Journal of Plastic Reconstructive and Aesthetic Surgery最新文献_第10页

Letter response to Sutcliffe et al. (“Re: Single modality indocyanine green is feasible for sentinel node detection in head and neck cutaneous melanoma: A prospective cohort study”) 对Sutcliffe等人的回复（“回复：单模态吲哚菁绿可用于头颈部皮肤黑色素瘤前哨淋巴结检测：一项前瞻性队列研究”）。

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-11-12 DOI: 10.1016/j.bjps.2025.11.015

Rini Vyas, Christopher Jones, Aenone Harper Machin

引用次数: 0

How well does quantitative measurements of the lip and panel ratings of the lip outcomes correlate in adults treated for unilateral cleft, lip, and palate with Skoog lip repair in childhood 在成人单侧唇裂、唇裂和腭裂治疗中，唇部的定量测量和唇部结果的小组评分与儿童期Skoog唇部修复的相关性有多好？

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-11-14 DOI: 10.1016/j.bjps.2025.11.023

Roshan Peroz , Alberto Falk-Delgado , Omar Al-hili , David Schwarz , Malin Hakelius , Maria Mani

Background

Little is known about the long-term lip symmetry after cleft repair and correlation between objective measures and subjective human ratings. Therefore, we examined long-term lip asymmetry among adults who were treated for unilateral cleft, lip, and palate (UCLP) with the Skoog’s lip repair in their infancy. Furthermore, we investigated the correlation between patient-reported scores of lip appearance and percentage of lip asymmetry as measured using SymNose.

Patients and methods

The symmetry of the lip was measured twice using SymNose by two users on frontal uncropped photographs of 74 UCLP-treated adults at a mean follow-up of 37 years postlip surgery. Previously collected self-assessment of lip appearance and panel ratings (from professionals, laypersons, and cleft panels) of these photographs were included in this study.

Results

The overall median lip asymmetry was relatively low at 18%. Men exhibited slightly higher asymmetry than women (P<0.05). There was no difference between SymNose measurements taken by the two users (P>0.05). Intrarater agreement of both users ranged from good to excellent (intraclass correlation coefficient 0.84–0.96). The interrater agreement was moderate, (intraclass correlation coefficient 0.52–0.66). No significant correlation was found between the human ratings: self-assessment and panel assessments to that of lip asymmetry (%) measured using SymNose.

Conclusion

Although SymNose is confirmed to be a reliable tool for quantifying asymmetry, it does not correlate with subjective human ratings. Thus, it should be complemented with subjective assessment and clinical findings to define lip outcomes among patients with UCLP.

背景：关于唇裂修复后的长期唇对称以及客观测量与人类主观评分之间的关系，我们所知甚少。因此，我们研究了在婴儿期接受Skoog唇修复治疗的单侧唇腭裂（UCLP）成人的长期唇不对称。此外，我们研究了患者报告的嘴唇外观分数与使用SymNose测量的嘴唇不对称百分比之间的相关性。患者和方法：74名接受过uclp治疗的成年人在唇部手术后平均随访37年，两名用户使用SymNose对其正面未裁剪的照片进行了两次测量。本研究包括先前收集的这些照片的唇形和面板评分的自我评估（来自专业人士，外行人和唇裂面板）。结果：整体中唇不对称相对较低，为18%。男性的不对称性略高于女性（P0.05）。两名用户的内部一致性从好到优不等（类内相关系数0.84-0.96）。组间一致性中等（组内相关系数0.52 ~ 0.66）。没有发现人类评分：自我评估和小组评估与使用SymNose测量的嘴唇不对称（%）之间有显著的相关性。结论：虽然SymNose被证实是量化不对称性的可靠工具，但它与人类的主观评分无关。因此，它应该与主观评估和临床结果相补充，以确定患者的唇部预后。

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引用次数: 0

Pyriform, nasal base, and nasal deformity: A mediation analysis evaluating the mechanisms of secondary cleft lip nasal deformity 梨形、鼻底和鼻畸形：评估继发性唇裂鼻畸形机制的中介分析

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-10-31 DOI: 10.1016/j.bjps.2025.10.023

Zijun Li , Wanwen Dang , Wei Liang, Mengying Jin, Chenzhe Sun, Jingtao Yuan, Hongyu Shen, Yonghuan Zhen, Yang An

Background

The biomechanical relationship between maxillary defects and secondary cleft nasal deformities in adult patients remains unelucidated.

