High protein parenteral nutrition (HPPN) in the early postnatal period is a recommended strategy for very low birth weight (VLBW) infants. However, limited data is available on electrolyte changes when HPPN strategy is utilized. We investigated the impact of HPPN on the development of hypophosphatemia and hypokalemia in preterm VLBW newborns.A retrospective, single‐center study investigated the levels of phosphate and potassium in VLBW infants who received HPPN (amino acids intake up to 3.5 g/kg/day) during the first week of life. Preterm infants were divided into two subgroups: appropriate for gestational age (AGA) and small for gestational age (SGA) newborns. Clinical data were obtained from hospital database and medical records.Overall, 170 VLBW infants were included for the study analysis: 41 SGA (mean birth weight 752 ± 39 g) and 129 AGA infants (mean birth weight 994 ± 23 g). Phosphate and potassium levels were significantly lower in the SGA infants compared to AGA infants (Phosphate: 0.97 ± 0.07 mmol/l vs. 1.44 ± 0.04 mmol/l, p < 0.001; Potassium: 3.0 ± 0.1 mmol/l vs. 3.6 ± 0.1 mmol/l, p < 0.001).Repeated measurement of serum phosphate and potassium is recommended when HPPN strategy is utilized in preterm SGA infants where significant hypophosphatemia and hypokalemia might have serious clinical consequences.
{"title":"High protein intake can lead to serious hypophosphatemia and hypokalemia in growth restricted preterm newborns","authors":"P. Korček, Zbyněk Straňák","doi":"10.1002/jpr3.12029","DOIUrl":"https://doi.org/10.1002/jpr3.12029","url":null,"abstract":"High protein parenteral nutrition (HPPN) in the early postnatal period is a recommended strategy for very low birth weight (VLBW) infants. However, limited data is available on electrolyte changes when HPPN strategy is utilized. We investigated the impact of HPPN on the development of hypophosphatemia and hypokalemia in preterm VLBW newborns.A retrospective, single‐center study investigated the levels of phosphate and potassium in VLBW infants who received HPPN (amino acids intake up to 3.5 g/kg/day) during the first week of life. Preterm infants were divided into two subgroups: appropriate for gestational age (AGA) and small for gestational age (SGA) newborns. Clinical data were obtained from hospital database and medical records.Overall, 170 VLBW infants were included for the study analysis: 41 SGA (mean birth weight 752 ± 39 g) and 129 AGA infants (mean birth weight 994 ± 23 g). Phosphate and potassium levels were significantly lower in the SGA infants compared to AGA infants (Phosphate: 0.97 ± 0.07 mmol/l vs. 1.44 ± 0.04 mmol/l, p < 0.001; Potassium: 3.0 ± 0.1 mmol/l vs. 3.6 ± 0.1 mmol/l, p < 0.001).Repeated measurement of serum phosphate and potassium is recommended when HPPN strategy is utilized in preterm SGA infants where significant hypophosphatemia and hypokalemia might have serious clinical consequences.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":" 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139620638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Konrad Becker, Hera Becker, Teresa Riedl‐Seifert, Markus Waitz, Andreas Jenke
Sodium homeostasis in extremely low birth weight (ELBW) infants is critical. While a lack of sodium delays growth, excessive supplementation increases morbidity.We performed a single‐center retrospective study on sodium and fluid management during the first 2 weeks of live including all ELBW infants born between June 1, 2017 and May 31, 2019.Forty‐seven patients (median GA 26 + 6 weeks, median BW 845 g) were included. Mean sodium intake was above the ESPGHAN recommendation, 4.58 mmol/kg/day during the first 2 days and 1.99 mmol/kg/day during the following period. Incidence of PDA, IVH, and ROP was directly associated with sodium intake (OR 1.6, 1.3, and 1.4, respectively), but not with fluid supplementation. No association to BPD was found. The most important source for inadvertent sodium intake were 0.9% saline given by arterial lines. Sodium supplementation did not correlate directly with serum sodium levels, but a linear regression model combining sodium intake and fluid supplementation was able to predict serum sodium changes 24–48 h in advance (correlation coefficient of 0.294, p < 0.05).Sodium application substantially exceeded ESPGHAN recommendations in ELBW infants. An excess in sodium was associated with an overall increased morbidity, justifying increased efforts to identify inadvertent sodium sources in these patients with the aim to decrease sodium excess.
