首页 > 最新文献

Annals of the Academy of Medicine, Singapore最新文献

英文 中文
Predictors of early removal of intragastric balloon due to intolerance: Insights from a multiethnic Asian cohort. 因不耐受而提前移除胃内球囊的预测因素:来自多种族亚洲队列的启示。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-27 DOI: 10.47102/annals-acadmedsg.2023257
Amadora Choo, Eugene Lim, Alvin Eng, Weng Hoong Chan, Ravishankar Asokkumar, Jeremy Tan, Ai Shan Tan, Agnes Chong, Yumni Binte Md Shahrin, Xuan Wang, Phong Ching Lee, Chin Hong Lim

Introduction: Intolerance frequently limits the use of intragastric balloons (IGBs) in the treatment of obesity. This includes refractory nausea, vomiting and abdominal discomfort. Our study aims to identify predictors of balloon intolerance and early removal, which will help to guide patient selection for this intervention and peri-procedure care.

Method: We conducted a retrospective cohort study of 54 consecutive patients who underwent IGB insertion from July 2017 to July 2022 in a single tertiary institution in Singapore. Forty-seven (87.0%) patients completed therapy, while 7 patients (13.0%) had early removal of the balloon due to intolerance. Characteristics of both groups were compared.

Results: Multivariate analysis revealed significant associations between early balloon removal and both depression (P=0.012) and anxiety (P=0.001) after adjusting for age, sex, ethnicity, height, nulliparity, balloon type and volume. Univariate analysis revealed that anxiety was the main risk factor (P=0.004, odds ratio 9.111, 95% confidence interval 1.624-51.124), while depression was no longer a significant predictor.

Conclusion: Identifying predictors of balloon intolerance and early removal can enhance patient selection and improve peri-procedural care. In patients with a history of depression or anxiety, it is important to ensure adequate counselling and preparation prior to balloon insertion.

