Clinical and Preventive Medicine最新文献

{"title":"HEART RATE VARIABILITY DURING PHYSICAL EFFORT IN PATIENTS WITH METASTATIC OVARIAN CANCER AND CONCOMITANT OBESITY","authors":"Viktoriia V. Yevsieieva, Volodimyr I. Cherniy, Kateryna V. Kharchenko, Yuriy B. Lisun, Ludmila M. Polukhovich","doi":"10.31612/2616-4868.7.2023.04","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.04","url":null,"abstract":"Introduction. One of the main factors affecting postoperative outcomes in patients with advanced ovarian cancer is the cardiopulmonary status. Several studies have reported that preoperative multifactorial rehabilitation and physical fitness can lead to reduced postoperative morbidity, mortality, shorter length of stay, and improved quality of life in cancer patients. The issue of adaptability to physical activity of overweight and obese patients who undergoing debulking surgery is insufficiently studied. The study of compensatory changes that occur in physically inactive obese patients remains relevant, especially against the background of neoadjuvant chemotherapy, in the conditions of preoperative preparation with ERAS-recommended physical activity. The aim of the study is to determine the differences between women with advanced ovarian cancer and obesity compared to women with normal weight in terms of heart rate variability during exercise. To assess the adaptive capabilities to physical activity of patients with advanced ovarian cancer and obesity at the stage of preoperative preparation, who undergoing debulking surgery. Result. Achieved METs, peak HR, CI, and HR recovery were higher in nonobese women, whereas training had no significant effect in obese women. Women who had already received neoadjuvant CT achieved a lower level of MET (6.8 ± 3.2 vs. 8.9 ± 4.1; P < 0.001). Also, peak HR and CI were lower in women after neoadjuvant CT (126±27 vs. 138±20; P = 0.001 and 0.65±0.22 vs. 0.71±0.22; P = 0.001, respectively). BMI was a significant predictor of exercise capacity only in the obese subgroup, whereas age, peak HR, and prior adjuvant HT were always significantly associated with METs achieved. Conclusions. No significant difference was found between trained and untrained women with comorbid obesity in HR behavior or physical capacity. Different heart rate behavior in patients of this group is thus explained by obesity as such, regardless of the degree of physical training.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"2000 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF ULTRASOUND DIAGNOSTICS IN ASSESSING THE THICKNESS OF THE COLON WALL IN PATIENTS WITH ULCERATIVE COLITIS AND CONCOMITANT ARTERIAL HYPERTENSION","authors":"Andriy E. Dorofeyev, Alina V. Khairnasova","doi":"10.31612/2616-4868.7.2023.06","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.06","url":null,"abstract":"Мета дослідження. За допомогою трансабдомінальної ультразвукової діагностики оцінити товщину стінки товстого кишечника у пацієнтів з неспецифічним виразковим колітом та супутньою артеріальною гіпертензією. Матеріали та методи. Обстежено 96 пацієнтів. З них сформовано дві групи: основна (група І) – пацієнти з неспецифічним виразковим колітом із супутньою артеріальною гіпертензією (n=49; вік – 41,2±12,32 року, M±SD років) та контрольна (група ІІ) – пацієнти з неспецифічним виразковим колітом без супутньої артеріальної гіпертензії (n=47; вік – 40,2±10,85 років). Діагноз неспецифічного виразкового коліту був підтверджений за допомогою колоноскопії з біопсією та подальшим патогістологічним дослідженням. Ендоскопічна оцінка тяжкості неспецифічного виразкового коліту проводилася за Mayo ulcerative colitis system. В усіх пацієнтів був зібраний анамнез, проводився загальноклінічний огляд, амбулаторне вимірювання артеріального тиску, колоноскопія, трансабдомінальна ультразвукова діагностика товстого кишечника. Статистична обробка отриманих даних проводилась з використанням критеріїв оцінки вірогідності. Результати. В ході дослідження встановлено, що в І групі відзначалося більш виражене потовщення залученої у запальний процес стінки товстої кишки ніж в ІІ групі (p<0,05), що обумовлено системним запальним процесом та наявністю супутньої АГ. Висновки. Проведене дослідження доводить, що амбулаторне вимірювання артеріального тиску у пацієнтів із неспецифічним виразковим колітом є обов’язковою процедурою. Адже несвоєчасна діагностика супутньої артеріальної гіпертензії може впливати на перебіг та ранній рецидив неспецифічного виразкового коліту. Перевагами трансабдомінальної ультразвукової діагностики кишечника є доступність, порівняно невелика ціна, добра переносимість, відсутність радіаційного впливу та, головне, неінвазивність методу для оцінки активності захворювання.