{"title":"Excessive sodium supplementation but not fluid load is correlated with overall morbidity in extremely low birth weight infants","authors":"Konrad Becker, Hera Becker, Teresa Riedl‐Seifert, Markus Waitz, Andreas Jenke","doi":"10.1002/jpr3.12036","DOIUrl":"https://doi.org/10.1002/jpr3.12036","url":null,"abstract":"Sodium homeostasis in extremely low birth weight (ELBW) infants is critical. While a lack of sodium delays growth, excessive supplementation increases morbidity.We performed a single‐center retrospective study on sodium and fluid management during the first 2 weeks of live including all ELBW infants born between June 1, 2017 and May 31, 2019.Forty‐seven patients (median GA 26 + 6 weeks, median BW 845 g) were included. Mean sodium intake was above the ESPGHAN recommendation, 4.58 mmol/kg/day during the first 2 days and 1.99 mmol/kg/day during the following period. Incidence of PDA, IVH, and ROP was directly associated with sodium intake (OR 1.6, 1.3, and 1.4, respectively), but not with fluid supplementation. No association to BPD was found. The most important source for inadvertent sodium intake were 0.9% saline given by arterial lines. Sodium supplementation did not correlate directly with serum sodium levels, but a linear regression model combining sodium intake and fluid supplementation was able to predict serum sodium changes 24–48 h in advance (correlation coefficient of 0.294, p < 0.05).Sodium application substantially exceeded ESPGHAN recommendations in ELBW infants. An excess in sodium was associated with an overall increased morbidity, justifying increased efforts to identify inadvertent sodium sources in these patients with the aim to decrease sodium excess.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"67 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Meneghelli, Silvia Toniazzo, Elena Priante, M. E. Cavicchiolo, Francesca De Terlizzi, Paola Gaio, Paolo Spinella, Giovanna Verlato
The aim of our study was to collect data on complementary feeding (CF) in preterm infants (PIs).We enrolled PI ≤ 34 weeks of gestational age discharged from the neonatal intensive care unit (NICU) of the University Hospital of Padova. At 12 months of corrected age (CA), CF was investigated with questionnaires to the parents and a 24‐h dietary recall. In a subgroup of newborns, we also evaluated bone status at a CA of 12 months using quantitative ultrasound.We studied 167 ex PI at 1 year of CA. CF was introduced in 67.1% of them between 5 and 8 months of chronological age, with fruit as the first food (81%, n = 136). Sweet drinks were consumed by 17.4% of our sample, and salt was added in 33.5% of cases. PIs, at 1 year CA, introduced extra energy compared to the theoretical requirement (121 ± 31 kcal/kg/day) and higher protein intake than recommended (39 ± 11 g/day), while the intake of both total lipids and carbohydrates was slightly lower. Vitamins and minerals were adequate, except vitamin D. Regarding bone status, we found a correlation between vitamin D intakes from the diet and bone parameters (metacarpus‐bone transmission time: r = 0.36, p = 0.01) at 1 year of CA.Our population of PIs started CF in agreement with current suggestions though with a notable heterogeneity and with some mistakes. Vitamin D intake was correlated with bone status at 1 year of CA.
