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Functional networks of reward and punishment processing and their molecular profiles predicting the severity of young adult drinking 预测青壮年酗酒严重程度的奖惩处理功能网络及其分子图谱
Pub Date : 2024-02-07 DOI: 10.1101/2024.02.06.24302417
Yashuang Li, Lin Yang, Dongmei Hao, Yu Chen, Bao Li, Youjun Liu, Yiyao Ye-Lin, Chiang-Shan R. Li, Guangfei Li
Background Alcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to reward and punishment and the molecular profiles of the connectivity features predicting alcohol use severity in young adults.
背景 酒精滥用与惩罚和奖赏处理的改变有关。在此,我们研究了神经网络对奖赏和惩罚的反应,以及预测青壮年酗酒严重程度的连接特征的分子图谱。
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引用次数: 0
Trends and Adverse Outcomes of Xylazine Misuse: A Digital Surveillance Study 滥用赛拉嗪的趋势和不良后果:数字监控研究
Pub Date : 2024-02-01 DOI: 10.1101/2024.01.31.24302075
Akshaya Srikanth Bhagavathula, Wafa A Aldhaleei, Seongjin Kim
Background: Xylazine is an animal tranquilizer without approved medical use in humans that is increasingly being misused as an adulterant in illicit drugs. This study aimed to characterize national trends and adverse outcomes associated with the emerging misuse of xylazine using digital surveillance data.Methods: We examined online search trends and social media discussions related to xylazine misuse in the U.S. from 2019 to 2023 using Google Searches data and conducted Joinpoint regression to assess trends. We also examined social media attention using Almetric attention score and analyzed reports on xylazine in the FDA Adverse Event Reporting System (FAERS) through September 2023 using logistic regression.Results: Our analysis revealed an overall increasing trend in online searches for XYLAZINE nationally, with an average monthly percentage change of 4.6% (95% CI: 3.9 to 5.1, P trend <0.001), indicating growing awareness. On social media, mentions of xylazine rose exponentially starting in late 2021. Analysis of the FAERS data identified 94 reports of adverse events related to xylazine, most of which involved men (70.2%), with a mean age of 36.5 (SD: 14.3) years. Alarmingly, these xylazine-linked adverse events had an 87.2% fatality rate, which increased over 40-fold with concurrent fentanyl use (reported OR: 40.5, 95% CI: 4.0 to 407.4, P = 0.002).Conclusions: These findings underscore the urgent need for greater public health awareness, harm reduction strategies, and enhanced surveillance targeting the worsening xylazine addiction and overdose crisis.
背景:异丙嗪是一种动物镇静剂,未经批准可用于人类医疗,但越来越多的人将其作为非法药物的掺杂物滥用。本研究旨在利用数字监控数据,描述与新出现的滥用甲苯噻嗪相关的全国趋势和不良后果:我们使用谷歌搜索数据研究了2019年至2023年美国与恶用甲苯嗪相关的在线搜索趋势和社交媒体讨论,并进行了Joinpoint回归以评估趋势。我们还使用 Almetric 关注度评分检查了社交媒体的关注度,并使用逻辑回归分析了 FDA 不良事件报告系统(FAERS)中截至 2023 年 9 月有关恶嗪的报告:我们的分析表明,在全国范围内,"赛拉嗪 "的在线搜索量总体呈上升趋势,平均每月百分比变化率为 4.6%(95% CI:3.9 至 5.1,P 趋势为 0.001),这表明人们的认知度在不断提高。在社交媒体上,从 2021 年末开始,关于赛拉嗪的提及率呈指数级上升。对FAERS数据的分析发现了94份与甲苯磺咪唑相关的不良事件报告,其中大部分涉及男性(70.2%),平均年龄为36.5岁(标准差:14.3岁)。令人震惊的是,这些与赛拉嗪相关的不良事件的致死率高达 87.2%,如果同时使用芬太尼,致死率会增加 40 倍以上(报告 OR:40.5,95% CI:4.0 至 407.4,P = 0.002):这些发现突出表明,针对日益恶化的异丙嗪成瘾和用药过量危机,迫切需要提高公共卫生意识、采取减少伤害的策略和加强监测。
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引用次数: 0
Comparative effectiveness of extended release naltrexone and sublingual buprenorphine for treatment of opioid use disorder among Medicaid patients 缓释纳曲酮和丁丙诺啡舌下含服治疗医疗补助患者阿片类药物使用障碍的疗效比较
Pub Date : 2024-01-24 DOI: 10.1101/2024.01.24.24301555
