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Costa’s concavity inequality for dependent variables based on the multivariate Gaussian copula 基于多元高斯copula的因变量的Costa凹性不等式
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-04-12 DOI: 10.1017/jpr.2022.128
An extension of Shannon’s entropy power inequality when one of the summands is Gaussian was provided by Costa in 1985, known as Costa’s concavity inequality. We consider the additive Gaussian noise channel with a more realistic assumption, i.e. the input and noise components are not independent and their dependence structure follows the well-known multivariate Gaussian copula. Two generalizations for the first- and second-order derivatives of the differential entropy of the output signal for dependent multivariate random variables are derived. It is shown that some previous results in the literature are particular versions of our results. Using these derivatives, concavity of the entropy power, under certain mild conditions, is proved. Finally, special one-dimensional versions of our general results are described which indeed reveal an extension of the one-dimensional case of Costa’s concavity inequality to the dependent case. An illustrative example is also presented.
1985年,Costa对其中一个被加数是高斯的Shannon熵权不等式进行了扩展,称为Costa凹性不等式。我们用一个更现实的假设来考虑加性高斯噪声信道,即输入和噪声分量不是独立的,它们的依赖结构遵循众所周知的多元高斯copula。导出了相依多元随机变量输出信号微分熵的一阶和二阶导数的两个推广。研究表明,文献中先前的一些结果是我们结果的特定版本。利用这些导数,在一定的温和条件下,证明了熵权的凹性。最后,描述了我们的一般结果的特殊一维版本,这确实揭示了Costa凹性不等式的一维情况对相依情况的扩展。并举例说明。
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引用次数: 0
FOXP1 Haploinsufficiency Contributes to the Development of Congenital Diaphragmatic Hernia. FOXP1单倍体缺陷导致先天性膈疝的形成
IF 0.4 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-03-28 eCollection Date: 2024-03-01 DOI: 10.1055/s-0043-1767731
Katherine E Pendleton, Andres Hernandez-Garcia, Jennifer M Lyu, Ian M Campbell, Chad A Shaw, Julie Vogt, Frances A High, Patricia K Donahoe, Wendy K Chung, Daryl A Scott

FOXP1 encodes a transcription factor involved in tissue regulation and cell-type-specific functions. Haploinsufficiency of FOXP1 is associated with a neurodevelopmental disorder: autosomal dominant mental retardation with language impairment with or without autistic features. More recently, heterozygous FOXP1 variants have also been shown to cause a variety of structural birth defects including central nervous system (CNS) anomalies, congenital heart defects, congenital anomalies of the kidney and urinary tract, cryptorchidism, and hypospadias. In this report, we present a previously unpublished case of an individual with congenital diaphragmatic hernia (CDH) who carries an approximately 3.8 Mb deletion. Based on this deletion, and deletions previously reported in two other individuals with CDH, we define a CDH critical region on chromosome 3p13 that includes FOXP1 and four other protein-coding genes. We also provide detailed clinical descriptions of two previously reported individuals with CDH who carry de novo, pathogenic variants in FOXP1 that are predicted to trigger nonsense-mediated mRNA decay. A subset of individuals with putatively deleterious FOXP4 variants has also been shown to develop CDH. Since FOXP proteins function as homo- or heterodimers and the homologs of FOXP1 and FOXP4 are expressed at the same time points in the embryonic mouse diaphragm, they may function together as a dimer, or in parallel as homodimers, to regulate gene expression during diaphragm development. Not all individuals with heterozygous, loss-of-function changes in FOXP1 develop CDH. Hence, we conclude that FOXP1 acts as a susceptibility factor that contributes to the development of CDH in conjunction with other genetic, epigenetic, environmental, and/or stochastic factors.

