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Horner syndrome secondary to otomastoiditis 耳乳突炎继发的Horner综合征。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104648
Praveen Jeyaseelan MD, Daniel Timothy Harrast
A 5-year-old girl was brought to the emergency room with unequal pupil size, fever, and ear pain. Computed tomography and magnetic resonance imaging showed left otomastoiditis complicated with a subperiosteal abscess in the posteromedial left temporomandibular joint. Magnetic resonance angiography revealed enhancement of the left canalicular carotid vessel wall due to adjacent inflammatory process, with irritation of post synaptic sympathetic fibers, causing left Horner syndrome. Horner syndrome can be caused by apical lung tumors, carotid artery dissection, and metastatic neuroblastoma, but otomastoiditis is an uncommon etiology. Recognition and further workup of anisocoria is crucial to management of extracranial complications of otomastoiditis.
一名5岁女孩因瞳孔大小不等、发烧和耳痛被送往急诊室。计算机断层扫描和磁共振成像显示左侧耳乳突炎并发骨膜下脓肿在左颞下颌关节后内侧。磁共振血管造影显示左侧颈小管血管壁因邻近炎性过程而增强,突触后交感纤维受到刺激,导致左侧Horner综合征。霍纳综合征可由肺顶端肿瘤、颈动脉夹层和转移性神经母细胞瘤引起,但耳乳突炎是一种罕见的病因。识别和进一步检查异角是处理耳乳突炎颅外并发症的关键。
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引用次数: 0
How do we fix this mess? 我们如何解决这个烂摊子?
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104649
R. Michael Siatkowski MD, MBA
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引用次数: 0
Modified Nishida’s procedure combined with medial rectus recession in a case of Moebius syndrome 改良西田手术合并内侧直肌萎缩一例莫比乌斯综合征。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104652
Sowmya Raveendra Murthy MS, FICO, Sahil Sharma MS, FPOS
Moebius syndrome is a rare congenital disorder in which bilateral abduction is impaired, resulting in moderate- to large-angle esotropia. Various surgical procedures have been developed to correct esotropia in Moebius syndrome, including bilateral medial rectus (bimedial) recessions for moderate angles and bimedial recessions combined with vertical rectus transpositions or superior rectus transpositions for larger deviations. We describe a case of Moebius syndrome treated with modified Nishida’s procedure and bimedial recession to correct large-angle esotropia.
莫比乌斯综合征是一种罕见的先天性疾病,其双侧外展受损,导致中到大角度内斜视。各种外科手术已经发展到矫正莫比乌斯综合征的内斜视,包括双侧内侧直肌(双内侧)衰退用于中等角度,双内侧衰退联合垂直直肌转位或上直肌转位用于较大偏差。我们描述一例莫比乌斯综合征的治疗与改进的西田手术和双内侧退行矫正大角度内斜视。
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引用次数: 0
Socioeconomic trends of adult strabismus in the United States: an analysis of the All of Us database 美国成人斜视的社会经济趋势:对全美数据库的分析。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104655
Alexander C. Lieu BS, Evan H. Walker MS, Shira L. Robbins MD, David B. Granet MD , Jolene C. Rudell MD, PhD

Purpose

To determine associations of income and education level with a diagnosis of strabismus and to identify socioeconomic variables that may affect timely access to diagnosis.

Methods

Annual income, highest level of education completed, and ZIP code income, high school completion, poverty, and socioeconomic deprivation metrics were collected from 413,360 participants in the database. A χ2 test was used to determine significant differences in distributions of income, education, and ZIP code metrics in 3,734 strabismus patients compared with the overall database.

Results

Participants living in ZIP codes with lower multidimensional deprivation indices (less deprivation) are more likely to be diagnosed with strabismus. Participants with annual income below $10,000 (10.10%) or who completed education between fifth grade and a high school diploma or GED (20.06%) are less likely to receive a diagnosis for certain strabismus subtypes. Participants with annual income over $200,000 (7.07%), advanced degrees (27.02%), living in ZIP codes with higher income, and higher high school completion rates were more likely to be diagnosed with certain strabismus subtypes.