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"612 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF THE RISK OF PARENTS’ DISSATISFACTION WITH THE QUALITY OF PROVIDING MEDICAL AID TO CHILDREN WITH RESPIRATORY DISEASES","authors":"Yevheniia I. Vezhnovets, Yurii B. Yashchenko","doi":"10.31612/2616-4868.7.2023.10","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.10","url":null,"abstract":"Introduction. Reforming the health care system requires defining criteria for assessing patients’ dissatisfaction with the quality of medical care. It is known that the previous experience of communication with a doctor affects the quality of further interaction and compliance with medical recommendations. The aim was to predict the risk of parents’ dissatisfaction with the quality of medical care for children with respiratory diseases, depending on the number and reasons for visits to pediatricians and family general practitioners (GP), by the results of the questionnaire. Materials and methods. Overall, 171 parents were questioned (87.72 %). The analysis was by logistic regression models using the statistical analysis package MedCalc v.19.4.1 (MedCalc Software Inc, Broekstraat, Belgium, 1993-2020). Results. The results of the study show that 125 (83.3 %) parents rated satisfaction with the quality of medical care for children with respiratory diseases (RD) in health care facilities as 5 points by a five-point scale. The univariate analysis showed a significant relationship between the risk of parents’ dissatisfaction with the quality of medical care for RD children and the number of ARI visits to the GPs per year (p<0.05), namely: the increase in the number of visits is associated with significant decrease in parental dissatisfaction with quality of medical care, for every next visit (p = 0.040), OR = 0.31 (95 % CI 0.10-0.95). The area under the curve of operational characteristics AUC = 0.66 (95 % CI 0.58-0.74) indicates a weak relationship between the risk of parental dissatisfaction and the number of ARI visits to the GPs per year. When using the stepwise regression, 4 factor features were selected for multivariate analysis, namely: the number of cases of acute respiratory viral infections in a child per year, the number of pneumonias in a child during life, the number of visits to the PHC (primary health care) physician, and to the PHC pediatrician per year. According to this model, an increase in the number of visits to the GP is associated with decrease in parents’ dissatisfaction with the quality of medical care, for each repeated visit (when standardizing by the number of ARI cases in a child per year, the number of pneumonia cases in a child, and the number of visits to the PHC pediatrician) (p = 0.026), OR = 0.25 (95 % CI 0.08-0.85). Conclusions. The multifactorial factor logistic regression of the parental dissatisfaction with the quality of medical care for ARI children included 4 factors, including the number of cases of acute respiratory viral infections in a child per year, the number of pneumonias in a child during life, the number of visits to the GP, and to the PCH pediatrician per year. For every next RD-associated visit to the physician, the risk of dissatisfaction with the medical care quality significantly reduces. Positive previous experience of communication between parents and the GP leads to further satisfaction w","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"310 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK REDUCTION ASSESSMENT: EPIDEMIOLOGY AND NOVEL APPROACHES","authors":"Olga V. Sribna, Olena O. Kvasha","doi":"10.31612/2616-4868.7.2023.15","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.15","url":null,"abstract":"Introduction. Today, there are new approaches to assessing the potential impact of alternative nicotine delivery systems, such as systemic toxicology and biomarker assessment. The modern development of science and technology, including laboratory research, allows for a detailed assessment of the biological effects of a substance or complex of substances on the human body as a whole. The aim of the study: to compare and assess based on literature data possibility to broaden the standard approach for risk reduction assessment for lifestyle (potentially correctable) risk factors, especially tobacco smoking (TS). While epidemiology remains a golden standard for risk reduction assessment, novel approaches are based on preventive or system toxicology analysis and biomarkers of harm evaluation, thus it is crucial to understand both benefits and limitations of novel and standard approaches to complete risk reduction assessment for potentially correctable risk factors. Materials and methods. The thematic scientific papers, published predominantly during the last decade, constituted the study material. The research methodology involved bibliosemantic method and structural and logical analysis. Results and discussion. Level of modern scientific development already can help us to assess the harm made by new/emerging products based on epidemiological, toxicological data and evaluation of biomarkers of potential harm for specific risk or disease. For TS biomarkers of harm are mostly well established and include 15 Harmful and Potentially Harmful Constituents (HPHCs) of tobacco smoke and their metabolites in the body. Reduction in Total-3-OH-B[a]P, S-PMA, COHb and other can show reduction in harm and risk caused by new/emerging product. So far most comprehensive analysis of reduction in HPHCs and biomarkers manifestation was concluded for tobacco heating system as TS alternative. Switching from cigarettes to THS for 5 days resulted in 56 % to 96 % reductions in 15 exposure biomarkers in the THS group compared to the TS group. These values approached the decrease in effect observed in the group of complete refusal of TS. Similar observations were made for the 90-day studies, where the reduction observed on day 5 was maintained until the end of the three-month studies and confirmed by other 3 clinical studies. Conclusions. In general, the results of the risk reduction assessment based on novel approaches confirms that THS is an acceptable alternative to cigarettes for adult smokers, and based on the positive biological effects, the transition to THS represents a lower risk for the smoker’s body with regard to the effects of HPHCs.