Pub Date : 2024-08-22DOI: 10.1016/j.oooo.2024.08.012
John K. Brooks DDS, Youstina Hanna, Amer Al-mefleh
Stiff person spectrum disorder (SPSD) is a rare progressive autoimmune neuromuscular syndrome, primarily resulting in severely painful spasms and rigidity of the axial and appendicular musculature. Affected individuals are predisposed to develop an array of other neuropathies, including cerebellar ataxia and seizure activity, ophthalmologic abnormalities, and other autoimmune-based systemic diseases, notably type 1 diabetes mellitus, thyroiditis, pernicious anemia, and malignancy. Limited information exists in the oral medicine literature regarding SPSD. Thus, the objective of this paper is to review the clinicopathologic features of SPSD, with particular emphasis on head and neck involvement. Additionally, clinical guidelines for dental management of affected individuals and a summary of surgical procedures and outcomes performed in the head and neck are provided. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
{"title":"Stiff person spectrum disorder: overview with emphasis on head and neck comorbidities","authors":"John K. Brooks DDS, Youstina Hanna, Amer Al-mefleh","doi":"10.1016/j.oooo.2024.08.012","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.012","url":null,"abstract":"Stiff person spectrum disorder (SPSD) is a rare progressive autoimmune neuromuscular syndrome, primarily resulting in severely painful spasms and rigidity of the axial and appendicular musculature. Affected individuals are predisposed to develop an array of other neuropathies, including cerebellar ataxia and seizure activity, ophthalmologic abnormalities, and other autoimmune-based systemic diseases, notably type 1 diabetes mellitus, thyroiditis, pernicious anemia, and malignancy. Limited information exists in the oral medicine literature regarding SPSD. Thus, the objective of this paper is to review the clinicopathologic features of SPSD, with particular emphasis on head and neck involvement. Additionally, clinical guidelines for dental management of affected individuals and a summary of surgical procedures and outcomes performed in the head and neck are provided. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-21DOI: 10.1016/j.oooo.2024.08.001
Zhuoxuan Chen MD, Yingying Hong PhD, Zhenni Zhao MD, Ningxiang Wu MD, Xiaokun Ma MD, Linlin Chen PhD, Ran Zhang PhD
Laser capture microdissection (LCM) was used to pinpoint the mutated tissue in ameloblastoma and investigate whether B-Raf proto-oncogene, serine/threonine kinase ( mutation is the main pathogenic gene in classic ameloblastoma. A total of 24 patients with ameloblastoma scheduled to undergo surgery between 2000 and 2024 were included in the study. LCM was used to isolate tumor cells. Oxford nanopore technology (ONT) was used to analyze the collected cells. GO and KEGG enrichment analyses were then performed on the 300 most highly expressed genes in the epithelial tissue and mesenchyme. Mandibular follicular ameloblastoma showed V600E mutations in all epithelial cells but not in the mesenchyme. The mutation rate was significantly higher in mandibular ameloblastomas compared to the maxilla ( < .05). RNA-seq showed that traditional follicular ameloblastoma epithelium was enriched in “growth factor receptor binding” and “angiogenesis regulation,” while the mesenchyme was enriched in “ECM receptor interaction.” KEGG enrichment analysis showed differential gene expression, mainly in MAPK and PI3K-AKT pathways. Classical follicular ameloblastoma shows the presence of V600E mutation in epithelial tissue, with a higher mutation rate in the mandible than in the maxilla. The signaling pathways of MAPK and PI3K may be significantly involved in epithelial signal transduction.
