Pub Date : 2024-09-06DOI: 10.1016/j.oooo.2024.08.014
Giovanni Salzano XXX, Simona Barone XXX, Pietro De Luca XXX, Gerardo Borriello XXX, Luigi Angelo Vaira XXX, Stefania Troise XXX, Vincenza Granata XXX, Umberto Committeri XXX, Francesco Perri XXX, Maria Esposito XXX, Fabio di Blasi XXX, Marzia Petrocelli XXX, Franco Ionna XXX, Luigi Califano XXX, Giovanni Dell'Aversana Orabona XXX, Arianna Di Stadio XXX
The aim of this study was to investigate the correlation among inflammatory biomarkers, such as the systemic immune-inflammation index (SII), the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), and the recurrence of pleomorphic adenomas (PAs).
{"title":"Predictive value of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and systemic inflammatory index for detection of recurrence of pleomorphic adenoma of the major salivary glands: a multicenter study","authors":"Giovanni Salzano XXX, Simona Barone XXX, Pietro De Luca XXX, Gerardo Borriello XXX, Luigi Angelo Vaira XXX, Stefania Troise XXX, Vincenza Granata XXX, Umberto Committeri XXX, Francesco Perri XXX, Maria Esposito XXX, Fabio di Blasi XXX, Marzia Petrocelli XXX, Franco Ionna XXX, Luigi Califano XXX, Giovanni Dell'Aversana Orabona XXX, Arianna Di Stadio XXX","doi":"10.1016/j.oooo.2024.08.014","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.014","url":null,"abstract":"The aim of this study was to investigate the correlation among inflammatory biomarkers, such as the systemic immune-inflammation index (SII), the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), and the recurrence of pleomorphic adenomas (PAs).","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-05DOI: 10.1016/j.oooo.2024.08.016
Gabriella C. Speakman DDS, Kristin K. McNamara XXX, John R. Kalmar XXX, Prokopios P. Argyris XXX
Sarcomatoid squamous cell carcinoma (sSCC) represents an uncommon histopathologic variant of squamous cell carcinoma (SCC). We examined the clinicopathologic and immunophenotypic characteristics, including SATB2 expression, of 10 cases of oral sSCCs.
{"title":"SATB2 expression in oral sarcomatoid (spindle cell) squamous cell carcinoma: clinicopathologic and immunophenotypic characterization of 10 cases","authors":"Gabriella C. Speakman DDS, Kristin K. McNamara XXX, John R. Kalmar XXX, Prokopios P. Argyris XXX","doi":"10.1016/j.oooo.2024.08.016","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.016","url":null,"abstract":"Sarcomatoid squamous cell carcinoma (sSCC) represents an uncommon histopathologic variant of squamous cell carcinoma (SCC). We examined the clinicopathologic and immunophenotypic characteristics, including SATB2 expression, of 10 cases of oral sSCCs.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-04DOI: 10.1016/j.oooo.2024.08.023
Petra Pandurevic, Ian Furst DDS MSc, Mark Roger Darling BChD MSc (Dent) MSc (Med) MChD
{"title":"Ulcerated mass and radiolucency of the left mandible","authors":"Petra Pandurevic, Ian Furst DDS MSc, Mark Roger Darling BChD MSc (Dent) MSc (Med) MChD","doi":"10.1016/j.oooo.2024.08.023","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.023","url":null,"abstract":"","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the clinical and radiological outcomes of employing collagen membranes with pouch and nonpouch techniques to repair extensive maxillary sinus membrane perforation.
评估采用胶原蛋白膜和无膜袋技术修复广泛性上颌窦膜穿孔的临床和放射学效果。
{"title":"A retrospective comparative study of extensive sinus membrane perforations repairing using collagen membranes with pouch and nonpouch techniques","authors":"Liang Xia DDS MD, Zonghe Xu DDS MD, Duohong Zou DDS PhD","doi":"10.1016/j.oooo.2024.08.019","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.019","url":null,"abstract":"To evaluate the clinical and radiological outcomes of employing collagen membranes with pouch and nonpouch techniques to repair extensive maxillary sinus membrane perforation.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claudin (CLD), a major component of tight junctions, is a four-transmembrane protein, and 24 subtypes have been reported in humans. CLD expression is highly tissue-specific; CLD1 has been reported to be expressed in the skin and mucosa. There have been few reports on CLD1 expression and its function in oral cancer.
