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Stability of Asthma Phenotypes in the Spanish Cohort of the MEGA Project. MEGA 项目西班牙队列中哮喘表型的稳定性。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-18 Epub Date: 2024-11-26 DOI: 10.18176/jiaci.1026
M J Rial, D Betancor, J A Cañas, J M Olaguibel, J M Rodrigo-Muñoz, M J Alvarez-Puebla, E Arismendi, B Barroso, I Bobolea, B Cárdaba, M J Cruz, E Curto, V Del Pozo, J Domínguez-Ortega, A Garcia de la Fuente, F J González-Barcala, J A Luna-Porta, C Martínez-Rivera, J Mullol, X Muñoz, C Picado, V Plaza, S Quirce, L Soto-Retes, M Valverde-Monge, J Sastre
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引用次数: 0
Sunflower (Helianthus annuus) Seed Allergy. 向日葵(Helianthus annuus)种子过敏。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-18 Epub Date: 2023-12-12 DOI: 10.18176/jiaci.0965
C Galleani, M C Diéguez, B Cabanillas, C Martín-Arriscado Arroba, A Enríquez-Matas, J F Crespo

Background and objectives: Sunflower seed is one of the most common edible seeds. Its consumption is growing. Cases of sunflower seed allergy have been reported since the 1970s. However, there are few data on the prevalence and clinical manifestations of sunflower seed allergy. To improve our understanding of sunflower seed allergy.

Methods: We evaluated the clinical and immunological features of patients with sunflower seed allergy diagnosed in the allergy department of a tertiary hospital in Madrid over a 5-year period.

Results: Forty-seven patients reported adverse reactions after ingestion of sunflower seed and were sensitized specifically to sunflower seed, as determined by skin prick test (median, 8 mm) or specific IgE (median, 1.10 kUA/L). Most reactions were adult-onset and were preceded by a history of atopy and other food allergies, predominantly to peach, peanut, and nuts. The clinical presentation of sunflower seed allergy ranged from mild to severe, with many patients experiencing severe reactions, in which epinephrine was underused. Repeated exposures to sunflower seed in the same patient showed severity of symptoms to vary. Levels of sunflower seed IgE were strongly correlated with levels of IgE to nonspecific lipid transfer proteins, while the severity of the reactions did not differ significantly according to sensitization to the proteins.

Conclusion: Our findings reveal variability in the clinical presentations of sunflower seed allergy on repeated exposures and underuse of epinephrine in anaphylaxis. We highlight the importance of strict avoidance of sunflower seed and accurate prescription and administration of epinephrine in allergic patients.