{"title":"Differences in BRAF V600E mutation between the epithelium and mesenchyme in classic ameloblastoma","authors":"Zhuoxuan Chen MD, Yingying Hong PhD, Zhenni Zhao MD, Ningxiang Wu MD, Xiaokun Ma MD, Linlin Chen PhD, Ran Zhang PhD","doi":"10.1016/j.oooo.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.001","url":null,"abstract":"Laser capture microdissection (LCM) was used to pinpoint the mutated tissue in ameloblastoma and investigate whether B-Raf proto-oncogene, serine/threonine kinase ( mutation is the main pathogenic gene in classic ameloblastoma. A total of 24 patients with ameloblastoma scheduled to undergo surgery between 2000 and 2024 were included in the study. LCM was used to isolate tumor cells. Oxford nanopore technology (ONT) was used to analyze the collected cells. GO and KEGG enrichment analyses were then performed on the 300 most highly expressed genes in the epithelial tissue and mesenchyme. Mandibular follicular ameloblastoma showed V600E mutations in all epithelial cells but not in the mesenchyme. The mutation rate was significantly higher in mandibular ameloblastomas compared to the maxilla ( < .05). RNA-seq showed that traditional follicular ameloblastoma epithelium was enriched in “growth factor receptor binding” and “angiogenesis regulation,” while the mesenchyme was enriched in “ECM receptor interaction.” KEGG enrichment analysis showed differential gene expression, mainly in MAPK and PI3K-AKT pathways. Classical follicular ameloblastoma shows the presence of V600E mutation in epithelial tissue, with a higher mutation rate in the mandible than in the maxilla. The signaling pathways of MAPK and PI3K may be significantly involved in epithelial signal transduction.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-21DOI: 10.1016/j.oooo.2024.07.016
Thaís Cristina Esteves Pereira DDS, Erison Santana dos Santos DDS MSc, João Adolfo Costa Hanemann DDS MSc PhD, Pablo Agustin Vargas DDS MSc PhD FRCPath, Márcio Ajudarte Lopes DDS MSc PhD, Willie F.P. van Heerden BChD MChD FC Path SA PhD DSc MASSAf, Caroline Bissonnette DMD MS, René Luis Panico DDS PhD, Wilfredo Alejandro González-Arriagada DDS MSc PhD, Mario Nava-Villalba DDS PhD, Karen Patricia Domínguez Gallagher DDS MSc PhD, Ronell Bologna Molina DDS PhD, Cristina Saldivia-Siracusa DDS MSc, Paswach Wiriyakijja DDS MSc PhD, Raghu Anekal Radhakrishnan MDS PhD, Arwa Mohammad Farag BDS DMSc Dip ABOM Dip ABOP FDS RCSEd, Toru Nagao DDS DMSc PhD, Yu-Feng Huang DDS MSD PhD, Richeal Ni Riordain MBBS BDS MA PhD MFD FFD FDSOM, Márcio Diniz-Freitas DDS PhD, Hélios Bertin MD PhD, Camile S. Farah BDSc MDSc OralMed OralPath PhD FRACDS OralMed, Adalberto Mosqueda-Taylor DDS MSc, Danyel Elias da Cruz Perez DDS MSc PhD, Keith David Hunter BSc BDS FDSRCSEd PhD FRCPath FHEA, Alessandro Villa DDS MSc PhD, Alan Roger Santos-Silva DDS MSc PhD FAAOM
To describe the historical evolution and dissemination of the Oral Medicine and Oral and Maxillofacial Pathology international societies and associations across the globe, and to provide insights into their significant contributions toward oral health promotion. This review was conducted in accordance with the JBI Scoping Review Methodology Group guidance. The reporting followed the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews (PRISMA-ScR). Search strategy was applied to 5 databases (MEDLINE/PubMed, Scopus, Embase, Web of Science, Latin American and Caribbean Health Sciences (LILACS)) and grey literature (Google Scholar, Open Grey and ProQuest), as well as additional sources, such as organization websites. Eighty-nine sources were included in this review. Forty-six professional associations/societies were identified, of which 39 represented a country or geopolitical region, 2 represented continents, 2 represented multinational organizations and 3 multinational study groups. Documentation of the historical establishment and development of Oral Medicine and Oral and Maxillofacial Pathology organizations worldwide is limited and describing these processes remains challenging. Analysis of global data reveals heterogeneous development and distribution, resulting in disparities in accessibility and standardization. Further efforts toward oral health promotion should be implemented.