FOXP1 是一种参与组织调节和细胞特异功能的转录因子。FOXP1 的单倍体缺陷与一种神经发育障碍有关:常染色体显性智力低下,伴有或不伴有自闭症特征的语言障碍。最近,杂合子 FOXP1 变异也被证明可导致多种结构性先天缺陷,包括中枢神经系统(CNS)异常、先天性心脏缺陷、先天性肾脏和泌尿道异常、隐睾症和尿道下裂。在本报告中,我们发现了一例之前未发表过的先天性膈疝(CDH)患者,该患者携带约 3.8 Mb 的缺失。根据这一缺失以及之前报道的另外两名 CDH 患者的缺失,我们在 3p13 染色体上定义了一个 CDH 关键区域,其中包括 FOXP1 和其他四个蛋白编码基因。我们还对之前报道的两名 CDH 患者进行了详细的临床描述,这两名患者携带 FOXP1 的新致病变异,预计会引发无义介导的 mRNA 衰减。有研究表明,一部分携带可能致癌的 FOXP4 变体的患者也会发展为 CDH。由于 FOXP 蛋白具有同源或异源二聚体的功能,而且 FOXP1 和 FOXP4 的同源物在胚胎小鼠膈肌的同一时间点表达,因此它们可能作为二聚体或作为同源二聚体在膈肌发育过程中共同调节基因表达。并非所有 FOXP1 杂合子功能缺失的个体都会患 CDH。因此,我们得出结论:FOXP1 是一种易感因素,它与其他遗传、表观遗传、环境和/或随机因素共同作用,导致 CDH 的发生。
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引用次数: 0
The Berkelmans–Pries dependency function: A generic measure of dependence between random variables Berkelmans-Pries相关性函数:随机变量之间相关性的一般度量
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-03-23 DOI: 10.1017/jpr.2022.118
Guus Berkelmans, S. Bhulai, R. D. van der Mei, Joris Pries
Measuring and quantifying dependencies between random variables (RVs) can give critical insights into a dataset. Typical questions are: ‘Do underlying relationships exist?’, ‘Are some variables redundant?’, and ‘Is some target variable Y highly or weakly dependent on variable X?’ Interestingly, despite the evident need for a general-purpose measure of dependency between RVs, common practice is that most data analysts use the Pearson correlation coefficient to quantify dependence between RVs, while it is recognized that the correlation coefficient is essentially a measure for linear dependency only. Although many attempts have been made to define more generic dependency measures, there is no consensus yet on a standard, general-purpose dependency function. In fact, several ideal properties of a dependency function have been proposed, but without much argumentation. Motivated by this, we discuss and revise the list of desired properties and propose a new dependency function that meets all these requirements. This general-purpose dependency function provides data analysts with a powerful means to quantify the level of dependence between variables. To this end, we also provide Python code to determine the dependency function for use in practice.
测量和量化随机变量(RV)之间的相关性可以为数据集提供关键的见解。典型的问题是:“潜在的关系存在吗?”有些变量是多余的吗?’,和“某个目标变量Y高度或弱依赖于变量X吗?”有趣的是,尽管明显需要对RV之间的相关性进行通用测量,但通常的做法是,大多数数据分析师使用Pearson相关系数来量化RV之间的依赖性,而相关系数本质上只是线性相关性的测量。尽管已经进行了许多尝试来定义更通用的依赖性度量,但对于标准的通用依赖性函数还没有达成共识。事实上,依赖函数的几个理想性质已经被提出,但没有太多的论证。受此启发,我们讨论并修改了所需属性的列表,并提出了一个满足所有这些要求的新依赖函数。这种通用的依赖函数为数据分析师提供了一种强大的手段来量化变量之间的依赖程度。为此,我们还提供了Python代码来确定在实践中使用的依赖函数。
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引用次数: 0
Asymptotic persistence time formulae for multitype birth–death processes 多类型生-死过程的渐近持续时间公式
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-03-21 DOI: 10.1017/jpr.2022.102
F. Ball, D. Clancy
Abstract We consider a class of processes describing a population consisting of k types of individuals. The process is almost surely absorbed at the origin within finite time, and we study the expected time taken for such extinction to occur. We derive simple and precise asymptotic estimates for this expected persistence time, starting either from a single individual or from a quasi-equilibrium state, in the limit as a system size parameter N tends to infinity. Our process need not be a Markov process on $ {mathbb Z}_+^k$ ; we allow the possibility that individuals’ lifetimes may follow more general distributions than the exponential distribution.