{"title":"Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells","authors":"Tadayoshi Nobumoto DDS PhD, Sachiko Yamasaki DDS PhD, Atsuko Hamada DDS PhD, Mirai Higaki DDS PhD, Nanako Ito DDS PhD, Fumitaka Obayashi DDS PhD, Yasutaka Ishida DDS PhD, Tomoaki Hamana DDS PhD, Tomoaki Shintani DDS PhD, Ryouji Tani DDS PhD, Koichi Koizumi DDS PhD, Souichi Yanamoto DDS PhD, Yasutaka Hayashido DDS PhD","doi":"10.1016/j.oooo.2024.08.020","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.020","url":null,"abstract":"Claudin (CLD), a major component of tight junctions, is a four-transmembrane protein, and 24 subtypes have been reported in humans. CLD expression is highly tissue-specific; CLD1 has been reported to be expressed in the skin and mucosa. There have been few reports on CLD1 expression and its function in oral cancer.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-31DOI: 10.1016/j.oooo.2024.08.018
Nathaly de Oliveira Ciaramicolo DDS MS, Gabriela Barbosa Bisson DDS MS, Osny Ferreira Jr. DDS MSc
Carbolic acid or phenol is considered a chemical agent that produces intense facial rejuvenation when used correctly, however, solutions containing this substance are dangerous and their action must be controlled. The aim of this study was to collect information on the adverse effects of the use of phenolic compounds for facial esthetic purposes. Phenol promotes the denaturation and coagulation of epidermal keratin proteins, deep chemical peels carried out with phenol, when well indicated and properly conducted, produce incomparable results, however, the ignorant use of these solutions can produce ectropion, keloids, and unsightly scars on the face and neck, in addition, systemic absorption is related to hepatorenal and cardiac toxicity. Although the cardiotoxicity of phenol is well described in the literature, its carcinogenic potential is still unknown and further studies are needed. It is known that the substance induces unscheduled DNA synthesis, inducing genetic mutation. Successful results depend on a balance among art and technique and safety standards. Future research investigating the carcinogenic potential of phenol peels is desirable to ensure patient safety and adequate information for professionals. We believe that the indiscriminate use of phenol peels can cause serious problems for patients and their general health. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
石碳酸或苯酚被认为是一种化学制剂，如果使用得当，可以产生强烈的面部年轻化效果，然而，含有这种物质的溶液是危险的，其作用必须受到控制。本研究旨在收集有关将酚类化合物用于面部美容的不良影响的信息。酚会促进表皮角蛋白的变性和凝固，使用酚进行深层化学换肤，如果适应症明确且操作得当，会产生无与伦比的效果，但如果不加注意地使用这些溶液，则会在面部和颈部产生外翻、瘢痕疙瘩和难看的疤痕，此外，全身吸收还与肝肾和心脏毒性有关。虽然文献中对苯酚的心脏毒性有详细描述，但其致癌潜力尚不清楚，需要进一步研究。众所周知，该物质会诱导计划外的 DNA 合成，从而诱发基因突变。成功的结果取决于艺术和技术与安全标准之间的平衡。为了确保患者的安全和为专业人员提供足够的信息，今后最好对苯酚去皮的致癌潜力进行调查研究。我们认为，滥用苯酚换肤可对患者及其总体健康造成严重问题。(Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
{"title":"Adverse effects associated with the irresponsible use of phenol peeling - literature review","authors":"Nathaly de Oliveira Ciaramicolo DDS MS, Gabriela Barbosa Bisson DDS MS, Osny Ferreira Jr. DDS MSc","doi":"10.1016/j.oooo.2024.08.018","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.018","url":null,"abstract":"Carbolic acid or phenol is considered a chemical agent that produces intense facial rejuvenation when used correctly, however, solutions containing this substance are dangerous and their action must be controlled. The aim of this study was to collect information on the adverse effects of the use of phenolic compounds for facial esthetic purposes. Phenol promotes the denaturation and coagulation of epidermal keratin proteins, deep chemical peels carried out with phenol, when well indicated and properly conducted, produce incomparable results, however, the ignorant use of these solutions can produce ectropion, keloids, and unsightly scars on the face and neck, in addition, systemic absorption is related to hepatorenal and cardiac toxicity. Although the cardiotoxicity of phenol is well described in the literature, its carcinogenic potential is still unknown and further studies are needed. It is known that the substance induces unscheduled DNA synthesis, inducing genetic mutation. Successful results depend on a balance among art and technique and safety standards. Future research investigating the carcinogenic potential of phenol peels is desirable to ensure patient safety and adequate information for professionals. We believe that the indiscriminate use of phenol peels can cause serious problems for patients and their general health. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-31DOI: 10.1016/j.oooo.2024.08.017
Samuel D. Raffaelli DDS, Timothy W. Neal DDS MD, Jonathan J. Jelmini DDS MD, Roderick Y. Kim DDS MD MBA FACS, Fayette C. Williams DDS MD FACS