导言:在治疗肥胖症的过程中,胃内气球(IGBs)的不耐受性经常会限制其使用。这包括难治性恶心、呕吐和腹部不适。我们的研究旨在确定球囊不耐受和早期移除的预测因素,这将有助于指导患者选择这种干预措施和术前护理:我们对 2017 年 7 月至 2022 年 7 月期间在新加坡一家三级医疗机构接受 IGB 植入术的 54 名连续患者进行了回顾性队列研究。47名患者(87.0%)完成了治疗,7名患者(13.0%)因不耐受而提前移除球囊。对两组患者的特征进行了比较:多变量分析显示,在调整了年龄、性别、种族、身高、无阴道、球囊类型和容量后,早期球囊移除与抑郁(P=0.012)和焦虑(P=0.001)之间存在显著关联。单变量分析显示,焦虑是主要的风险因素(P=0.004,几率比9.111,95%置信区间1.624-51.124),而抑郁不再是重要的预测因素:结论:识别球囊不耐受和早期移除的预测因素可以提高患者选择率,改善围手术期护理。对于有抑郁或焦虑病史的患者,必须确保在球囊插入前进行充分的咨询和准备。
{"title":"Predictors of early removal of intragastric balloon due to intolerance: Insights from a multiethnic Asian cohort.","authors":"Amadora Choo, Eugene Lim, Alvin Eng, Weng Hoong Chan, Ravishankar Asokkumar, Jeremy Tan, Ai Shan Tan, Agnes Chong, Yumni Binte Md Shahrin, Xuan Wang, Phong Ching Lee, Chin Hong Lim","doi":"10.47102/annals-acadmedsg.2023257","DOIUrl":"10.47102/annals-acadmedsg.2023257","url":null,"abstract":"<p><strong>Introduction: </strong>Intolerance frequently limits the use of intragastric balloons (IGBs) in the treatment of obesity. This includes refractory nausea, vomiting and abdominal discomfort. Our study aims to identify predictors of balloon intolerance and early removal, which will help to guide patient selection for this intervention and peri-procedure care.</p><p><strong>Method: </strong>We conducted a retrospective cohort study of 54 consecutive patients who underwent IGB insertion from July 2017 to July 2022 in a single tertiary institution in Singapore. Forty-seven (87.0%) patients completed therapy, while 7 patients (13.0%) had early removal of the balloon due to intolerance. Characteristics of both groups were compared.</p><p><strong>Results: </strong>Multivariate analysis revealed significant associations between early balloon removal and both depression (P=0.012) and anxiety (P=0.001) after adjusting for age, sex, ethnicity, height, nulliparity, balloon type and volume. Univariate analysis revealed that anxiety was the main risk factor (P=0.004, odds ratio 9.111, 95% confidence interval 1.624-51.124), while depression was no longer a significant predictor.</p><p><strong>Conclusion: </strong>Identifying predictors of balloon intolerance and early removal can enhance patient selection and improve peri-procedural care. In patients with a history of depression or anxiety, it is important to ensure adequate counselling and preparation prior to balloon insertion.</p>","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facing death alone: An exploration of terminally ill individuals living alone in palliative care. 独自面对死亡:对在姑息关怀中独自生活的临终病人的探索。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-27 DOI: 10.47102/annals-acadmedsg.2023426
Paul Bashyam, Ching Sian Yap, XiangYi Chen, Zhi Zheng Yeo
{"title":"Facing death alone: An exploration of terminally ill individuals living alone in palliative care.","authors":"Paul Bashyam, Ching Sian Yap, XiangYi Chen, Zhi Zheng Yeo","doi":"10.47102/annals-acadmedsg.2023426","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2023426","url":null,"abstract":"","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimising paediatric urinary tract infection diagnos. 优化儿科尿路感染诊断。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-27 DOI: 10.47102/annals-acadmedsg.2024288
Marcus Wing Choy Loe, Jiahui Li, Kee Thai Yeo
{"title":"Optimising paediatric urinary tract infection diagnos.","authors":"Marcus Wing Choy Loe, Jiahui Li, Kee Thai Yeo","doi":"10.47102/annals-acadmedsg.2024288","DOIUrl":"10.47102/annals-acadmedsg.2024288","url":null,"abstract":"","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2023 guidelines on the management of psoriasis by the Dermatological Society of Singapore. 新加坡皮肤病学会制定的 2023 年银屑病管理指南。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-27 DOI: 10.47102/annals-acadmedsg.2023367
Hazel H Oon, Chris Tan, Derrick Chen Wee Aw, Wei-Sheng Chong, Hong Yi Koh, Ying-Ying Leung, Kar Seng Lim, Jiun Yit Pan, Eugene Sern-Ting Tan, Ki Wei Tan, Siew Nee Tham, Colin Theng, Su-Ni Wong

Introduction: Psoriasis is a multisystem, chronic, inflammatory dermatological disease. In routine clinical practice, the management of psoriasis varies significantly. The current study aimed to develop a set of practice guidelines relevant to dermatology practice in Singapore.

Method: The Psoriasis Therapeutic Guidelines Workgroup, comprising members of the Dermato-logical Society of Singapore with a subspecialisation in psoriasis, was convened to develop the guidelines. Clinical questions on selected topics were generated and refined by the workgroup. A literature search using PubMed was performed on their assigned topics from June 2013 to December 2023. The articles were included and graded based on the level of evidence.

Results: The guidelines address topics ranging from clinical assessment to practical considerations in the management of mild, moderate and severe psoriasis, including delivery of care, referrals to specialists and adherence to treatment. The recommended therapies include phototherapy, methotrexate, acitretin, cyclosporine; apremilast; topical corticoste-roids, calcipotriol, topical calcineurin inhibitors; and biologics (i.e. adalimumab, infliximab, secukinumab, ixekizumab, ustekinumab, etanercept) either in combina-tion or as monotherapy. Common therapeutic concerns relating to biologic use were addressed. Recommendations on generalised pustular psoriasis, palmoplantar pustular psoriasis and psoriatic arthritis were also made. Patients on systemic therapy would receive appropriate vaccine counselling. Therapeutic implica-tions in special populations, such as pregnant/ lactating women, children, the elderly, those undergo-ing surgery and those suffering from specific infections and cancer were addressed.