Conclusions

Participants diagnosed with strabismus tend to have higher incomes, an advanced degree, and reside in more affluent ZIP codes, whereas those with lower income and education levels are less likely to be diagnosed. These findings reveal potential socioeconomic disparities in access to ophthalmic diagnostic services and care. Findings emphasize the importance of addressing socioeconomic barriers in eye care to enable equitable access.
目的:确定收入和教育水平与斜视诊断的关系,并确定可能影响及时获得诊断的社会经济变量。方法:从数据库中收集了413360名参与者的年收入、高教育水平、邮政编码收入、高中毕业程度、贫困和社会经济剥夺指标。采用χ2检验来确定3734名斜视患者的收入、教育程度和邮政编码指标分布与整个数据库的显著差异。结果:居住在多维剥夺指数较低的邮政编码地区的参与者更容易被诊断为斜视。年收入低于10,000美元(10.10%)或完成五年级到高中文凭或GED教育(20.06%)的参与者不太可能被诊断为某些斜视亚型。年收入超过20万美元(7.07%)、高学历(27.02%)、居住在收入较高的邮政编码地区、高中毕业率较高的参与者更有可能被诊断为某些斜视亚型。结论:被诊断为斜视的参与者往往收入较高,学历较高,居住在更富裕的邮政编码,而那些收入和教育水平较低的人不太可能被诊断为斜视。这些发现揭示了在获得眼科诊断服务和护理方面潜在的社会经济差异。研究结果强调了解决眼科保健中的社会经济障碍以实现公平获取的重要性。
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引用次数: 0
Epidemiology of strabismus among adults in the United States: insights from the All of Us database 美国成人斜视的流行病学:来自全美数据库的见解。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104657
Alexander C. Lieu BS, Evan H. Walker MS, Shira L. Robbins MD, David B. Granet MD , Jolene C. Rudell MD, PhD

Purpose

To determine the prevalence of adult-diagnosed strabismus and its associations with sex, age, and race in a large, diverse population database in the United States.

Methods

Sex, age, and race data were collected from 413,457 individuals in the All of Us database. The χ2 test with post hoc pairwise comparisons was used to determine significant differences in distributions of sex, age, and race data in 3,734 strabismus patients compared with the overall database.

Results

There is a higher proportion of males among patients with strabismus compared with the overall database (43.34% vs 38.34% [P < 0.001]). There is a significantly higher proportion of patients aged over 65 years among patients with strabismus compared with the overall database (45.77% vs 24.7% [P < 0.001]). There is also a significantly different racial distribution of individuals with strabismus compared with the overall database (P < 0.001). Pairwise comparisons showed a significantly lower proportion of Asian individuals among patients with strabismus or heterotropia, a lower proportion of Black individuals with most subtypes, and a higher proportion of White individuals among patients with any strabismus.

