Pub Date : 2024-03-26DOI: 10.1101/2024.03.25.24304856
Jessica Polizzi, Jenna Tosto-Mancuso, Laura Tabacof, Jamie Wood, David Putrino
Introduction: Long COVID involves debilitating symptoms, many of which mirror those observed with dysautonomia, and care must be taken with traditional autonomic rehabilitation to avoid post-exertional malaise/post-exertional symptom exacerbation. Resonant breathing exercises require less exertion and can potentially improve autonomic function. The objective of this work was to report on the impact of a resonant breathing program on self-reported symptoms and wellbeing in people with Long COVID. Methods: A retrospective analysis of de-identified data was completed in a convenience sample of people with Long Covid, who participated in the Meo Health (formerly known as Stasis HP) resonant breathing program. Participants completed baseline and follow up surveys. Results: Data were available for 99 participants. Most measures of symptoms and wellbeing improved at follow up, with the largest differences per participant seen in sense of wellness (47.3%, p<0.0001), ability to focus (57.5%, p<0.0001), ability to breathe (47.5%, p<0.0001), ability to control stress (61.8%, p<0.0001) and sleep quality (34.9%, p=0.0002). Most (92%) participants reported improvement at follow up on the Patient Global Impression of Change Scale. Conclusion: Self-reported symptoms and wellbeing improved in people with Long COVID completing resonant breathing. Resonant breathing can be considered as an option within the broader treatment plan of people with Long COVID.
简介：长期慢性阻塞性脉管炎（COVID）会导致衰弱症状，其中许多症状与自律神经失调症相似，因此在进行传统的自律神经康复治疗时必须小心谨慎，以避免运动后不适/运动后症状加重。共振呼吸练习需要的运动量较小，有可能改善自律神经功能。这项工作的目的是报告共振呼吸计划对长COVID患者自述症状和健康的影响：对参加 Meo Health（前身为 Stasis HP）共振呼吸计划的长焦虑症患者进行了方便抽样调查，对去标识化数据进行了回顾性分析。参与者完成了基线和后续调查：99 名参与者的数据可用。大多数症状和健康状况在随访时都有所改善，每位参与者在健康感（47.3%，p<0.0001）、专注能力（57.5%，p<0.0001）、呼吸能力（47.5%，p<0.0001）、控制压力能力（61.8%，p<0.0001）和睡眠质量（34.9%，p=0.0002）方面的差异最大。大多数参与者（92%）在随访时报告说，患者总体变化印象量表（Patient Global Impression of Change Scale）上的情况有所改善：结论：长COVID患者完成共振呼吸后，其自我报告的症状和健康状况均有所改善。共振呼吸可作为长COVID患者更广泛治疗计划中的一种选择。
{"title":"Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID","authors":"Jessica Polizzi, Jenna Tosto-Mancuso, Laura Tabacof, Jamie Wood, David Putrino","doi":"10.1101/2024.03.25.24304856","DOIUrl":"https://doi.org/10.1101/2024.03.25.24304856","url":null,"abstract":"Introduction: Long COVID involves debilitating symptoms, many of which mirror those observed with dysautonomia, and care must be taken with traditional autonomic rehabilitation to avoid post-exertional malaise/post-exertional symptom exacerbation. Resonant breathing exercises require less exertion and can potentially improve autonomic function. The objective of this work was to report on the impact of a resonant breathing program on self-reported symptoms and wellbeing in people with Long COVID.\u0000Methods: A retrospective analysis of de-identified data was completed in a convenience sample of people with Long Covid, who participated in the Meo Health (formerly known as Stasis HP) resonant breathing program. Participants completed baseline and follow up surveys.\u0000Results: Data were available for 99 participants. Most measures of symptoms and wellbeing improved at follow up, with the largest differences per participant seen in sense of wellness (47.3%, p<0.0001), ability to focus (57.5%, p<0.0001), ability to breathe (47.5%, p<0.0001), ability to control stress (61.8%, p<0.0001) and sleep quality (34.9%, p=0.0002). Most (92%) participants reported improvement at follow up on the Patient Global Impression of Change Scale.\u0000Conclusion: Self-reported symptoms and wellbeing improved in people with Long COVID completing resonant breathing. Resonant breathing can be considered as an option within the broader treatment plan of people with Long COVID.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140301407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Getting down to the floor and rising to a standing position (Floor Sitting-Rising | FSR) is a fundamental task for independent living and participation across the lifespan. Multiple studies have reported activity limitations in FSR among adults and individuals with musculoskeletal and neurological impairments. However, few studies have investigated FSR assessments and the body structures and functions contributing to FSR performance. Objectives: To describe assessments that measure FSR in adulthood, including their psychometric properties, and to determine if impairments in body structures and functions contribute to limitations in FSR performance in adults with orthopedic or neurological disability. Design: Google Scholar, Pubmed, CINHAL (Medline), and Rehab Measures will be searched for studies that report the full FSR transition. Studies must be original research in the adult population. Result: We will categorize studies based on aims, study type, population characteristics, and abilities. We will narratively synthesize results, discuss potential personal and environmental factors influencing FSR, and identify the gaps in the literature to inform future research directions. Conclusion: This review of FSR assessments will provide recommendations for methods to evaluate FSR and its movement strategies and consider impairments that may influence performance.
