Pub Date : 2024-08-05eCollection Date: 2024-11-01DOI: 10.1002/jpr3.12116
Mark Ambert, Jasmine Patterson, Racha Khalaf
{"title":"The role of endoscopy in gastric button battery ingestions: A case and literature review.","authors":"Mark Ambert, Jasmine Patterson, Racha Khalaf","doi":"10.1002/jpr3.12116","DOIUrl":"10.1002/jpr3.12116","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"572-573"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-31eCollection Date: 2024-11-01DOI: 10.1002/jpr3.12115
David G Cairney, Paul Fineron, Andrew J Kirby, Paul Henderson, Peter M Gillett
We present a case of an 8-week-old infant with acute bloody diarrhoea and subsequent passage of an intestinal cast. An extensive immune and infection work-up did not reveal a causative aetiology. Histopathology indicated the cast represented an intestinal pseudomembrane. 16S bacterial polymersae chain reaction of the pathology specimen was negative. The infant required a period of parenteral nutrition due to diarrhoeal losses but made a full recovery and had no sequelae from this illness. Intestinal casts are a rare occurrence, particularly in paediatrics. It prompts a wide differential which includes acute infection, immunodeficiency and ischaemia. Accurate quantification of stool losses, appropriate nutrition support and liaison with microbiology colleagues were essential in this case.
{"title":"Spontaneous excretion of a pseudomembranous intestinal cast in an infant with an acute diarrhoeal illness: A case report and literature review.","authors":"David G Cairney, Paul Fineron, Andrew J Kirby, Paul Henderson, Peter M Gillett","doi":"10.1002/jpr3.12115","DOIUrl":"10.1002/jpr3.12115","url":null,"abstract":"<p><p>We present a case of an 8-week-old infant with acute bloody diarrhoea and subsequent passage of an intestinal cast. An extensive immune and infection work-up did not reveal a causative aetiology. Histopathology indicated the cast represented an intestinal pseudomembrane. 16S bacterial polymersae chain reaction of the pathology specimen was negative. The infant required a period of parenteral nutrition due to diarrhoeal losses but made a full recovery and had no sequelae from this illness. Intestinal casts are a rare occurrence, particularly in paediatrics. It prompts a wide differential which includes acute infection, immunodeficiency and ischaemia. Accurate quantification of stool losses, appropriate nutrition support and liaison with microbiology colleagues were essential in this case.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"497-500"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acquired colonic stenosis is extremely rare in infants and surgical resection is the mainstay of treatment. Endoscopic balloon dilation has shown success in treating bowel stenosis from inflammatory bowel disease but its application in infants with colonic strictures of other origin has not been widely explored. We report a 4-week-old male infant who developed significant abdominal distension due to progressive colonic stenosis, occurring 2 weeks following balloon valvuloplasty for his severe valvular pulmonary stenosis. The progressive colonic stenosis was successfully managed through endoscopic balloon dilation. Following this procedure, he exhibited clinical improvement, with subsequent imaging revealing no remaining stricture. Over the 16-month follow-up period, no clinical features suggestive of constipation or lower gut obstruction were observed. This case serves as evidence that endoscopic balloon dilation is a promising and safe therapeutic option for treating colonic stenosis in infants.