帕多瓦大学医院新生儿重症监护室（NICU）收治了胎龄小于 34 周的早产儿，我们的研究旨在收集早产儿辅食喂养（CF）方面的数据。在12个月校正年龄（CA）时，通过对父母的问卷调查和24小时饮食回忆对CF进行了调查。在新生儿亚组中，我们还使用定量超声波对 12 个月大时的骨骼状况进行了评估。67.1%的新生儿在 5 到 8 个月大时开始进食 CF，其中水果是第一种食物（81%，n = 136）。17.4%的样本食用甜饮料，33.5%的样本添加了盐。与理论需要量相比，婴儿在 1 岁时摄入的能量（121 ± 31 千卡/千克/天）有所增加，蛋白质摄入量（39 ± 11 克/天）也高于建议摄入量，而总脂类和碳水化合物的摄入量则略低。关于骨质状况，我们发现在 CA 1 年时，饮食中维生素 D 的摄入量与骨质参数（掌骨-骨传递时间：r = 0.36，p = 0.01）之间存在相关性。维生素 D 摄入量与 CA 1 年后的骨骼状况相关。
{"title":"Complementary feeding in infants born preterm: Aspects needing improvement","authors":"M. Meneghelli, Silvia Toniazzo, Elena Priante, M. E. Cavicchiolo, Francesca De Terlizzi, Paola Gaio, Paolo Spinella, Giovanna Verlato","doi":"10.1002/jpr3.12032","DOIUrl":"https://doi.org/10.1002/jpr3.12032","url":null,"abstract":"The aim of our study was to collect data on complementary feeding (CF) in preterm infants (PIs).We enrolled PI ≤ 34 weeks of gestational age discharged from the neonatal intensive care unit (NICU) of the University Hospital of Padova. At 12 months of corrected age (CA), CF was investigated with questionnaires to the parents and a 24‐h dietary recall. In a subgroup of newborns, we also evaluated bone status at a CA of 12 months using quantitative ultrasound.We studied 167 ex PI at 1 year of CA. CF was introduced in 67.1% of them between 5 and 8 months of chronological age, with fruit as the first food (81%, n = 136). Sweet drinks were consumed by 17.4% of our sample, and salt was added in 33.5% of cases. PIs, at 1 year CA, introduced extra energy compared to the theoretical requirement (121 ± 31 kcal/kg/day) and higher protein intake than recommended (39 ± 11 g/day), while the intake of both total lipids and carbohydrates was slightly lower. Vitamins and minerals were adequate, except vitamin D. Regarding bone status, we found a correlation between vitamin D intakes from the diet and bone parameters (metacarpus‐bone transmission time: r = 0.36, p = 0.01) at 1 year of CA.Our population of PIs started CF in agreement with current suggestions though with a notable heterogeneity and with some mistakes. Vitamin D intake was correlated with bone status at 1 year of CA.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"48 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Kherati, Archana Bansal, J. Oleksiewicz, A. Kadir, Natasha Burgess, Sabrina Barr, Sandhia Naik, Nick Crof, Marco Gasparetto
The objective of this study was to explore the correlation between paediatric Crohn's disease (CD) characteristics, bone health and growth parameters at diagnosis and follow‐up.Retrospective data was collected for 47 children aged 4–16 who were newly diagnosed with CD between January 2018 and December 2019. Mean follow‐up time was 2.5 years.Eleven (24%) children had growth delay at diagnosis, which persisted in 4 (44%) of 9 recorded children at follow‐up. Of the 35 children tested, 20 (57%) had inadequate Vitamin D levels (<50 mmol/L) at diagnosis. Thirty‐seven (79%) children had a dual‐energy X‐ray absorptiometry scan at diagnosis, with 20 of them having at least 1 low Z‐score. Children with poorer bone mineral density and bone mineral concentration Z‐scores for age had a younger age at diagnosis (p = .042 and p = .021), more severe disease (p = .04 and p = .029) and a lower BMI (p < .001) at diagnosis. Children diagnosed with CD ≥11 years had a lower‐than‐expected height velocity (p < .0001 and p < .001). Multivariate regression analysis demonstrated an older age of diagnosis was a significant predictor of a lower height velocity at follow‐up.Disease severity and age of diagnosis are important CD‐related factors that influence bone health and growth. Vitamin D is an accessible component that if optimised can improve all three factors. Monitoring and optimising each aspect systematically has the potential to enable children to achieve their bone health and growth potentials.
