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Successful Desensitization to Lenalidomide in Leukocytoclastic Vasculitis. 成功脱敏来那度胺治疗白细胞减少性血管炎
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2024-07-08 DOI: 10.18176/jiaci.1002
I Fernández-Concha, K Pose, L de Las Vecillas, M Lluch-Bernal, M Tomás-Pérez, T Soto, A López de la Guía, R Cabañas
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引用次数: 0
SQ HDM Sublingual Immunotherapy Tablet for the Treatment of HDM Allergic Rhinitis and Asthma Improves Subjective Sleepiness and Insomnia: An Exploratory Analysis of the Real-life CARIOCA Study. 用于治疗HDM过敏性鼻炎和哮喘的SQ HDM舌下免疫治疗片可改善主观嗜睡和失眠:真实生活 CARIOCA 研究的探索性分析。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2023-09-04 DOI: 10.18176/jiaci.0934
D Jaffuel, E Serrano, C Leroyer, A Chartier, P Demoly

Background: Knowledge of the effectiveness of house dust mite (HDM) sublingual immunotherapy (SLIT) in allergic rhinitis (AR) and asthma associated sleep disorders remains incomplete. A noninterventional study was conducted to assess the effect of the standardized quality (SQ) HDM SLIT tablet on safety and symptoms in adults with respiratory allergies caused by HDM. The study also assessed the status of insomnia and daytime sleepiness in patients with AR and/or asthma-associated sleep disorders treated with the SQ HDM SLIT tablet.

Methods: This was a 12-month multicenter, longitudinal, and prospective study. Participants started the SQ HDM SLIT tablet for moderateto-severe HDM-induced AR that was persistent despite the use of symptom relieving medication or HDM-induced asthma-associated sleep disorders that were not well controlled with inhaled corticosteroids and were associated with mild-to-severe HDM-induced AR. Sleep symptoms were measured using the Insomnia Severity Index (ISI) questionnaire and the Epworth Sleepiness Scale (ESS).

Results: A total of 1526 adult patients were enrolled, and 1483 were eventually included in the analysis. At baseline, 41.5% of patients reported sleep disorders; of these, 77.0% had insomnia and 28.9% experienced excessive daytime sleepiness. Insomnia was significantly more frequent among patients with uncontrolled AR (83.1%) than among those with controlled AR (52.6%) (P<.0001). Over time, 48.3% and 59.7% of patients, respectively, reported an improvement greater than the minimal clinically important difference in the ISI and ESS scales.

Conclusion: In patients with HDM-induced AR and/or asthma-associated sleep disorders, an improvement in subjective insomnia and sleepiness was observed after 1 year of treatment with the SQ HDM SLIT tablet in a real-life setting.

背景:有关屋尘螨(HDM)舌下免疫疗法(SLIT)对过敏性鼻炎(AR)和哮喘相关睡眠障碍的疗效的了解仍不全面。我们开展了一项非干预性研究,以评估标准化质量(SQ)HDM SLIT 片剂对由 HDM 引起的呼吸道过敏成人的安全性和症状的影响。该研究还评估了接受 SQ HDM SLIT 片剂治疗的 AR 和/或哮喘相关睡眠障碍患者的失眠和白天嗜睡状况:这是一项为期 12 个月的多中心、纵向和前瞻性研究。参与者开始服用 SQ HDM SLIT 片剂的原因是:中度至重度 HDM 引起的哮喘,尽管使用了缓解症状的药物,但症状仍持续存在;或 HDM 引起的哮喘相关睡眠障碍,吸入皮质类固醇不能很好地控制,且与轻度至重度 HDM 引起的哮喘相关。睡眠症状采用失眠严重程度指数(ISI)问卷和埃普沃思嗜睡量表(ESS)进行测量:共有 1526 名成年患者参与研究,最终有 1483 人被纳入分析。基线时,41.5%的患者报告有睡眠障碍,其中77.0%的患者失眠,28.9%的患者白天过度嗜睡。失眠症在未控制的 AR 患者中的发生率(83.1%)明显高于在控制的 AR 患者中的发生率(52.6%):在现实生活中,对于 HDM 引起的 AR 和/或哮喘相关睡眠障碍患者,使用 SQ HDM SLIT 片剂治疗 1 年后,主观失眠和嗜睡情况有所改善。
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引用次数: 0
Sensitization to Quercus ilex Pollen Is Clinically Relevant in Patients With Seasonal Pollen Allergy. 对柞树花粉过敏与季节性花粉过敏患者的临床症状有关。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2024-02-21 DOI: 10.18176/jiaci.0998
M Lluch-Bernal, M Pedrosa, J Domínguez-Ortega, M Colque-Bayona, J Correa-Borit, E Phillips-Anglés, C Gómez-Traseira, S Quirce, R Rodríguez-Pérez
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引用次数: 0
Nonasthmatic Eosinophilic Bronchitis: A Systematic Review of Current Treatment Options. 非哮喘性嗜酸性支气管炎回顾。当前治疗方案的系统回顾。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2023-12-19 DOI: 10.18176/jiaci.0984
D Betancor, M Valverde-Monge, B Barroso, A Gomez-Lopez, J Sastre

