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Reply to: Successful Isatuximab Desensitization in a Patient With Refractory Multiple Myeloma and Indolent Systemic Mastocytosis. 回复:一位难治性多发性骨髓瘤和系统性乳腺增生症患者的伊沙妥昔单抗脱敏治疗获得成功。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-06-17 Epub Date: 2024-01-26 DOI: 10.18176/jiaci.0992
M C Torres Górriz, J Borrás Cuartero, C G Pesántez Méndez, C I Stein Coronado, E Enrique
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引用次数: 0
Strongyloidiasis in the Allergology Department of a Tertiary Hospital in Valencia Province (Spain): A Retrospective Study (2010-2023). 西班牙瓦伦西亚省某三级医院过敏症科的圆线虫病:一项回顾性研究(2010-2023)
IF 7.2 3区 医学 Q1 ALLERGY Pub Date : 2024-06-17 Epub Date: 2023-11-15 DOI: 10.18176/jiaci.0955
M D de Las Marinas Alvarez, C S Romero, R Felix Toledo, M Alvariño Martín, C Martorell Calatayud, J C Cerdá Mir, D Navalpotro Rodríguez, A Martorell Aragones
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引用次数: 0
Rapid Clearance of Corticosteroid-Resistant Targetoid Acute Generalized Exanthematous Pustulosis Using an IL-17A Inhibitor: A Case Report. 应用IL-17A抑制剂快速清除皮质类固醇耐药靶向药物急性全身性水肿:一例报告。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-06-17 Epub Date: 2023-09-05 DOI: 10.18176/jiaci.0946
J Wen, Y Wang, B Wang, B Jiang, J Lan, J Yang, J Tao, C Shen, Y Li
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引用次数: 0
Efficacy of Mepolizumab for the Treatment of Eosinophilic Cystitis: A Report of 2 Cases. 美波珠单抗治疗嗜酸性膀胱炎的疗效:两例报告。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-06-17 Epub Date: 2023-10-18 DOI: 10.18176/jiaci.0954
L Trefond, L Guy, C Darcha, A Gallon, R Thomas-Monier, K Berdugo, P Smets, L Olagne, J Stievenart, D Fayard, P Cathebras, O Aumaitre, L Boyer, M Andre, J E Kahn
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引用次数: 0
Sensorineural Hearing Loss Is an Unrecognized Complication of Common Variable Immunodeficiency. 感觉神经性听力损失(SNHL)是常见可变免疫缺陷(CVID)的一种未被认识的并发症。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-06-17 Epub Date: 2023-10-31 DOI: 10.18176/jiaci.0956
G Tessarin, M Baronio, L Gazzurelli, S Rossi, A Caravaggio, R Badolato, V Lougaris
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引用次数: 0
Deconstructing Adverse Reactions to Amoxicillin- Clavulanic Acid: The Importance of Time of Onset. 解构阿莫西林-克拉维酸的不良反应:发病时间的重要性。
IF 7.2 3区 医学 Q1 ALLERGY Pub Date : 2024-06-17 Epub Date: 2023-02-23 DOI: 10.18176/jiaci.0896
N P Freundt-Serpa, M Salas-Cassinello, A Gonzalo-Fernández, N Marchán-Pinedo, I Doña, I Serrano-García, A M Humanes-Navarro, G Bogas, M Labella, L Sánchez-Morillas, M J Torres, M Fernández-Rivas

Background and objective: Amoxicillin-clavulanic acid (AX-CL) is the most consumed ß-lactam antibiotic worldwide. We aimed to establish the different phenotypes of ß-lactam allergy in patients reporting a reaction to AX-CL and to investigate the differences between immediate and nonimmediate onset.

Methods: We performed a cross-sectional retrospective study at Hospital Clínico San Carlos (HCSC), Madrid and Hospital Regional Universitario de Málaga (HRUM), Málaga, Spain. We included patients reporting reactions with AX-CL who underwent the allergy workup between 2017 and 2019. Data on the reported reaction and allergy work-up were collected. Reactions were classified as immediate and nonimmediate with a 1-hour cut-off.

Results: The study population comprised 372 patients (HCSC 208, HRUM 164). There were 90 immediate reactions (24.2%), 252 nonimmediate reactions (67.7%), and 30 reactions with unknown latency (8.1%). Allergy to ß-lactams was ruled out in 266 patients (71.5%) and confirmed in 106 patients (28.5%). The final main diagnosis in the overall population was allergy to aminopenicillins (7.3%), to CL (7%), to penicillin (6.5%), and to ß-lactams (5.9%). Allergy was confirmed in 77.2% and 14.3% of immediate and nonimmediate reactions, respectively, with a relative risk of 5.06 (95%CI, 3.64-7.02) for an allergy diagnosis in those reporting immediate reactions. Only 2/54 patients with a late-positive intradermal test (IDT) result for CL were diagnosed with CL allergy.

Conclusion: Allergy was diagnosed in a minority of the study population. However, given that it was diagnosed 5 times more frequently in patients reporting immediate reactions, this classification proved useful for risk stratification. Late-positive IDT results for CL have no diagnostic value. Therefore, the late IDT reading for CL could be removed from the diagnostic work-up.