摘要我们考虑一类描述由k类个体组成的群体的过程。这个过程几乎可以肯定在有限的时间内在原点被吸收,我们研究了这种灭绝发生所需的预期时间。我们从单个个体或准平衡状态出发,在系统大小参数N趋于无穷大的极限下,推导出该预期持续时间的简单而精确的渐近估计。我们的过程不必是${mathbb Z}_+^k$上的马尔可夫过程;我们允许个体的寿命可能遵循比指数分布更一般的分布。
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引用次数: 0
Strong feller and ergodic properties of the (1+1)-affine process (1+1)-仿射过程的强费勒和遍历性质
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-03-14 DOI: 10.1017/jpr.2022.100
Shukai Chen, Zenghu Li
Abstract We prove some estimates for the variations of transition probabilities of the (1+1)-affine process. From these estimates we deduce the strong Feller and the ergodic properties of the total variation distance of the process. The key strategy is the pathwise construction and analysis of several Markov couplings using strong solutions of stochastic equations.
摘要证明了(1+1)-仿射过程跃迁概率变化的一些估计。根据这些估计,我们推导出过程总变异距离的强费勒和遍历性质。关键策略是利用随机方程的强解对若干马尔可夫耦合进行路径构造和分析。
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引用次数: 2
The Bruss–Robertson–Steele inequality 布鲁斯-罗伯逊-斯蒂尔不等式
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-03-13 DOI: 10.1017/jpr.2022.122
L. Rogers
Abstract The Bruss–Robertson–Steele (BRS) inequality bounds the expected number of items of random size which can be packed into a given suitcase. Remarkably, no independence assumptions are needed on the random sizes, which points to a simple explanation; the inequality is the integrated form of an $omega$ -by- $omega$ inequality, as this note proves.
BRS不等式限定了一个给定行李箱中可装的随机大小物品的期望数量。值得注意的是,随机大小不需要独立性假设,这指向了一个简单的解释;这个不等式是$ $ × $ $不等式的积分形式,正如本注所证明的那样。
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引用次数: 0
An efficient method for generating a discrete uniform distribution using a biased random source 利用有偏随机源生成离散均匀分布的有效方法
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-03-07 DOI: 10.1017/jpr.2022.111
Xiaoyu Lei
Abstract We present an efficient algorithm to generate a discrete uniform distribution on a set of p elements using a biased random source for p prime. The algorithm generalizes Von Neumann’s method and improves the computational efficiency of Dijkstra’s method. In addition, the algorithm is extended to generate a discrete uniform distribution on any finite set based on the prime factorization of integers. The average running time of the proposed algorithm is overall sublinear: $operatorname{O}!(n/log n)$ .
摘要提出了一种利用p素数的有偏随机源在p元素集合上生成离散均匀分布的有效算法。该算法推广了Von Neumann方法,提高了Dijkstra方法的计算效率。此外,将该算法推广到在任意有限集上基于整数的质因数分解生成离散均匀分布。本文算法的平均运行时间总体上是次线性的:$operatorname{O}!(n/log n)$。
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引用次数: 0
On the probability of rumour survival among sceptics 论谣言在怀疑论者中存活的可能性
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-03-02 DOI: 10.1017/jpr.2022.113
N. Esmaeeli, F. Sajadi
Abstract We study a sceptical rumour model on the non-negative integer line. The model starts with two spreaders at sites 0, 1 and sceptical ignorants at all other natural numbers. Then each sceptic transmits the rumour, independently, to the individuals within a random distance on its right after s/he receives the rumour from at least two different sources. We say that the process survives if the size of the set of vertices which heard the rumour in this fashion is infinite. We calculate the probability of survival exactly, and obtain some bounds for the tail distribution of the final range of the rumour among sceptics. We also prove that the rumour dies out among non-sceptics and sceptics, under the same condition.