The purpose of this study was to measure the frequency of peri-implant reactive tissue development in a cohort of patients following immediate implant supported prosthetic rehabilitation in fibula free flaps at our institution and to document 2 cases of management based on our institution's experience. To address this question of study design, a case series was performed from October 2014 to May 2022. We included patients that underwent a fibula free flap reconstruction of the mandible or maxilla with immediate implant placement and dental prostheses fabrication. Forty-four patients met the inclusion criteria, and, among the participants, a total of 26 male patients (59%) and 18 female patients (41%) were evaluated, with 185 implants placed all together. Twenty patients (45%) were treated for benign pathology, 12 with malignant pathology (27%), 5 with trauma (11%), and 7 with osteoradionecrosis (16%). Postoperative peri-implant reactive tissues were seen to develop at 39 of the implant sites (21%). Reactive tissues were found to be a common complication in patients treated with fibular free flap reconstructions involving implant rehabilitation. Our institution noted that local excision of such reactive tissues, in addition to silver nitrate cauterization and topical steroid application, may provide reasonable success in dealing with these occurrences. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
{"title":"Evaluation of postoperative peri-implant reactive tissues following implant supported prosthetic rehabilitation in fibula free flaps","authors":"Samuel D. Raffaelli DDS, Timothy W. Neal DDS MD, Jonathan J. Jelmini DDS MD, Roderick Y. Kim DDS MD MBA FACS, Fayette C. Williams DDS MD FACS","doi":"10.1016/j.oooo.2024.08.017","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.017","url":null,"abstract":"The purpose of this study was to measure the frequency of peri-implant reactive tissue development in a cohort of patients following immediate implant supported prosthetic rehabilitation in fibula free flaps at our institution and to document 2 cases of management based on our institution's experience. To address this question of study design, a case series was performed from October 2014 to May 2022. We included patients that underwent a fibula free flap reconstruction of the mandible or maxilla with immediate implant placement and dental prostheses fabrication. Forty-four patients met the inclusion criteria, and, among the participants, a total of 26 male patients (59%) and 18 female patients (41%) were evaluated, with 185 implants placed all together. Twenty patients (45%) were treated for benign pathology, 12 with malignant pathology (27%), 5 with trauma (11%), and 7 with osteoradionecrosis (16%). Postoperative peri-implant reactive tissues were seen to develop at 39 of the implant sites (21%). Reactive tissues were found to be a common complication in patients treated with fibular free flap reconstructions involving implant rehabilitation. Our institution noted that local excision of such reactive tissues, in addition to silver nitrate cauterization and topical steroid application, may provide reasonable success in dealing with these occurrences. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-31DOI: 10.1016/j.oooo.2024.08.013
José Vitor Mota Lemos, Joyce Ohana de Lima Martins, Larissa Carvalho Machado, Lara Rabelo Aragão, Maria Elisa Quezado Lima Verde, Cláudia do Ó. Pessoa, Maria Júlia Barbosa Bezerra, Ana Paula Negreiros Nunes Alves, Paulo Goberlânio de Barros Silva
The study aimed to evaluate digoxin, an RORγt inhibitor, in Medication-Related Osteonecrosis of the Jaws (MRONJ) in male rats treated with zoledronic acid (ZA). Forty male Wistar rats were divided into a negative control group (0.1 mL/kg saline), a positive control group (ZA, 0.20 mg/kg), and three test groups treated with ZA and digoxin at 1 (DG1), 2 (DG2), or 4 (DG4) mg/kg. These groups received treatment three times weekly. ZA was administered intravenously on days 0, 7, and 14, followed by extraction of the left lower first molar on day 42, a final ZA dose on day 49, and euthanasia on day 70. Analyses included radiographic, histomorphometric, and immunohistochemical evaluation of the mandibles, western blotting of gingiva, and mechanical tests on femurs. Statistical analysis was performed using ANOVA/Bonferroni tests ( < .05). Digoxin reduced radiolucency of MRONJ ( < .001), inflammatory cells, empty osteocyte lacunae ( < .001), apoptotic osteoclasts ( < .001), and Caspase-3-positive osteocytes ( = .021). ZA increased immunoreactivity for most markers except c-Fos, while digoxin reduced interleukin 17, TNF-α, IL-6, IL-2, FOXP3, c-Jun, NFκB ( < .001), TGF-β ( = .009), RANKL ( = .035), and OPG ( = .034). Digoxin also reversed RORγt expression ( < .001), increased diarrhea scores ( = .028), renal and cardiac indexes ( < .001), and enhanced femur mechanical properties ( < .013). Digoxin attenuated MRONJ by inhibiting RORγt and reducing the Th17 response.
