Pub Date : 2024-06-17Epub Date: 2024-01-26DOI: 10.18176/jiaci.0992
M C Torres Górriz, J Borrás Cuartero, C G Pesántez Méndez, C I Stein Coronado, E Enrique
{"title":"Reply to: Successful Isatuximab Desensitization in a Patient With Refractory Multiple Myeloma and Indolent Systemic Mastocytosis.","authors":"M C Torres Górriz, J Borrás Cuartero, C G Pesántez Méndez, C I Stein Coronado, E Enrique","doi":"10.18176/jiaci.0992","DOIUrl":"10.18176/jiaci.0992","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"216-217"},"PeriodicalIF":6.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17Epub Date: 2023-11-15DOI: 10.18176/jiaci.0955
M D de Las Marinas Alvarez, C S Romero, R Felix Toledo, M Alvariño Martín, C Martorell Calatayud, J C Cerdá Mir, D Navalpotro Rodríguez, A Martorell Aragones
{"title":"Strongyloidiasis in the Allergology Department of a Tertiary Hospital in Valencia Province (Spain): A Retrospective Study (2010-2023).","authors":"M D de Las Marinas Alvarez, C S Romero, R Felix Toledo, M Alvariño Martín, C Martorell Calatayud, J C Cerdá Mir, D Navalpotro Rodríguez, A Martorell Aragones","doi":"10.18176/jiaci.0955","DOIUrl":"10.18176/jiaci.0955","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"188-190"},"PeriodicalIF":7.2,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17Epub Date: 2023-09-05DOI: 10.18176/jiaci.0946
J Wen, Y Wang, B Wang, B Jiang, J Lan, J Yang, J Tao, C Shen, Y Li
{"title":"Rapid Clearance of Corticosteroid-Resistant Targetoid Acute Generalized Exanthematous Pustulosis Using an IL-17A Inhibitor: A Case Report.","authors":"J Wen, Y Wang, B Wang, B Jiang, J Lan, J Yang, J Tao, C Shen, Y Li","doi":"10.18176/jiaci.0946","DOIUrl":"10.18176/jiaci.0946","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"196-197"},"PeriodicalIF":6.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17Epub Date: 2023-10-18DOI: 10.18176/jiaci.0954
L Trefond, L Guy, C Darcha, A Gallon, R Thomas-Monier, K Berdugo, P Smets, L Olagne, J Stievenart, D Fayard, P Cathebras, O Aumaitre, L Boyer, M Andre, J E Kahn
{"title":"Efficacy of Mepolizumab for the Treatment of Eosinophilic Cystitis: A Report of 2 Cases.","authors":"L Trefond, L Guy, C Darcha, A Gallon, R Thomas-Monier, K Berdugo, P Smets, L Olagne, J Stievenart, D Fayard, P Cathebras, O Aumaitre, L Boyer, M Andre, J E Kahn","doi":"10.18176/jiaci.0954","DOIUrl":"10.18176/jiaci.0954","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"202-204"},"PeriodicalIF":6.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17Epub Date: 2023-10-31DOI: 10.18176/jiaci.0956
G Tessarin, M Baronio, L Gazzurelli, S Rossi, A Caravaggio, R Badolato, V Lougaris
{"title":"Sensorineural Hearing Loss Is an Unrecognized Complication of Common Variable Immunodeficiency.","authors":"G Tessarin, M Baronio, L Gazzurelli, S Rossi, A Caravaggio, R Badolato, V Lougaris","doi":"10.18176/jiaci.0956","DOIUrl":"10.18176/jiaci.0956","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"190-192"},"PeriodicalIF":6.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-17Epub Date: 2023-02-23DOI: 10.18176/jiaci.0896
N P Freundt-Serpa, M Salas-Cassinello, A Gonzalo-Fernández, N Marchán-Pinedo, I Doña, I Serrano-García, A M Humanes-Navarro, G Bogas, M Labella, L Sánchez-Morillas, M J Torres, M Fernández-Rivas
Background and objective: Amoxicillin-clavulanic acid (AX-CL) is the most consumed ß-lactam antibiotic worldwide. We aimed to establish the different phenotypes of ß-lactam allergy in patients reporting a reaction to AX-CL and to investigate the differences between immediate and nonimmediate onset.
Methods: We performed a cross-sectional retrospective study at Hospital Clínico San Carlos (HCSC), Madrid and Hospital Regional Universitario de Málaga (HRUM), Málaga, Spain. We included patients reporting reactions with AX-CL who underwent the allergy workup between 2017 and 2019. Data on the reported reaction and allergy work-up were collected. Reactions were classified as immediate and nonimmediate with a 1-hour cut-off.