Rachael K Ross, Edward V Nunes, Mark Olfson, Matisyahu Shulman, Noa Krawczyk, Elizabeth Stuart, Kara Rudolph
Aims: To compare the real-world effectiveness of extended release naltrexone (XR-NTX) and sublingual buprenorphine (SL-BUP) for the treatment of opioid use disorder (OUD) Design: An observational active comparator, new user cohort study Setting: Medicaid claims records for patients in New Jersey and California, 2016-2019 Participants/Cases: Adult Medicaid patients aged 18-64 years who initiated XR-NTX or SL-BUP for maintenance treatment of OUD and did not use medications for OUD in the 90-days before initiation Comparators: New initiation with XR-NTX versus SL-BUP for the treatment of OUD Measurements: We examined two outcomes up to 180 days after medication initiation, 1) composite of medication discontinuation and death, and 2) composite of overdose and death Findings: Our cohort included 1,755 XR-NTX and 9,886 SL-BUP patients. In adjusted analyses, treatment with XR-NTX was more likely to result in discontinuation or death by the end of follow-up than treatment with SL-BUP: cumulative risk 76% (95% confidence interval [CI] 75%, 78%) versus 62% (95% CI 61%, 63%), respectively (risk difference 14 percentage points, 95% CI 13, 16). There was minimal difference in the cumulative risk of overdose or death by the end of follow-up: XR-NTX 3.8% (95% CI 2.9%, 4.7%) versus SL-BUP 3.3% (95% 2.9%, 3.7%); risk difference 0.5 percentage points, 95% CI -0.5, 1.5. Results were consistent across sensitivity analyses. Conclusions: Longer medication retention is important because risks of negative outcomes are elevated after discontinuation. Our results support selection of SL-BUP over XR-NTX. However, most patients discontinued medication by 6 months indicating that more effective tools are needed to improve medication retention, particularly after initiation with XR-NTX, and to identify which patients do best on which medication.
目的:比较缓释纳曲酮(XR-NTX)和舌下丁丙诺啡(SL-BUP)治疗阿片类药物使用障碍(OUD)的实际效果:观察性主动比较研究、新用户队列研究 设定: 新泽西州患者的医疗补助报销记录2016-2019 年新泽西州和加利福尼亚州患者的医疗补助报销记录 参与者/病例:开始使用 XR-NTX 或 SL-BUP 维持治疗 OUD 的 18-64 岁成年医疗补助患者,且在开始使用前 90 天内未使用过治疗 OUD 的药物:新开始使用 XR-NTX 或 SL-BUP 治疗 OUD 测量:我们研究了用药后 180 天内的两个结果:1)停药和死亡的综合结果;2)用药过量和死亡的综合结果:我们的队列包括 1,755 名 XR-NTX 和 9,886 名 SL-BUP 患者。在调整分析中,XR-NTX 治疗比 SL-BUP 治疗更有可能在随访结束时导致停药或死亡:累积风险分别为 76%(95% 置信区间 [CI] 75%,78%)和 62%(95% 置信区间 61%,63%)(风险差异为 14 个百分点,95% 置信区间 13%,16%)。随访结束时用药过量或死亡的累积风险差异很小:XR-NTX 为 3.8%(95% CI 为 2.9%,4.7%),SL-BUP 为 3.3%(95% CI 为 2.9%,3.7%);风险差异为 0.5 个百分点,95% CI 为 -0.5,1.5。敏感性分析结果一致。结论由于停药后出现不良后果的风险会升高,因此延长用药时间非常重要。我们的结果支持选择 SL-BUP 而不是 XR-NTX。然而,大多数患者在 6 个月后就停药了,这表明需要更有效的工具来提高药物保留率,尤其是在开始使用 XR-NTX 后,并确定哪些患者服用哪种药物效果最好。
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引用次数: 0
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex 与酒精使用障碍相关的凹凸核和背外侧前额叶皮层 DNA 甲基化
Pub Date : 2024-01-17 DOI: 10.1101/2024.01.17.23300238
Julie D. White, Melyssa S. Minto, Caryn Willis, Bryan C. Quach, Shizhong Han, Ran Tao, Amy Deep-Soboslay, Lea Zillich, Shaunna L. Clark, Edwin J. C. G. van den Oord, Thomas M. Hyde, R. Dayne Mayfield, Bradley T. Webb, Eric O. Johnson, Joel E. Kleinman, Laura J. Bierut, Dana B. Hancock
Background Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms underlying the development and progression of AUD remain limited. Here, we interrogate AUD-associated DNA methylation (DNAm) changes within and across addiction-relevant brain regions: the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC).