{"title":"Digoxin attenuates bisphosphonate related osteonecrosis of the jaws by RORγt-dependent Th17 response in male rats","authors":"José Vitor Mota Lemos, Joyce Ohana de Lima Martins, Larissa Carvalho Machado, Lara Rabelo Aragão, Maria Elisa Quezado Lima Verde, Cláudia do Ó. Pessoa, Maria Júlia Barbosa Bezerra, Ana Paula Negreiros Nunes Alves, Paulo Goberlânio de Barros Silva","doi":"10.1016/j.oooo.2024.08.013","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.013","url":null,"abstract":"The study aimed to evaluate digoxin, an RORγt inhibitor, in Medication-Related Osteonecrosis of the Jaws (MRONJ) in male rats treated with zoledronic acid (ZA). Forty male Wistar rats were divided into a negative control group (0.1 mL/kg saline), a positive control group (ZA, 0.20 mg/kg), and three test groups treated with ZA and digoxin at 1 (DG1), 2 (DG2), or 4 (DG4) mg/kg. These groups received treatment three times weekly. ZA was administered intravenously on days 0, 7, and 14, followed by extraction of the left lower first molar on day 42, a final ZA dose on day 49, and euthanasia on day 70. Analyses included radiographic, histomorphometric, and immunohistochemical evaluation of the mandibles, western blotting of gingiva, and mechanical tests on femurs. Statistical analysis was performed using ANOVA/Bonferroni tests ( < .05). Digoxin reduced radiolucency of MRONJ ( < .001), inflammatory cells, empty osteocyte lacunae ( < .001), apoptotic osteoclasts ( < .001), and Caspase-3-positive osteocytes ( = .021). ZA increased immunoreactivity for most markers except c-Fos, while digoxin reduced interleukin 17, TNF-α, IL-6, IL-2, FOXP3, c-Jun, NFκB ( < .001), TGF-β ( = .009), RANKL ( = .035), and OPG ( = .034). Digoxin also reversed RORγt expression ( < .001), increased diarrhea scores ( = .028), renal and cardiac indexes ( < .001), and enhanced femur mechanical properties ( < .013). Digoxin attenuated MRONJ by inhibiting RORγt and reducing the Th17 response.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-31DOI: 10.1016/j.oooo.2024.08.015
Firdevs Aşantoğrol MDS DDS, Ayşe Nur Koruyucu MDS DDS
The aim was to evaluate changes in trabecular and cortical mandibular bone caused by antihypertensive (AHT) drugs through fractal analysis. This retrospective study included 230 patients who were taking AHT medication and had no conditions affecting bone metabolism other than hypertension. A control group of 230 healthy, sex-matched individuals was also included. Patients were divided into subgroups according to AHT drugs: thiazide diuretics (TDs), beta-blockers (BBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), and a combination of drugs. The fractal dimension (FD) was calculated bilaterally in 5 regions of interest (ROI 1 – ROI 5) including 4 trabecular regions and 1 cortical region using Image J software. Mean FD values were significantly higher in all ROIs for the study group compared to the control group ( < .001). FDs were significantlty higher for BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROIs 1, 2, and 4; for ACEI and CCB subgroups compared to controls in ROI 3; and for TD, BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROI 5 ( < .001). AHTs may increase FD values of the trabecular and cortical structures. Assessment of the effects of AHT drugs is essential for predicting the prognosis for bone healing after tooth extraction, osseointegration after implant surgery or other surgical procedures.
{"title":"Evaluation of antihypertensive drug-induced changes in mandibular bone using fractal analysis","authors":"Firdevs Aşantoğrol MDS DDS, Ayşe Nur Koruyucu MDS DDS","doi":"10.1016/j.oooo.2024.08.015","DOIUrl":"https://doi.org/10.1016/j.oooo.2024.08.015","url":null,"abstract":"The aim was to evaluate changes in trabecular and cortical mandibular bone caused by antihypertensive (AHT) drugs through fractal analysis. This retrospective study included 230 patients who were taking AHT medication and had no conditions affecting bone metabolism other than hypertension. A control group of 230 healthy, sex-matched individuals was also included. Patients were divided into subgroups according to AHT drugs: thiazide diuretics (TDs), beta-blockers (BBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), and a combination of drugs. The fractal dimension (FD) was calculated bilaterally in 5 regions of interest (ROI 1 – ROI 5) including 4 trabecular regions and 1 cortical region using Image J software. Mean FD values were significantly higher in all ROIs for the study group compared to the control group ( < .001). FDs were significantlty higher for BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROIs 1, 2, and 4; for ACEI and CCB subgroups compared to controls in ROI 3; and for TD, BB, ACEI, ARB, CCB, and combined subgroups compared to controls in ROI 5 ( < .001). AHTs may increase FD values of the trabecular and cortical structures. Assessment of the effects of AHT drugs is essential for predicting the prognosis for bone healing after tooth extraction, osseointegration after implant surgery or other surgical procedures.","PeriodicalId":501075,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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