Conclusions

These results suggest that there is a lower proportion of females, Asian, and Black participants with diagnosed strabismus compared with the overall population in the All of Us database. These findings may indicate that strabismus affects patient populations differently, or that there is differential access to care and diagnosis of strabismus across sex, age, and race.
目的:在美国一个大型、多样化的人口数据库中确定成人诊断的斜视患病率及其与性别、年龄和种族的关系。方法:从All of Us数据库中收集了413457个人的性别、年龄和种族数据。采用事后两两比较的χ2检验来确定3734例斜视患者的性别、年龄和种族数据分布与整个数据库的差异。结果:斜视患者中男性比例高于整体数据库(43.34% vs 38.34% [P < 0.001])。在斜视患者中,65岁以上患者的比例明显高于整体数据库(45.77% vs 24.7% [P < 0.001])。与整个数据库相比,斜视个体的种族分布也有显著差异(P < 0.001)。两两比较显示,在斜视或异斜视患者中,亚洲人的比例明显较低,大多数亚型的黑人患者比例较低,而在任何斜视患者中,白人患者比例较高。结论:这些结果表明,与All of Us数据库中的总体人群相比,女性、亚洲人和黑人被诊断为斜视的比例较低。这些发现可能表明斜视对患者群体的影响不同,或者斜视的治疗和诊断在性别、年龄和种族上存在差异。
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引用次数: 0
Cavitary retinoblastoma with MYCN amplification 伴有MYCN扩增的腔体视网膜母细胞瘤。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104607
Kathryn E. Tobert BA , Nicole Liberio MD , Kerri Becktell MD , Aparna Ramasubramanian MD
MYCN amplification within the tumor has emerged as an important factor in the oncogenesis of a subset of retinoblastomas, most of which are caused by pathogenic variants in the RB1 gene. We present the case of a 3-month-old girl with unilateral cavitary retinoblastoma that initially responded well to intra-arterial chemotherapy but later recurred. After enucleation, the tumor was found to exhibit MYCN amplification, but there were no RB1 variants. Retinoblastoma tumors with MYCN amplification are known to carry a poor prognosis and often require enucleation. On the contrary, cavitary retinoblastomas tend to be well differentiated, with favorable prognosis. To our knowledge, this is the first report of a MYCN-amplified tumor presenting as cavitary retinoblastoma.
肿瘤内MYCN扩增已成为视网膜母细胞瘤亚群癌变的重要因素,其中大多数是由RB1基因的致病性变异引起的。我们提出一个病例3个月大的女孩单侧腔视网膜母细胞瘤,最初对动脉化疗反应良好,但后来复发。去核后,发现肿瘤表现出MYCN扩增,但没有RB1变异。已知MYCN扩增的视网膜母细胞瘤预后较差,通常需要去核。相反,空腔性视网膜母细胞瘤往往分化良好,预后良好。据我们所知,这是首例mycn扩增的肿瘤表现为空腔性视网膜母细胞瘤。
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引用次数: 0
Restrictive strabismus caused by infantile myositis masquerading as Duane retraction syndrome 婴儿肌炎引起的限制性斜视伪装成Duane挛缩综合征。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104611
Weiyi Xia MD , Jing Yao MD , Xinyi Zhao MD, Chao Jiang MD, Ling Ling MBBS, Chen Zhao MD
We report a rare case of restrictive strabismus in a pediatric patient who was initially misdiagnosed with Duane retraction syndrome (DRS) because she had large-angle exotropia, restricted adduction, globe retraction, narrowing of the palpebral fissure, and downshoot on attempted adduction. Notably, the parents first observed strabismus at 12 months of age, with photographs taken before 6 months of age revealing no ocular misalignment. Despite the absence of typical inflammatory signs, the temporal discrepancy, characterized by delayed onset inconsistent with congenital DRS, prompted further investigation. Subsequent magnetic resonance imaging demonstrated no typical appearances of DRS or other intracranial abnormalities but revealed fusiform enlargement of the lateral rectus muscle, raising suspicion of orbital myositis. Surgical exploration confirmed fibrosis of the lateral rectus muscle. Strabismus surgery involving recession of the fibrotic lateral rectus muscle resulted in improved alignment and motility.
我们报告一例罕见的限制性斜视的儿童患者,她最初被误诊为Duane内收综合征(DRS),因为她有大角度外斜视,内收受限,眼球内收,睑裂狭窄,内收失败。值得注意的是,父母第一次观察到斜视是在12个月大的时候,6个月前拍摄的照片显示没有眼睛错位。尽管没有典型的炎症体征,但时间差异的特征是延迟发作,与先天性DRS不一致,这促使进一步的研究。随后的磁共振成像显示没有典型的DRS或其他颅内异常,但显示外侧直肌梭状扩大,引起眶肌炎的怀疑。手术探查证实外直肌纤维化。斜视手术涉及到纤维性外侧直肌的衰退,结果是矫正和运动得到改善。
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引用次数: 0
Acquired macular atrophy leads to the correct diagnosis of CLDN19-related disease in a child with nephropathy 获得性黄斑萎缩导致肾病患儿cldn19相关疾病的正确诊断。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104610
Arif O. Khan MD
Biallellic CLDN19 pathogenic variants cause syndromic macular atrophy or pseudocoloboma (familial hypomagnesemia with hypercalciuria and nephrocalcinosis). Macular atrophic lesions in children with CLDN19-related disease have been reported as stable over follow-up, although it remains unclear whether they are congenital or acquired (developmental). This report highlights the case of an infant with nephropathy and high myopia for whom acquired macular atrophy redirected genetic studies and led to the diagnosis of CLDN19-related disease.
双等位基因CLDN19致病变异引起综合征性黄斑萎缩或假结肠瘤(家族性低镁血症伴高钙尿症和肾钙质沉着症)。据报道,患有cldn19相关疾病的儿童黄斑萎缩病变在随访中稳定,尽管尚不清楚它们是先天性的还是获得性的(发育性的)。本报告重点报道了一例患有肾病和高度近视的婴儿,其获得性黄斑萎缩重定向了基因研究,并导致了cldn19相关疾病的诊断。
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引用次数: 0
Pediatric azathioprine-induced pterygium formation in a patient with Crohn’s disease: a possible sign of ultraviolet photosensitization 克罗恩病患者小儿硫唑嘌呤诱导的翼状胬肉形成:紫外线光敏化的可能迹象。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104609
Ahmed Magid Wanas MSc, FRCOphth, Alan Connor FRCOphth
We present the case of a 15-year-old boy on long-term azathioprine treatment for Crohn’s disease who developed bilateral pterygia. He had no family history of pterygium formation, and he lived in a northern English town with a low ultraviolet (UV) index. This case highlights a possible association between azathioprine intake and development of pterygium, possibly attributable to UVA photosensitization.
我们提出的情况下,一个15岁的男孩长期硫唑嘌呤治疗克罗恩病谁发展双侧翼状胬肉。他没有翼状胬肉形成的家族史,他住在英国北部一个紫外线指数较低的城镇。这个病例强调了氮唑嘌呤的摄入和翼状胬肉的发展之间可能的联系,可能归因于UVA光敏。翼状胬肉主要是由于长期暴露于紫外线a (UVA)而发展起来的。已知服用硫唑嘌呤的患者发生非黑色素瘤皮肤癌(NMSC)的几率更高,因为这种药物对皮肤的UVA光敏作用。这增加了一种可能性,即服用硫唑嘌呤的个体的眼部组织的UVA光敏化可能会增加翼状胬肉的可能性,即使在儿科年龄组,翼状胬肉通常被认为很罕见。
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引用次数: 0
Predictors of access to pediatric eye care appointments 获得儿科眼科护理预约的预测因素。
IF 1.3 4区 医学 Q3 OPHTHALMOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.jaapos.2025.104639
Thomas H. Diehl BS , Davina A. Malek MD , Kara M. Cavuoto MD