Objectives

This study aimed to investigate the pathophysiology of cleft lip nasal deformity by comprehensively measuring parameters using preoperative computed tomography (CT) records.

Methods

Retrospective analysis of 56 adult patients with unilateral cleft (24.2±6.2 years) using CT data. Patients were stratified by alveolar cleft involvement with pyriform margin (type I/II) and with or without palate involvement. Parameters were categorized into the maxillary, nasal base, and nasal tip and analyzed using linear regression. Additionally, mediation analysis was used to evaluate nasal base's intermediary role in transmitting skeletal effects.

Results

Results demonstrated preserved nasal base projection on the cleft side despite pyriform depression. Compensatory subcutaneous soft tissue thickening was significantly greater at cleft-side landmarks (p < 0.01). Additionally, cleft-side nostril sill height (p = 0.032) and mucosal surface area (Δ = 106.08 mm², p = 0.048) showed significant reductions. Linear regression revealed several significant associations between pyriform and nasal tip deformities; however, mediation analysis showed most nasal base parameters did not statistically mediate this relationship. Notably, cleft alveolar defects exhibited indirect effects on columellar tilt through nostril sill mediation (p = 0.048).

Conclusions

Skeletal displacement in cleft deformities minimally influences nasal morphology. Compensatory soft tissue adaptations maintain nasal base projection despite the underlying bony discrepancies, making nasal base augmentation unbeneficial for nasal deformity. However, the nostril sill emerges as a critical mediator of columella deviations while mucosal lining could possibly impact tip projection.

背景上颌缺损与成人继发性鼻裂畸形之间的生物力学关系尚不清楚。目的利用术前计算机断层扫描（CT）记录综合测量各项参数，探讨唇裂鼻畸形的病理生理机制。方法回顾性分析56例成人单侧唇裂患者（24.2±6.2岁）的CT资料。患者按累及梨状缘的牙槽裂（I/II型）和累及或不累及上颚进行分层。参数分为上颌、鼻底和鼻尖，并使用线性回归进行分析。此外，采用中介分析来评价鼻基在骨骼效应传递中的中介作用。结果结果显示，裂唇侧的鼻基底突起虽有梨状凹陷，但仍得以保留。代偿性皮下软组织增厚在左侧标志处显著增加（p < 0.01）。此外，左侧鼻孔高度（p = 0.032）和粘膜表面积（Δ = 106.08 mm²，p = 0.048）均显著降低。线性回归显示梨状和鼻尖畸形之间存在显著的相关性；然而，中介分析显示，大多数鼻基参数在统计上没有中介作用。值得注意的是，肺泡裂缺陷通过鼻孔间隙介导对小柱倾斜有间接影响（p = 0.048）。结论骨移位对腭裂畸形鼻形态影响最小。尽管潜在的骨差异，代偿性软组织适应维持鼻基底突出，使得鼻基底增大对鼻畸形不利。然而，鼻孔仍然是小柱偏离的关键介质，而粘膜衬里可能影响鼻尖投射。

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引用次数: 0

Chondrocutaneous composite grafts are a viable option for nasal alar defects larger than 1.5 cm 对于大于1.5 cm的鼻翼缺损，软骨-皮肤复合移植是一种可行的选择

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-11-12 DOI: 10.1016/j.bjps.2025.11.009

Daehee Jeong , William Y. Zhu , Braedon Quinlan , Mckenzie Maloney , Carl F. Schanbacher

Introduction

Nasal reconstructions are one of the most commonly performed plastic surgery procedures. The complex anatomy and critical functionality of the nose demand precise surgical approaches and planning. This is especially pertinent for subunits such as the ala. Chondrocutaneous composite grafts from the ear are excellent options for alar reconstruction, but are limited to a maximum diameter of 1.5 cm, according to historic guidelines. This study compared complication rates associated with composite grafts that are greater and smaller than the reported size limit.