摘要研究了非负整数线上的怀疑谣言模型。该模型首先在0和1处设置两个传播者,在所有其他自然数处设置持怀疑态度的无知者。然后,每个怀疑论者在从至少两个不同的来源收到谣言后,将谣言独立地传播给其右侧随机距离内的个人。我们说,如果以这种方式听到谣言的顶点集的大小是无限的,则该过程存活。我们精确地计算了生存概率,并得到了怀疑论者最终谣言范围尾部分布的一些边界。我们还证明,在同样的条件下,谣言在不怀疑论者和怀疑论者中间消失。
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引用次数: 2
Robustness of iterated function systems of Lipschitz maps Lipschitz映射迭代函数系统的鲁棒性
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-02-28 DOI: 10.1017/jpr.2022.107
L. Hervé, J. Ledoux
Abstract Let ${X_n}_{nin{mathbb{N}}}$ be an ${mathbb{X}}$ -valued iterated function system (IFS) of Lipschitz maps defined as $X_0 in {mathbb{X}}$ and for $ngeq 1$ , $X_n;:!=;F(X_{n-1},vartheta_n)$ , where ${vartheta_n}_{n ge 1}$ are independent and identically distributed random variables with common probability distribution $mathfrak{p}$ , $F(cdot,cdot)$ is Lipschitz continuous in the first variable, and $X_0$ is independent of ${vartheta_n}_{n ge 1}$ . Under parametric perturbation of both F and $mathfrak{p}$ , we are interested in the robustness of the V-geometrical ergodicity property of ${X_n}_{nin{mathbb{N}}}$ , of its invariant probability measure, and finally of the probability distribution of $X_n$ . Specifically, we propose a pattern of assumptions for studying such robustness properties for an IFS. This pattern is implemented for the autoregressive processes with autoregressive conditional heteroscedastic errors, and for IFS under roundoff error or under thresholding/truncation. Moreover, we provide a general set of assumptions covering the classical Feller-type hypotheses for an IFS to be a V-geometrical ergodic process. An accurate bound for the rate of convergence is also provided.
设${X_n}_{nin{mathbb{N}}}$为一个${mathbb{X}}$值的Lipschitz映射迭代函数系统(IFS),定义为$X_0 in {mathbb{X}}$和$ngeq 1$, $X_n;:!=;F(X_{n-1},vartheta_n)$,其中${vartheta_n}_{n ge 1}$为具有共同概率分布的独立同分布随机变量,$mathfrak{p}$, $F(cdot,cdot)$在第一个变量上为Lipschitz连续,$X_0$独立于${vartheta_n}_{n ge 1}$。在F和$mathfrak{p}$的参数扰动下,我们感兴趣的是${X_n}_{nin{mathbb{N}}}$的v几何遍历性的鲁棒性,它的不变概率测度的鲁棒性,最后是$X_n$的概率分布的鲁棒性。具体来说,我们提出了一种假设模式来研究IFS的这种鲁棒性。该模式适用于具有自回归条件异方差误差的自回归过程,以及舍入误差或阈值/截断下的IFS。此外,我们还提供了一组一般假设,涵盖了经典的feller型假设,以证明IFS是一个v几何遍历过程。并给出了收敛速度的精确界。
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引用次数: 1
On ordered system signature and its dynamic version for coherent systems with applications 相干系统的有序系统签名及其动态版本
IF 1 4区 数学 Q3 STATISTICS & PROBABILITY Pub Date : 2023-02-28 DOI: 10.1017/jpr.2022.110
He Yi, N. Balakrishnan, Xiang Li
Abstract The notion of ordered system signature, originally defined for independent and identical coherent systems, is first extended to the case of independent and non-identical coherent systems, and then some key properties that help simplify its computation are established. Through its use, a dynamic ordered system signature is defined next, which facilitates a systematic study of dynamic properties of several coherent systems under a life test. The theoretical results established here are then illustrated through some specific examples. Finally, the usefulness in the evaluation of aging used systems of the concepts introduced is demonstrated.
摘要最初为独立和完全相同的相干系统定义的有序系统签名的概念,首先推广到独立和完全不同的相干系统的情况,然后建立了一些有助于简化其计算的关键性质。通过使用它,接下来定义了一个动态有序系统签名,这有助于系统地研究几个相干系统在寿命测试下的动态特性。然后通过一些具体的例子说明了本文建立的理论结果。最后,论证了所引入的概念在老化使用系统评价中的实用性。
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引用次数: 0
期刊
Journal of Applied Probability
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