Conclusion: These guidelines were developed for dermatologists, family physicians, rheumatologists and other specialists to support their selection of appropriate management options.

简介银屑病是一种多系统、慢性、炎症性皮肤病。在常规临床实践中,银屑病的治疗方法差异很大。本研究旨在制定一套与新加坡皮肤科实践相关的实践指南:牛皮癣治疗指南工作组由新加坡皮肤医学会的牛皮癣专科成员组成,负责制定指南。工作组就选定主题提出了临床问题,并对其进行了改进。从 2013 年 6 月到 2023 年 12 月,工作组使用 PubMed 对指定主题进行了文献检索。根据证据水平对文章进行了收录和分级:该指南涉及轻度、中度和重度银屑病管理中从临床评估到实际注意事项的多个主题,包括护理服务、转诊至专科医生和坚持治疗。推荐的疗法包括光疗、甲氨蝶呤、阿昔曲汀、环孢素;阿普仑司特;外用皮质类固醇激素、钙泊三醇、外用钙化蛋白抑制剂;以及生物制剂(即阿达木单抗、英夫利昔单抗、secukinumab、ixekizumab、ustekinumab、etanercept)联合或单药治疗。会议还讨论了与生物制剂使用有关的常见治疗问题。此外,还就泛发性脓疱型银屑病、掌跖脓疱型银屑病和银屑病关节炎提出了建议。接受系统治疗的患者将接受适当的疫苗咨询。此外,还讨论了特殊人群的治疗问题,如孕妇/哺乳期妇女、儿童、老人、手术患者以及特定感染和癌症患者:这些指南是为皮肤科医生、家庭医生、风湿病医生和其他专科医生制定的,以帮助他们选择适当的治疗方案。
{"title":"2023 guidelines on the management of psoriasis by the Dermatological Society of Singapore.","authors":"Hazel H Oon, Chris Tan, Derrick Chen Wee Aw, Wei-Sheng Chong, Hong Yi Koh, Ying-Ying Leung, Kar Seng Lim, Jiun Yit Pan, Eugene Sern-Ting Tan, Ki Wei Tan, Siew Nee Tham, Colin Theng, Su-Ni Wong","doi":"10.47102/annals-acadmedsg.2023367","DOIUrl":"10.47102/annals-acadmedsg.2023367","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a multisystem, chronic, inflammatory dermatological disease. In routine clinical practice, the management of psoriasis varies significantly. The current study aimed to develop a set of practice guidelines relevant to dermatology practice in Singapore.</p><p><strong>Method: </strong>The Psoriasis Therapeutic Guidelines Workgroup, comprising members of the Dermato-logical Society of Singapore with a subspecialisation in psoriasis, was convened to develop the guidelines. Clinical questions on selected topics were generated and refined by the workgroup. A literature search using PubMed was performed on their assigned topics from June 2013 to December 2023. The articles were included and graded based on the level of evidence.</p><p><strong>Results: </strong>The guidelines address topics ranging from clinical assessment to practical considerations in the management of mild, moderate and severe psoriasis, including delivery of care, referrals to specialists and adherence to treatment. The recommended therapies include phototherapy, methotrexate, acitretin, cyclosporine; apremilast; topical corticoste-roids, calcipotriol, topical calcineurin inhibitors; and biologics (i.e. adalimumab, infliximab, secukinumab, ixekizumab, ustekinumab, etanercept) either in combina-tion or as monotherapy. Common therapeutic concerns relating to biologic use were addressed. Recommendations on generalised pustular psoriasis, palmoplantar pustular psoriasis and psoriatic arthritis were also made. Patients on systemic therapy would receive appropriate vaccine counselling. Therapeutic implica-tions in special populations, such as pregnant/ lactating women, children, the elderly, those undergo-ing surgery and those suffering from specific infections and cancer were addressed.</p><p><strong>Conclusion: </strong>These guidelines were developed for dermatologists, family physicians, rheumatologists and other specialists to support their selection of appropriate management options.</p>","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond survival: Addressing gaps in psychosocial support for survivors of childhood cancer. 超越生存:解决儿童癌症幸存者社会心理支持方面的差距。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-24 DOI: 10.47102/annals-acadmedsg.2024250
Yin Ting Cheung
{"title":"Beyond survival: Addressing gaps in psychosocial support for survivors of childhood cancer.","authors":"Yin Ting Cheung","doi":"10.47102/annals-acadmedsg.2024250","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2024250","url":null,"abstract":"","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating urinary characteristics and optimal urine white blood cell threshold in paediatric urinary tract infection: A prospective observational study. 调查儿科尿路感染的尿液特征和最佳尿白细胞阈值:前瞻性观察研究
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-19 DOI: 10.47102/annals-acadmedsg.202477
Jean Nee Teo, Yong Teck Teo, Sashikumar Ganapathy, Matthias Maiwald, Yong Hong Ng, Shu-Ling Chong