{"title":"Progressive colonic stenosis in an infant: Successful treatment with endoscopic balloon dilation.","authors":"Korppong Plubjang, Kanticha Chatpermporn, Nimmita Srisan, Paisarn Vejchapipat, Teerasak Phewplung, Atchara Mahayosnond, Palittiya Sintusek","doi":"10.1002/jpr3.12114","DOIUrl":"10.1002/jpr3.12114","url":null,"abstract":"<p><p>Acquired colonic stenosis is extremely rare in infants and surgical resection is the mainstay of treatment. Endoscopic balloon dilation has shown success in treating bowel stenosis from inflammatory bowel disease but its application in infants with colonic strictures of other origin has not been widely explored. We report a 4-week-old male infant who developed significant abdominal distension due to progressive colonic stenosis, occurring 2 weeks following balloon valvuloplasty for his severe valvular pulmonary stenosis. The progressive colonic stenosis was successfully managed through endoscopic balloon dilation. Following this procedure, he exhibited clinical improvement, with subsequent imaging revealing no remaining stricture. Over the 16-month follow-up period, no clinical features suggestive of constipation or lower gut obstruction were observed. This case serves as evidence that endoscopic balloon dilation is a promising and safe therapeutic option for treating colonic stenosis in infants.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"501-504"},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Judith N. Blinder, Tal Dror, Patrice L. Weiss, M. Beeri
Children who are unable to eat and drink orally require temporary or permanent enteral nutritional support via tube feeding. The objective was to describe a weaning program held at a children's rehabilitation hospital and to review the long‐term outcomes of the transition from tube nutrition to oral feeding.The parents of 82 children who took part in the ALYN intervention program from 2011 to 2022 were requested to participate in a telephone survey to learn about their child's status related to eating, education, social wellbeing, and overall health. They also provided feedback concerning their experience with the tube‐weaning program and their current reliance on support for eating‐related issues.The parents of 35 (39%) children responded. Their mean ± SD age at the time of treatment were 2.1 ± 1.76, and the mean ± SD age at the time of the survey 8.85 ± 3.96 years. Their mean current zBMI is −0.7. Overall, parents were very satisfied with the child's eating (4.7 out of 5) ± 0.7, and few reported that the child's eating affected the family mealtime routine (2.1 out of 5) ± 1.3. The children's age at weaning was significantly correlated with parental reports of concern with the child's current eating ability, with younger ages at weaning associated with lower parental concern.The data demonstrated that despite the complexity of the participants, most children succeed in achieving long‐term independent eating, good nutritional status, and social participation around mealtimes.
{"title":"Long‐term implications of a multidisciplinary tube‐weaning program: Parental perspectives","authors":"Judith N. Blinder, Tal Dror, Patrice L. Weiss, M. Beeri","doi":"10.1002/jpr3.12112","DOIUrl":"https://doi.org/10.1002/jpr3.12112","url":null,"abstract":"Children who are unable to eat and drink orally require temporary or permanent enteral nutritional support via tube feeding. The objective was to describe a weaning program held at a children's rehabilitation hospital and to review the long‐term outcomes of the transition from tube nutrition to oral feeding.The parents of 82 children who took part in the ALYN intervention program from 2011 to 2022 were requested to participate in a telephone survey to learn about their child's status related to eating, education, social wellbeing, and overall health. They also provided feedback concerning their experience with the tube‐weaning program and their current reliance on support for eating‐related issues.The parents of 35 (39%) children responded. Their mean ± SD age at the time of treatment were 2.1 ± 1.76, and the mean ± SD age at the time of the survey 8.85 ± 3.96 years. Their mean current zBMI is −0.7. Overall, parents were very satisfied with the child's eating (4.7 out of 5) ± 0.7, and few reported that the child's eating affected the family mealtime routine (2.1 out of 5) ± 1.3. The children's age at weaning was significantly correlated with parental reports of concern with the child's current eating ability, with younger ages at weaning associated with lower parental concern.The data demonstrated that despite the complexity of the participants, most children succeed in achieving long‐term independent eating, good nutritional status, and social participation around mealtimes.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"65 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20eCollection Date: 2024-11-01DOI: 10.1002/jpr3.12113
Hanna Distel, Kelley Hutchins, Prashant J Purohit, Rodolfo E Bégué
We report a case of moderately severe acute pancreatitis, hyperglycemia, acidosis, splenic, superior mesenteric, and portal vein thrombosis in relation to multisystem inflammatory syndrome in children (MIS-C). The patient responded well to intravenous immune globulin, corticosteroids, antibiotics, systemic anticoagulation, and drainage of peripancreatic fluid. The case highlights the polymorphic presentation of MIS-C and advises high level of suspicion for unusual, severe cases unresponsive to routine care.