Methods

A retrospective review was conducted for 53 patients who received auricular composite grafts for alar repair following Mohs micrographic surgery. Complications, including graft loss, infection, postoperative bleeding, hematoma, and functional deficits, were noted. Additionally, patients who received esthetic revisions were observed.

Results

Thirty-two grafts were <1.5 cm in diameter, and 21 were >1.5 cm in diameter. One patient had a postoperative complication, and 7 received esthetic revisional procedures. There were no significant size-dependent differences in complication rates (p = 0.396). There was a significant difference in esthetic revision rates between grafts greater than and smaller than 1.5 cm in diameter.

Conclusion

We present the first study examining the validity of using 1.5 cm as the upper diameter bound for composite grafts. Our results indicate that composite grafts are safe and effective for reconstruction of nasal ala defects >1.5 cm. These larger grafts may benefit from minor esthetic adjustments once they have healed.

鼻重建术是最常见的整形手术之一。鼻子复杂的解剖结构和关键的功能需要精确的手术方法和计划。这对于像ala这样的亚单位尤其重要。耳部软骨皮肤复合移植物是鼻翼重建的绝佳选择，但根据历史指南，其最大直径限制在1.5厘米。本研究比较了大于和小于报道尺寸限制的复合移植物的并发症发生率。方法回顾性分析53例莫氏显微摄影术后耳廓复合移植修复鼻翼的临床资料。并发症包括移植物丢失、感染、术后出血、血肿和功能缺陷。此外，还观察了接受美学修复的患者。结果移植物直径1.5 cm 32个，直径1.5 cm 21个。1例患者出现术后并发症，7例患者接受了美学修复手术。并发症发生率无明显尺寸依赖性差异（p = 0.396）。直径大于和小于1.5 cm的移植物在美观修复率上有显著差异。结论本研究首次验证了以1.5 cm为上径界作为复合移植物的有效性。结果表明，复合植体修复1.5 cm鼻翼缺损是安全有效的。这些较大的移植物在愈合后可以进行轻微的美学调整。

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引用次数: 0

A practical method for flap perforator selection: Qualitative hemodynamic evaluation with conventional and portable ultrasound 一种实用的皮瓣穿支选择方法：常规和便携式超声定性血流动力学评价。

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-11-28 DOI: 10.1016/j.bjps.2025.11.056

Paloma Malagón , Takumi Yamamoto

引用次数: 0

Superior gluteal artery perforator flap for autologous breast reconstruction: Refined surgical technique, outcomes, and patient satisfaction 臀上动脉穿支皮瓣用于自体乳房重建：精细的手术技术、结果和患者满意度。

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-11-29 DOI: 10.1016/j.bjps.2025.11.062

J.M. Buijtendijk , E.D.H. Zonnevylle , D.A. Young-Afat

Background

Deep inferior epigastric perforator (DIEP) flaps are the gold standard for autologous breast reconstructions, but alternatives are needed when the abdomen is not optional. The superior gluteal artery perforator (SGAP) flap, using the gluteal region as donor site, is such an alternative. However, SGAP-flaps are not widely used for breast reconstructions due to technical and anatomical challenges, and potential donor site deformity. This study presents a slightly modified SGAP-flap harvesting technique for breast reconstructions aimed at optimizing outcomes and describes surgical and patient-reported outcomes.

Methods

An observational study (retrospective and cross-sectional) was conducted by including all women who underwent SGAP-flap breast reconstruction between May 2012 and March 2024 in a high-volume cancer center. Patient and surgical characteristics, (un)planned surgical revision rates, and patient-reported satisfaction were assessed using BREAST-Q (91% response rate).

Results

In total, 33 SGAP-flap breast reconstructions were performed in 26 patients. Mean ischemia time was 156 min. Four major complications (12%) requiring unplanned surgical intervention occurred, with no (partial) flap loss (i.e., 100% flap survival). Four flaps underwent planned secondary corrections (12%) of the donor site. Patient-reported donor site deformity and/or dissatisfaction was infrequent (n=2). Five patients underwent SGAP-flap on one side and DIEP-flap reconstruction contralaterally (15%), with similarly high patient-reported satisfaction and well-being scores for both sides.