{"title":"Floor Sitting Rising in Adults with and without Disability: A Scoping Review Protocol","authors":"Jehan Abdulmohsen Alomar, Haoyu Li, Keri Fisher, Miriam King, Lori Quinn","doi":"10.1101/2024.03.20.24303720","DOIUrl":"https://doi.org/10.1101/2024.03.20.24303720","url":null,"abstract":"Background: Getting down to the floor and rising to a standing position (Floor Sitting-Rising | FSR) is a fundamental task for independent living and participation across the lifespan. Multiple studies have reported activity limitations in FSR among adults and individuals with musculoskeletal and neurological impairments. However, few studies have investigated FSR assessments and the body structures and functions contributing to FSR performance. Objectives: To describe assessments that measure FSR in adulthood, including their psychometric properties, and to determine if impairments in body structures and functions contribute to limitations in FSR performance in adults with orthopedic or neurological disability. Design: Google Scholar, Pubmed, CINHAL (Medline), and Rehab Measures will be searched for studies that report the full FSR transition. Studies must be original research in the adult population. Result: We will categorize studies based on aims, study type, population characteristics, and abilities. We will narratively synthesize results, discuss potential personal and environmental factors influencing FSR, and identify the gaps in the literature to inform future research directions. Conclusion: This review of FSR assessments will provide recommendations for methods to evaluate FSR and its movement strategies and consider impairments that may influence performance.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.1101/2024.03.20.24302631
Xin Ran Chu, Tanmoy Newaz, Elbert Tom, Allison Yang, Taylor Chomiak, Bin Hu
OBJECTIVE: This study explores the effects of physical activities on cognitive performance in healthy subjects, specifically evaluating Serial Subtract 7 Test (SST) performance during a cognitive-stepping dual task influenced by the 6-Minute Walking Test (6MWT) with and without music. METHODS: A controlled experiment was conducted using the Ambulosono device to standardize walking exercises. 54 high school students participated, undergoing the 6MWT in different scenarios: Verbal 6-Minute Walking Test (6MWT) or Music-Guided Walking (MU). Final data from 43 students was used in the analysis. The SST measured cognitive changes in both single-task and dual-task conditions. RESULTS: The 6MWT significantly enhanced cognitive performance in both single and dual-task conditions. However, the addition of music did not show a substantial improvement in cognitive performance. The findings indicated the positive impact of 6MWT on cognitive abilities, irrespective of musical accompaniment. CONCLUSIONS: This research contributes to the understanding of how physical exercises can modulate cognitive functions in healthy individuals. It highlights the potential of 6MWT in enhancing cognitive performance, suggesting further exploration into the role of physical activity in cognitive health.