{"title":"Multisystem inflammatory syndrome in children presenting as acute severe necrotizing pancreatitis: A case report.","authors":"Hanna Distel, Kelley Hutchins, Prashant J Purohit, Rodolfo E Bégué","doi":"10.1002/jpr3.12113","DOIUrl":"10.1002/jpr3.12113","url":null,"abstract":"<p><p>We report a case of moderately severe acute pancreatitis, hyperglycemia, acidosis, splenic, superior mesenteric, and portal vein thrombosis in relation to multisystem inflammatory syndrome in children (MIS-C). The patient responded well to intravenous immune globulin, corticosteroids, antibiotics, systemic anticoagulation, and drainage of peripancreatic fluid. The case highlights the polymorphic presentation of MIS-C and advises high level of suspicion for unusual, severe cases unresponsive to routine care.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 4","pages":"567-571"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ramakrishna, Karthik Ageeru, M. Kasala, R. Krupanandan, Karnan Perumal, S. Malleeswaran, Rajanikanth V. Patcha, Joy Varghese, M. S. Reddy, B. Ramachandran, K. Sadasivam
Dengue fever (DF) is one of the common vector‐borne infections in tropical and subtropical regions worldwide. Liver involvement in DF is common and includes a wide spectrum of clinical and laboratory manifestations ranging from mild transaminitis to acute liver failure (ALF). Dengue ALF has a high mortality rate. The role of liver transplant (LT) in ALF is uncertain mainly due to co‐existing multiorgan dysfunction and the risk of re‐infection as a consequence of post‐transplant immunosuppression. Here, we report the first paediatric living donor auxiliary orthotopic LT in an adolescent boy who developed ALF due to dengue. LT for ALF associated with severe dengue may be an option for patients with isolated liver involvement not responding to standard medical management.
{"title":"The first paediatric living donor auxiliary orthotopic liver transplant for dengue acute liver failure","authors":"S. Ramakrishna, Karthik Ageeru, M. Kasala, R. Krupanandan, Karnan Perumal, S. Malleeswaran, Rajanikanth V. Patcha, Joy Varghese, M. S. Reddy, B. Ramachandran, K. Sadasivam","doi":"10.1002/jpr3.12103","DOIUrl":"https://doi.org/10.1002/jpr3.12103","url":null,"abstract":"Dengue fever (DF) is one of the common vector‐borne infections in tropical and subtropical regions worldwide. Liver involvement in DF is common and includes a wide spectrum of clinical and laboratory manifestations ranging from mild transaminitis to acute liver failure (ALF). Dengue ALF has a high mortality rate. The role of liver transplant (LT) in ALF is uncertain mainly due to co‐existing multiorgan dysfunction and the risk of re‐infection as a consequence of post‐transplant immunosuppression. Here, we report the first paediatric living donor auxiliary orthotopic LT in an adolescent boy who developed ALF due to dengue. LT for ALF associated with severe dengue may be an option for patients with isolated liver involvement not responding to standard medical management.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"129 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastroschisis and omphalocele are common malformations of the anterior abdominal wall and can lead to significant morbidity and mortality in neonates. Despite advances in surgical care, these conditions remain challenging to manage effectively.This retrospective institutional study aimed to assess the management outcomes of neonates with anterior abdominal wall defects, specifically gastroschisis and omphalocele, in the Neonatal Intensive Care Unit (NICU) of Tikur Anbessa Specialized Hospital (TASH) (Tertiary Hospital).A retrospective review was conducted on cases of gastroschisis and omphalocele managed in the NICU of TASH from August 2018 to August 2022. Patient charts of neonates with omphalocele and gastroschisis were identified and retrieved from the NICU records. The collected data were analyzed using statistical software such as SPSS.The study included a total of 50 neonates with abdominal wall defects, consisting of 39 cases of omphalocele and 11 cases of gastroschisis. Maternal age ranged from 18 to 40 years, with a mean age of 27.6 ± 4.5 years. Associated malformations were documented in 33.3% of omphalocele cases and 18.2% of gastroschisis cases. Cardiac anomalies were the most frequently associated malformation with omphalocele. Surgical intervention was performed in 27.3% of gastroschisis cases (3 out of 11) and 41% of omphalocele cases (16 out of 39). The postsurgery mortality rate was 12.5% for both major and minor omphaloceles, with 11 deaths occurring in gastroschisis cases. Sepsis was identified as the cause of death in all neonates who did not survive.The study revealed a significantly higher mortality rate in gastroschisis cases compared to omphalocele cases. Sepsis was identified as the primary cause of death in the neonates. These findings underscore the importance of effective management strategies to prevent and manage sepsis in neonates with abdominal wall defects.