Introduction: While the definitive diagnosis of urinary tract infection (UTI) requires a positive urine culture, the likelihood of UTI can be determined by urinalysis that includes white blood cell (WBC) count. We aimed to determine the optimal urine WBC threshold in urinalysis to predict UTIs in children presenting at the emergency department (ED).

Method: We performed a prospective observational study in the ED at KK Women's and Children's Hospital for children below 18 years old who underwent both urine microscopy and urine cultures, between 10 January and 7 November 2022. We assessed the various urine WBC thresholds associated with culture-proven UTIs using sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, and area under receiver operating characteristic curve.

Results: We found a culture-proven UTI rate of 460/1188 (38.7%) among all patients analysed, and 278/998 (27.9%) among those with nitrite-negative urine samples. Among all patients, a urinalysis WBC threshold of 100/μL had a sensitivity of 82.2% (95% confidence interval [CI] 78.4-85.5) and negative predictive value of 86.2% (95% CI 83.6-88.4). Among those who were nitrite-negative, a WBC threshold of ≥100/μL resulted in a potential missed rate of 48/278 (17.3%). By lowering the WBC threshold to ≥10/μL, the potential missed cases reduced to 6/278 (2.2%), with an estimated increase in 419 urine cultures annually.

Conclusion: A urine microscopy WBC threshold of ≥100/μL results in a clinically significant number of missed UTIs. Implementation of various thresholds should consider both the potential missed UTI rate and the required resource utilisation.