Nonasthmatic eosinophilic bronchitis is characterized by persistent dry or barely productive cough and bronchial eosinophilia without airway obstruction or bronchial hyperreactivity. It is primarily a chronic disease, in which some patients have clinical and pathophysiological relapses, while others progress to asthma or chronic obstructive pulmonary disease. It accounts for 5% to 30% of cases referred for chronic cough. Exposure to common inhalants and occupational sensitizers has been proposed as a possible cause of the disease, although the etiology and underlying mechanisms are uncertain. Some features are similar to those of asthma, such as airway eosinophilia, inflammatory mediator levels, and airway remodeling. Differences in airway pathophysiology, such as the location of airway inflammation and levels of IL-13 and PGE-2, have been reported. Sputum cell count is the gold standard test for diagnosis, and other biomarkers, such as exhaled nitric oxide, could support the diagnosis. A systematic review of treatments for the disease shows that while inhaled corticosteroids are the primary option, the appropriate dose, the type of corticosteroid, and the duration of treatment remain unknown. Treatment duration is inversely correlated with the relapse rate. Increased doses of inhaled corticosteroids, oral corticosteroids, and leukotriene receptor antagonists are recommended in persistent disease. Anti-IL-5 biologics could be promising in this disease. Studies that investigate biomarkers for diagnosis and prognosis are necessary, as are randomized controlled studies for second-line treatments.

非哮喘性嗜酸性粒细胞支气管炎的特点是持续干咳或几乎无痰,支气管嗜酸性粒细胞增多,但无气道阻塞或支气管高反应性。它主要是一种慢性疾病,一些患者会出现临床和病理生理复发,而另一些患者则会发展为哮喘或慢性阻塞性肺病。在因慢性咳嗽而转诊的病例中,该病占 5%至 30%。有人认为,接触常见吸入剂和职业致敏剂可能是该病的病因,但其病因和基本机制尚不确定。该病的某些特征与哮喘相似,如气道嗜酸性粒细胞增多、炎症介质水平和气道重塑。有报道称,气道病理生理学存在差异,如气道炎症的部位以及 IL-13 和 PGE-2 的水平。痰细胞计数是诊断的金标准检验,呼出的一氧化氮等其他生物标志物也可支持诊断。对该病治疗方法的系统回顾显示,虽然吸入皮质类固醇是主要的选择,但适当的剂量、皮质类固醇的类型和治疗持续时间仍是未知数。治疗持续时间与复发率成反比。对于顽固性疾病,建议增加吸入皮质类固醇、口服皮质类固醇和白三烯受体拮抗剂的剂量。抗IL-5生物制剂对这种疾病很有希望。有必要对诊断和预后的生物标志物进行研究,并对二线治疗方法进行随机对照研究。
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引用次数: 0
Cold Urticaria due to Amoxicillin-Clavulanic Acid. 阿莫西林-克拉维酸引起的寒冷性荨麻疹。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2024-02-14 DOI: 10.18176/jiaci.0999
Ö Özdemir
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引用次数: 0
Buckwheat-Induced Refractory Anaphylaxis in a Hospitalized Patient. 一名住院病人因荞麦引发的难治性过敏性休克
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2024-05-10 DOI: 10.18176/jiaci.1001
A Domínguez Estirado, C Cuevas Bravo, F Skrabski, L Baptista Serna, B Bartolomé Zavala, M Labrador-Horrillo, P Tornero Molina
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引用次数: 0
Role of Thymic Stromal Lymphopoietin in the Pathophysiology of Asthma and Clinical and Biological Effects of Blockade With Tezepelumab. 胸腺基质淋巴细胞生成素在哮喘病理生理学中的作用以及使用特珠单抗阻断的临床和生物学效应
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2024-07-26 DOI: 10.18176/jiaci.1012
C Venegas Garrido, P Nair, I Dávila, L Pérez de Llano