本研究旨在探讨儿科克罗恩病（CD）特征、骨骼健康和生长参数在诊断和随访时的相关性。研究人员收集了2018年1月至2019年12月期间新诊断为CD的47名4-16岁儿童的回顾性数据。平均随访时间为2.5年。11名儿童（24%）在诊断时出现生长迟缓，9名记录在案的儿童中有4名（44%）在随访时仍有生长迟缓。在接受检测的 35 名儿童中，20 人（57%）在诊断时维生素 D 水平不足（<50 mmol/L）。37名儿童（79%）在确诊时接受了双能X射线吸收扫描，其中20名儿童至少有一项Z-分数偏低。骨矿密度和骨矿浓度Z值较低的儿童确诊时年龄较小（p = .042 和 p = .021），病情较重（p = .04 和 p = .029），确诊时体重指数较低（p < .001）。被诊断为 CD ≥11岁的儿童的身高速度低于预期（p < .0001 和 p < .001）。多变量回归分析表明，诊断年龄越大，随访时身高速度越低的预测因素越明显。维生素 D 是一种可获得的成分，如果得到优化，可改善所有这三个因素。系统地监测和优化每个方面有可能使儿童实现其骨骼健康和生长潜力。
{"title":"The impact of age, disease severity, and BMI on bone health and growth in children and young people with Crohn's disease","authors":"R. Kherati, Archana Bansal, J. Oleksiewicz, A. Kadir, Natasha Burgess, Sabrina Barr, Sandhia Naik, Nick Crof, Marco Gasparetto","doi":"10.1002/jpr3.12037","DOIUrl":"https://doi.org/10.1002/jpr3.12037","url":null,"abstract":"The objective of this study was to explore the correlation between paediatric Crohn's disease (CD) characteristics, bone health and growth parameters at diagnosis and follow‐up.Retrospective data was collected for 47 children aged 4–16 who were newly diagnosed with CD between January 2018 and December 2019. Mean follow‐up time was 2.5 years.Eleven (24%) children had growth delay at diagnosis, which persisted in 4 (44%) of 9 recorded children at follow‐up. Of the 35 children tested, 20 (57%) had inadequate Vitamin D levels (<50 mmol/L) at diagnosis. Thirty‐seven (79%) children had a dual‐energy X‐ray absorptiometry scan at diagnosis, with 20 of them having at least 1 low Z‐score. Children with poorer bone mineral density and bone mineral concentration Z‐scores for age had a younger age at diagnosis (p = .042 and p = .021), more severe disease (p = .04 and p = .029) and a lower BMI (p < .001) at diagnosis. Children diagnosed with CD ≥11 years had a lower‐than‐expected height velocity (p < .0001 and p < .001). Multivariate regression analysis demonstrated an older age of diagnosis was a significant predictor of a lower height velocity at follow‐up.Disease severity and age of diagnosis are important CD‐related factors that influence bone health and growth. Vitamin D is an accessible component that if optimised can improve all three factors. Monitoring and optimising each aspect systematically has the potential to enable children to achieve their bone health and growth potentials.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"86 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139386070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-27eCollection Date: 2024-02-01DOI: 10.1002/jpr3.12017
Andrew Farrar, Paola Blanco, Abigail Fabbrini, Lindsey Armstrong, Jonathan Metts, Hector Monforte, Sara Karjoo, Paul Danielson, Michael Wilsey
This case report describes a 17-year-old patient with a low-grade appendiceal mucinous neoplasm. The patient presented with non-bloody diarrhea, abdominal pain, and weight loss. A colonoscopy revealed a cecal polypoid mass that required laparoscopic surgery. The residual appendix was dilated with myxoglobulosis and histopathology confirmed the diagnosis of a low-grade appendiceal mucinous neoplasm staged pT3Nx. The potential risk of pseudomyxoma peritonei is a serious complication of these tumors. Surveillance plans include computed tomography abdomen and pelvis, and tumor markers every 6 months for the next 2 years. This case highlights the importance of considering appendiceal malignancy in patients with abdominal pain and weight loss, despite the rarity of the disease. It also emphasizes the need for careful monitoring due to the possible complications associated with these tumors. Treatment and prognosis for appendiceal neoplasms depend on the histopathologic characteristics, tumor-nodes-metastasis stage, tumor grade, and presence of peritoneal disease.