{"title":"Anterior abdominal wall defects and their management outcomes in Tikur Anbessa Specialized Hospital, neonatal intensive care unit","authors":"Abebe Habtamu, Tenagne Million","doi":"10.1002/jpr3.12110","DOIUrl":"https://doi.org/10.1002/jpr3.12110","url":null,"abstract":"Gastroschisis and omphalocele are common malformations of the anterior abdominal wall and can lead to significant morbidity and mortality in neonates. Despite advances in surgical care, these conditions remain challenging to manage effectively.This retrospective institutional study aimed to assess the management outcomes of neonates with anterior abdominal wall defects, specifically gastroschisis and omphalocele, in the Neonatal Intensive Care Unit (NICU) of Tikur Anbessa Specialized Hospital (TASH) (Tertiary Hospital).A retrospective review was conducted on cases of gastroschisis and omphalocele managed in the NICU of TASH from August 2018 to August 2022. Patient charts of neonates with omphalocele and gastroschisis were identified and retrieved from the NICU records. The collected data were analyzed using statistical software such as SPSS.The study included a total of 50 neonates with abdominal wall defects, consisting of 39 cases of omphalocele and 11 cases of gastroschisis. Maternal age ranged from 18 to 40 years, with a mean age of 27.6 ± 4.5 years. Associated malformations were documented in 33.3% of omphalocele cases and 18.2% of gastroschisis cases. Cardiac anomalies were the most frequently associated malformation with omphalocele. Surgical intervention was performed in 27.3% of gastroschisis cases (3 out of 11) and 41% of omphalocele cases (16 out of 39). The postsurgery mortality rate was 12.5% for both major and minor omphaloceles, with 11 deaths occurring in gastroschisis cases. Sepsis was identified as the cause of death in all neonates who did not survive.The study revealed a significantly higher mortality rate in gastroschisis cases compared to omphalocele cases. Sepsis was identified as the primary cause of death in the neonates. These findings underscore the importance of effective management strategies to prevent and manage sepsis in neonates with abdominal wall defects.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"72 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anthony Price, Tandis Rastegarlari, Sanober Khowaja, Kade Thompson, A. Lahiji, Michelle M. Felicella, Jing He, Annie Goodwin
Chronic intestinal pseudo‐obstruction (CIPO) is a rare, severe, and often debilitating condition that can result in significant morbidity and mortality amongst the pediatric population. Eosinophilic myenteric ganglionitis is a rare inflammatory neuropathy of the myenteric plexus with characteristic eosinophilic infiltration with and without hypogangliosis. The disorder has been previously documented as a cause of CIPO. We report the case of a 14‐year‐old male with no clear obstructive cause who, after multiple visits with a myriad of tests and workups, underwent surgical exploratory laparoscopy with the pathology returning a diagnosis of eosinophilic myenteric ganglionitis with unique lymphocytic and eosinophilic cell components.
{"title":"Eosinophilic myenteric ganglionitis: A case in a 14‐year‐old‐male","authors":"Anthony Price, Tandis Rastegarlari, Sanober Khowaja, Kade Thompson, A. Lahiji, Michelle M. Felicella, Jing He, Annie Goodwin","doi":"10.1002/jpr3.12108","DOIUrl":"https://doi.org/10.1002/jpr3.12108","url":null,"abstract":"Chronic intestinal pseudo‐obstruction (CIPO) is a rare, severe, and often debilitating condition that can result in significant morbidity and mortality amongst the pediatric population. Eosinophilic myenteric ganglionitis is a rare inflammatory neuropathy of the myenteric plexus with characteristic eosinophilic infiltration with and without hypogangliosis. The disorder has been previously documented as a cause of CIPO. We report the case of a 14‐year‐old male with no clear obstructive cause who, after multiple visits with a myriad of tests and workups, underwent surgical exploratory laparoscopy with the pathology returning a diagnosis of eosinophilic myenteric ganglionitis with unique lymphocytic and eosinophilic cell components.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"119 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141666635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naomi E. B. Tjaden, Michael Acord, Jane Minturn, Myron Allukian, P. Mamula
Intestinal webs are either congenital or acquired. There are few reported cases of either chemotherapy or nonsteroidal anti‐inflammatory medications leading to acquired intestinal webs in adults. There are limited descriptions of endoscopic interventions used for therapy of numerous duodenal webs in pediatrics. Here, we describe a 32‐month‐old patient undergoing chemotherapy who had multiple duodenal webs. The patient was diagnosed after failed gastrojejunostomy tube exchange via atypical contrast filling pattern and direct visualization with endoscopy. This patient likely has acquired duodenal webs from the combination of nonsteroidal anti‐inflammatory drug containing chemotherapy treatment and repeated tube trauma. Treatment involved serial esophagogastroduodenoscopy with a combination of endoscopic therapy including balloon dilation and incisional therapy with insulated‐tip knife and cautery scissors. The patient now tolerates G‐tube feedings.