{"title":"Brief Physical Activity Selectively Modulates the Performance of Serial Subtract 7 in Young Adults: A Wearable Sensor-based, Randomized, Control Study","authors":"Xin Ran Chu, Tanmoy Newaz, Elbert Tom, Allison Yang, Taylor Chomiak, Bin Hu","doi":"10.1101/2024.03.20.24302631","DOIUrl":"https://doi.org/10.1101/2024.03.20.24302631","url":null,"abstract":"OBJECTIVE: This study explores the effects of physical activities on cognitive performance in healthy subjects, specifically evaluating Serial Subtract 7 Test (SST) performance during a cognitive-stepping dual task influenced by the 6-Minute Walking Test (6MWT) with and without music. METHODS: A controlled experiment was conducted using the Ambulosono device to standardize walking exercises. 54 high school students participated, undergoing the 6MWT in different scenarios: Verbal 6-Minute Walking Test (6MWT) or Music-Guided Walking (MU). Final data from 43 students was used in the analysis. The SST measured cognitive changes in both single-task and dual-task conditions. RESULTS: The 6MWT significantly enhanced cognitive performance in both single and dual-task conditions. However, the addition of music did not show a substantial improvement in cognitive performance. The findings indicated the positive impact of 6MWT on cognitive abilities, irrespective of musical accompaniment. CONCLUSIONS: This research contributes to the understanding of how physical exercises can modulate cognitive functions in healthy individuals. It highlights the potential of 6MWT in enhancing cognitive performance, suggesting further exploration into the role of physical activity in cognitive health.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.1101/2024.03.20.24304370
Lucia Ferrulli, Martina Zaninetti, Michele Margelli, Filippo Maselli, Giovanni Galeoto
ABSTRACT Background: Thoracic discopathy refers to the degeneration or herniation of one or more discs in the thoracic spine, which can cause thoracic-chest related pain. Thoracic-chest related pain can be challenging to diagnose and treat, as it can have various causes, including musculoskeletal, neurological, and visceral. Objectives: This scoping review aims to provide an overview of the current scientific literature on the thoracic discopathy and the thoracic-chest related pain, by examining the available scientific research, as well as to identify any existing gaps in knowledge. Eligibility criteria: The databases of Medline, Cinahl, Cochrane, Prospero were searched using key terms: thoracic, chest, dorsal, disc, hernia, radiculopathy, myelopathy, and pain. We also have searched for Grey literature on clinicaltrial.gov and google scholar. Inclusion criteria: adult population (over 18 years old); thoracic discopathy or thoracic-chest related pain; Italian or English language; no context, geographical or temporal limits. Exclusion criteria: unspecified pathologies and symptoms (as non- specific back pain, low back pain) and specific pathologies without any interest of thoracic disc (as spinal synovial cysts, spinal arachnoid webs, lung herniation ecc).
摘要背景：胸椎椎间盘病变是指胸椎的一个或多个椎间盘发生退变或突出，从而引起胸胸部相关疼痛。胸-胸相关疼痛的病因多种多样，包括肌肉骨骼、神经和内脏原因，因此诊断和治疗胸-胸相关疼痛极具挑战性。目的：本范围综述旨在通过研究现有的科学研究，概述当前有关胸椎椎间盘病变和胸-胸相关疼痛的科学文献，并找出现有的知识空白。资格标准：在 Medline、Cinahl、Cochrane、Prospero 等数据库中使用关键术语进行搜索：胸椎、胸部、背侧、椎间盘、疝气、根神经病、脊髓病和疼痛。我们还在 clinicaltrial.gov 和 google scholar 上搜索了灰色文献。排除标准：未指定的病理和症状（如非特异性背痛、腰痛）以及与胸椎间盘无关的特异性病理（如脊柱滑膜囊肿、脊柱蛛网膜、肺疝ecc）。
{"title":"Thoracic discopathy and thoracic-chest related pain: a scoping review","authors":"Lucia Ferrulli, Martina Zaninetti, Michele Margelli, Filippo Maselli, Giovanni Galeoto","doi":"10.1101/2024.03.20.24304370","DOIUrl":"https://doi.org/10.1101/2024.03.20.24304370","url":null,"abstract":"ABSTRACT\u0000Background: Thoracic discopathy refers to the degeneration or herniation of one or more discs in the thoracic spine, which can cause thoracic-chest related pain. Thoracic-chest related pain can be challenging to diagnose and treat, as it can have various causes, including musculoskeletal, neurological, and visceral. Objectives: This scoping review aims to provide an overview of the current scientific literature on the thoracic discopathy and the thoracic-chest related pain, by examining the available scientific research, as well as to identify any existing gaps in knowledge. Eligibility criteria: The databases of Medline, Cinahl, Cochrane, Prospero were searched using key terms: thoracic, chest, dorsal, disc, hernia, radiculopathy, myelopathy, and pain.\u0000We also have searched for Grey literature on clinicaltrial.gov and google scholar.\u0000Inclusion criteria: adult population (over 18 years old); thoracic discopathy or thoracic-chest related pain; Italian or English language; no context, geographical or temporal limits.\u0000Exclusion criteria: unspecified pathologies and symptoms (as non- specific back pain, low back pain) and specific pathologies without any interest of thoracic disc (as spinal synovial cysts, spinal arachnoid webs, lung herniation ecc).","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Motor rehabilitation is a central contributor to motor recovery after stroke. This process could be hampered by stroke-associated cognitive impairments, such as the capability to rapidly follow instructions (Rapid instructed task learning, RITL). RITL was never directly studied in old adults and subjects with stroke. The aim of this study was to assess RITL following stroke and its underlying cognitive determinants. Methods: 31 subjects with chronic stroke and 36 age-matched controls completed a computerized cognitive examination that included an anti-saccade task for measuring prepotent inhibition and processing speed and stimulus-response association task (NEXT) for measuring RITL and proactive inhibition. Results: RITL abilities were impaired after stroke, together with prepotent inhibition and processing speed. A correlation analysis revealed that RITL is associated with prepotent inhibition abilities and with processing speed. Conclusions: Subjects with stroke show impairments in the ability to follow instructions, that may be related to their impaired prepotent inhibition and processing speed. The causal effect of RITL impairments on the responsivity to rehabilitation and on motor recovery should be examined.