背景和目的:葵花籽是最常见的食用种子之一,其消费量正在不断增长。自 20 世纪 70 年代以来,就有关于葵花籽过敏的病例报告。然而,有关葵花籽过敏的发病率和临床表现的数据却很少。为了加深对葵花籽过敏的了解:方法:我们评估了马德里一家三甲医院过敏科在 5 年内确诊的葵花籽过敏患者的临床和免疫学特征:结果:47 名患者在摄入葵花籽后出现不良反应,并通过皮肤点刺试验(中位数为 8 mm)或特异性 IgE(中位数为 1.10 kUA/L)确定对葵花籽有特异性过敏反应。他们中的大多数人在成年后对葵花籽产生过敏反应,之前曾有过过敏史和其他食物过敏史,主要是对桃、花生和坚果过敏。葵花籽过敏的临床表现从轻微到严重不等,严重反应的患者比例很高,而且往往治疗不足。同一患者在反复接触葵花籽后,症状的严重程度也不尽相同。葵花籽 IgE 的水平与非特异性脂质转移蛋白的 IgE 水平密切相关,但根据对这些蛋白的致敏程度,反应的严重程度并无明显差异:我们的研究结果表明,反复接触葵花籽过敏的临床表现存在差异,过敏性休克时肾上腺素的使用不足。我们强调,过敏患者必须严格避免食用葵花籽,并准确开具处方和使用肾上腺素。
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引用次数: 0
Armelline Almond Allergy: The First Reported Case. Armelline杏仁过敏:第一例报道。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-18 Epub Date: 2024-12-05 DOI: 10.18176/jiaci.1033
L Alessi, S Cirrincione, B Aiuto, E Gosso, L Cavallarin, M G Giuffrida, G Monti, C Lamberti
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引用次数: 0
Two Nonimmediate Reactions to Oxaliplatin and Docetaxel Confirmed by Lymphocyte Transformation Test and Treated With Successful Rapid Desensitization Procedures. 淋巴细胞转化试验证实奥沙利铂和多西紫杉醇两种非立即反应,并成功进行快速脱敏治疗。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-18 Epub Date: 2024-12-19 DOI: 10.18176/jiaci.1030
M P Berges-Gimeno, A Barra-Castro, C Fernandez-Lozano, E Solano-Solares, N Martinez-Jañez, C Pueyo-Lopez, J Martínez-Botas
{"title":"Two Nonimmediate Reactions to Oxaliplatin and Docetaxel Confirmed by Lymphocyte Transformation Test and Treated With Successful Rapid Desensitization Procedures.","authors":"M P Berges-Gimeno, A Barra-Castro, C Fernandez-Lozano, E Solano-Solares, N Martinez-Jañez, C Pueyo-Lopez, J Martínez-Botas","doi":"10.18176/jiaci.1030","DOIUrl":"10.18176/jiaci.1030","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"70-72"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ozenoxacin-Induced Contact Dermatitis With Tolerance to Ciprofloxacin. 氧氟沙星诱发的接触性皮炎对环丙沙星耐受。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-18 Epub Date: 2024-11-13 DOI: 10.18176/jiaci.1031
M N Otero-Fernández, E Laffond-Yges, R M Castillo-Loja, A Cabrera-Núñez, M E Mazoteras-Martínez, F J Muñoz-Bellido, I Dávila
{"title":"Ozenoxacin-Induced Contact Dermatitis With Tolerance to Ciprofloxacin.","authors":"M N Otero-Fernández, E Laffond-Yges, R M Castillo-Loja, A Cabrera-Núñez, M E Mazoteras-Martínez, F J Muñoz-Bellido, I Dávila","doi":"10.18176/jiaci.1031","DOIUrl":"10.18176/jiaci.1031","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"72-73"},"PeriodicalIF":6.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Far Are We From Achieving Delabeling of False Penicillin/ß-Lactam Allergy Alerts? A Population Problem. 我们离消除青霉素/ß-内酰胺过敏警报误报还有多远?人口问题。
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-18 Epub Date: 2024-05-09 DOI: 10.18176/jiaci.1004
M A Tejedor-Alonso, M Perez-Encinas, S Sanz Márquez, J J Martinez Simon, L Moreno-Nuñez, A Gonzalez-Moreno, J Macias-Iglesias, A Rosado-Ingelmo

Interest in finding efficient ways to remove penicillin allergy alerts has grown as a result of awareness of the considerable excess of falsenegative diagnoses in patients with penicillin allergy labels (90%-95%), the poorer course with non-ß-lactam antibiotics, the increase in bacterial resistance, and the fact that these problems can affect up to 20% of the population in some countries. The strategies proposed have generated many publications in countries where the number of allergists to conduct such studies is low. In many cases where delabeling is performed, the risk of ß-lactam allergy is low, and a single penicillin challenge is sufficient to delabel the alert. However, other less "ultrarapid" strategies can be used to administer a ß-lactam during an admission for infection and thus postpone delabeling until traditional drug allergy consultations. However, the definitive withdrawal of ß-lactam alerts is threatened by nonremoval of alerts in electronic health records and by the reactivation or nonsynchronization of alerts between electronic systems at different levels of care. Allergy departments need to reflect on how to implement practices that enable rapid and efficient delabeling of drug allergy alerts, especially in patients with major comorbidities.

