Indium is a critical metal that can be concentrated in skarn deposits. However, not all skarn deposits exhibit indium mineralization. The controlling factors of indium mineralization in skarn deposits are unclear. We investigate the sphalerite trace element, geological setting, geochemical compositions of related intrusions, and hydrothermal physicochemical conditions of 47 skarn deposits worldwide to unravel the critical factors for indium mineralization. The deposits are classified into four types according to the indium content in sphalerite. The In-rich skarn deposits are predominantly distributed in the intra-continental extension setting. The In-rich skarn deposits show higher SiO2 values and Rb/δEu ratios, and lower MgO contents than the In-poor deposits, indicating that the evolution process evaluates the indium enrichment in magma. The Sr-Nd-Hf isotopes suggest that In-rich skarns are almost or partly derived from the partial melting of metasedimentary rocks; however, In-poor deposits are dominantly derived from the melting of the mafic lower crust. The similar hydrothermal temperatures (200 to 300 °C), salinities (4 to 12 NaCl wt%), and δ34S (–5 to 10 ‰) between In-rich and In-poor deposits imply that the indium contents in sphalerite may be irrelevant to these conditions. The In and Cu contents define a solubility limit (CIn=CCu), indicating that the Cu activity controls the maximum indium contents in sphalerite. The study highlights that the skarn-related indium mineralization is a coupled consequence of the magma sources, evolution, and hydrothermal Cu activity.
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