背景 酒精使用障碍(AUD)对公共健康有着深远的影响。然而,人们对 AUD 发生和发展的分子机制的了解仍然有限。在这里,我们研究了成瘾相关脑区(即伏隔核(NAc)和背外侧前额叶皮层(DLPFC))内和之间与 AUD 相关的 DNA 甲基化(DNAm)变化。
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引用次数: 0
Prevalence of Substance Use and related Behaviors among Tertiary Students: A Cross-sectional Survey in Yaounde, Cameroon 大专学生中药物使用及相关行为的普遍性:喀麦隆雅温得横断面调查
Pub Date : 2024-01-10 DOI: 10.1101/2024.01.09.24301042
Michel Franck Edzamba, Fabrice Zobel Lekeumo Cheuyem, Adidja Amani, Tatiana Mossus
Background: The use of psychoactive substances is a major global public health problem. People aged 15-24 years are more likely to abuse psychoactive substances than the general population. Substances use among youth, especially students in higher education is increasing rapidly worldwide. This study aimed to assess the prevalence of substances use among university students and to describe their behavioral profiles.Methods: An institutional-based descriptive and cross-sectional study was conducted from September to October 2023 at the Yaounde 1 University in Cameroon. A convenience non probabilistic sampling method were used to recruit consenting students. The data collectors were medical students who were trained for 2 days and given appropriate instructions before the survey. The data collected were reviewed and checked for completeness before being entered. All data were coded and entered into Microsoft Excel 2016. Descriptive statistics were performed using R Statistics 4.3.1. Qualitative data were collected from all participants through interviews.Results: A total of 191 university students were enrolled in the study. The median age was 20 years. They were predominantly male (66.5%) and aged between 20-25. The prevalence of substance use was 66% for alcohol consumption, 33.5% for smoking habits and 26.7% for drug use. The main motivations for substance use were companionship, thrill-seeking and curiosity. More than a third of students were polysubstance users (35.1%). Most participants were aware of the academic consequence (85.9%) and almost all (93.7%) acknowledged the physical and psycho-social consequences of substance use.Conclusion: There is a high rate of psychoactive substance use among university students. Therefore, effective campus-based counseling, peer education, and national surveillance systems that can monitor risky behaviors among university students should be implemented.