{"title":"Mapping oral medicine (stomatology) & oral and maxillofacial pathology international organizations: a scoping review of global data and historical analysis","authors":"Thaís Cristina Esteves Pereira DDS, Erison Santana dos Santos DDS MSc, João Adolfo Costa Hanemann DDS MSc PhD, Pablo Agustin Vargas DDS MSc PhD FRCPath, Márcio Ajudarte Lopes DDS MSc PhD, Willie F.P. van Heerden BChD MChD FC Path SA PhD DSc MASSAf, Caroline Bissonnette DMD MS, René Luis Panico DDS PhD, Wilfredo Alejandro González-Arriagada DDS MSc PhD, Mario Nava-Villalba DDS PhD, Karen Patricia Domínguez Gallagher DDS MSc PhD, Ronell Bologna Molina DDS PhD, Cristina Saldivia-Siracusa DDS MSc, Paswach Wiriyakijja DDS MSc PhD, Raghu Anekal Radhakrishnan MDS PhD, Arwa Mohammad Farag BDS DMSc Dip ABOM Dip ABOP FDS RCSEd, Toru Nagao DDS DMSc PhD, Yu-Feng Huang DDS MSD PhD, Richeal Ni Riordain MBBS BDS MA PhD MFD FFD FDSOM, Márcio Diniz-Freitas DDS PhD, Hélios Bertin MD PhD, Camile S. Farah BDSc MDSc OralMed OralPath PhD FRACDS OralMed, Adalberto Mosqueda-Taylor DDS MSc, Danyel Elias da Cruz Perez DDS MSc PhD, Keith David Hunter BSc BDS FDSRCSEd PhD FRCPath FHEA, Alessandro Villa DDS MSc PhD, Alan Roger Santos-Silva DDS MSc PhD FAAOM","doi":"10.1016/j.oooo.2024.07.016","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.07.016","url":null,"abstract":"To describe the historical evolution and dissemination of the Oral Medicine and Oral and Maxillofacial Pathology international societies and associations across the globe, and to provide insights into their significant contributions toward oral health promotion. This review was conducted in accordance with the JBI Scoping Review Methodology Group guidance. The reporting followed the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews (PRISMA-ScR). Search strategy was applied to 5 databases (MEDLINE/PubMed, Scopus, Embase, Web of Science, Latin American and Caribbean Health Sciences (LILACS)) and grey literature (Google Scholar, Open Grey and ProQuest), as well as additional sources, such as organization websites. Eighty-nine sources were included in this review. Forty-six professional associations/societies were identified, of which 39 represented a country or geopolitical region, 2 represented continents, 2 represented multinational organizations and 3 multinational study groups. Documentation of the historical establishment and development of Oral Medicine and Oral and Maxillofacial Pathology organizations worldwide is limited and describing these processes remains challenging. Analysis of global data reveals heterogeneous development and distribution, resulting in disparities in accessibility and standardization. Further efforts toward oral health promotion should be implemented.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.oooo.2024.08.010
Petros Yoon DDS, Brittany Klein DDS, Lama Alabdulaaly BDS DMSc, Abdulrahman Nakshabandi BDS, Mandlin Almousa DDS, Laurel Henderson DDS, Malak Al-Hadlaq BDS DMSc, Amal Bajonaid BDS DMSc, Piamkamon Vacharotayangul DDS PhD, Nathaniel Treister DMD DMSc, Stephen Sonis DMD DMSc
The objective of this study was to characterize the current oral medicine (OM) workforce by examining the distribution of OM diplomates (OMDs) across the Unites States and to determine the need for expanding access to care. The OMD access was calculated based on the OMDs per 10,000 state population from the 2020 US Census data as well as their distance from state capitals and most populated cities. OMD penetrance in hospitals and cancer centers was assessed at National Cancer Care Network (NCCN) cancer centers, and Best Hospitals as reported in the 2022 US News and World Report (USNWR). OMDs are present in 64% of the states with an uneven geographic distribution. Primary workplaces included dental schools (47%), hospitals (30%), and private practices (19%). Of the OMDs in private practice, 57% limited their practice to OM. OMDs were noted at 28% of NCCN cancer centers, 30% of USNWR Best Hospitals for Cancer, and 20% of USNWR Best Hospitals. There is low density and uneven distribution of OMDs with approximately one-third of the population without access to an OMD in their state, thus limiting access to care. This suggests both vast opportunities for growth and expansion of OM, as well as challenges in developing and training the necessary workforce. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