{"title":"Appendiceal mucinous neoplasm in adolescence: Diagnosis, management, and surveillance.","authors":"Andrew Farrar, Paola Blanco, Abigail Fabbrini, Lindsey Armstrong, Jonathan Metts, Hector Monforte, Sara Karjoo, Paul Danielson, Michael Wilsey","doi":"10.1002/jpr3.12017","DOIUrl":"10.1002/jpr3.12017","url":null,"abstract":"<p><p>This case report describes a 17-year-old patient with a low-grade appendiceal mucinous neoplasm. The patient presented with non-bloody diarrhea, abdominal pain, and weight loss. A colonoscopy revealed a cecal polypoid mass that required laparoscopic surgery. The residual appendix was dilated with myxoglobulosis and histopathology confirmed the diagnosis of a low-grade appendiceal mucinous neoplasm staged pT3Nx. The potential risk of pseudomyxoma peritonei is a serious complication of these tumors. Surveillance plans include computed tomography abdomen and pelvis, and tumor markers every 6 months for the next 2 years. This case highlights the importance of considering appendiceal malignancy in patients with abdominal pain and weight loss, despite the rarity of the disease. It also emphasizes the need for careful monitoring due to the possible complications associated with these tumors. Treatment and prognosis for appendiceal neoplasms depend on the histopathologic characteristics, tumor-nodes-metastasis stage, tumor grade, and presence of peritoneal disease.</p>","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 1","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-27eCollection Date: 2024-02-01DOI: 10.1002/jpr3.12019
Geoffrey Daves, Aakash Goyal, Shannon Kelley
{"title":"Are we in the GI tract? Trachealization of the esophagus in a 10-year-old boy without eosinophilic esophagitis.","authors":"Geoffrey Daves, Aakash Goyal, Shannon Kelley","doi":"10.1002/jpr3.12019","DOIUrl":"10.1002/jpr3.12019","url":null,"abstract":"","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"5 1","pages":"93-94"},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Berger, Ayelet Gavri, Stuart Jesin, Tzipi Strauss, Batia Weiss
Umbilical venous catheters are commonly inserted in critically ill newborns and can lead to severe complications when misplaced. We report a preterm female with a prenatal diagnosis of duodenal atresia who presented 2 days after the surgical repair with abdominal distension, hemodynamic instability, elevated liver enzymes with severe cholestatic jaundice, and a hepatic collection on abdominal sonography. An urgent explorative laparotomy demonstrated a large amount of white, milky‐appearing fluid in the abdominal cavity. Together with the sonographic findings, this led to the diagnosis of hepatic total parenteral nutrition extravasation. Upon removal of the umbilical venous catheter line, the infant's clinical state rapidly improved; however, cholestasis continued for months, with a very slow resolution. During follow‐up, the liver enzymes normalized, and a complete resolution of the liver collection was observed, without drainage.
{"title":"Hepatic extravasation of total parenteral nutrition following umbilical venous catheter insertion: A rare complication","authors":"T. Berger, Ayelet Gavri, Stuart Jesin, Tzipi Strauss, Batia Weiss","doi":"10.1002/jpr3.12031","DOIUrl":"https://doi.org/10.1002/jpr3.12031","url":null,"abstract":"Umbilical venous catheters are commonly inserted in critically ill newborns and can lead to severe complications when misplaced. We report a preterm female with a prenatal diagnosis of duodenal atresia who presented 2 days after the surgical repair with abdominal distension, hemodynamic instability, elevated liver enzymes with severe cholestatic jaundice, and a hepatic collection on abdominal sonography. An urgent explorative laparotomy demonstrated a large amount of white, milky‐appearing fluid in the abdominal cavity. Together with the sonographic findings, this led to the diagnosis of hepatic total parenteral nutrition extravasation. Upon removal of the umbilical venous catheter line, the infant's clinical state rapidly improved; however, cholestasis continued for months, with a very slow resolution. During follow‐up, the liver enzymes normalized, and a complete resolution of the liver collection was observed, without drainage.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"14 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlijn Mussies, Gilles Duvoisin, Angela Le, S. Birro, Sarah Hulbert, Taher I. Omari, M. A. Benninga, M. V. van Wijk, U. Krishnan
Abnormalities of gastric function in children with esophageal atresia (EA) could potentially contribute to gastrointestinal symptoms and reduced quality of life (QOL). Therefore, we aimed to determine the feasibility and clinical usefulness of gastric function testing in children with EA.The validated PedsQL Gastrointestinal Symptoms Questionnaire (PedsQL‐GI) was completed to assess gastrointestinal symptoms and symptom‐related QOL. Gastric emptying and gastric myoelectrical activity were studied using 13C‐gastric emptying octanoic acid breath test (13C‐GEBT) and surface electrogastrography (EGG). Correlations between 13C‐GEBT and EGG parameters and PedsQL‐GI scores were investigated.Fifteen patients (four males) were included (median age: 6 [3.0–8.5] years). Mean PedsQL‐GI scores as reported by the children were comparable to the healthy population. However, parents reported a diminished QOL. Gastric function tests (gastric emptying and/or surface EGG) showed abnormalities in 12 patients (80%). Patients with abnormal slow waves showed abnormal gastric emptying coefficient more often. There was no significant association between 13C‐GEBT nor EGG results and PedsQL‐GI scores.13C‐GEBT and EGG can be used to evaluate gastric function in patients with EA. Abnormal gastric function tests were present in 80% of our cohort. However, abnormal gastric function did not significantly correlate with reported gastrointestinal symptom‐related QOL.