背景:使用精神活性物质是一个重大的全球性公共卫生问题。与普通人群相比,15-24 岁的人群更有可能滥用精神活性物质。在全球范围内,青少年尤其是高校学生使用药物的人数正在迅速增加。本研究旨在评估大学生使用药物的普遍程度,并描述他们的行为特征:方法:2023 年 9 月至 10 月,在喀麦隆雅温得第一大学开展了一项以机构为基础的描述性横断面研究。在征得学生同意后,采用了方便的非概率抽样方法。数据收集者是医科学生,他们接受了为期两天的培训,并在调查前获得了适当的指导。收集到的数据在输入之前都经过了审核和检查,以确保数据的完整性。所有数据均已编码并输入 Microsoft Excel 2016。使用 R Statistics 4.3.1 进行描述性统计。通过访谈收集了所有参与者的定性数据:共有 191 名大学生参与了研究。年龄中位数为 20 岁。他们主要为男性(66.5%),年龄在 20-25 岁之间。饮酒、吸烟和吸毒的比例分别为 66%、33.5% 和 26.7%。使用药物的主要动机是陪伴、寻求刺激和好奇。超过三分之一的学生使用多种药物(35.1%)。大多数参与者(85.9%)意识到使用药物对学业造成的后果,几乎所有参与者(93.7%)都承认使用药物对身体和社会心理造成的后果:结论:大学生使用精神活性物质的比例很高。结论:大学生使用精神活性物质的比例很高,因此,应实施有效的校园咨询、同伴教育和国家监测系统,以监测大学生的危险行为。
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引用次数: 0
Attitudes of chronic pain patients on long-term opioid therapy toward opioid tapering. 长期接受阿片类药物治疗的慢性疼痛患者对阿片类药物减量的态度。
Pub Date : 2023-12-19 DOI: 10.1101/2023.12.19.23300217
Rami Jabakhanji, Freesia Tokunaga, Gaelle Rached, Andrew David Vigotsky, James W Griffith, Thomas Schnitzer, A Vania Apkarian
The chronic pain and opioid addiction epidemics interact with each other, potentially exacerbating each respective condition. Despite having modest efficacy, millions of chronic pain patients in the USA continue to use opioids as their primary source of pain management. The Centers for Disease Control recommends opioid tapering to diminish the risk of opioid dependence in chronic pain patients. However, tapering, even with physician oversight, can introduce additional harm. Thus, many pain clinicians remain ambivalent about undertaking opioid tapering. Here, we surveyed attitudes on the topic from the viewpoint of chronic pain patients who have been consuming opioids over long duration. We queried 127 chronic pain patients (pain duration = 13.5 +/- 9.6 years) on long-term opioids (10.3 +/- 8.2 years), primarily consuming hydrocodone or oxycodone. Sixty-six percent of participants were ″very″ or ″extremely″ interested in participating in an opioid tapering study. Patients emphasized the importance of controlling their pain during opioid tapering, and over 50% were also worried about craving symptoms. Both the desire for tapering and the worry of pain control were more pronounced in participants with a higher magnitude of ongoing back pain. The study demonstrates that most chronic pain patients using opioids are interested in decreasing opioid consumption. Yet, they worry about losing control of their chronic pain. These results imply patient-physician strategies that may aid the engagement of both parties in opioid tapering.
慢性疼痛和阿片类药物成瘾的流行相互影响,可能会加剧各自的病情。尽管疗效一般,但美国仍有数百万慢性疼痛患者将阿片类药物作为治疗疼痛的主要药物。美国疾病控制中心建议逐渐减少阿片类药物的用量,以降低慢性疼痛患者对阿片类药物产生依赖的风险。然而,即使有医生的监督,减量也会带来额外的伤害。因此,许多疼痛科临床医生对进行阿片类药物减量仍持矛盾态度。在此,我们从长期服用阿片类药物的慢性疼痛患者的角度调查了他们对此问题的态度。我们询问了 127 名长期服用阿片类药物(10.3 +/- 8.2 年)的慢性疼痛患者(疼痛持续时间 = 13.5 +/- 9.6 年),他们主要服用氢可酮或羟考酮。66%的参与者表示 "非常 "或 "非常 "有兴趣参加阿片类药物减量研究。患者强调了在阿片类药物减量过程中控制疼痛的重要性,50% 以上的患者还担心会出现渴求症状。在持续背痛程度较高的参与者中,减量的愿望和对疼痛控制的担忧都更为明显。这项研究表明,大多数使用阿片类药物的慢性疼痛患者都希望减少阿片类药物的用量。然而,他们担心失去对慢性疼痛的控制。这些结果意味着医生和患者可以采取一些策略,帮助双方参与阿片类药物的减量治疗。
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引用次数: 0
Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis 促炎症脂质介质与抗炎症专业促溶解介质之间的平衡失调与酒精性肝炎患者的高炎症性有关
Pub Date : 2023-12-17 DOI: 10.1101/2023.12.15.23300034
Wei Li, Ying Xia, Jing Yang, Arun J. Sanyal, Vijay H. Shah, Naga P. Chalasani, Qigui Yu
Background Chronic excessive alcohol consumption leads to a spectrum of alcohol-associated liver diseases (ALD), including alcoholic hepatitis (AH). AH is characterized by intense systemic and liver inflammation, posing significant risks of health complications and mortality. While inflammation is a crucial defense mechanism against injury and infection, its timely resolution is essential to prevent tissue damage and restore tissue homeostasis. The resolution of inflammation is an actively regulated process, primarily governed by specialized pro-resolving mediators (SPMs), lipid metabolites derived from ω-6 and ω-3 poly-unsaturated fatty acids (PUFAs). We investigated the balance between pro-inflammatory lipid mediators (PLMs) and SPMs in the ω-6 and ω-3 PUFA metabolic pathways and examined the impact of alcohol abstinence on rectifying the dysregulated biosynthesis of PLMs and SPMs in AH patients.