{"title":"The Oral Medicine workforce and impact on access to care in the United States","authors":"Petros Yoon DDS, Brittany Klein DDS, Lama Alabdulaaly BDS DMSc, Abdulrahman Nakshabandi BDS, Mandlin Almousa DDS, Laurel Henderson DDS, Malak Al-Hadlaq BDS DMSc, Amal Bajonaid BDS DMSc, Piamkamon Vacharotayangul DDS PhD, Nathaniel Treister DMD DMSc, Stephen Sonis DMD DMSc","doi":"10.1016/j.oooo.2024.08.010","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.010","url":null,"abstract":"The objective of this study was to characterize the current oral medicine (OM) workforce by examining the distribution of OM diplomates (OMDs) across the Unites States and to determine the need for expanding access to care. The OMD access was calculated based on the OMDs per 10,000 state population from the 2020 US Census data as well as their distance from state capitals and most populated cities. OMD penetrance in hospitals and cancer centers was assessed at National Cancer Care Network (NCCN) cancer centers, and Best Hospitals as reported in the 2022 US News and World Report (USNWR). OMDs are present in 64% of the states with an uneven geographic distribution. Primary workplaces included dental schools (47%), hospitals (30%), and private practices (19%). Of the OMDs in private practice, 57% limited their practice to OM. OMDs were noted at 28% of NCCN cancer centers, 30% of USNWR Best Hospitals for Cancer, and 20% of USNWR Best Hospitals. There is low density and uneven distribution of OMDs with approximately one-third of the population without access to an OMD in their state, thus limiting access to care. This suggests both vast opportunities for growth and expansion of OM, as well as challenges in developing and training the necessary workforce. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.oooo.2024.08.008
Edson Luiz Cetira-Filho DDS MSc PhD, Paulo Goberlânio de Barros Silva DDS MSc PhD, Isabelle de Fátima Vieira Camelo Maia CP, Deysi Viviana Tenazoa Wong MSc PhD, Roberto César Pereira Lima-Júnior Sc PhD, Ravy Jucá Farias DDS, Mayara Alves dos Anjos DDS student, Said Goncalves da Cruz Fonseca CP MSc PhD, Thyciana Rodrigues Ribeiro DDS MSc PhD, Fábio Wildson Gurgel Costa DDS MSc PhD
To compare the effect of different preemptive and preventive analgesia strategies involving oral coadministration of ibuprofen-arginine (770 mg)–Ib-Ar and dexamethasone (8 mg)-DX, and their respective placebos (P-Ib-Ar and P-DX), four evaluation groups on inflammatory and laboratory parameters, impact on quality of life, pain catastrophizing perception and sleep quality related after lower third molar surgery. A randomized split-mouth, triple-blind, controlled clinical trial was conducted with 48 volunteers. They were allocated depending on the use of Ib-Ar or DX, 1 hour before surgery or immediately postoperatively, discriminating the groups: G1 (Ib-Ar + DX), G2 (Ib-Ar + P-DX), G3 (P-Ib-Ar + DX), and G4 (P-Ib-Ar + P-DX). Pain peaks occurred after 2 h (P-Ib-Ar groups) ( = .003), while the other groups showed peak pain after 4 h ( < .05). Regarding the edema: groups treated with placebos measurements significantly reduced without returning to baseline ( < .001). Regarding laboratory parameters: MPO and MDA levels, the G1 group ( < .001) was the only one showing significant reduction. The use of preemptive and preventive analgesia strategies of Ib-Ar and DX showed that the combined use delayed peak pain, with no difference in edema and trismus. The benefit of coadministration of both strategies was superior to isolated use of drugs.