Conclusions

High patient-reported satisfaction, and low complication and donor site deformity rates were observed in patients undergoing autologous breast reconstruction using a slightly refined SGAP-flap technique. This technique may be considered as an acceptable alternative for DIEP-flap breast reconstructions.

背景：深下腹穿支（DIEP）皮瓣是自体乳房重建的金标准，但当腹部不可选择时，需要其他选择。臀上动脉穿支（SGAP）皮瓣，利用臀区作为供体，就是这样一种选择。然而，由于技术和解剖学上的挑战以及潜在的供区畸形，sgap皮瓣并未广泛用于乳房重建。本研究提出了一种略为改进的sgap皮瓣采集技术用于乳房重建，旨在优化结果，并描述了手术和患者报告的结果。方法：一项观察性研究（回顾性和横断面），纳入2012年5月至2024年3月在一个大容量癌症中心接受sgap皮瓣乳房重建术的所有女性。使用BREAST-Q评估患者和手术特征、（未计划的）手术翻修率和患者报告的满意度（91%的有效率）。结果：26例患者共行33例sgap皮瓣乳房重建术。平均缺血时间156 min。发生了四个主要并发症（12%），需要进行计划外的手术干预，没有（部分）皮瓣丢失（即皮瓣存活率100%）。4个皮瓣在供区进行了计划的二次矫正（12%）。患者报告供体部位畸形和/或不满意的情况很少（n=2）。5例患者接受了单侧sgap -皮瓣和对侧diep -皮瓣重建（15%），患者报告的满意度和两侧幸福感评分相似。结论：采用略为改良的sgap皮瓣技术进行自体乳房重建，患者满意度高，并发症低，供区畸形率低。该技术可被认为是diep皮瓣乳房重建的一种可接受的替代方法。

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引用次数: 0

Response to Correspondence on: ‘First experience from 200 cases with a new breast tissue expander for multi-stage pre-pectoral breast reconstruction after mastectomy’ 对以下回复的回复：“200例新型乳腺组织扩张器用于乳房切除术后多阶段胸前乳房重建的首次经验”。

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-11-06 DOI: 10.1016/j.bjps.2025.11.002

Y. Harder, F. Bonomi, L. Guggenheim, N. Peradze, C. Parodi, D. Schmauss, A. Weinzierl, E. Limido

引用次数: 0

National trends in utilization and timing of flap reconstruction for lower extremity Gustilo–Anderson III fractures: A National Inpatient Sample analysis 全国下肢古斯蒂洛-安德森III型骨折皮瓣重建的使用趋势和时机：一项全国住院患者样本分析

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-10-28 DOI: 10.1016/j.bjps.2025.10.032

Dylan K. Kim, Paul A. Asadourian, Brianna M. Peet, Christine H. Rohde, Jarrod T. Bogue

Background

Recent research has suggested that the timing of successful flap reconstruction for lower extremity Gustilo–Anderson III fractures may be extended past 72 h of injury. This analysis incorporated a national database to assess the trends in flap reconstruction and relationship between reconstruction timing and short-term postoperative complications.

Methods

Admissions for lower extremity Gustilo–Anderson III fractures were identified in the 2016–2022 National Inpatient Sample. The main outcomes of interest were reconstruction using either pedicled or free flap and occurrence of in-hospital wound-related complications. Multivariable logistic regression models were used to evaluate the predictors of flap reconstruction and effect of reconstruction timing on the likelihood of in-hospital complications (p < 0.05).

Results

The final cohort included 58,580 cases. Flap reconstruction was performed in 3830 (6.5%) cases. Lower median neighborhood income (odds ratio [OR]: 0.89, 95% confidence interval [CI]: 0.80–0.99, p = 0.031) predicted lower odds of flap reconstruction, whereas higher institutional plastic surgery volume conferred higher odds (OR: 1.23, 95% CI: 1.19–1.27, p < 0.001 per 100 cases). Flap reconstruction performed 4–7 days after admission predicted similar odds (OR: 1.31, 95% CI: 0.79–2.17, p = 0.29) of developing postoperative complications when compared to reconstruction within 3 days. Free flaps did not predict significantly different odds of complications when compared to pedicled flaps (OR: 1.02, 95% CI: 0.77–1.35, p = 0.88).