{"title":"Rapid Instructed Task Learning is impaired after stroke and associated with impairments in prepotent inhibition and processing speed.","authors":"Reut Binyamin Netser, Anat Shkedy-Rabani, Lior Shmuelof","doi":"10.1101/2024.03.20.24304593","DOIUrl":"https://doi.org/10.1101/2024.03.20.24304593","url":null,"abstract":"Background: Motor rehabilitation is a central contributor to motor recovery after stroke. This process could be hampered by stroke-associated cognitive impairments, such as the capability to rapidly follow instructions (Rapid instructed task learning, RITL). RITL was never directly studied in old adults and subjects with stroke. The aim of this study was to assess RITL following stroke and its underlying cognitive determinants. Methods: 31 subjects with chronic stroke and 36 age-matched controls completed a computerized cognitive examination that included an anti-saccade task for measuring prepotent inhibition and processing speed and stimulus-response association task (NEXT) for measuring RITL and proactive inhibition. Results: RITL abilities were impaired after stroke, together with prepotent inhibition and processing speed. A correlation analysis revealed that RITL is associated with prepotent inhibition abilities and with processing speed.\u0000Conclusions: Subjects with stroke show impairments in the ability to follow instructions, that may be related to their impaired prepotent inhibition and processing speed. The causal effect of RITL impairments on the responsivity to rehabilitation and on motor recovery should be examined.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.1101/2024.03.20.24304574
Ronit Aviram, Yisrael Parmet, Simona Bar-Haim
Objective. To compare the impacts of gym training and circuit Zoom-tele-training on health parameters in ambulatory adults with spastic cerebral palsy. Methods. Participants were divided into three groups: The Gym-group that underwent resistance-and-aerobic training program (n=12), the Zoom-group that underwent a circuit Zoom-tele-training program (n=14), and the Control-group that was on a waitlist and underwent no training (n=14). The two training gropes exercised bi-weekly for 12-week. Measurements included blood pressure, waist circumference, BMI, 15-repetition maximum-strength tests, and a LALA aerobic shuttle test analyzed using a linear mixed model. Results. Weight circumference decreased in both the Gym and Zoom groups (P=.0202 and P=.0014 respectively). In addition, in both these groups systolic (P=.018, P=.0001 respectively) and diastolic (P=.086 -marginal significance, P<.0001 respectively) blood pressure decreased, with a more pronounced reduction in the diastolic blood pressure for the Zoom-group (P=.043). Maximum aerobic speed increased (P<.0001) in the Zoom-group, with the Gym-group achieving the same speed with a lower peak heart rate (P=.0144). Strength significantly improved in the Zoom group for row (P=.05) and knee-extension (P<.0001) exercises. The Gym group improved in all strength measures (Row P<.0001, Chest-press P<.0001, and Knee-extension P<.0001). The Gym-group gains were greater than the Zoom-group in the row (P<.0001) and knee-extension (P=.005) exercises. The Control-group experienced a rise in BMI (P=.0256), waist circumference (P=.056 marginal significance), and systolic blood pressure (P=.055 marginal significance). Conclusion. Both exercise programs effectively reduced health-risk factors. The Zoom-group excelled in improving aerobic capacity and diastolic blood pressure, while the Gym-group demonstrated superior strength gains. Not exercising was detrimental to body mass, waist circumference, and blood pressure. Impact. Exercise programs enhance long life heath and prevent health deterioration in adults with cerebral palsy. Results endorse using waist circumference and blood pressure measures as valuable clinical outcomes for adults with cerebral palsy.