{"title":"Preemptive vs preventive coadministration of ibuprofen L-arginine and dexamethasone in lower third molar surgeries: a randomized controlled trial","authors":"Edson Luiz Cetira-Filho DDS MSc PhD, Paulo Goberlânio de Barros Silva DDS MSc PhD, Isabelle de Fátima Vieira Camelo Maia CP, Deysi Viviana Tenazoa Wong MSc PhD, Roberto César Pereira Lima-Júnior Sc PhD, Ravy Jucá Farias DDS, Mayara Alves dos Anjos DDS student, Said Goncalves da Cruz Fonseca CP MSc PhD, Thyciana Rodrigues Ribeiro DDS MSc PhD, Fábio Wildson Gurgel Costa DDS MSc PhD","doi":"10.1016/j.oooo.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.008","url":null,"abstract":"To compare the effect of different preemptive and preventive analgesia strategies involving oral coadministration of ibuprofen-arginine (770 mg)–Ib-Ar and dexamethasone (8 mg)-DX, and their respective placebos (P-Ib-Ar and P-DX), four evaluation groups on inflammatory and laboratory parameters, impact on quality of life, pain catastrophizing perception and sleep quality related after lower third molar surgery. A randomized split-mouth, triple-blind, controlled clinical trial was conducted with 48 volunteers. They were allocated depending on the use of Ib-Ar or DX, 1 hour before surgery or immediately postoperatively, discriminating the groups: G1 (Ib-Ar + DX), G2 (Ib-Ar + P-DX), G3 (P-Ib-Ar + DX), and G4 (P-Ib-Ar + P-DX). Pain peaks occurred after 2 h (P-Ib-Ar groups) ( = .003), while the other groups showed peak pain after 4 h ( < .05). Regarding the edema: groups treated with placebos measurements significantly reduced without returning to baseline ( < .001). Regarding laboratory parameters: MPO and MDA levels, the G1 group ( < .001) was the only one showing significant reduction. The use of preemptive and preventive analgesia strategies of Ib-Ar and DX showed that the combined use delayed peak pain, with no difference in edema and trismus. The benefit of coadministration of both strategies was superior to isolated use of drugs.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-16DOI: 10.1016/j.oooo.2024.08.009
Renata C. Campelo DDS MSc, Bruno B. Benatti DDS PhD, Joana A.B. de Sousa DDS MSc, Gilvan C. Nascimento MD PhD, Rossana S.S. Azulay MD PhD, Manuel dos S. Faria MD PhD, Marcelo Magalhães PhD, Vandilson P. Rodrigues DDS PhD
To investigate the stimulated salivary flow (SSF) and unstimulated salivary flow (USF) in adults with acromegaly and to identify possible clinical factors associated with salivary flow. A case-control study was conducted with a group composed of adults diagnosed with acromegaly (n = 29, mean age = 50.2 years) and a control group (n = 29, mean age = 54.3 years). Variables for socio-demographic characterization, lifestyle habits, and diabetes diagnosis, body mass index (BMI), cervical circumference (CC) and abdominal circumference (AC) were collected. USF and SSF variables were analyzed as outcomes. Unpaired t-test, Pearson's correlation, and multivariate regression models were used for statistical analysis. Both groups were 44.8% male and 55.2% female. Diabetes was present in 55.2% of the acromegaly group and in 51.7% of the controls ( = .792). The acromegaly group had a higher USF than the control group (0.50 mL/min versus 0.22 mL/min). SSF showed a direct correlation with CC (r = 0.470, = .010). Acromegaly was associated with higher USF (standardized coefficient = 0.780, = .039), and age was inversely related to USF (standardized coefficient = −0.333, = .013). The findings suggest that adults with acromegaly have an increased USF and that being older is associated with a decrease in USF.
