Pub Date : 2024-04-12Epub Date: 2023-10-31DOI: 10.18176/jiaci.0945
I Jáuregui Presa, A Sala-Cunill, J Martí-Garrido, M Nieto Cid, S I Corrales Vargas, S Lizarza Mendizábal, M T Asensio Sánchez, P Ribó González, S Quirce, M C Sánchez Hernández, A Joral Badas, C Vidal, D Antolín-Amérigo, B Veleiro, M Lázaro Sastre
{"title":"Profile of Patients With Moderate-to-Severe Atopic Dermatitis and Chronic Urticaria Undergoing Biological Treatment in Hospital Allergy Units in Spain: First Report of the Alergodata Registry.","authors":"I Jáuregui Presa, A Sala-Cunill, J Martí-Garrido, M Nieto Cid, S I Corrales Vargas, S Lizarza Mendizábal, M T Asensio Sánchez, P Ribó González, S Quirce, M C Sánchez Hernández, A Joral Badas, C Vidal, D Antolín-Amérigo, B Veleiro, M Lázaro Sastre","doi":"10.18176/jiaci.0945","DOIUrl":"10.18176/jiaci.0945","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"131-133"},"PeriodicalIF":7.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12Epub Date: 2024-01-15DOI: 10.18176/jiaci.0989
J Domínguez-Ortega, C Colás, J Delgado Romero, A Habernau Mena, A Montoro Ferrer, P Barranco Sanz, P Prieto Montaño, J Fraj Lázaro, P Galindo Bonilla, M Gil Melcón, M M Lluch Bernal, R González Pérez, D Antolín-Amérigo, J Montoro Lacomba, A L Valero Santiago, S Sanchez-Garcia, A Del Cuvillo
{"title":"Baseline Clinical Characteristics and Phenoendotypes of Patients With Severe Asthma in Alergodata: The Spanish Allergy Society Registry.","authors":"J Domínguez-Ortega, C Colás, J Delgado Romero, A Habernau Mena, A Montoro Ferrer, P Barranco Sanz, P Prieto Montaño, J Fraj Lázaro, P Galindo Bonilla, M Gil Melcón, M M Lluch Bernal, R González Pérez, D Antolín-Amérigo, J Montoro Lacomba, A L Valero Santiago, S Sanchez-Garcia, A Del Cuvillo","doi":"10.18176/jiaci.0989","DOIUrl":"10.18176/jiaci.0989","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"135-138"},"PeriodicalIF":7.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12Epub Date: 2023-09-04DOI: 10.18176/jiaci.0928
M Bantulà, E Arismendi, J Roca-Ferrer, C Picado
{"title":"IL1R2 Gene Expression Is Downregulated in Obesity- Associated Asthma.","authors":"M Bantulà, E Arismendi, J Roca-Ferrer, C Picado","doi":"10.18176/jiaci.0928","DOIUrl":"10.18176/jiaci.0928","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"120-122"},"PeriodicalIF":7.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10527738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12Epub Date: 2023-12-19DOI: 10.18176/jiaci.0983
L de Las Vecillas, S Quirce
The allergic march comprises the sequential appearance of a series of allergic comorbidities. However, variability in the onset and progression of allergic diseases generates a heterogeneous scenario that does not follow a linear and single trajectory. Almost half of the pediatric population presents at least 1 allergy symptom. However, only 4%-6% present multimorbidity, with several allergic diseases co-occurring. It has recently been shown that although they share etiological mechanisms and risk factors, allergic diseases arise independently. In most cases, progression is not consecutive, or at least not the same in all patients. TH2-mediated inflammation, epithelial barrier dysfunction, and genetic predisposition play a fundamental role in the etiology of allergic diseases, on which the interaction with the exposome acts decisively. Therefore, studying diseases from an omics point of view is essential when attempting to describe the various trajectories of allergic progression and to propose effective interventions to prevent multimorbidity. In this narrative review, we provide an overview of the current perception of the allergic march, including clinical observations, omics data, risk factors, and measures aimed at modifying its course or even preventing its onset.
