种异体半腱肌韧带。7名患者失去随访(1名拒绝参与,6名无法联系)。其余22名患者组成研究队列。女性17例,男性5例,手术时平均年龄49±11岁,年龄范围32 ~ 71岁。对他们的电子医疗记录进行审查,以收集人口统计数据、使用视觉模拟量表(VAS)进行疼痛、并发症和再手术。在最近的随访中也联系了患者,以记录VAS疼痛,主观肩值(SSV)和美国肩关节外科医生(ASES)肩部评分。当患者经历疼痛缓解,没有出现任何并发症或需要再次手术时,手术被认为是成功的。平均随访时间为4±3年(1 ~ 12年)。结果:SCJ重建与疼痛缓解和整体肩功能显著改善相关。术前VAS平均为6±1.5分(范围4-9)。在最近的随访中,平均疼痛评分为0.5±1.5分(范围,0-6),SSV的中位评分为90分(IRQ 60-98), ASES的中位评分为80分(IQR 70-81)。22例患者中有21例报告了对术后结果的高满意度,其中1例患者由于肩部活动范围有限而部分满意。1例患者报告持续切口周围麻木。在最近一次随访时没有再手术。结论:内侧锁骨切除术和韧带重建似乎与原发性SCJ性骨关节炎患者的总体预后良好,患者满意度高,再手术率低相关。
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引用次数: 0
PTP1B as a Novel Therapeutic Target in Frozen Shoulder: Evidence from Human Capsular Tissue Analysis. PTP1B作为冻疮治疗的新靶点:来自人囊组织分析的证据。
IF 2.9 2区 医学 Q1 ORTHOPEDICS Pub Date : 2026-01-22 DOI: 10.1016/j.jse.2025.12.016
Yu-Hang Yang, Wen-Jing Li, Zi-Yan Huang, Xi-Wu Liao, Xiao-Qin Li, Rui-Li Sun, Ji-Zu Wang, Xing-Bo Wang, Ning Ding, Song-Bo Shi, Shu-Jin Wu, Qing-Shan Yang

Background: Frozen shoulder (FS) is a common fibroinflammatory disorder of the glenohumeral joint capsule, characterized by persistent pain and progressive restriction of range of motion. The fibroblast-to-myofibroblast transition is a central pathological event driving capsular fibrosis, yet the molecular regulators underlying this process remain poorly defined. Protein tyrosine phosphatase 1B (PTP1B) has emerged as a key regulator of fibrosis in multiple organs, but its role in musculoskeletal fibrosis, particularly in FS, has not been investigated.

Methods: In this prospective case-control study, glenohumeral capsular tissues were collected from 21 patients with idiopathic FS and 21 matched controls with rotator cuff tears during arthroscopic surgery. Tissue samples were evaluated using histology, immunofluorescence, and Western blotting. Clinical function was assessed preoperatively using the American Shoulder and Elbow Surgeons and Constant-Murley scores.

Results: FS patients exhibited significantly worse functional outcomes across all domains, including pain, range of motion, and activities of daily living. Histopathological analysis revealed pronounced fibroblast proliferation, dense collagen deposition, hypervascularity, and perivascular adipocyte accumulation in FS capsules compared to controls. Critically, PTP1B expression was significantly upregulated in FS tissues. PTP1B immunoreactivity was prominently localized to α-SMA+ myofibroblasts. Co-localization studies confirmed an enrichment of PTP1B within activated myofibroblasts, indicating its specific involvement in fibrotic transdifferentiation.

Conclusion: This study identified PTP1B as a novel biomarker that was upregulated in FS and was specifically associated with myofibroblast activation and capsular fibrosis. These findings position PTP1B as a promising therapeutic target for mitigating fibrosis and functional impairment in FS.

背景:肩周炎(FS)是一种常见的肩关节囊纤维炎性疾病,以持续疼痛和进行性活动范围受限为特征。成纤维细胞到肌成纤维细胞的转变是驱动荚膜纤维化的中心病理事件,然而这一过程背后的分子调节因子仍不明确。蛋白酪氨酸磷酸酶1B (PTP1B)已成为多器官纤维化的关键调节因子,但其在肌肉骨骼纤维化,特别是FS中的作用尚未被研究。方法:在这项前瞻性病例对照研究中,在关节镜手术中收集了21例特发性FS患者和21例匹配对照的肩袖撕裂患者的肩关节囊组织。使用组织学、免疫荧光和Western blotting对组织样本进行评估。术前使用美国肩肘外科医生和Constant-Murley评分评估临床功能。结果:FS患者在所有领域表现出明显更差的功能结果,包括疼痛、运动范围和日常生活活动。组织病理学分析显示,与对照组相比,FS胶囊中有明显的成纤维细胞增殖、致密胶原沉积、血管肥大和血管周围脂肪细胞积累。关键是,PTP1B在FS组织中的表达显著上调。PTP1B的免疫反应性主要局限于α-SMA+肌成纤维细胞。共定位研究证实了活化的肌成纤维细胞中PTP1B的富集,表明其特异性参与了纤维化转分化。结论:本研究发现PTP1B是一种新的生物标志物,在FS中上调,并与肌成纤维细胞激活和荚膜纤维化特异性相关。这些发现将PTP1B定位为缓解FS纤维化和功能损伤的有希望的治疗靶点。
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Journal of Shoulder and Elbow Surgery
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