背景:阿莫西林-克拉维酸(AX-CL)是全球使用量最大的贝他内酰胺类抗生素。我们旨在确定使用 AX-CL 后出现反应的患者对倍他内酰胺过敏的不同表型,并研究即刻发病和非即刻发病之间的差异:西班牙圣卡洛斯医院(HCSC)和马拉加地区大学医院(HRUM)进行的横断面回顾性研究。研究纳入了2017年至2019年期间报告AX-CL反应并完成过敏检查的患者。收集了报告的反应和过敏检查数据。反应分为即刻反应和非即刻反应,以 1 小时为分界点:我们纳入了 372 名患者(HCSC 208 人,HRUM 164 人)。其中90例(24.2%)为即刻反应,252例(67.7%)为非即刻反应,30例(8.1%)潜伏期不明。266名患者(71.5%)排除了对倍他内酰胺过敏的可能,106名患者(28.5%)得到确诊。所有患者的最终主要诊断结果是对氨基青霉素类(7.3%)、CL(7%)、青霉素(6.5%)和倍他内酰胺类(5.9%)过敏。在即刻反应和非即刻反应中,分别有 77.2% 和 14.3% 的患者被确诊为过敏,在报告即刻反应的患者中,过敏诊断的相对风险为 5.06(95%CI 3.64-7.02)。只有 2/54 名对 CL 的皮内试验(IDT)呈晚期阳性的患者被确诊为对 CL 过敏:结论:在整个研究人群中,只有少数人被确诊为对 CL 过敏,但在报告有即刻反应的人群中,确诊过敏的频率要高出 5 倍,因此这种分类有助于进行风险分层。对 CL 的晚期 IDT 阳性没有诊断价值,其晚期读数可从诊断工作中检索到。
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引用次数: 0
Identification of the Protein a-L-Fucosidase as the Possible Cause of Allergy to Cardamom. 确定蛋白 a-L -岩藻糖苷酶可能是小豆蔻过敏的原因。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-06-01 DOI: 10.18176/jiaci.0957
L Bernal-Rubio, E Martínez-Alonso, C Fernández-Lozano, F J Sola-Martínez, J Martínez-Botas, A Alcázar, B de la Hoz-Caballer
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引用次数: 0
A Case of Transient Pediatric Pork-Cat Syndrome Caused by Sensitization to Albumin. 一例因对白蛋白过敏而引起的一过性小儿猪猫综合征。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-06-01 DOI: 10.18176/jiaci.0959
E Ramírez-Mateo, C Fernández-Lozano, A De-Andrés-Martín, D González-De-Olano
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引用次数: 0
Global Lung Initiative as Diagnostic Criteria in Asthma-COPD Overlap Syndrome: Prevalence and Disease Characterization in a Real-Life Asthma Cohort. 全球肺部倡议作为哮喘-慢性阻塞性肺疾病重叠综合征的诊断标准:现实生活中哮喘队列中的患病率和疾病特征。
IF 7.2 3区 医学 Q1 ALLERGY Pub Date : 2024-06-01 DOI: 10.18176/jiaci.0966
D Betancor, M Otal, J M Olaguibel, J M Rodrigo-Muñoz, M J Alvarez Puebla, E Arismendi, P Barranco, B Barroso, I Bobolea, B Cárdaba, M J Cruz, E Curto, V Del Pozo, J Domínguez-Ortega, F J González-Barcala, J A Luna-Porta, C Martínez-Rivera, J Mullol, X Muñoz, C Picado, V Plaza, S Quirce, M J Rial, I Roibás-Veiga, L Soto-Retes, A Valero, M Valverde-Monge, J Sastre
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引用次数: 0
IgE-Mediated Sensitization to Blo t 21 and Blo t 5 Is Associated With Asthma in the Tropics: A Case-Control Study. IgE 介导的对 Blo t 21 和 Blo t 5 的过敏与热带地区的哮喘有关:病例对照研究。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2024-06-01 DOI: 10.18176/jiaci.0892
J Zakzuk, K Donado, E Mondol, V Marrugo, R Regino, J F López, K Hernandez, D Mercado, R Dennis, L Puerta, L Caraballo

Background and objective: Sensitization to Blomia tropicalis is associated with asthma in various tropical and subtropical countries; however, information about the specific molecular components associated with this disease is scarce. Using molecular diagnosis, we sought to identify B tropicalis allergens associated with asthma in Colombia.

Methods: Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.

Results: Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.

Conclusion: Although Blo t 5 and Blo t 21 are considered common sensitizers, this is the first report of their association with asthma. Both components should be included in molecular panels for diagnosis of allergy in the tropics.

背景和目的:在多个热带和亚热带国家,对热带布洛米氏菌的过敏与哮喘有关;然而,与该疾病相关的特定分子成分的信息却很少。通过分子诊断,我们试图找出哥伦比亚与哮喘有关的热带疫霉菌过敏原:方法:在哥伦比亚多个城市(巴兰基亚、波哥大、麦德林、卡利和圣安德烈斯)开展的一项全国流行病学研究中,使用内部 ELISA 系统测定了哮喘患者(272 人)和对照组(298 人)对 8 种 B 型热带病重组过敏原(Blo t 2、5、7、8、10、12、13 和 21)的特异性 IgE(sIgE)。研究样本包括儿童和成人(平均 [SD] 年龄为 28 [17] 岁)。使用 ELISA 抑制法评估了 Blo t 5 和 Blo t 21 之间的交叉反应:结果:在哥伦比亚多个城市(巴兰基亚、波哥大、麦德林、卡利和圣安德烈斯)进行的一项全国流行病学研究中,使用内部 ELISA 系统测定了哮喘患者(人数=272)和对照组(人数=298)对 8 种 B 型热带病重组过敏原(Blo t 2、5、7、8、10、12、13 和 21)的特异性 IgE(sIgE)。研究样本包括儿童和成人(平均 [SD] 年龄为 28 [17] 岁)。使用 ELISA 抑制法评估了 Blo t 5 和 Blo t 21 之间的交叉反应:尽管Blo t 5和Blo t 21被认为是常见的致敏物质,但这是首次报道它们与哮喘的关系。在热带地区,这两种成分都应被纳入过敏诊断的分子检测中。
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Journal of Investigational Allergology and Clinical Immunology
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