Conclusion

Socioeconomic and clinical factors were found to be the predictors of flap reconstruction after complex lower extremity injuries. Flap reconstruction within the first 3 days after admission continues to have the lowest rates of wound-related complications; however, our findings indicate that reconstruction up to 7 days carries similar risk of in-hospital complications.

最近的研究表明，下肢Gustilo-Anderson III型骨折成功皮瓣重建的时间可以延长至损伤后72小时。该分析纳入了一个国家数据库，以评估皮瓣重建的趋势以及重建时间与短期术后并发症的关系。方法在2016-2022年全国住院患者样本中确定下肢gustillo - anderson III型骨折的治疗任务。研究的主要结果是带蒂皮瓣或游离皮瓣的重建以及院内伤口相关并发症的发生。采用多变量logistic回归模型评估皮瓣重建的预测因素及重建时间对院内并发症发生可能性的影响（p < 0.05）。结果最终纳入58,580例病例。皮瓣重建3830例（6.5%）。较低的社区收入中位数（比值比[OR]: 0.89, 95%可信区间[CI]: 0.80-0.99, p = 0.031）预测皮瓣重建的几率较低，而较高的机构整形手术数量则具有较高的几率（OR: 1.23, 95% CI: 1.19-1.27, p <； 0.001 / 100例）。入院后4-7天进行皮瓣重建与3天内进行皮瓣重建相比，发生术后并发症的几率相似（OR: 1.31, 95% CI: 0.79-2.17, p = 0.29）。与带蒂皮瓣相比，游离皮瓣的并发症发生率无显著差异（OR: 1.02, 95% CI: 0.77-1.35, p = 0.88）。结论社会经济因素和临床因素是复杂下肢损伤后皮瓣重建的预测因素。入院后3天内皮瓣重建的伤口相关并发症发生率最低；然而，我们的研究结果表明，长达7天的重建具有相似的院内并发症风险。

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引用次数: 0

A systematic review and meta-analysis of dynamic external fixation for intra-articular fractures of the hand 动态外固定治疗手部关节内骨折的系统回顾和荟萃分析

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-10-31 DOI: 10.1016/j.bjps.2025.10.046

Eliot N. Haddad , Grace Jaramillo , Sara G. Yacoub , Bahar Bassiri Gharb , Antonio Rampazzo

Background

A consolidated review of the dynamic external fixation (DEF) technique for intra-articular hand fractures is not available.

Methods

A systematic review following the PRISMA guidelines included studies on clinical outcomes of DEF for intra-articular hand fractures.

Results

A total of 88 studies published between 1978 and 2024 were included with 1357 patients (average age: 36.4 years) and information on 1355 finger fractures was available. The ring finger (30.8%) and proximal interphalangeal joint (PIPJ) (86.8%) were the most affected. Among the known injury mechanisms, sport-related causes were the most frequent (27.3%). Four DEF device classes were identified: commercial, early DEF, pins and rubbers traction system (PRTS), and other Kirschner-wire (K-wire) fixations. Across all studies, only eight cases of deep infection were reported (0.6%). The average trauma to surgery time was 18.1 days, and devices were removed, on average, 35.9 days after implementation. Grip strength was 85.2% of the contralateral, uninjured side for 333 patients. PIPJ range of motion (ROM) averaged 79.3° (n = 1077), with early DEF being the highest (89.4°) and commercial being the lowest (71.7°) (p < 0.001). Pain at last follow-up was 19% (n = 970, QM p = 0.15) and patient satisfaction was 90% (n = 420, QM p = 0.11). There was no difference between device classes for radiological outcomes or complications except for pin-tract infection, with a total estimated prevalence of 147 per 1000 cases (Commercial: 110, Early DEF: 56, and Other K-wire: 151, PRTS: 189, I² = 23.6%, QM p = 0.005).

Conclusion

DEF achieves radiological union in an estimated 95% of patients with 90% satisfaction rate.