The airway epithelium is the first line of defense of the respiratory system against the external environment. It plays an active role in the initiation of immune and allergic responses against potential hazards. Among the various specialized cells and cytokines that participate in epithelium-induced responses, alarmins are particularly interesting, given their ample role in mediating T2 and non-T2 inflammatory mechanisms involved in the pathogenesis of asthma. Thymic stromal lymphopoietin (TSLP) is an alarmin with broad effects in asthma that result from its widespread action on multiple cell types, including eosinophils, mast cells, dendritic cells, and group-2 innate lymphoid cells. Its role in allergy-mediated responses, eosinophilic inflammation, airway hyperresponsiveness, mucus hyperproduction, viral tolerance, and airway remodeling is of the utmost importance, as more comprehensive asthma assessments have been developed to explore these pathogenic features. Therefore, blockade with targeting molecules, such as monoclonal antibodies, has emerged as a promising therapeutic option, particularly in patients with multiple pathogenic pathways. In this review, we examine the roles of alarmins (mainly TSLP) in the pathogenesis of asthma and clinical expression and discuss the effects of inhibiting TSLP on several inflammatory and clinical outcomes. We also review the literature supporting treatment with anti-TSLP biologics and the unanswered questions and unmet needs associated with targeting alarmins in asthma.

背景:气道上皮是呼吸系统抵御外界环境的第一道防线。它在启动针对潜在危害的免疫和过敏反应中发挥着积极作用。在参与上皮诱导反应的各种特化细胞和细胞因子中,alarmins 尤为引人关注,因为它们在介导哮喘发病机制中的 T2 和非 T2 炎症机制方面发挥着重要作用。胸腺基质淋巴细胞生成素(TSLP)是一种对哮喘有广泛影响的促过敏物质,它对多种细胞类型(包括嗜酸性粒细胞、肥大细胞、树突状细胞和第 2 组先天性淋巴细胞)具有广泛作用。它在过敏介导的反应、嗜酸性粒细胞炎症、气道高反应性、粘液分泌亢进、病毒耐受性和气道重塑中的作用至关重要,因为已开发出更全面的哮喘评估方法来探索这些致病特征。因此,使用靶向分子(如单克隆抗体)进行阻断已成为一种很有前景的治疗方法,尤其是对有多种致病途径的患者。在这篇综述中,我们研究了促哮喘素(主要是 TSLP)在哮喘发病机制和临床表现中的作用,并讨论了抑制 TSLP 对几种炎症和临床结果的影响。我们还回顾了支持使用抗 TSLP 生物制剂进行治疗的文献,以及与哮喘中抗哮喘蛋白靶向相关的未解之谜和未满足的需求。
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引用次数: 0
Contact System Activation and Bradykinin Generation in Patients With Idiopathic Angioedema. 特发性血管性水肿患者的接触系统激活和缓激肽生成。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2024-02-21 DOI: 10.18176/jiaci.0996
C Suffritti, P Calzari, F Depetri, S Griffini, E Grovetti, R Santacroce, M Margaglione, M Cugno
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引用次数: 0
Age and Geographical Location Determine the Molecular Pattern of Walnut Allergy in Madrid, Spain. 年龄和地理位置决定了西班牙马德里核桃过敏的分子模式。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2024-07-08 DOI: 10.18176/jiaci.1005
L Ortega-Martín, S Fernández-Bravo, E Nuñez-Borque, V Esteban, C Pastor-Vargas, M de Las Heras, J Sastre, J Cuesta-Herranz
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引用次数: 0
Allergy to Cypress and Olive Pollen: Clinical Phenotypes and Allergen Recognition. 柏树和橄榄花粉过敏:临床表型和过敏原识别。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-10-23 Epub Date: 2023-08-04 DOI: 10.18176/jiaci.0917
M D Alonso-Díaz de Durana, E Pérez-Fernández, M Villalba, L Martín-Pedraza, M Fernández-Rivas