{"title":"Clinical factors associated with salivary flow rate in adults with acromegaly","authors":"Renata C. Campelo DDS MSc, Bruno B. Benatti DDS PhD, Joana A.B. de Sousa DDS MSc, Gilvan C. Nascimento MD PhD, Rossana S.S. Azulay MD PhD, Manuel dos S. Faria MD PhD, Marcelo Magalhães PhD, Vandilson P. Rodrigues DDS PhD","doi":"10.1016/j.oooo.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.009","url":null,"abstract":"To investigate the stimulated salivary flow (SSF) and unstimulated salivary flow (USF) in adults with acromegaly and to identify possible clinical factors associated with salivary flow. A case-control study was conducted with a group composed of adults diagnosed with acromegaly (n = 29, mean age = 50.2 years) and a control group (n = 29, mean age = 54.3 years). Variables for socio-demographic characterization, lifestyle habits, and diabetes diagnosis, body mass index (BMI), cervical circumference (CC) and abdominal circumference (AC) were collected. USF and SSF variables were analyzed as outcomes. Unpaired t-test, Pearson's correlation, and multivariate regression models were used for statistical analysis. Both groups were 44.8% male and 55.2% female. Diabetes was present in 55.2% of the acromegaly group and in 51.7% of the controls ( = .792). The acromegaly group had a higher USF than the control group (0.50 mL/min versus 0.22 mL/min). SSF showed a direct correlation with CC (r = 0.470, = .010). Acromegaly was associated with higher USF (standardized coefficient = 0.780, = .039), and age was inversely related to USF (standardized coefficient = −0.333, = .013). The findings suggest that adults with acromegaly have an increased USF and that being older is associated with a decrease in USF.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-16DOI: 10.1016/j.oooo.2024.08.007
Sangeetha Yogarajah BDS, Fiona Tasker MBBS IntBSc MRCP PGDip, Barbara Carey MB BCh BAO BDS FDS (OM) RCSI, Fiona Lewis MD FRCP
The oral cavity is a common site for mucosal conditions which may be confined to the mouth, or may manifest as mucocutaneous involvement at other sites, including the anogenital region. This retrospective analysis aimed to assess the appropriateness of oral medicine referrals to a specialized vulval clinic and review the prevalence of oral disease associated with vulval involvement of the same condition. One hundred thirty-six patients referred from oral medicine to the vulval service at Guy's Hospital were analyzed. Retrospective data collated included: reason(s) for referral, onset of oral and genital symptoms, oral diagnosis, vulval diagnosis, correlation between the oral and vulval diagnosis, and discharge at first appointment. Forty-nine percent (n = 67) of the patients had oral and vulval manifestations of the same disease. The majority of these patients (n = 63) were diagnosed with vulval lichen planus, of whom 61 had concomitant oral lichen planus involvement (97%). Other associated oral and vulval diseases included aphthous ulceration, Behçet's disease, dryness secondary to Sjögren's disease, Crohn's disease, and mucous membrane pemphigoid. The remaining 51% (n = 69) of the patients presented with independent vulval conditions unrelated to their oral disease. Clinicians should recognize the association between genital symptoms and oral disease and refer to specialist allied services, as appropriate. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
{"title":"Oral and vulval disease: Prevalence, associations, and management recommendations for the oral medicine clinician","authors":"Sangeetha Yogarajah BDS, Fiona Tasker MBBS IntBSc MRCP PGDip, Barbara Carey MB BCh BAO BDS FDS (OM) RCSI, Fiona Lewis MD FRCP","doi":"10.1016/j.oooo.