背景:由于人们意识到青霉素过敏标签患者的假阴性诊断率相当高(90%-95%)、使用非ß-内酰胺类抗生素的疗效较差、细菌耐药性增加,以及在某些国家这些问题可能会影响多达 20% 的人口,因此人们对寻找消除青霉素过敏警报的有效方法越来越感兴趣。在开展此类研究的过敏学家人数较少的国家,所提出的策略已发表了许多论文。在很多情况下,ß-内酰胺类药物过敏的风险很低,一次青霉素挑战就足以解除警报。然而,也可以采用其他不那么 "超快速 "的策略,在入院治疗感染期间使用ß-内酰胺类药物,从而将解除标签的时间推迟到传统的药物过敏会诊之后。然而,ß-内酰胺类药物警报的最终撤消受到电子健康记录中警报未撤消以及不同级别医疗机构电子系统之间警报重新激活或不同步的威胁。过敏科需要反思如何快速有效地解除药物过敏警报,尤其是对有重大并发症的患者。
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引用次数: 0
Predictive Factors and Optimization of Omalizumab in Chronic Spontaneous Urticaria: A Multicenter Study of 257 Patients.
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-14 DOI: 10.18176/jiaci.1053
J Ceravalls, A M Giménez-Arnau, V Expósito-Serrano, N Fernández Chico, A Lara Moya, I Bielsa, P Ribó, B Mascaró-Hereza, M Bonfill-Ortí, J Spertino, E Serra, C Baliu-Piqué, G Melé-Ninot
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引用次数: 0
Validation of an Environmental Exposure Chamber for Assessment of Allergy to Grass Pollen.
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-13 DOI: 10.18176/jiaci.1036
I García-Gutiérrez, C Solórzano-Zepeda, V Sánchez-García, E Ramírez-Mateo, D Antolín-Amérigo, Y Zheng, A Rioja Carrera, I León Hernando, M E Hernando Pérez, B De la Hoz Caballer

Background: An environmental exposure chamber (EEC) is a health facility that enables allergic symptoms to be induced in a controlled manner in persons sensitized to a dispersed allergen. We performed a study at our institution to technically and clinically validate an EEC in patients allergic to grass pollen.

Methods: We developed a new EEC inside a clean room (ISO-8 class) measuring 15.6 m². During the technical validation, the patient's exposure conditions were simulated by ensuring homogeneous distribution of the allergen with a particle disperser and monitoring both particle and pollen grain concentrations. Temperature, pressure, and humidity were also registered. A total of 31 volunteers were exposed to Phleum pratense pollen in the EEC. Of these, 25 were allergic (cases), with symptoms of rhinoconjunctivitis with or without asthma, and 6 were not (controls). One control and 2 cases were exposed twice to check reproducibility, generating a total of 34 challenges. The test was stopped once the positivity criterion was reached or the patient completed 90 minutes in the EEC.

Results: Both the stability of particle concentrations and approximation to the pollen sample concentration were guaranteed. All challenges with controls were negative. Among the cases, 15% of challenges were negative and 85% were positive. No severe or late reactions were observed. Volunteers exposed twice to the same pollen had the same result in both challenges.

Conclusion: Our EEC proved to be a specific, safe, and reproducible tool for the diagnosis of grass pollen allergy.

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引用次数: 0
Safety and Efficacy of the First Venom Immunotherapy for Allergy to Vespa velutina nigrithorax: Interim Analysis of the W-STING Study.
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-13 DOI: 10.18176/jiaci.1058
F Carballada, A Parra, T Liñares, N Giangrande, S Varela, Á Meijide, M Castro, A I Tabar
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引用次数: 0
Bioinformatics-Based Prediction of B- and T-Cell Epitopes in R-Mandelonitrile Lyase, a Recently Described Peach Allergen.
IF 6.1 3区 医学 Q1 ALLERGY Pub Date : 2025-02-11 DOI: 10.18176/jiaci.1052
M A López-Matas, L Martín-López, F Vílchez-Sánchez, M Pedrosa, R Rodríguez-Pérez, J Domínguez-Ortega, J Carnés
{"title":"Bioinformatics-Based Prediction of B- and T-Cell Epitopes in R-Mandelonitrile Lyase, a Recently Described Peach Allergen.","authors":"M A López-Matas, L Martín-López, F Vílchez-Sánchez, M Pedrosa, R Rodríguez-Pérez, J Domínguez-Ortega, J Carnés","doi":"10.18176/jiaci.1052","DOIUrl":"https://doi.org/10.18176/jiaci.1052","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"0"},"PeriodicalIF":6.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Investigational Allergology and Clinical Immunology
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