{"title":"Thirty‐two‐month‐old with multiple duodenal webs diagnosed after failed gastrojejunostomy exchange successfully treated with combination endoscopic therapy","authors":"Naomi E. B. Tjaden, Michael Acord, Jane Minturn, Myron Allukian, P. Mamula","doi":"10.1002/jpr3.12107","DOIUrl":"https://doi.org/10.1002/jpr3.12107","url":null,"abstract":"Intestinal webs are either congenital or acquired. There are few reported cases of either chemotherapy or nonsteroidal anti‐inflammatory medications leading to acquired intestinal webs in adults. There are limited descriptions of endoscopic interventions used for therapy of numerous duodenal webs in pediatrics. Here, we describe a 32‐month‐old patient undergoing chemotherapy who had multiple duodenal webs. The patient was diagnosed after failed gastrojejunostomy tube exchange via atypical contrast filling pattern and direct visualization with endoscopy. This patient likely has acquired duodenal webs from the combination of nonsteroidal anti‐inflammatory drug containing chemotherapy treatment and repeated tube trauma. Treatment involved serial esophagogastroduodenoscopy with a combination of endoscopic therapy including balloon dilation and incisional therapy with insulated‐tip knife and cautery scissors. The patient now tolerates G‐tube feedings.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"113 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This case report details a novel case of Wernicke encephalopathy (WE) in a 16‐year‐old boy with obesity and chronic cannabis use. Despite the absence of alcohol use disorder, this adolescent developed classic symptoms of WE, challenging the conventional diagnostic framework. Clinical suspicion for WE was supported by typical magnetic resonance imaging findings, low thiamine levels and rapid clinical improvement postintravenous thiamine supplementation. This case underscores the need for heightened clinical vigilance for WE in patients who present with neurologic symptoms who endorse history of persistent emesis, regardless of their history of alcohol use. It also supports the preemptive administration of thiamine in those at risk of deficiency.
本病例报告详细介绍了一例新型韦尼克脑病（Wernicke encephalopathy，WE）病例，患者是一名 16 岁男孩，患有肥胖症并长期吸食大麻。尽管没有酒精使用障碍，这名青少年却出现了典型的韦尼克脑病症状，这对传统诊断框架提出了挑战。典型的磁共振成像结果、低硫胺素水平以及静脉补充硫胺素后临床症状的迅速改善都支持了临床上对 WE 的怀疑。本病例强调，对于出现神经系统症状并有持续性呕吐病史的患者，无论其是否有饮酒史，临床上都需要提高对 WE 的警惕。该病例还支持对有可能缺乏硫胺素的患者进行先期硫胺素补充。
{"title":"Wernicke encephalopathy in a pediatric patient with cannabinoid hyperemesis: A novel case report","authors":"Melissa Munroe, Zalan Shah, Aniruddh Setya","doi":"10.1002/jpr3.12109","DOIUrl":"https://doi.org/10.1002/jpr3.12109","url":null,"abstract":"This case report details a novel case of Wernicke encephalopathy (WE) in a 16‐year‐old boy with obesity and chronic cannabis use. Despite the absence of alcohol use disorder, this adolescent developed classic symptoms of WE, challenging the conventional diagnostic framework. Clinical suspicion for WE was supported by typical magnetic resonance imaging findings, low thiamine levels and rapid clinical improvement postintravenous thiamine supplementation. This case underscores the need for heightened clinical vigilance for WE in patients who present with neurologic symptoms who endorse history of persistent emesis, regardless of their history of alcohol use. It also supports the preemptive administration of thiamine in those at risk of deficiency.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" 405","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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