Purpose

To investigate predictors of access to pediatric eye care appointments in the United States.

Methods

A comprehensive list of pediatric ophthalmologists and optometrists was compiled, and offices were contacted to respond to a structured telephone survey regarding private insurance and Medicaid acceptance and appointment availability. Simple logistic regressions were used to assess risk factors affecting proportions of successful appointments and appointment wait times. Multivariable analysis adjusted for potential confounding factors, including physician type, practice type, geographic location, insurance type, and race majority in county. The main outcome measures were percentages of successful appointments, predictors associated with higher chances for a successful appointment, and average appointment wait times.

Results

A total of 925 offices of 1,528 providers were contacted (62% ophthalmologists). The percentage of successful appointments was significantly lower with ophthalmologists (39.7%) than optometrists (65.6% [P < 0.001]). Average wait times for successful appointments were significantly shorter at the offices of optometrists (25.4 ± 36.5 days) versus ophthalmologists (52.8 ± 58.3 days [P < 0.001]). Medicaid patients had a statistically significantly lower appointment success rate (37.2%) compared with the privately insured (62.0% [P < 0.001]), and their average wait times were 46.5 ± 56.19 days, compared with 40.0 ± 50.7 days for privately insured patients (P < 0.093). In majority White counties, appointments booked 50.2% (95% CI, 48.4-52.0) compared with 41.3% (95% CI, 34.6-48.0) in predominantly minority counties (P = 0.014).

Conclusions

Disparities in the proportions of booked appointments and wait times for pediatric eye care visits based on insurance type, provider type, and demographics underscore the need for increased access to pediatric eye care.
目的:研究美国儿童眼科就诊的预测因素。方法:编制了一份全面的儿童眼科医生和验光师名单,并联系了他们的办公室,对私人保险和医疗补助的接受情况和预约情况进行了结构化的电话调查。使用简单的逻辑回归来评估影响成功预约比例和预约等待时间的风险因素。多变量分析调整了潜在的混杂因素,包括医生类型、执业类型、地理位置、保险类型和县种族多数。主要的结果测量是成功预约的百分比,与成功预约的高机会相关的预测因素,以及平均预约等待时间。结果:共联系925个诊所,1528名眼科医生(62%)。眼科医生的预约成功率(39.7%)明显低于验光师(65.6%)[P < 0.001]。验光师预约成功的平均等待时间(25.4±36.5天)明显短于眼科医生(52.8±58.3天[P < 0.001])。医疗补助患者的预约成功率(37.2%)低于私人参保患者(62.0% [P < 0.001]),平均等待时间(46.5±56.19天)低于私人参保患者(40.0±50.7天)(P < 0.093)。在大多数白人县,预约率为50.2% (95% CI, 48.4-52.0),而在主要少数民族县,预约率为41.3% (95% CI, 34.6-48.0) (P = 0.014)。结论:根据保险类型、医疗服务提供者类型和人口统计数据,儿童眼科就诊预约比例和等待时间的差异强调了增加儿童眼科就诊的必要性。
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引用次数: 0
期刊
Journal of Aapos
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