{"title":"Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study","authors":"Carlijn Mussies, Gilles Duvoisin, Angela Le, S. Birro, Sarah Hulbert, Taher I. Omari, M. A. Benninga, M. V. van Wijk, U. Krishnan","doi":"10.1002/jpr3.12021","DOIUrl":"https://doi.org/10.1002/jpr3.12021","url":null,"abstract":"Abnormalities of gastric function in children with esophageal atresia (EA) could potentially contribute to gastrointestinal symptoms and reduced quality of life (QOL). Therefore, we aimed to determine the feasibility and clinical usefulness of gastric function testing in children with EA.The validated PedsQL Gastrointestinal Symptoms Questionnaire (PedsQL‐GI) was completed to assess gastrointestinal symptoms and symptom‐related QOL. Gastric emptying and gastric myoelectrical activity were studied using 13C‐gastric emptying octanoic acid breath test (13C‐GEBT) and surface electrogastrography (EGG). Correlations between 13C‐GEBT and EGG parameters and PedsQL‐GI scores were investigated.Fifteen patients (four males) were included (median age: 6 [3.0–8.5] years). Mean PedsQL‐GI scores as reported by the children were comparable to the healthy population. However, parents reported a diminished QOL. Gastric function tests (gastric emptying and/or surface EGG) showed abnormalities in 12 patients (80%). Patients with abnormal slow waves showed abnormal gastric emptying coefficient more often. There was no significant association between 13C‐GEBT nor EGG results and PedsQL‐GI scores.13C‐GEBT and EGG can be used to evaluate gastric function in patients with EA. Abnormal gastric function tests were present in 80% of our cohort. However, abnormal gastric function did not significantly correlate with reported gastrointestinal symptom‐related QOL.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"53 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138957188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Liaw, Jason Park, Bradley Barth, Jacobo Santolaya
Filiform polyposis (FP) is a morphologic variant of pseudopolyposis associated with inflammatory conditions of the gastrointestinal tract, namely, inflammatory bowel disease. Pediatric cases are uncommon in the literature. Here, we present a pediatric patient with FP arising from ulcerative colitis (UC). He initially presented at 7 years of age for an acute UC flare and was found to have classical pseudopolyposis. A follow‐up colonoscopy at age 9 showed the evolution of classical pseudopolyposis to FP. The patient clinically improved with sulfasalazine monotherapy and remained in remission based on consistent pediatric ulcerative colitis activity index scores of zero and normal‐range inflammatory markers. Repeat surveillance colonoscopy at age 14 showed persistent and diffuse FP in the background of healthy colonic mucosa. This case documents the development of FP from classical pseudopolyps in the setting of an asymptomatic patient in clinical remission.
{"title":"Evolution of filiform polyposis from classical pseudopolyposis in a pediatric ulcerative colitis patient","authors":"Victor Liaw, Jason Park, Bradley Barth, Jacobo Santolaya","doi":"10.1002/jpr3.12020","DOIUrl":"https://doi.org/10.1002/jpr3.12020","url":null,"abstract":"Filiform polyposis (FP) is a morphologic variant of pseudopolyposis associated with inflammatory conditions of the gastrointestinal tract, namely, inflammatory bowel disease. Pediatric cases are uncommon in the literature. Here, we present a pediatric patient with FP arising from ulcerative colitis (UC). He initially presented at 7 years of age for an acute UC flare and was found to have classical pseudopolyposis. A follow‐up colonoscopy at age 9 showed the evolution of classical pseudopolyposis to FP. The patient clinically improved with sulfasalazine monotherapy and remained in remission based on consistent pediatric ulcerative colitis activity index scores of zero and normal‐range inflammatory markers. Repeat surveillance colonoscopy at age 14 showed persistent and diffuse FP in the background of healthy colonic mucosa. This case documents the development of FP from classical pseudopolyps in the setting of an asymptomatic patient in clinical remission.","PeriodicalId":501015,"journal":{"name":"JPGN reports","volume":"84 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：