{"title":"Regarding \"Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Induced by Meropenem in a Patient Receiving Avelumab and Subsequent Flare-up\".","authors":"Öner Özdemir","doi":"10.18176/jiaci.1133","DOIUrl":"https://doi.org/10.18176/jiaci.1133","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isamar De Agrela-Mendes, Ana Entrala, Elsa Phillips-Angles, Tamara Pérez-Robles, Rosario Cabañas, Teresa Caballero
{"title":"Long-term Prophylaxis With Lanadelumab in Patients With Angioedema Due to C1 Inhibitor Deficiency: A Real-life Study in Spain.","authors":"Isamar De Agrela-Mendes, Ana Entrala, Elsa Phillips-Angles, Tamara Pérez-Robles, Rosario Cabañas, Teresa Caballero","doi":"10.18176/jiaci.1120","DOIUrl":"https://doi.org/10.18176/jiaci.1120","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Moreno-Conde, Jesús Moreno-Conde, Pedro Guardia-Martínez, Ángel Vilches-Arenas, Claudia Rodríguez, Virginia De Luque-Piñana
Background and objectives: Asthma is a chronic respiratory condition whose prevalence varies across different regions and populations. In Andalusia, detailed data on the characteristics of asthma patients are lacking, thus limiting effective clinical management and health care planning. Objective: Our objective was to characterize patients diagnosed with asthma in Andalusia.
Material and methods: To our knowledge, this study comprises the largest cohort of asthma patients in Spain. We characterized 726 006 asthma patients based on prevalence, exacerbations, comorbidities, and pharmacological treatment. We covered the whole population, with subanalyses comparing rural-urban settings and coastal-inland regions.
Results: The overall prevalence of asthma in Andalusia was 8.57%. The disease was more prevalent in females, although it was more common in males until the age of 15 years. The most frequent comorbidities were arthrosis and spondylosis. Almost three-quarters (70.73%) of newly diagnosed asthma patients received treatment, the most common being SABAs (31.56%), LTRAs (16.13%), and systemic corticosteroids (13.94%). After initial treatment, 35.15% of patients did not receive follow-up care. Treatment was stepped up in 28.68%, stepped down in 20.75%, and switched in 15.43%.
Conclusions: Our results provide a detailed characterization of the Andalusian population in terms of prevalence, comorbidities, and treatment trajectories and proved consistent with findings from other Spanish regions. We also observed geographical discrepancies in asthma prevalence when comparing rural-urban settings and coastal-inland regions.
{"title":"Prevalence, Treatment Trajectories, and Environmental Exacerbation Factors in Asthma: A Regional Study in Andalusia.","authors":"Alberto Moreno-Conde, Jesús Moreno-Conde, Pedro Guardia-Martínez, Ángel Vilches-Arenas, Claudia Rodríguez, Virginia De Luque-Piñana","doi":"10.18176/jiaci.1096","DOIUrl":"https://doi.org/10.18176/jiaci.1096","url":null,"abstract":"<p><strong>Background and objectives: </strong>Asthma is a chronic respiratory condition whose prevalence varies across different regions and populations. In Andalusia, detailed data on the characteristics of asthma patients are lacking, thus limiting effective clinical management and health care planning. Objective: Our objective was to characterize patients diagnosed with asthma in Andalusia.</p><p><strong>Material and methods: </strong>To our knowledge, this study comprises the largest cohort of asthma patients in Spain. We characterized 726 006 asthma patients based on prevalence, exacerbations, comorbidities, and pharmacological treatment. We covered the whole population, with subanalyses comparing rural-urban settings and coastal-inland regions.</p><p><strong>Results: </strong>The overall prevalence of asthma in Andalusia was 8.57%. The disease was more prevalent in females, although it was more common in males until the age of 15 years. The most frequent comorbidities were arthrosis and spondylosis. Almost three-quarters (70.73%) of newly diagnosed asthma patients received treatment, the most common being SABAs (31.56%), LTRAs (16.13%), and systemic corticosteroids (13.94%). After initial treatment, 35.15% of patients did not receive follow-up care. Treatment was stepped up in 28.68%, stepped down in 20.75%, and switched in 15.43%.</p><p><strong>Conclusions: </strong>Our results provide a detailed characterization of the Andalusian population in terms of prevalence, comorbidities, and treatment trajectories and proved consistent with findings from other Spanish regions. We also observed geographical discrepancies in asthma prevalence when comparing rural-urban settings and coastal-inland regions.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catalase and Hypersensitivity to Avocado.","authors":"Öner Özdemir","doi":"10.18176/jiaci.1128","DOIUrl":"10.18176/jiaci.1128","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Cross-Reactive Allergens in Mushroom Allergy: A Case Report in a 17-Year-Old Girl in Japan.","authors":"Makoto Nojo, Shintaro Suzuki, Tomoki Uno, Yoshitaka Uchida, Yoshito Miyata, Hironori Sagara, Akihiko Tanaka","doi":"10.18176/jiaci.1125","DOIUrl":"https://doi.org/10.18176/jiaci.1125","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strongyloides stercoralis Infection, Imatinib, and DRESS.","authors":"Öner Özdemir","doi":"10.18176/jiaci.1129","DOIUrl":"https://doi.org/10.18176/jiaci.1129","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro De la Torre Carrión, Estela S Castromil-Benito, Jorge Parrón-Ballesteros, Luisa Iglesias-Pena, Carlos Pastor-Vargas, Montserrat Fernandez-Rivas