{"title":"The Multiple Trajectories of the Allergic March.","authors":"L de Las Vecillas, S Quirce","doi":"10.18176/jiaci.0983","DOIUrl":"10.18176/jiaci.0983","url":null,"abstract":"<p><p>The allergic march comprises the sequential appearance of a series of allergic comorbidities. However, variability in the onset and progression of allergic diseases generates a heterogeneous scenario that does not follow a linear and single trajectory. Almost half of the pediatric population presents at least 1 allergy symptom. However, only 4%-6% present multimorbidity, with several allergic diseases co-occurring. It has recently been shown that although they share etiological mechanisms and risk factors, allergic diseases arise independently. In most cases, progression is not consecutive, or at least not the same in all patients. TH2-mediated inflammation, epithelial barrier dysfunction, and genetic predisposition play a fundamental role in the etiology of allergic diseases, on which the interaction with the exposome acts decisively. Therefore, studying diseases from an omics point of view is essential when attempting to describe the various trajectories of allergic progression and to propose effective interventions to prevent multimorbidity. In this narrative review, we provide an overview of the current perception of the allergic march, including clinical observations, omics data, risk factors, and measures aimed at modifying its course or even preventing its onset.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"75-84"},"PeriodicalIF":7.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12Epub Date: 2023-09-15DOI: 10.18176/jiaci.0931
A Agulló-García, C Colás Sanz, L Martínez-Lostao, G Salamanca Fernández, L Ferrer Clavería, J L Cubero Saldaña, S V Lozano Andaluz, E Carbajo Martínez, M T Villalba Díaz
{"title":"Clinical and Molecular Profiles in Patients Allergic to Amaranthaceae.","authors":"A Agulló-García, C Colás Sanz, L Martínez-Lostao, G Salamanca Fernández, L Ferrer Clavería, J L Cubero Saldaña, S V Lozano Andaluz, E Carbajo Martínez, M T Villalba Díaz","doi":"10.18176/jiaci.0931","DOIUrl":"10.18176/jiaci.0931","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"123-125"},"PeriodicalIF":7.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12Epub Date: 2023-01-16DOI: 10.18176/jiaci.0888
Y J Li, H K Ko, S W Pan, J Y Feng, K C Su, Y Li, S N Yang, Y H Hsiao, D W Perng
Background and objectives: Background: Static lung hyperinflation (SLH) measured using body plethysmography in patients with asthma is associated with poor outcomes. The severity of SLH may be associated with small airway dysfunction (SAD), which can be measured using impulse oscillometry (IOS). Objective: This study aims to determine the correlation between SLH and SAD in patients with severe asthma and assess the improvement in SLH and SAD with treatment.
Methods: We analyzed data from patients who were enrolled in the Taiwan Severe Asthma Registry, which comprises a prospective observational cohort. Plethysmography and IOS were performed regularly. The relationship between spirometry and IOS parameters was determined. Changes in the clinical outcomes in response to treatment were analyzed.
Results: Of 107 patients with severe asthma, 83 (77.6%) had SLH based on an increased residual volume to total lung capacity ratio (RV/ TLC). Most patients were older women with worse pulmonary function and SAD than those without SLH. SAD, defined as increased airway resistance/reactance, was significantly correlated with SLH. Airway reactance at 5 Hz (X5) ≤-0.21 kPa/(L/s) detected SLH with an area under the receiver operating characteristic curve of 0.84 (P<.0001; sensitivity, 85.2%; and specificity, 83.3%). After 12 months, patients who received add-on biologics (vs those who did not) had significantly reduced exacerbations, fractional exhaled nitric oxide level, and blood eosinophil counts, as well as improved forced expiratory volume in the first second, X5, and a trend toward reduced RV/TLC ratio.
Conclusions: In severe asthma, airway reactance (X5) could be a novel parameter for assessing SLH.
背景和目的：哮喘患者通过体压测量仪（Pleth）测量的静态肺过度充气（SLH）与不良预后有关。SLH的严重程度可能与小气道功能障碍（SAD）有关，而小气道功能障碍可通过脉冲振荡仪（IOS）测量。本研究旨在确定重症哮喘患者 SLH 和 SAD 之间的相关性，以及 SLH 和 SAD 在治疗后的改善情况：我们分析了台湾重症哮喘登记患者的数据，这是一项前瞻性观察队列。我们定期对患者进行肺活量测定和肺活量指数测定。确定了肺活量和 IOS 参数之间的关系。结果：在107名重症哮喘患者中，83人（77.6%）有残气量与总肺活量（RV/TLC）比值增大的SLH。与无 SLH 的患者相比，大多数患者为老年女性，肺功能和 SAD 均较差。气道阻力/反应性增加导致的 SAD 与 SLH 显著相关。5 Hz (X5) 时气道反应≤ -0.21 [kPa/(L/s)] 可检测出 SLH，接收器操作特征曲线下面积为 0.84（p < 0.0001，灵敏度 = 85.2%，特异性 = 83.3%）。12个月后，与未接受生物制剂治疗的患者相比，接受附加生物制剂治疗的患者病情加重、呼出一氧化氮分数水平、血液嗜酸性粒细胞计数明显减少，第一秒用力呼气容积X5有所改善，RV/TLC比值呈下降趋势：结论：在重症哮喘患者中，气道反应X5可能是评估SLH的一个新参数。