{"title":"Health-Related Effects of Real-Time Circuit Tele-Training and Gym Resistance-Aerobic Training in Ambulatory Adults with Cerebral Palsy","authors":"Ronit Aviram, Yisrael Parmet, Simona Bar-Haim","doi":"10.1101/2024.03.20.24304574","DOIUrl":"https://doi.org/10.1101/2024.03.20.24304574","url":null,"abstract":"Objective. To compare the impacts of gym training and circuit Zoom-tele-training on health parameters in ambulatory adults with spastic cerebral palsy. Methods. Participants were divided into three groups: The Gym-group that underwent resistance-and-aerobic training program (n=12), the Zoom-group that underwent a circuit Zoom-tele-training program (n=14), and the Control-group that was on a waitlist and underwent no training (n=14). The two training gropes exercised bi-weekly for 12-week. Measurements included blood pressure, waist circumference, BMI, 15-repetition maximum-strength tests, and a LALA aerobic shuttle test analyzed using a linear mixed model.\u0000Results. Weight circumference decreased in both the Gym and Zoom groups (P=.0202 and P=.0014 respectively). In addition, in both these groups systolic (P=.018, P=.0001 respectively) and diastolic (P=.086 -marginal significance, P<.0001 respectively) blood pressure decreased, with a more pronounced reduction in the diastolic blood pressure for the Zoom-group (P=.043). Maximum aerobic speed increased (P<.0001) in the Zoom-group, with the Gym-group achieving the same speed with a lower peak heart rate (P=.0144). Strength significantly improved in the Zoom group for row (P=.05) and knee-extension (P<.0001) exercises. The Gym group improved in all strength measures (Row P<.0001, Chest-press P<.0001, and Knee-extension P<.0001). The Gym-group gains were greater than the Zoom-group in the row (P<.0001) and knee-extension (P=.005) exercises. The Control-group experienced a rise in BMI (P=.0256), waist circumference (P=.056 marginal significance), and systolic blood pressure (P=.055 marginal significance). Conclusion. Both exercise programs effectively reduced health-risk factors. The Zoom-group excelled in improving aerobic capacity and diastolic blood pressure, while the Gym-group demonstrated superior strength gains. Not exercising was detrimental to body mass, waist circumference, and blood pressure.\u0000Impact. Exercise programs enhance long life heath and prevent health deterioration in adults with cerebral palsy. Results endorse using waist circumference and blood pressure measures as valuable clinical outcomes for adults with cerebral palsy.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.1101/2024.03.17.24304427
Sabine Felser, Julia Rogahn, Änne Glass, Lars Arne Bonke, Daniel Fabian Strüder, Jana Stolle, Susann Schulze, Markus Blaurock, Ursula Kriesen, Christian Junghanss, Christina Grosse-Thie
Introduction Patients with head and neck cancer (PwHNC) benefit from targeted exercise interventions: symptom relief, compensation for dysfunction, improvement in quality of life (QoL). Data on acceptance physical interventions in PwHNC are rare. The ‘OSHO #94’ trial investigates the short- and medium-term effects of individualized home exercise in PwHNC on QoL, physical activity and functionality. The study includes a feasibility phase in order to evaluate the acceptance (Phase A), followed by a consecutive QoL endpoint Phase B. Here we present the study protocol as well as the feasibility results. Methods and analysis This prospective, multicentre, single-arm intervention study includes PwHNC ≥18 years of age in aftercare or palliative care with stable remission under immunotherapy. The study opened in January 01, 2021, with estimated completion by December 31, 2024. The PwHNC receive an individualized home exercise program consisting of mobilization, coordination, strengthening and stretching exercises. This should be carried out at least three times a week over 12 weeks for 15 to 30 minutes, supplemented by aerobic training two to three times a week for 30 minutes (intervention). Once weekly telephone calls with a physiotherapist are performed. Subsequently, there is a 12-week follow-up (FU) without exercise specifications/contact. Outcomes are measured before and after the intervention and following the FU. Primary outcome of the feasibility phase (Phase A, n = 25) was the determination of the dropout rate during the intervention with a termination cut off if more than 30% PwHNC withdrew premature. The primary outcome of phases A + B (N = 53) are the change in global QoL score from pre- to post-intervention (EORTC QLQ-C30). Secondary outcomes include clinical and patient-reported measures, training details as well as functional diagnostic data (e.g. level of physical activity, training frequency, flexibility, fall risk and aerobic performance). Results 25 PwHNC were enrolled onto the feasibility cohort. Only16% (4/25 patients) did not complete the study. Therefore, individualized home exercise programs in PwHNC seem feasible recruitment of PwHNC for phase B continued. The dropout rate was adjusted from 30% (N = 60) to 20% (N = 53, calculated sample size n = 42 PwHNC and 20% (n = 11) to dropout). Ethics and dissemination The study protocol was approved by the Ethics Committee of the University of Rostock, University of Halle-Wittenberg and University of Greifswald. The findings will be disseminated in peer-reviewed journals and academic conferences. Trial registration German Registry of Clinical Trials DRKS00023883.