背景 长期过量饮酒会导致一系列酒精相关肝病(ALD),包括酒精性肝炎(AH)。酒精性肝炎以全身和肝脏的强烈炎症为特征,具有严重的健康并发症和死亡风险。炎症是抵御损伤和感染的重要防御机制,及时消除炎症对防止组织损伤和恢复组织平衡至关重要。炎症的消解是一个主动调节的过程,主要由专门的促消解介质(SPMs)--从ω-6 和ω-3 多不饱和脂肪酸(PUFAs)中提取的脂质代谢物--所调控。我们研究了ω-6和ω-3多不饱和脂肪酸代谢途径中促炎脂质介质(PLMs)和SPMs之间的平衡,并探讨了戒酒对纠正AH患者PLMs和SPMs生物合成失调的影响。
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引用次数: 0
Disproportionate increase in cannabis use among individuals with serious psychological distress and association with psychiatric hospitalization and outpatient service use in the National Survey on Drug Use and Health 2009-2019 2009-2019 年全国药物使用和健康状况调查》中有严重心理困扰的人使用大麻的比例增长以及与精神病住院和门诊服务使用的关联
Pub Date : 2023-12-17 DOI: 10.1101/2023.12.15.23300036
Andrew S Hyatt, Michael William Flores, Benjamin Lê Cooke
Aims Estimate trends in levels of cannabis use among adults with and without serious psychological distress (SPD) in the United States from 2009-2019, and to ascertain whether cannabis use among individuals with SPD was associated with inpatient psychiatric hospitalization and outpatient mental health care.
目的 估计 2009-2019 年期间美国有严重心理困扰(SPD)和无严重心理困扰(SPD)的成年人吸食大麻的水平趋势,并确定有严重心理困扰(SPD)的人吸食大麻是否与精神科住院治疗和门诊精神保健有关。
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引用次数: 0
Leveraging neuroscience education to address stigma related to opioid use disorder (OUD) in the community: A pilot study 利用神经科学教育解决社区中与阿片类药物使用障碍(OUD)相关的污名化问题:试点研究
Pub Date : 2023-12-13 DOI: 10.1101/2023.12.11.23299824
Evan J. Kyzar, Melissa Arbuckle, Adam Abba-Aji, Krishna Balachandra, Joseph Cooper, Adriane Dela Cruz, Ellen Edens, Brady Heward, Michael Jibson, Ayana Jordan, Daniel Moreno-De-Luca, Hannah Pazderka, Mohit Singh, Jeremy Weleff, Bernice Yau, Justin Young, David A. Ross, National Neuroscience Curriculum Initiative (NNCI)
Opioid use disorder (OUD) and overdose deaths are a public health crisis. One contributing factor is stigma towards people who use opioids. We developed and conducted a public-facing, half-day educational event designed to challenge misperceptions about OUD from a contemporary neuroscience perspective. Participants engaged with three different resources on the neurobiology of addiction; at the end of the event, they rated its effectiveness. We also collected and compared pre- and post-event composite OUD stigma scales. Participants rated our approach and the overall event as highly effective. Additionally, OUD stigma scores were lower immediately following the event, and this decrease was primarily driven by decreased internalized stigma. Here, we demonstrate an effective proof-of-concept that an accessible, public-facing, neuroscience education event may reduce OUD stigma in the community.