导言:尿路感染(UTI)的明确诊断需要尿培养阳性结果,而UTI的可能性可通过包括白细胞(WBC)计数在内的尿液分析来确定。我们的目的是确定在尿液分析中预测急诊科(ED)儿童尿路感染的最佳尿白细胞阈值:我们在 KK 妇女儿童医院急诊科开展了一项前瞻性观察研究,研究对象是 2022 年 1 月 10 日至 11 月 7 日期间接受尿液镜检和尿培养的 18 岁以下儿童。我们使用敏感性、特异性、阳性和阴性预测值、阳性和阴性似然比以及接收者操作特征曲线下面积评估了与培养证实的 UTI 相关的各种尿白细胞阈值:我们发现,在所有接受分析的患者中,经培养证实的尿毒症发病率为 460/1188(38.7%),而在亚硝酸盐阴性尿样的患者中,经培养证实的尿毒症发病率为 278/998(27.9%)。在所有患者中,尿检白细胞阈值为 100/μL 的灵敏度为 82.2%(95% 置信区间 [CI] 78.4-85.5),阴性预测值为 86.2%(95% 置信区间 83.6-88.4)。在亚硝酸盐阴性者中,白细胞阈值≥100/μL的潜在漏检率为48/278(17.3%)。将白细胞阈值降低到≥10/μL后,潜在漏检病例减少到6/278(2.2%),估计每年增加419例尿培养:结论:尿液显微镜检查白细胞阈值≥100/μL会导致大量临床漏诊UTI。实施各种阈值时应同时考虑潜在的漏检率和所需的资源利用率。
{"title":"Investigating urinary characteristics and optimal urine white blood cell threshold in paediatric urinary tract infection: A prospective observational study.","authors":"Jean Nee Teo, Yong Teck Teo, Sashikumar Ganapathy, Matthias Maiwald, Yong Hong Ng, Shu-Ling Chong","doi":"10.47102/annals-acadmedsg.202477","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.202477","url":null,"abstract":"<p><strong>Introduction: </strong>While the definitive diagnosis of urinary tract infection (UTI) requires a positive urine culture, the likelihood of UTI can be determined by urinalysis that includes white blood cell (WBC) count. We aimed to determine the optimal urine WBC threshold in urinalysis to predict UTIs in children presenting at the emergency department (ED).</p><p><strong>Method: </strong>We performed a prospective observational study in the ED at KK Women's and Children's Hospital for children below 18 years old who underwent both urine microscopy and urine cultures, between 10 January and 7 November 2022. We assessed the various urine WBC thresholds associated with culture-proven UTIs using sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, and area under receiver operating characteristic curve.</p><p><strong>Results: </strong>We found a culture-proven UTI rate of 460/1188 (38.7%) among all patients analysed, and 278/998 (27.9%) among those with nitrite-negative urine samples. Among all patients, a urinalysis WBC threshold of 100/μL had a sensitivity of 82.2% (95% confidence interval [CI] 78.4-85.5) and negative predictive value of 86.2% (95% CI 83.6-88.4). Among those who were nitrite-negative, a WBC threshold of ≥100/μL resulted in a potential missed rate of 48/278 (17.3%). By lowering the WBC threshold to ≥10/μL, the potential missed cases reduced to 6/278 (2.2%), with an estimated increase in 419 urine cultures annually.</p><p><strong>Conclusion: </strong>A urine microscopy WBC threshold of ≥100/μL results in a clinically significant number of missed UTIs. Implementation of various thresholds should consider both the potential missed UTI rate and the required resource utilisation.</p>","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental wellness and health-related quality of life of young adult survivors of childhood cancer in Singapore. 新加坡儿童癌症年轻成年幸存者的心理健康和与健康相关的生活质量。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-16 DOI: 10.47102/annals-acadmedsg.202445
Francis Jia Yi Fong, Bryan Wei Zhi Wong, Jamie Si Pin Ong, Beron Wei Zhong Tan, Michaela Su-Fern Seng, Ah Moy Tan, Raymond Reinaldo Tanugroho

Introduction: Childhood cancer survivors (CCS) are at risk of experiencing psychological distress years after completing cancer treatments. We aimed to assess the prevalence and associated risk factors affecting psychological distress and health-related quality of life (HRQOL) among CCS in Singapore, and compare with their siblings without a history of or existing cancer as control.

Method: We recruited 143 young adult CCS aged ≥18 years attending survivorship clinics at KK Women's and Children's Hospital in Singapore who were in remission for ≥5 years and treatment-free for ≥2 years, and 57 siblings. CCS and siblings were matched at a 1:1 ratio based on sociodemographic factors yielding 46 pairs for comparison. Among CCS participants, 79 (55.2%) were male, 86 (60.1%) had leukaemia, 29 (20.3%) had solid tumours, 15 (10.5%) had lymphoma and 13 (9.1%) had brain tumours. All participants completed the Brief Symptom Inventory-18 (BSI-18) and Medical Outcomes Short Form-36 (MOS SF-36) questionnaires from August 2021 to July 2022.