{"title":"Feasibility of individualized home exercise programs for patients with head and neck cancer – study protocol and first results of a multicentre single-arm intervention trial (OSHO #94)","authors":"Sabine Felser, Julia Rogahn, Änne Glass, Lars Arne Bonke, Daniel Fabian Strüder, Jana Stolle, Susann Schulze, Markus Blaurock, Ursula Kriesen, Christian Junghanss, Christina Grosse-Thie","doi":"10.1101/2024.03.17.24304427","DOIUrl":"https://doi.org/10.1101/2024.03.17.24304427","url":null,"abstract":"Introduction Patients with head and neck cancer (PwHNC) benefit from targeted exercise interventions: symptom relief, compensation for dysfunction, improvement in quality of life (QoL). Data on acceptance physical interventions in PwHNC are rare. The ‘OSHO #94’ trial investigates the short- and medium-term effects of individualized home exercise in PwHNC on QoL, physical activity and functionality. The study includes a feasibility phase in order to evaluate the acceptance (Phase A), followed by a consecutive QoL endpoint Phase B. Here we present the study protocol as well as the feasibility results.\u0000Methods and analysis This prospective, multicentre, single-arm intervention study includes PwHNC ≥18 years of age in aftercare or palliative care with stable remission under immunotherapy. The study opened in January 01, 2021, with estimated completion by December 31, 2024. The PwHNC receive an individualized home exercise program consisting of mobilization, coordination, strengthening and stretching exercises. This should be carried out at least three times a week over 12 weeks for 15 to 30 minutes, supplemented by aerobic training two to three times a week for 30 minutes (intervention). Once weekly telephone calls with a physiotherapist are performed. Subsequently, there is a 12-week follow-up (FU) without exercise specifications/contact. Outcomes are measured before and after the intervention and following the FU. Primary outcome of the feasibility phase (Phase A, n = 25) was the determination of the dropout rate during the intervention with a termination cut off if more than 30% PwHNC withdrew premature. The primary outcome of phases A + B (N = 53) are the change in global QoL score from pre- to post-intervention (EORTC QLQ-C30). Secondary outcomes include clinical and patient-reported measures, training details as well as functional diagnostic data (e.g. level of physical activity, training frequency, flexibility, fall risk and aerobic performance).\u0000Results 25 PwHNC were enrolled onto the feasibility cohort. Only16% (4/25 patients) did not complete the study. Therefore, individualized home exercise programs in PwHNC seem feasible recruitment of PwHNC for phase B continued. The dropout rate was adjusted from 30% (N = 60) to 20% (N = 53, calculated sample size n = 42 PwHNC and 20% (n = 11) to dropout).\u0000Ethics and dissemination The study protocol was approved by the Ethics Committee of the University of Rostock, University of Halle-Wittenberg and University of Greifswald. The findings will be disseminated in peer-reviewed journals and academic conferences.\u0000Trial registration German Registry of Clinical Trials DRKS00023883.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140165918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-16DOI: 10.1101/2024.03.13.24304245
Joanne Donoghue, Hallie Zwibel, William G Werner
This study compared an Aeron office chair and a commercial gaming chair (GC) on muscle stiffness (MS), performance, and perceptions during a 2-hour gaming session. Thirty-three esports players (23 ± 4.9) signed consent to participate in this mixed-methods randomized study. Subjects played League of Legends (LoL) in a controlled environment for two 2-hour sessions. MS was measured using oscillation frequency. Investigators recorded evaluations, game statistics, and player perceptions. Descriptive statistics showed lower MS in the thoracic and lumbar region (left -4.4% vs. 0.32%; -2.7% vs. -2.1%; right 0.2% vs. 8.3%; 7% vs. 10.8%). The upper shoulder was higher in the GC only on the right (9.2% vs. -6.4; left 4.7 vs. 7.5). Most participants preferred the GC (58%), and players won 25% more and achieved 15% more kills in the GC. The GC exhibited lower levels of muscle stiffness in the thoracic and lumbar regions. This data suggests that the GC is the preferred choice among this group of LoL gamers and is associated with enhanced performance.