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"2007 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEGENERATIVE INTERVERTEBRAL DISC DISEASE: DIFFICULTIES IN DEFINITION OF THE CONCEPT AND EPIDEMIOLOGY OF THE PHENOMENON. BRIEF COMMUNICATION","authors":"V. Medvediev, Myroslava O. Marushchenko, Vitaliy I. Tsymbaliuk","doi":"10.31612/2616-4868.7.2023.14","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.14","url":null,"abstract":"The aim. The significant prevalence of intervertebral discs chronic pathology in the human population against the background of the lack of a clear and unified definition of the concept of «degenerative [intervertebral] disc disease» (DDD) creates difficulties in the study and formation of treatment protocols for this pathology. This study aims to clarify the epidemiological characteristics and terminological features of the pathology of the intervertebral discs covered by the term «DDD». Materials and methods. A systematic search in pubmed and related scientific and professional databases for publications devoted to DDD’s terminological features and epidemiology was conducted. In the analysis, the papers in which DDD and semantically related concepts and clinical phenomena are included as the primary research objects. Results. Based on the analysis, it is found that there is no unified defining the concept of DDD, which includes both initial degenerative changes in the disc, regardless of the manifestation of the pain syndrome, and conditions with a clear pathomorphological picture, such as intervertebral disc herniation, degenerative spinal stenosis, etc. DDD is pathophysiological and conventional; its list of pathomorphological and clinical correlates still needs to be completed. Clinical phenomena, considered the most certain correlates of DDD, can be caused by other pathological processes. Currently, the only but somewhat inaccurate indicator of the prevalence of back pain in the human population is the epidemiological characteristic of back pain, which, according to available calculations, can reach 800 million people at any given time, i.e., 10 % of the human population. Uncertainty regarding the semantics of the term DDD makes it challenging to unify research results and develop effective clinical protocols. Conclusions. The meaning of the term DDD remains unclear and non-unified, and the epidemiological characteristics of the phenomenon of back pain can only be used with significant caution for a rough estimate of the prevalence of clinically significant forms of ddd. Unifying and clarifying terminology, prevalence, and identification of benchmark etiological factors of DDD will allow to improve treatment protocols for this pathology and improve its results.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"1982 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF EMOTIONAL INTELLIGENCE OF ELITE WOMEN’S HANDBALL PLAYERS ON THE CHOICE OF STRESS COPING STRATEGIES","authors":"T. Petrovska, L. Arnautova, B. Palamar, Irene V. Khmelnitska, Svitlana V. Fedorchuk, Tetiana M. Bulhakova, Iryna O. Kohut","doi":"10.31612/2616-4868.7.2023.07","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.07","url":null,"abstract":"Introduction. The problem of finding optimal strategies for overcoming stress by elite athletes remains relevant. Many authors study the problem of stress resistance in sports from the standpoint of forming a set of athlete’s personal qualities. The emotional intelligence is such athlete’s personal characteristics that affect the ability to withstand competitive stress. The aim of the study: to establish a relation between coping strategies and emotional intelligence of elite women’s handball players. Materials and methods: Athletes of the Ukrainian national women’s handball team (21 players aged 17 to 28, experience in this sport from 5 to 19 years) took part in the research. The following methods: questionnaire «Ways of coping behaviour» by R. Lazarus, the Nelson-Hall methodology devised to diagnose EI, was used. Data was processed by non-parametric descriptive statistics, Shapiro-Wilk normality test, and correlation analysis. Results: Strategies using by athletes to increase the ability of the psyche to adapt to anxiety, the level of emotional intelligence and its components, the characteristics of motivation to succeed and motivation to avoid failure have been identified. 