阿片类药物使用障碍(OUD)和用药过量致死是一场公共卫生危机。其中一个原因是人们对阿片类药物使用者的偏见。我们开发并举办了一次面向公众的半天教育活动,旨在从当代神经科学的角度挑战人们对 OUD 的误解。参与者使用了有关成瘾神经生物学的三种不同资源;活动结束时,他们对活动效果进行了评分。我们还收集并比较了活动前和活动后的 OUD 耻辱感综合量表。参与者认为我们的方法和整个活动非常有效。此外,活动结束后,OUD 耻辱感得分立即降低,而这种降低主要是由于内化耻辱感的减少。在此,我们展示了一个有效的概念验证,即面向公众的神经科学教育活动可以减少社区对 OUD 的污名化。
{"title":"Leveraging neuroscience education to address stigma related to opioid use disorder (OUD) in the community: A pilot study","authors":"Evan J. Kyzar, Melissa Arbuckle, Adam Abba-Aji, Krishna Balachandra, Joseph Cooper, Adriane Dela Cruz, Ellen Edens, Brady Heward, Michael Jibson, Ayana Jordan, Daniel Moreno-De-Luca, Hannah Pazderka, Mohit Singh, Jeremy Weleff, Bernice Yau, Justin Young, David A. Ross, National Neuroscience Curriculum Initiative (NNCI)","doi":"10.1101/2023.12.11.23299824","DOIUrl":"https://doi.org/10.1101/2023.12.11.23299824","url":null,"abstract":"Opioid use disorder (OUD) and overdose deaths are a public health crisis. One contributing factor is stigma towards people who use opioids. We developed and conducted a public-facing, half-day educational event designed to challenge misperceptions about OUD from a contemporary neuroscience perspective. Participants engaged with three different resources on the neurobiology of addiction; at the end of the event, they rated its effectiveness. We also collected and compared pre- and post-event composite OUD stigma scales. Participants rated our approach and the overall event as highly effective. Additionally, OUD stigma scores were lower immediately following the event, and this decrease was primarily driven by decreased internalized stigma. Here, we demonstrate an effective proof-of-concept that an accessible, public-facing, neuroscience education event may reduce OUD stigma in the community.","PeriodicalId":501282,"journal":{"name":"medRxiv - Addiction Medicine","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138715386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Buprenorphine, Methadone and Substance-Use on COVID-19 Morbidity and Mortality 丁丙诺啡、美沙酮及药物使用对COVID-19发病率和死亡率的影响
Pub Date : 2023-11-27 DOI: 10.1101/2023.11.24.23298995
Nicholaus Christian, Xin Zhou, Rajiv Radhakrishnan
Objectives Substance use disorder has been associated with increased morbidity in COVID-19 infection. However, less is known about the impact of active substance use and medications for opioid use disorder (MOUD) on COVID-19 outcomes. We conducted a retrospective cohort study to evaluate the impact of substance use, namely cannabis, cocaine, alcohol, sedative and opioid use as well as buprenorphine or methadone = on COVID-19 morbidity and mortality.
物质使用障碍与COVID-19感染的发病率增加有关。然而,人们对活性物质使用和阿片类药物使用障碍(mod)药物对COVID-19结局的影响知之甚少。我们进行了一项回顾性队列研究,以评估物质使用(即大麻、可卡因、酒精、镇静剂和阿片类药物使用以及丁丙诺啡或美沙酮)对COVID-19发病率和死亡率的影响。
{"title":"Effects of Buprenorphine, Methadone and Substance-Use on COVID-19 Morbidity and Mortality","authors":"Nicholaus Christian, Xin Zhou, Rajiv Radhakrishnan","doi":"10.1101/2023.11.24.23298995","DOIUrl":"https://doi.org/10.1101/2023.11.24.23298995","url":null,"abstract":"<strong>Objectives</strong> Substance use disorder has been associated with increased morbidity in COVID-19 infection. However, less is known about the impact of active substance use and medications for opioid use disorder (MOUD) on COVID-19 outcomes. We conducted a retrospective cohort study to evaluate the impact of substance use, namely cannabis, cocaine, alcohol, sedative and opioid use as well as buprenorphine or methadone = on COVID-19 morbidity and mortality.","PeriodicalId":501282,"journal":{"name":"medRxiv - Addiction Medicine","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138522288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
medRxiv - Addiction Medicine
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