这项研究比较了 Aeron 办公椅和商用游戏椅（GC）在 2 小时游戏过程中对肌肉僵硬度（MS）、表现和感知的影响。33 名电竞选手（23 ± 4.9）签字同意参加这项混合方法随机研究。受试者在受控环境中进行了两次为期 2 小时的《英雄联盟》（LoL）游戏。MS使用振荡频率进行测量。描述性统计显示，胸椎和腰椎区域的 MS 值较低（左侧 -4.4% vs. 0.32%；-2.7% vs. -2.1%；右侧 0.2% vs. 8.3%；7% vs. 10.8%）。肩上部仅右侧的 GC 更高（9.2% 对 -6.4；左侧 4.7 对 7.5）。大多数参与者更喜欢 GC（58%），在 GC 中，球员的胜率提高了 25%，杀敌数提高了 15%。这些数据表明，GC 是这群 LoL 游戏玩家的首选，并且与提高成绩有关。
{"title":"Aeron vs. Gaming Chair - Performance, Perception and Muscle Stiffness in Video Game Players: A Comparative Investigation","authors":"Joanne Donoghue, Hallie Zwibel, William G Werner","doi":"10.1101/2024.03.13.24304245","DOIUrl":"https://doi.org/10.1101/2024.03.13.24304245","url":null,"abstract":"This study compared an Aeron office chair and a commercial gaming chair (GC) on muscle stiffness (MS), performance, and perceptions during a 2-hour gaming session.\u0000Thirty-three esports players (23 ± 4.9) signed consent to participate in this mixed-methods randomized study. Subjects played League of Legends (LoL) in a controlled environment for two 2-hour sessions. MS was measured using oscillation frequency. Investigators recorded evaluations, game statistics, and player perceptions.\u0000Descriptive statistics showed lower MS in the thoracic and lumbar region (left -4.4% vs. 0.32%; -2.7% vs. -2.1%; right 0.2% vs. 8.3%; 7% vs. 10.8%). The upper shoulder was higher in the GC only on the right (9.2% vs. -6.4; left 4.7 vs. 7.5). Most participants preferred the GC (58%), and players won 25% more and achieved 15% more kills in the GC.\u0000The GC exhibited lower levels of muscle stiffness in the thoracic and lumbar regions. This data suggests that the GC is the preferred choice among this group of LoL gamers and is associated with enhanced performance.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"129 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140149719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.1101/2024.03.11.24303896
Diana Carolina Zona, Carlos D Páez-Mora, Teddy Angarita-Sierra, Matilde E Rojas-Paredes, Daniela Cano-Trejos
BACKGROUND: Although moderate and severe COVID-19 patients have shown obstructive and restrictive disorders in pulmonary function after recovery from the disease, studies evaluating the effectiveness of rehabilitation programs that seek to improve lung function are scarce. AIM: Herein, we evaluate changes in lung function and perceived dyspnea in Covid-19 patients after undergoing 12 weeks of a PR program. DESIGN: Retrospective observational study SETTING: Cesar, Colombia Neumocesar Pneumological Center. POPULATION: 100 outpatients with a history of Covid-19 METHODS: We evaluated respiratory function using spirometry parameters, as well as the mMRC dyspnea scale for perceived dyspnea in 100 patients with a history of Covid-19. We used univariate and multivariate statistical approaches to assess changes in lung function and perceived dyspnea before and after a PR program to determine whether gender, age, height, weight, comorbidities, and oxygen delivery system affect the recovery of lung function and perceived dyspnea. RESULTS: We found that PR treatment has positive effects on respiratory pathologies caused by SARS-CoV-2 infection regardless of patient gender, indicating that rehabilitation provided benefits regardless of the physical characteristics of the patients. Both univariate and multivariate statistical analyses indicated that FVC, FEV1, FEF 25-75, and mMRC are robust diagnostic indicators of lung function recovery and perceived dyspnea. Both invasive and non-invasive positive pressure ventilatory support had deleterious effects on lung function prolongating patient recovery. CONCLUSIONS: Rehabilitation programs can benefit patients facing respiratory pathologies caused by SARS-CoV-2 infection. Additional research on the long-term effects of the sequelae of Covid-19 is needed. A large sample of patients is needed to clarify the effects of therapy on respiratory function. CLINICAL REHABILITATION IMPACT: PR programs have positive effects on patients facing respiratory pathologies caused by SARS-CoV-2 infection.