61.9 % of elite women’s handball players showed a low level of general emotional intelligence; 38.1 % of people showed a middle level. Correlation analysis between athletes’ choice of coping strategies and manifestations of emotional intelligence revealed certain patterns. «Confrontational coping» correlated with empathy (r = 0.45). Coping «Distancing» correlated with self-control (r = 0.59) and self-motivation (r = 0.53). Coping «Positive reappraisal» correlated with emotional awareness (r = 0.47), self-emotion management (r = 0.52) and overall emotional intelligence (r = 0.59). Coping «Self-control» had a positive correlation with self-motivation (r = 0.53). Conclusions: The obtained results give grounds to assert the expediency of applying the correction of emotional intelligence by increasing one in the practice of psychological training of athletes, which will increase their stress resistance.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"2013 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF PSYCHOLOGICAL SELECTION OF APPLICANTS FOR HIGHER EDUCATION IN DANGEROUS PROFESSIONS","authors":"Аnatolii М. Hrynzovskyi, S. Kalashchenko, Ihor I. Prykhodko, O. Lutsak, Serhii V. Bielai","doi":"10.31612/2616-4868.7.2023.11","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.11","url":null,"abstract":"The aim of the study. It was compared the adaptive potential and readiness to perform professional duties among the medical students and cadets of NANGU. Materials and methods. There were 134 respondents, who took part in a survey which was based on «Adaptability» questionnaire by A. Maklakov. The total time of the survey was thirty minutes. The criteria included respondents at the age from 18-30 and their regular physical activity for at least three times a week. The criteria included respondents at the age from 18-30 and their regular physical activity for at least three times a week. Among the exclusion criteria were duty or night shift in the hospital, taking psychotropic drugs, acute respiratory viral diseases during the survey period. Results and discussion. Average indices of NANGU cadets belong to the third group of human adaptive abilities (satisfactory abilities), meanwhile the medical students show the prevailing indices of the fourth group (unsatisfactory abilities). Medical students demonstrate lower indices of neuropsychological stability (28,13±12,97 c.u.), comparing to cadets (13,29±9,01 c.u.; t1-2 = 6,87, at p  0,001). The group of medical students demonstrates worse indices on all scales of the «Adaptability» questionnaire, except for the «Probability» scale, comparing to the group of NANGU cadets. It is worth mentioning that medical students reveal greater self-criticism, introversion, they tend to self-reflection that hinders the process of secondary adaptation in society and reduces resistance to stressful conditions. Conclusions. It indicates a poor adaptation to the requirements of professional activity and determines the need to conduct mandatory psychological selection among medical students during admission to an educational institution. In the future, the level and development of adaptive capabilities of young professionals among students might become one of the main reasons for their change of professional area and subsequently might lead to significant loss of state economic resources which were spent on their training.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"2008 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERECTILE DYSFUNCTION TREATMENT USING SUBCUTANEOUS IMPLANTS WITH A LONG-TERM EFFECT","authors":"Mykola Boiko, Anton S. Glebov, Sergii P. Pasiechnikov, Oleksandr Boiko","doi":"10.31612/2616-4868.7.2023.03","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.03","url":null,"abstract":"Introduction. The article describes a new method of improving erectile function by incerting long-acting subcutaneous implants with the phosphodiesterase 5 (PDE 5) inhibitor. The aim of the study: To evaluate the effectiveness of tadalafil in the treatment of erectile dysfunction using bioidentical pellets. Materials and methods: The study included 10 men under 65 years of age who had suffered from erectile dysfunction for more than 1 year. For the examination before and 4 months after the intervention, the following were performed: filling out the MIEF-5 questionnaire, phical examination, Doppler of penile vessels, «Erection Hardness Scale», laboratory examination (general and biochemical blood tests, general urine analysis and hormonal testing, including determination of the levels of total testosterone, free testosterone, prolactin, estradiol and dehydroepiandrosterone sulfate. All patients received implants with bioidentical tadalafil 75 mg. The pellet was inserted in a sterile operating room through a 3 mm skin incision in the outer quadrant of the gluteal region and inserting the substance into the subcutaneous fat. Results: All patients showed an improvement in MIEF-5 from 14.7 ± 2.75 to 20.7 ± 1.49, an increase in systolic blood flow velocity and penile rigidity at the tenth minute after prostaglandin E1 injection on Doppler vascular examination. Conclusion: This study demonstrated the efficacy of tadalafil by pellet administration in the treatment of erectile dysfunction in men younger than 65 years.