Results: The study population comprised 372 patients (HCSC 208, HRUM 164). There were 90 immediate reactions (24.2%), 252 nonimmediate reactions (67.7%), and 30 reactions with unknown latency (8.1%). Allergy to ß-lactams was ruled out in 266 patients (71.5%) and confirmed in 106 patients (28.5%). The final main diagnosis in the overall population was allergy to aminopenicillins (7.3%), to CL (7%), to penicillin (6.5%), and to ß-lactams (5.9%). Allergy was confirmed in 77.2% and 14.3% of immediate and nonimmediate reactions, respectively, with a relative risk of 5.06 (95%CI, 3.64-7.02) for an allergy diagnosis in those reporting immediate reactions. Only 2/54 patients with a late-positive intradermal test (IDT) result for CL were diagnosed with CL allergy.
Conclusion: Allergy was diagnosed in a minority of the study population. However, given that it was diagnosed 5 times more frequently in patients reporting immediate reactions, this classification proved useful for risk stratification. Late-positive IDT results for CL have no diagnostic value. Therefore, the late IDT reading for CL could be removed from the diagnostic work-up.
{"title":"Deconstructing Adverse Reactions to Amoxicillin- Clavulanic Acid: The Importance of Time of Onset.","authors":"N P Freundt-Serpa, M Salas-Cassinello, A Gonzalo-Fernández, N Marchán-Pinedo, I Doña, I Serrano-García, A M Humanes-Navarro, G Bogas, M Labella, L Sánchez-Morillas, M J Torres, M Fernández-Rivas","doi":"10.18176/jiaci.0896","DOIUrl":"10.18176/jiaci.0896","url":null,"abstract":"<p><strong>Background and objective: </strong>Amoxicillin-clavulanic acid (AX-CL) is the most consumed ß-lactam antibiotic worldwide. We aimed to establish the different phenotypes of ß-lactam allergy in patients reporting a reaction to AX-CL and to investigate the differences between immediate and nonimmediate onset.</p><p><strong>Methods: </strong>We performed a cross-sectional retrospective study at Hospital Clínico San Carlos (HCSC), Madrid and Hospital Regional Universitario de Málaga (HRUM), Málaga, Spain. We included patients reporting reactions with AX-CL who underwent the allergy workup between 2017 and 2019. Data on the reported reaction and allergy work-up were collected. Reactions were classified as immediate and nonimmediate with a 1-hour cut-off.</p><p><strong>Results: </strong>The study population comprised 372 patients (HCSC 208, HRUM 164). There were 90 immediate reactions (24.2%), 252 nonimmediate reactions (67.7%), and 30 reactions with unknown latency (8.1%). Allergy to ß-lactams was ruled out in 266 patients (71.5%) and confirmed in 106 patients (28.5%). The final main diagnosis in the overall population was allergy to aminopenicillins (7.3%), to CL (7%), to penicillin (6.5%), and to ß-lactams (5.9%). Allergy was confirmed in 77.2% and 14.3% of immediate and nonimmediate reactions, respectively, with a relative risk of 5.06 (95%CI, 3.64-7.02) for an allergy diagnosis in those reporting immediate reactions. Only 2/54 patients with a late-positive intradermal test (IDT) result for CL were diagnosed with CL allergy.</p><p><strong>Conclusion: </strong>Allergy was diagnosed in a minority of the study population. However, given that it was diagnosed 5 times more frequently in patients reporting immediate reactions, this classification proved useful for risk stratification. Late-positive IDT results for CL have no diagnostic value. Therefore, the late IDT reading for CL could be removed from the diagnostic work-up.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"177-187"},"PeriodicalIF":7.2,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Bernal-Rubio, E Martínez-Alonso, C Fernández-Lozano, F J Sola-Martínez, J Martínez-Botas, A Alcázar, B de la Hoz-Caballer
{"title":"Identification of the Protein a-L-Fucosidase as the Possible Cause of Allergy to Cardamom.","authors":"L Bernal-Rubio, E Martínez-Alonso, C Fernández-Lozano, F J Sola-Martínez, J Martínez-Botas, A Alcázar, B de la Hoz-Caballer","doi":"10.18176/jiaci.0957","DOIUrl":"10.18176/jiaci.0957","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"34 3","pages":"205-206"},"PeriodicalIF":6.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Ramírez-Mateo, C Fernández-Lozano, A De-Andrés-Martín, D González-De-Olano