{"title":"Airway Reactance Predicts Static Lung Hyperinflation in Severe Asthma.","authors":"Y J Li, H K Ko, S W Pan, J Y Feng, K C Su, Y Li, S N Yang, Y H Hsiao, D W Perng","doi":"10.18176/jiaci.0888","DOIUrl":"10.18176/jiaci.0888","url":null,"abstract":"<p><strong>Background and objectives: </strong>Background: Static lung hyperinflation (SLH) measured using body plethysmography in patients with asthma is associated with poor outcomes. The severity of SLH may be associated with small airway dysfunction (SAD), which can be measured using impulse oscillometry (IOS). Objective: This study aims to determine the correlation between SLH and SAD in patients with severe asthma and assess the improvement in SLH and SAD with treatment.</p><p><strong>Methods: </strong>We analyzed data from patients who were enrolled in the Taiwan Severe Asthma Registry, which comprises a prospective observational cohort. Plethysmography and IOS were performed regularly. The relationship between spirometry and IOS parameters was determined. Changes in the clinical outcomes in response to treatment were analyzed.</p><p><strong>Results: </strong>Of 107 patients with severe asthma, 83 (77.6%) had SLH based on an increased residual volume to total lung capacity ratio (RV/ TLC). Most patients were older women with worse pulmonary function and SAD than those without SLH. SAD, defined as increased airway resistance/reactance, was significantly correlated with SLH. Airway reactance at 5 Hz (X5) ≤-0.21 kPa/(L/s) detected SLH with an area under the receiver operating characteristic curve of 0.84 (P<.0001; sensitivity, 85.2%; and specificity, 83.3%). After 12 months, patients who received add-on biologics (vs those who did not) had significantly reduced exacerbations, fractional exhaled nitric oxide level, and blood eosinophil counts, as well as improved forced expiratory volume in the first second, X5, and a trend toward reduced RV/TLC ratio.</p><p><strong>Conclusions: </strong>In severe asthma, airway reactance (X5) could be a novel parameter for assessing SLH.</p>","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"106-117"},"PeriodicalIF":7.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10529459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B Barroso, A Gómez-López, M Valverde-Monge, D Betancor, M de Las Heras, J Sastre
{"title":"Hypersensitivity Reactions to the GLP-1 Receptor Agonists Liraglutide and Semaglutide: A Case Series.","authors":"B Barroso, A Gómez-López, M Valverde-Monge, D Betancor, M de Las Heras, J Sastre","doi":"10.18176/jiaci.0932","DOIUrl":"https://doi.org/10.18176/jiaci.0932","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"34 2","pages":"133-135"},"PeriodicalIF":7.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-09-04DOI: 10.18176/jiaci.0933
R Rodríguez-Pérez, S Del Pozuelo, E Pulido, C Brigido, P Carretero, M L Caballero
{"title":"Chemiluminescence-Based IgE Dot-Blot Assay in the Diagnosis of Anaphylaxis Caused by Prontosan.","authors":"R Rodríguez-Pérez, S Del Pozuelo, E Pulido, C Brigido, P Carretero, M L Caballero","doi":"10.18176/jiaci.0933","DOIUrl":"10.18176/jiaci.0933","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"34 2","pages":"141-142"},"PeriodicalIF":7.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-10-04DOI: 10.18176/jiaci.0944
C Shen, N Wu, L Yang, B Wang, T Liu, J Tao
{"title":"Dupilumab as Effective Therapy for Corticosteroid- Dependent/Resistant Type 2 Inflammation-Related Cutaneous Adverse Reactions.","authors":"C Shen, N Wu, L Yang, B Wang, T Liu, J Tao","doi":"10.18176/jiaci.0944","DOIUrl":"10.18176/jiaci.0944","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":"34 2","pages":"145-147"},"PeriodicalIF":7.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23Epub Date: 2023-06-21DOI: 10.18176/jiaci.0919
I Cerecedo, A López-Picado, M G Hernández-Núñez, M A Rubio-Herrera, B de la Hoz, S Infante, S Vázquez-Cortés, F J Ruano, C Gómez-Traseira, N P Freundt-Serpa, J Martínez-Botas, M Fernández-Rivas
{"title":"Milk Ladder for Reintroduction of Cow's Milk in Infants With IgE-Mediated Cow's Milk Allergy: Version Adapted to the Spanish Population.","authors":"I Cerecedo, A López-Picado, M G Hernández-Núñez, M A Rubio-Herrera, B de la Hoz, S Infante, S Vázquez-Cortés, F J Ruano, C Gómez-Traseira, N P Freundt-Serpa, J Martínez-Botas, M Fernández-Rivas","doi":"10.18176/jiaci.0919","DOIUrl":"10.18176/jiaci.0919","url":null,"abstract":"","PeriodicalId":50173,"journal":{"name":"Journal of Investigational Allergology and Clinical Immunology","volume":" ","pages":"51-53"},"PeriodicalIF":7.2,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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