Results: There were 35 (24.5%) CCS who reported psychological distress in the BSI-18 Global Severity Index. Five (3.5%) and 31 (21.7%) CCS reported low HRQOL in the physical and mental composite scores, respectively. Mean scores between CCS and their siblings were not statistically significant across all domains of the BSI-18 and MOS SF-36. Associated risk factors for psychological distress and low HRQOL among CCS were history of psychiatric illness after cancer diagnosis and mood affected by the COVID-19 pandemic.

Conclusion: CCS reported significant psychological distress and low HRQOL although they were not statistically different from their siblings. A holistic and risk factor-centric follow-up programme can aid early detection and mitigation of psychological late effects for CCS and their families.

导言:儿童癌症幸存者(CCS)在完成癌症治疗数年后有可能出现心理困扰。我们的目的是评估新加坡儿童癌症幸存者的心理压力和健康相关生活质量(HRQOL)的发生率和相关风险因素,并将其与无癌症病史或现有癌症病史的兄弟姐妹作为对照进行比较:我们招募了 143 名年龄≥18 岁、在新加坡 KK 妇女与儿童医院幸存者门诊就诊的年轻成年 CCS(缓解期≥5 年且无治疗史≥2 年),以及 57 名兄弟姐妹。根据社会人口学因素,CCS 和兄弟姐妹按 1:1 的比例进行配对,得出 46 对进行比较。在 CCS 参与者中,79 人(55.2%)为男性,86 人(60.1%)患有白血病,29 人(20.3%)患有实体瘤,15 人(10.5%)患有淋巴瘤,13 人(9.1%)患有脑瘤。所有参与者在2021年8月至2022年7月期间完成了简明症状量表-18(BSI-18)和医疗结果简表-36(MOS SF-36)问卷调查:有35名(24.5%)CCS在BSI-18全球严重程度指数中报告了心理困扰,有5名(3.5%)和31名CCS在BSI-18全球严重程度指数中报告了心理困扰。分别有 5 名(3.5%)和 31 名(21.7%)慢性病患者在身体和心理综合评分中报告了较低的 HRQOL。在 BSI-18 和 MOS SF-36 的所有领域中,CCS 与其兄弟姐妹的平均得分在统计学上没有显著差异。CCS心理困扰和低HRQOL的相关风险因素是确诊癌症后有精神病史以及受COVID-19大流行影响的情绪:结论:尽管与同胞相比,CCS 的心理压力和 HRQOL 水平在统计学上没有差异,但他们的心理压力和 HRQOL 水平明显偏低。以风险因素为中心的综合随访计划有助于及早发现和减轻心理晚期效应对社区癌症患者及其家庭的影响。
{"title":"Mental wellness and health-related quality of life of young adult survivors of childhood cancer in Singapore.","authors":"Francis Jia Yi Fong, Bryan Wei Zhi Wong, Jamie Si Pin Ong, Beron Wei Zhong Tan, Michaela Su-Fern Seng, Ah Moy Tan, Raymond Reinaldo Tanugroho","doi":"10.47102/annals-acadmedsg.202445","DOIUrl":"10.47102/annals-acadmedsg.202445","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood cancer survivors (CCS) are at risk of experiencing psychological distress years after completing cancer treatments. We aimed to assess the prevalence and associated risk factors affecting psychological distress and health-related quality of life (HRQOL) among CCS in Singapore, and compare with their siblings without a history of or existing cancer as control.</p><p><strong>Method: </strong>We recruited 143 young adult CCS aged ≥18 years attending survivorship clinics at KK Women's and Children's Hospital in Singapore who were in remission for ≥5 years and treatment-free for ≥2 years, and 57 siblings. CCS and siblings were matched at a 1:1 ratio based on sociodemographic factors yielding 46 pairs for comparison. Among CCS participants, 79 (55.2%) were male, 86 (60.1%) had leukaemia, 29 (20.3%) had solid tumours, 15 (10.5%) had lymphoma and 13 (9.1%) had brain tumours. All participants completed the Brief Symptom Inventory-18 (BSI-18) and Medical Outcomes Short Form-36 (MOS SF-36) questionnaires from August 2021 to July 2022.