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.007","url":null,"abstract":"The oral cavity is a common site for mucosal conditions which may be confined to the mouth, or may manifest as mucocutaneous involvement at other sites, including the anogenital region. This retrospective analysis aimed to assess the appropriateness of oral medicine referrals to a specialized vulval clinic and review the prevalence of oral disease associated with vulval involvement of the same condition. One hundred thirty-six patients referred from oral medicine to the vulval service at Guy's Hospital were analyzed. Retrospective data collated included: reason(s) for referral, onset of oral and genital symptoms, oral diagnosis, vulval diagnosis, correlation between the oral and vulval diagnosis, and discharge at first appointment. Forty-nine percent (n = 67) of the patients had oral and vulval manifestations of the same disease. The majority of these patients (n = 63) were diagnosed with vulval lichen planus, of whom 61 had concomitant oral lichen planus involvement (97%). Other associated oral and vulval diseases included aphthous ulceration, Behçet's disease, dryness secondary to Sjögren's disease, Crohn's disease, and mucous membrane pemphigoid. The remaining 51% (n = 69) of the patients presented with independent vulval conditions unrelated to their oral disease. Clinicians should recognize the association between genital symptoms and oral disease and refer to specialist allied services, as appropriate. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-09DOI: 10.1016/j.oooo.2024.07.012
Yulang Xu BDS, Hanyao Huang MD, Chao Yang MSc, Yang Li MD, Chenghao Li MD, Bing Shi MD, Jingtao Li MD, Yan Wang MD, Qian Zheng MD, Ni Zeng MD
To improve medical students’ preclinical skills and enable them to quickly comprehend the procedure of posterior pharyngeal flap surgery, our teaching team developed a surgical simulator specifically for pharyngeal flap surgery. Thirteen undergraduate students and 8 first-year residents trained from March to May 2023 participated in simulated surgical training. Initially, multimedia were used to explain and demonstrate to them relevant anatomy, surgical principles, and procedural steps. This was followed by independent simulated surgeries by the students, culminating in the completion of a questionnaire. Independent samples test was used for statistical analysis. Before the simulated surgery, the residents had a greater understanding of the surgical design compared with the undergraduate students. After the simulated surgery, the residents showed not only significantly greater levels of understanding of the surgical design but also increased familiarity with the surgical process and enhanced confidence in independent surgery compared with the undergraduate students. Both groups showed a notable increase in familiarity with the surgical process and confidence in performing surgery independently after the simulated surgery. The surgical simulator demonstrates high clinical fidelity and provides tactile feedback that closely resembles reality. It significantly enhances the understanding and mastery of surgical techniques for young doctors, ultimately improving their surgical skills.
{"title":"Efficacy evaluation of a high-precision simulator of posterior pharyngeal flap pharyngoplasty","authors":"Yulang Xu BDS, Hanyao Huang MD, Chao Yang MSc, Yang Li MD, Chenghao Li MD, Bing Shi MD, Jingtao Li MD, Yan Wang MD, Qian Zheng MD, Ni Zeng MD","doi":"10.1016/j.oooo.2024.07.012","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.07.012","url":null,"abstract":"To improve medical students’ preclinical skills and enable them to quickly comprehend the procedure of posterior pharyngeal flap surgery, our teaching team developed a surgical simulator specifically for pharyngeal flap surgery. Thirteen undergraduate students and 8 first-year residents trained from March to May 2023 participated in simulated surgical training. Initially, multimedia were used to explain and demonstrate to them relevant anatomy, surgical principles, and procedural steps. This was followed by independent simulated surgeries by the students, culminating in the completion of a questionnaire. Independent samples test was used for statistical analysis. Before the simulated surgery, the residents had a greater understanding of the surgical design compared with the undergraduate students. After the simulated surgery, the residents showed not only significantly greater levels of understanding of the surgical design but also increased familiarity with the surgical process and enhanced confidence in independent surgery compared with the undergraduate students. Both groups showed a notable increase in familiarity with the surgical process and confidence in performing surgery independently after the simulated surgery. The surgical simulator demonstrates high clinical fidelity and provides tactile feedback that closely resembles reality. It significantly enhances the understanding and mastery of surgical techniques for young doctors, ultimately improving their surgical skills.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-09DOI: 10.1016/j.oooo.2024.08.005