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"364 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE PROGNOSTIC VALUE OF BLOOD MARKERS IN PREDICTION OF THE PROBABILITY OF THE DEVELOPMENT OF FIBROTIC PROCESS IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS","authors":"Anastasiia H. Sheiko, Kateryna V. Yurko, Hanna O. Solomennyk, Valerii V. Kucheriavchenko","doi":"10.31612/2616-4868.7.2023.01","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.01","url":null,"abstract":"Introduction. Recently, a negative trend of increasing the levels of prevalence, disability and mortality caused by chronic viral hepatitis C (HCV) infection has been determined. Around the world is defined 0.6-10.0 % suffer from chronic HCV (about 71 million with an annual increase of 1.75 million cases). Even higher are the levels of HCV seropositivity, which according to the WHO are about 100 million people (1.6 % of the world population). The WHO identified the need to improve the diagnosis of chronic HCV and to identify its asymptomatic forms and irreversible consequences (liver fibrosis and liver cirrhosis). Increasing the effectiveness of existing and developing new diagnostic approaches to improve early detection of chronic HCV and its consequences (liver fibrosis) is an urgent issue. The aim. To determine the prognostic possibilities of blood markers for the diagnosis of the development of the fibrotic process in chronic viral hepatitis C. Materials and methods. 78 people were examined: 47 (main group) – with chronic HCV and 31 – without chronic HCV (comparison group). Results. Probable associations with increased risks of development of LF in chronic HCV were: increased Mean Corpuscular Volume (MCV) (OR=4.305; 95.0 % CI 1.187-15.619; p=0.026) and Platelets (OR=0.955; 95.0 % CI 0.922-0.989; p=0.011), which indicated increased chances of developing LF in chronic HCV when exceeding the standard MCH indicators (by 4.305 times) and reduced chances – when increasing Platelets (on 4,5 %). Conclusions. Based on the research, it was determined that blood markers can be used as a significant predictor of the development of LF of patients with chronic HCV. Increased levels of MCH and Platelets in blood serum characterize a significant relationship with the development of LF in patients with chronic HCV, which indicates a significant influence of blood markers on the pathogenesis of LF in patients with chronic HCV.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"1986 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERYTHROPOIETIN SYNTESIS IN PATIENTS WITH CHRONIC HEART FAILURE DEPENDING ON COMORBID PATHOLOGY","authors":"N. Pavliukovych, Volodymyr V. Husak, O. Pavliukovych, V. Shuper, Serhii V. Shuper, Olena M. Husak","doi":"10.31612/2616-4868.7.2023.05","DOIUrl":"https://doi.org/10.31612/2616-4868.7.2023.05","url":null,"abstract":"Introduction. Decreased production of erythropoietin by the kidneys plays crucial role in the development of anemia in patients with chronic heart failure, especially on the background of comorbid diabetes mellitus type 2. In diabetic patients due to early damage of the kidney vessels and following erythropoietin deficiency anemia develops much earlier than clinically significant decrease of glomerular filtration rate. The aim of the study was to find out possible dependence of changes in the erythropoietinsynthesizing function of the kidneys on the degree of severity of anemic hypoxia in elderly and senile patients with chronic heart failure, including those with comorbid type 2 diabetes mellitus. Materials and methods. 120 patients with chronic heart failure of ischemic origin, type 2 diabetes mellitus and mild and moderate anemia were examined. Control group comprised 12 people with chronic heart failure without comorbid pathology. The examined groups were comparable in terms of gender and age, differing in the presence of comorbid diabetes mellitus and degree of severity of anemic syndrome. The level of erythropoietin in blood serum was determined by standard enzymelinked immunosorbent assay. Results. Type 2 diabetes mellitus in patients with chronic heart failure results in a significant decrease in erythropoietin production by 25 % compared to the control group (p<0,05). Comorbid to heart failure anemia leads to an increase in the level of erythropoietin by 74,4 % (р<0,05), and in the case of chronic heart failure and type 2 diabetes mellitus on the background of concomitant anemia – only by 39,5 % (р<0,05). As the severity of anemia in patients with chronic heart failure without diabetes progresses, the severity of the compensatory response of the kidneys to chronic anemic hypoxia is significantly higher than in patients with heart failure and comorbid type 2 diabetes. Conclusions. Diabetic nephropathy in patients with chronic heart failure and comorbid anemia leads to a significant deterioration of the erythropoietin-synthesizing function of the kidneys, complicating the course of both main and comorbid diseases.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"2009 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}