Background and objectives: Background: Cypress and olive pollen are the most prevalent sensitizers in the Mediterranean area. Some patients exhibit dual sensitization, which has not been well documented to date. Objective: To identify the allergens involved in dual cypress and olive allergy (C+O) and to study the relationship between phenotype and allergen sensitization.

Methods: C+O patients were selected. Those monosensitized to olive or cypress were used as a reference. Specific IgE to whole extracts and purified allergens from olive and cypress was determined. Immunoblotting was performed to analyze IgG and IgE binding using olive polyclonal antibodies and patients' sera, respectively. Mutual immunoblotting inhibition of olive and cypress extracts and inhibition of cypress extract immunoblotting with olive allergens were performed. Multiple correspondence analysis and hierarchical cluster classifications were conducted to analyze the relationships between the clinical presentation of C+O (symptoms, seasonality) and allergen profile.

Results: C+O patients were clustered in 4 phenotypes. The most frequent one (58.4%) was rhinoconjunctivitis in winter (February) and spring (May), with asthma in 38% of patients. Ole e 1 and Cup s 1 were the major allergens. Proteins homologous to Ole e 1, Ole e 9, and Ole e 11 in cypress pollen were identified and shown to inhibit IgE binding to cypress extract.

Conclusions: The exclusive C+O results from cosensitization to Cup s 1 and Ole e 1 and cross-reactivity due to previously unreported Ole e 1-like, Ole e 9-like, and Ole e 11-like allergens in cypress pollen. Our findings point to 4 clinical phenotypes of winter and/or spring or perennial rhinoconjunctivitis with and without asthma.

背景和目标:背景:柏树花粉和橄榄花粉是地中海地区最常见的致敏物质。一些患者表现出双重过敏,但迄今为止还没有很好的记录。目的:确定涉及双重过敏的过敏原:确定涉及柏树和橄榄双重过敏(C+O)的过敏原,并研究表型与过敏原致敏之间的关系:方法:筛选出 C+O 患者。方法:选择 C+O 患者,以对橄榄或扁柏单敏的患者为参照。测定对橄榄和柏树的整体提取物和纯化过敏原的特异性 IgE。分别使用橄榄多克隆抗体和患者血清进行免疫印迹,分析 IgG 和 IgE 的结合情况。进行了橄榄和柏树提取物的相互免疫印迹抑制以及柏树提取物与橄榄过敏原的免疫印迹抑制。对 C+O 的临床表现(症状、季节性)和过敏原谱之间的关系进行了多重对应分析和分层聚类分析:结果:C+O 患者分为 4 种表型。最常见的表型(58.4%)是冬季(2 月)和春季(5 月)的鼻结膜炎,38%的患者患有哮喘。Ole e 1 和 Cup s 1 是主要的过敏原。发现了与柏树花粉中的 Ole e 1、Ole e 9 和 Ole e 11 同源的蛋白质,并证明它们能抑制 IgE 与柏树提取物的结合:结论:柏树花粉中的类似 Ole e 1、类似 Ole e 9 和类似 Ole e 11 的过敏原导致了对 Cup s 1 和 Ole e 1 的共敏性和交叉反应,从而产生了独有的 C+O 症状。我们的研究结果指出了冬季和/或春季或常年性鼻结膜炎伴有或不伴有哮喘的 4 种临床表型。
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引用次数: 0
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Journal of Investigational Allergology and Clinical Immunology
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