{"title":"A Case of Transient Pediatric Pork-Cat Syndrome Caused by Sensitization to Albumin.","authors":"E Ramírez-Mateo, C Fernández-Lozano, A De-Andrés-Martín, D González-De-Olano","doi":"10.18176/jiaci.0959","DOIUrl":"10.18176/jiaci.0959","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"34 3","pages":"209-211"},"PeriodicalIF":6.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Betancor, M Otal, J M Olaguibel, J M Rodrigo-Muñoz, M J Alvarez Puebla, E Arismendi, P Barranco, B Barroso, I Bobolea, B Cárdaba, M J Cruz, E Curto, V Del Pozo, J Domínguez-Ortega, F J González-Barcala, J A Luna-Porta, C Martínez-Rivera, J Mullol, X Muñoz, C Picado, V Plaza, S Quirce, M J Rial, I Roibás-Veiga, L Soto-Retes, A Valero, M Valverde-Monge, J Sastre
{"title":"Global Lung Initiative as Diagnostic Criteria in Asthma-COPD Overlap Syndrome: Prevalence and Disease Characterization in a Real-Life Asthma Cohort.","authors":"D Betancor, M Otal, J M Olaguibel, J M Rodrigo-Muñoz, M J Alvarez Puebla, E Arismendi, P Barranco, B Barroso, I Bobolea, B Cárdaba, M J Cruz, E Curto, V Del Pozo, J Domínguez-Ortega, F J González-Barcala, J A Luna-Porta, C Martínez-Rivera, J Mullol, X Muñoz, C Picado, V Plaza, S Quirce, M J Rial, I Roibás-Veiga, L Soto-Retes, A Valero, M Valverde-Monge, J Sastre","doi":"10.18176/jiaci.0966","DOIUrl":"https://doi.org/10.18176/jiaci.0966","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"34 3","pages":"192-195"},"PeriodicalIF":7.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Zakzuk, K Donado, E Mondol, V Marrugo, R Regino, J F López, K Hernandez, D Mercado, R Dennis, L Puerta, L Caraballo
Background and objective: Sensitization to Blomia tropicalis is associated with asthma in various tropical and subtropical countries; however, information about the specific molecular components associated with this disease is scarce. Using molecular diagnosis, we sought to identify B tropicalis allergens associated with asthma in Colombia.
Methods: Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.
Results: Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.
Conclusion: Although Blo t 5 and Blo t 21 are considered common sensitizers, this is the first report of their association with asthma. Both components should be included in molecular panels for diagnosis of allergy in the tropics.
背景和目的:在多个热带和亚热带国家,对热带布洛米氏菌的过敏与哮喘有关;然而,与该疾病相关的特定分子成分的信息却很少。通过分子诊断,我们试图找出哥伦比亚与哮喘有关的热带疫霉菌过敏原:方法:在哥伦比亚多个城市(巴兰基亚、波哥大、麦德林、卡利和圣安德烈斯)开展的一项全国流行病学研究中,使用内部 ELISA 系统测定了哮喘患者(272 人)和对照组(298 人)对 8 种 B 型热带病重组过敏原(Blo t 2、5、7、8、10、12、13 和 21)的特异性 IgE(sIgE)。研究样本包括儿童和成人(平均 [SD] 年龄为 28 [17] 岁)。使用 ELISA 抑制法评估了 Blo t 5 和 Blo t 21 之间的交叉反应:结果:在哥伦比亚多个城市(巴兰基亚、波哥大、麦德林、卡利和圣安德烈斯)进行的一项全国流行病学研究中,使用内部 ELISA 系统测定了哮喘患者(人数=272)和对照组(人数=298)对 8 种 B 型热带病重组过敏原(Blo t 2、5、7、8、10、12、13 和 21)的特异性 IgE(sIgE)。研究样本包括儿童和成人(平均 [SD] 年龄为 28 [17] 岁)。使用 ELISA 抑制法评估了 Blo t 5 和 Blo t 21 之间的交叉反应:尽管Blo t 5和Blo t 21被认为是常见的致敏物质,但这是首次报道它们与哮喘的关系。在热带地区,这两种成分都应被纳入过敏诊断的分子检测中。
{"title":"IgE-Mediated Sensitization to Blo t 21 and Blo t 5 Is Associated With Asthma in the Tropics: A Case-Control Study.","authors":"J Zakzuk, K Donado, E Mondol, V Marrugo, R Regino, J F López, K Hernandez, D Mercado, R Dennis, L Puerta, L Caraballo","doi":"10.18176/jiaci.0892","DOIUrl":"10.18176/jiaci.0892","url":null,"abstract":"<p><strong>Background and objective: </strong>Sensitization to Blomia tropicalis is associated with asthma in various tropical and subtropical countries; however, information about the specific molecular components associated with this disease is scarce. Using molecular diagnosis, we sought to identify B tropicalis allergens associated with asthma in Colombia.</p><p><strong>Methods: </strong>Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.</p><p><strong>Results: </strong>Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés). The study sample included children and adults (mean [SD] age, 28 [17] years). Cross-reactivity between Blo t 5 and Blo t 21 was evaluated using ELISA-inhibition.</p><p><strong>Conclusion: </strong>Although Blo t 5 and Blo t 21 are considered common sensitizers, this is the first report of their association with asthma. Both components should be included in molecular panels for diagnosis of allergy in the tropics.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"34 3","pages":"157-166"},"PeriodicalIF":6.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}