</p><p><strong>Results: </strong>There were 35 (24.5%) CCS who reported psychological distress in the BSI-18 Global Severity Index. Five (3.5%) and 31 (21.7%) CCS reported low HRQOL in the physical and mental composite scores, respectively. Mean scores between CCS and their siblings were not statistically significant across all domains of the BSI-18 and MOS SF-36. Associated risk factors for psychological distress and low HRQOL among CCS were history of psychiatric illness after cancer diagnosis and mood affected by the COVID-19 pandemic.</p><p><strong>Conclusion: </strong>CCS reported significant psychological distress and low HRQOL although they were not statistically different from their siblings. A holistic and risk factor-centric follow-up programme can aid early detection and mitigation of psychological late effects for CCS and their families.</p>","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the accuracy and consistency of generative pretrained transformers in assigning Eastern Cooperative Oncology Group performance status. 评估生成式预训练变换器在指定东部合作肿瘤学组表现状态方面的准确性和一致性。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-13 DOI: 10.47102/annals-acadmedsg.202414
Chun En Yau, Qihuang Xie, Ren Yi Jonas Ho, Chun Yi Yau, Elaine Guan, Dawn Yi Xin Lee, Xinyan Zhou, Gerald Gui Ren Sng, Joshua Yi Min Tung, Andrew Fu Wah Ho, Ryan Shea Ying Cong Tan, Daniel Yan Zheng Lim
{"title":"Assessing the accuracy and consistency of generative pretrained transformers in assigning Eastern Cooperative Oncology Group performance status.","authors":"Chun En Yau, Qihuang Xie, Ren Yi Jonas Ho, Chun Yi Yau, Elaine Guan, Dawn Yi Xin Lee, Xinyan Zhou, Gerald Gui Ren Sng, Joshua Yi Min Tung, Andrew Fu Wah Ho, Ryan Shea Ying Cong Tan, Daniel Yan Zheng Lim","doi":"10.47102/annals-acadmedsg.202414","DOIUrl":"10.47102/annals-acadmedsg.202414","url":null,"abstract":"","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving landscape of sports injuries and recommendations on injury preventions: A retrospective analysis in Singapore. 不断变化的运动伤害情况和预防伤害的建议:新加坡的回顾性分析。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-13 DOI: 10.47102/annals-acadmedsg.2024240
Jade Chee, Francis Jia Yi Fong, Mingchang Wang, Yee Han Dave Lee
{"title":"Evolving landscape of sports injuries and recommendations on injury preventions: A retrospective analysis in Singapore.","authors":"Jade Chee, Francis Jia Yi Fong, Mingchang Wang, Yee Han Dave Lee","doi":"10.47102/annals-acadmedsg.2024240","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2024240","url":null,"abstract":"","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the role of technology in disseminating education to patients with chronic kidney disease. 评估技术在向慢性肾病患者传播教育方面的作用。
IF 2.5 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-12 DOI: 10.47102/annals-acadmedsg.2023251
Hui Boon Tay, Terina Ying Ying Seow, Chun Fan Lee, Lee Ying Yeoh
{"title":"Evaluating the role of technology in disseminating education to patients with chronic kidney disease.","authors":"Hui Boon Tay, Terina Ying Ying Seow, Chun Fan Lee, Lee Ying Yeoh","doi":"10.47102/annals-acadmedsg.2023251","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2023251","url":null,"abstract":"","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of the Academy of Medicine, Singapore
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1