背景：目前尚无关于手部关节内骨折动态外固定（DEF）技术的综合综述。方法根据PRISMA指南对DEF治疗手部关节内骨折的临床结果进行系统评价。结果共纳入1978 - 2024年间发表的88项研究，1357例患者（平均年龄36.4岁），1355例手指骨折。其中，无名指（30.8%）和近端指间关节（PIPJ）（86.8%）受影响最大。在已知的损伤机制中，运动相关原因最为常见（27.3%）。确定了四种DEF装置类别：商用，早期DEF，引脚和橡胶牵引系统（PRTS）和其他克氏丝（k -丝）固定。在所有研究中，仅报告了8例深部感染（0.6%）。创伤到手术的平均时间为18.1天，器械在实施后平均35.9天被取出。333例患者对侧未损伤侧握力为85.2%。PIPJ运动范围（ROM）平均为79.3°（n = 1077），早期DEF最高（89.4°），商业最低（71.7°）（p < 0.001）。最后一次随访疼痛率为19% (n = 970, QM p = 0.15)，患者满意度为90% （n = 420, QM p = 0.11）。除针道感染外，不同类型的器械在放射学结果或并发症方面没有差异，针道感染的总估计患病率为每1000例147例（商用：110例，早期DEF: 56例，其他k线：151例，PRTS: 189例，I2 = 23.6%, QM p = 0.005）。结论约95%的患者达到放射愈合，满意率达90%。

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引用次数: 0

Evaluation of resensibilization in flaps containing sensory nerves in the animal model: A systematic review of the literature 评估动物模型中包含感觉神经的皮瓣的再敏感性：对文献的系统回顾。

IF 2.4 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery

Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.bjps.2025.12.003

Stephanie N. Schulz , Julie Triolo , Dominik André-Lévigne, Daniel F. Kalbermatten, Srinivas Madduri, Patricia E. Engels

Growing interest is being given to the sensitization of flaps in the clinics. Although epineural coaptation with flaps was published decades ago, the method has not yet become the gold standard, and re-sensitization evaluation in patients is mainly done by clinical tests. These assessments are inherently subjective and depend heavily on the investigator. The aim of our study was to gain insight into the various methods used to assess re-sensitization of flaps in animal models. Subsequently, in a bench-to-bedside fashion, these methods could enrich future clinical trials by providing objective, patient- and investigator-independent outcome measures. A systematic search of PubMed, Embase, and the Cochrane Library was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Out of the 219 identified records, 15 studies involving a total of 421 animals met the inclusion criteria. Sensory testing was performed using either behavioral responses such as the cutaneous trunci muscle (CTM) reflex (3 studies, n=117), or immunohistochemical detection of sensory nerve markers including protein gene product 9.5 (PGP 9.5; 10 studies, n=225) and calcitonin gene-related peptide (CGRP; 9 studies, n=218). These tools offered measurable insights into reinnervation, although methodological variability limited direct comparisons. This review highlights the value of neuroprotein markers and behavioral tests in flap re-sensitization research. Standardization of these methods, along with the integration of proteomic approaches, could enhance the objectivity and translational relevance of future clinical studies.

越来越多的兴趣是给予敏感的皮瓣在诊所。虽然神经外贴合皮瓣在几十年前就已发表，但该方法尚未成为金标准，患者的再致敏评估主要通过临床试验完成。这些评估本质上是主观的，很大程度上取决于研究者。我们研究的目的是深入了解用于评估动物模型皮瓣再敏化的各种方法。随后，通过提供客观的、独立于患者和研究者的结果测量，这些方法可以丰富未来的临床试验。根据系统评价和荟萃分析指南的首选报告项目，对PubMed、Embase和Cochrane图书馆进行了系统搜索。在219份已确定的记录中，15项研究共涉及421只动物，符合纳入标准。通过行为反应如皮干肌（CTM）反射（3项研究，n=117）或感觉神经标记物免疫组织化学检测进行感觉测试，包括蛋白基因产物9.5 （PGP 9.5； 10项研究，n=225）和降钙素基因相关肽（CGRP； 9项研究，n=218）。这些工具为神经再生提供了可测量的见解，尽管方法的可变性限制了直接比较。本文综述了神经蛋白标志物和行为学试验在皮瓣再敏化研究中的价值。这些方法的标准化，以及蛋白质组学方法的整合，可以提高未来临床研究的客观性和翻译相关性。

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引用次数: 0