{"title":"Changes in lung function and dyspnea perception in Colombian Covid-19 patients after a 12-week pulmonary rehabilitation program.","authors":"Diana Carolina Zona, Carlos D Páez-Mora, Teddy Angarita-Sierra, Matilde E Rojas-Paredes, Daniela Cano-Trejos","doi":"10.1101/2024.03.11.24303896","DOIUrl":"https://doi.org/10.1101/2024.03.11.24303896","url":null,"abstract":"BACKGROUND: Although moderate and severe COVID-19 patients have shown obstructive and restrictive disorders in pulmonary function after recovery from the disease, studies evaluating the effectiveness of rehabilitation programs that seek to improve lung function are scarce.\u0000AIM: Herein, we evaluate changes in lung function and perceived dyspnea in Covid-19 patients after undergoing 12 weeks of a PR program.\u0000DESIGN: Retrospective observational study\u0000SETTING: Cesar, Colombia Neumocesar Pneumological Center.\u0000POPULATION: 100 outpatients with a history of Covid-19\u0000METHODS: We evaluated respiratory function using spirometry parameters, as well as the mMRC dyspnea scale for perceived dyspnea in 100 patients with a history of Covid-19. We used univariate and multivariate statistical approaches to assess changes in lung function and perceived dyspnea before and after a PR program to determine whether gender, age, height, weight, comorbidities, and oxygen delivery system affect the recovery of lung function and perceived dyspnea.\u0000RESULTS: We found that PR treatment has positive effects on respiratory pathologies caused by SARS-CoV-2 infection regardless of patient gender, indicating that rehabilitation provided benefits regardless of the physical characteristics of the patients. Both univariate and multivariate statistical analyses indicated that FVC, FEV1, FEF 25-75, and mMRC are robust diagnostic indicators of lung function recovery and perceived dyspnea. Both invasive and non-invasive positive pressure ventilatory support had deleterious effects on lung function prolongating patient recovery.\u0000CONCLUSIONS: Rehabilitation programs can benefit patients facing respiratory pathologies caused by SARS-CoV-2 infection. Additional research on the long-term effects of the sequelae of Covid-19 is needed. A large sample of patients is needed to clarify the effects of therapy on respiratory function. CLINICAL REHABILITATION IMPACT: PR programs have positive effects on patients facing respiratory pathologies caused by SARS-CoV-2 infection.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140149286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Early enteral nutrition is often recommended for patients with acute stroke who have difficulty with oral intake. This study aimed to develop a predictive model to assess the need for enteral nutrition in older patients with acute cerebrovascular disorders. The model employs a machine learning algorithm using observational parameters related to swallowing ability. Methods: Ninety patients experiencing a cerebrovascular accident for the first time were included in this study. Swallowing function was assessed using the Food Intake LEVEL Scale. Nine specific variables were used to create a model for determining the need for enteral nutrition. Initially, variable selection was conducted through correlation analysis. Subsequently, the data were randomly divided into training and test groups. Five machine learning methods were applied to identify the most effective algorithm: logistic regression, decision tree, random forest, support vector machine, and XG Boost. Results: Through correlation analysis, we identified the independent variables Functional Independence Measure, motor and cognitive scores and speech intelligibility. The logistic regression model demonstrated high performance (accuracy, 0.82; area under the curve, 0.82). Conclusion: We demonstrated that a predictive model, employing machine learning and integrating Functional Independence Measure motor and cognitive scores and speech intelligibility, exhibits superior predictive efficacy and ascertains the necessity for enteral nutrition. This model can be expediently appraised even by individuals not specialized in dysphagia. Additionally, it is applicable to patients who are incapable of adhering to conventional swallowing assessment protocols owing to compromised consciousness or cognitive impairments, or those with an exceptionally elevated risk of aspiration.
{"title":"Machine Learning in Acute Stroke Care: A Novel Model for Assessing the Need for Enteral Nutrition","authors":"Kazuhiro Okamoto, Keisuke Irie, Kengo Hoyano, Isao Matsushita","doi":"10.1101/2024.03.11.24304069","DOIUrl":"https://doi.org/10.1101/2024.03.11.24304069","url":null,"abstract":"Aim: Early enteral nutrition is often recommended for patients with acute stroke who have difficulty with oral intake. This study aimed to develop a predictive model to assess the need for enteral nutrition in older patients with acute cerebrovascular disorders. The model employs a machine learning algorithm using observational parameters related to swallowing ability.\u0000Methods: Ninety patients experiencing a cerebrovascular accident for the first time were included in this study. Swallowing function was assessed using the Food Intake LEVEL Scale. Nine specific variables were used to create a model for determining the need for enteral nutrition. Initially, variable selection was conducted through correlation analysis. Subsequently, the data were randomly divided into training and test groups. Five machine learning methods were applied to identify the most effective algorithm: logistic regression, decision tree, random forest, support vector machine, and XG Boost.\u0000Results: Through correlation analysis, we identified the independent variables Functional Independence Measure, motor and cognitive scores and speech intelligibility. The logistic regression model demonstrated high performance (accuracy, 0.82; area under the curve, 0.82).\u0000Conclusion: We demonstrated that a predictive model, employing machine learning and integrating Functional Independence Measure motor and cognitive scores and speech intelligibility, exhibits superior predictive efficacy and ascertains the necessity for enteral nutrition. This model can be expediently appraised even by individuals not specialized in dysphagia. Additionally, it is applicable to patients who are incapable of adhering to conventional swallowing assessment protocols owing to compromised consciousness or cognitive impairments, or those with an exceptionally elevated risk of aspiration.","PeriodicalId":501453,"journal":{"name":"medRxiv - Rehabilitation Medicine and Physical Therapy","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140149603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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