Luiz Eduardo Marinho-Vieira, Maria Clara Rodrigues Pinheiro, Deborah Queiroz Freitas, Reinhilde Jacobs, Christiano de Oliveira-Santos, Alexander Tadeu Sverzut, Matheus L. Oliveira
To investigate the reliability of gingival thickness measurements obtained from the registration of intraoral scans with cone beam computed tomography (CBCT) examinations at different acquisition modes. CBCT examinations of 9 porcine hemimandibles were acquired using the OP300 Maxio unit operating at the highest-dose protocol with the smallest voxel size as the reference standard for visualizing the gingival surface. Subsequently, the hemimandibles were surrounded by water to simulate soft tissue attenuation of radiation, and additional CBCT examinations were acquired in 4 modes: Endo, High-resolution, Standard-resolution, and Low-dose. These CBCT datasets were registered with corresponding intraoral scans obtained with the Carestream Dental 3600 intraoral scanning system using the Blue Sky Plan 4 software. Four oral radiologists measured the buccal gingival thickness on cross-sectional reconstructions at 4 measurement sites and 2 distances from the gingival margin in the CBCT reference standard examinations and examinations obtained with water and intraoral scan registration. Multifactorial analysis of variance was used to assess the influence of acquisition mode, measurement site, and distance from the gingival margin on measurements (α = 5%; statistical power = 90%). Buccal gingival thickness measurements obtained via CBCT after registration with intraoral scanning were not significantly influenced by acquisition mode ( = .153) or measurement site ( = .089). Gingival thickness measurements derived from the registration of intraoral scans with CBCT examinations at different acquisition modes appear to be reliable.
{"title":"Evaluation of gingival thickness obtained from intraoral scanning registration with cone beam computed tomography at different acquisition modes","authors":"Luiz Eduardo Marinho-Vieira, Maria Clara Rodrigues Pinheiro, Deborah Queiroz Freitas, Reinhilde Jacobs, Christiano de Oliveira-Santos, Alexander Tadeu Sverzut, Matheus L. Oliveira","doi":"10.1016/j.oooo.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.005","url":null,"abstract":"To investigate the reliability of gingival thickness measurements obtained from the registration of intraoral scans with cone beam computed tomography (CBCT) examinations at different acquisition modes. CBCT examinations of 9 porcine hemimandibles were acquired using the OP300 Maxio unit operating at the highest-dose protocol with the smallest voxel size as the reference standard for visualizing the gingival surface. Subsequently, the hemimandibles were surrounded by water to simulate soft tissue attenuation of radiation, and additional CBCT examinations were acquired in 4 modes: Endo, High-resolution, Standard-resolution, and Low-dose. These CBCT datasets were registered with corresponding intraoral scans obtained with the Carestream Dental 3600 intraoral scanning system using the Blue Sky Plan 4 software. Four oral radiologists measured the buccal gingival thickness on cross-sectional reconstructions at 4 measurement sites and 2 distances from the gingival margin in the CBCT reference standard examinations and examinations obtained with water and intraoral scan registration. Multifactorial analysis of variance was used to assess the influence of acquisition mode, measurement site, and distance from the gingival margin on measurements (α = 5%; statistical power = 90%). Buccal gingival thickness measurements obtained via CBCT after registration with intraoral scanning were not significantly influenced by acquisition mode ( = .153) or measurement site ( = .089). Gingival thickness measurements derived from the registration of intraoral scans with CBCT examinations at different acquisition modes appear to be reliable.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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