{"title":"Allergy to Bee Pollen Supplement: Identification of Major Royal Jelly Protein 1 as the Culprit Allergen.","authors":"Alejandro De la Torre Carrión, Estela S Castromil-Benito, Jorge Parrón-Ballesteros, Luisa Iglesias-Pena, Carlos Pastor-Vargas, Montserrat Fernandez-Rivas","doi":"10.18176/jiaci.1124","DOIUrl":"https://doi.org/10.18176/jiaci.1124","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teodorikez-Wilfox Jimenez-Rodriguez, Angela Rico Rodes, Amparo Burgos San Jose, María Del Cañizo Moreira, Laura Ureña Horno, Maria E Valerio Alonso, Andrea Cano Rodriguez, Clara P Gallego Velez, María P González Delgado, María Tasso Cereceda
{"title":"Omalizumab as Premedication for Hypersensitivity Reactions Refractory to Asparaginase Desensitization in Children With Acute Lymphoblastic Leukemia.","authors":"Teodorikez-Wilfox Jimenez-Rodriguez, Angela Rico Rodes, Amparo Burgos San Jose, María Del Cañizo Moreira, Laura Ureña Horno, Maria E Valerio Alonso, Andrea Cano Rodriguez, Clara P Gallego Velez, María P González Delgado, María Tasso Cereceda","doi":"10.18176/jiaci.1118","DOIUrl":"https://doi.org/10.18176/jiaci.1118","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin O Slusarenko, Klara F Borrmann, Claudia Knappe, Jonathan Vogel, Benjamin Schnautz, Stéphanie Kler, Tilo Biedermann, Knut Brockow, Ulf Darsow, Thalia Carreno Velazquez, Elisabetta Francescato, Simon J Hewings, Matthias F Kramer, Matthew D Heath, Gunnar Dittmar, Christiane Hilger, Ralph S Peters, Carsten B Schmidt-Weber, Bernadette Eberlein, Simon Blank
Background and objectives: Venom immunotherapy (VIT) is an effective treatment for yellow jacket venom (YJV) allergy. It is often based on mixtures of venom from different species. Recent taxonomic re-evaluation has revealed that widely used VIT preparations contain venom from Vespula alascensis, a North American species, rather than venom from the Palearctic Vespula vulgaris. To assess the allergenic relevance of V alascensis venom for European patients and evaluate its suitability for inclusion in VIT preparations.
Methods: The ability of V alascensis and V vulgaris venom to activate effector cells from YJV-allergic patients from Germany was compared using the basophil activation test. Patients' sIgE reactivity was assessed using ELISA, inhibition ELISA, CAP inhibition, and Western blot. Proteomic analysis of the venoms was also conducted.
Results: Basophil activation tests showed highly similar activation profiles for V alascensis and V vulgaris venoms. Moreover, ELISA and inhibition analyses revealed comparable overall sIgE reactivity for both venoms. In contrast, Western blot analysis demonstrated similar sIgE profiles for antigen 5 allergens, although phospholipase A1 allergens were differentially detected. Proteomic analysis revealed no differences in the major allergens of the 2 venoms.
Conclusion: This study demonstrates the functional similarity between V alascensis and V vulgaris venoms in allergic responses. Moreover, it highlights the clinical relevance of V alascensis for YJV-sensitized European patients and supports its inclusion in YJV VIT preparations in Europe.
{"title":"Assessing the Allergenic Relevance of Vespula alascensis Venom: Implications for Venom Immunotherapy.","authors":"Benjamin O Slusarenko, Klara F Borrmann, Claudia Knappe, Jonathan Vogel, Benjamin Schnautz, Stéphanie Kler, Tilo Biedermann, Knut Brockow, Ulf Darsow, Thalia Carreno Velazquez, Elisabetta Francescato, Simon J Hewings, Matthias F Kramer, Matthew D Heath, Gunnar Dittmar, Christiane Hilger, Ralph S Peters, Carsten B Schmidt-Weber, Bernadette Eberlein, Simon Blank","doi":"10.18176/jiaci.1108","DOIUrl":"https://doi.org/10.18176/jiaci.1108","url":null,"abstract":"<p><strong>Background and objectives: </strong>Venom immunotherapy (VIT) is an effective treatment for yellow jacket venom (YJV) allergy. It is often based on mixtures of venom from different species. Recent taxonomic re-evaluation has revealed that widely used VIT preparations contain venom from Vespula alascensis, a North American species, rather than venom from the Palearctic Vespula vulgaris. To assess the allergenic relevance of V alascensis venom for European patients and evaluate its suitability for inclusion in VIT preparations.</p><p><strong>Methods: </strong>The ability of V alascensis and V vulgaris venom to activate effector cells from YJV-allergic patients from Germany was compared using the basophil activation test. Patients' sIgE reactivity was assessed using ELISA, inhibition ELISA, CAP inhibition, and Western blot. Proteomic analysis of the venoms was also conducted.</p><p><strong>Results: </strong>Basophil activation tests showed highly similar activation profiles for V alascensis and V vulgaris venoms. Moreover, ELISA and inhibition analyses revealed comparable overall sIgE reactivity for both venoms. In contrast, Western blot analysis demonstrated similar sIgE profiles for antigen 5 allergens, although phospholipase A1 allergens were differentially detected. Proteomic analysis revealed no differences in the major allergens of the 2 venoms.</p><p><strong>Conclusion: </strong>This study demonstrates the functional similarity between V alascensis and V vulgaris venoms in allergic responses. Moreover, it highlights the clinical relevance of V alascensis for YJV-sensitized European patients and supports its inclusion in YJV VIT preparations in Europe.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":4.8,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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