An 11-month-old boy with nonscarring alopecia was referred for ophthalmic evaluation because of photophobia from the age of 4 months. Whole-exome sequencing identified a heterozygous mutation in the SREBF1 gene, confirming the diagnosis of hereditary mucoepithelial dysplasia. Ocular examination revealed meibomian gland dysfunction and superficial corneal vascularization and opacity. Impression cytology of the sclerocorneal limbus revealed atypical epithelial cells. The patient received treatment for meibomian gland dysfunction, dry eye, and ocular surface inflammation. With appropriate management and close follow-up over 7 years, corneal opacity improved greatly.
{"title":"Long-term follow-up of ocular involvement in hereditary mucoepithelial dysplasia","authors":"Sepehr Feizi MD, MSc , Mohammadreza Tahavvori MD , Seyed-Bagher Hosseini MD , Goldis Espandar MD , Peyman Mohammadi Torbati MD , Hamed Esfandiari MD","doi":"10.1016/j.jaapos.2024.103997","DOIUrl":"10.1016/j.jaapos.2024.103997","url":null,"abstract":"<div><div>An 11-month-old boy with nonscarring alopecia was referred for ophthalmic evaluation because of photophobia from the age of 4 months. Whole-exome sequencing identified a heterozygous mutation in the <em>SREBF1</em> gene, confirming the diagnosis of hereditary mucoepithelial dysplasia. Ocular examination revealed meibomian gland dysfunction and superficial corneal vascularization and opacity. Impression cytology of the sclerocorneal limbus revealed atypical epithelial cells. The patient received treatment for meibomian gland dysfunction, dry eye, and ocular surface inflammation. With appropriate management and close follow-up over 7 years, corneal opacity improved greatly.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 103997"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jaapos.2024.104002
Sharmila Segar MD , Amanda Ismail MD , Riya Shah BS , Chaesik Kim BSEE , Aditi Kappagantu BS , John Roarty MD
Purpose
To investigate the long-term outcomes associated with Ahmed glaucoma device capsulectomy in pediatric patients at a single institution over a period of nearly 10 years, from 2011 to 2021.
Methods
We retrospectively reviewed the medical records of pediatric glaucoma patients with FP-7 Ahmed glaucoma device capsulectomies performed by three surgeons. Surgical success was defined as post-capsulectomy IOP of <21 mm Hg at most recent follow-up without need for additional procedures, regardless of topical medications.
Results
A total of 22 capsulectomies of 22 eyes of 18 patients aged 1-17 years were reviewed. Median post-capsulectomy follow-up was 5.8 years. Etiologies of glaucoma were primary congenital glaucoma (50%), anterior segment dysgenesis (32%), Sturge-Weber syndrome (14%), and angle recession (5%). Pre-capsulectomy IOP was 30 ± 6.2 mm Hg, with first postoperative IOP of 15 ± 8.0 mm Hg. Surgical success was achieved with 5 capsulectomies (23%), with follow-up of 1.5-5.9 years. Post-capsulectomy complications included short-term hypotony in 1 eye (5%) and macular edema in 1 eye (5%). Eleven of 22 eyes (50%) had at least one repeat placement of Ahmed glaucoma device, with median time to repeat surgery of 80 months.
Conclusions
In pediatric glaucoma patients with glaucoma drainage device encapsulation, capsulectomy likely does not prevent additional surgery in most children over the long term, but may serve as a temporizing measure before other interventions.
{"title":"Long-term outcomes of Ahmed glaucoma drainage device capsulectomies in pediatric glaucoma patients","authors":"Sharmila Segar MD , Amanda Ismail MD , Riya Shah BS , Chaesik Kim BSEE , Aditi Kappagantu BS , John Roarty MD","doi":"10.1016/j.jaapos.2024.104002","DOIUrl":"10.1016/j.jaapos.2024.104002","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the long-term outcomes associated with Ahmed glaucoma device capsulectomy in pediatric patients at a single institution over a period of nearly 10 years, from 2011 to 2021.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the medical records of pediatric glaucoma patients with FP-7 Ahmed glaucoma device capsulectomies performed by three surgeons. Surgical success was defined as post-capsulectomy IOP of <21 mm Hg at most recent follow-up without need for additional procedures, regardless of topical medications.</div></div><div><h3>Results</h3><div>A total of 22 capsulectomies of 22 eyes of 18 patients aged 1-17 years were reviewed. Median post-capsulectomy follow-up was 5.8 years. Etiologies of glaucoma were primary congenital glaucoma (50%), anterior segment dysgenesis (32%), Sturge-Weber syndrome (14%), and angle recession (5%). Pre-capsulectomy IOP was 30 ± 6.2 mm Hg, with first postoperative IOP of 15 ± 8.0 mm Hg. Surgical success was achieved with 5 capsulectomies (23%), with follow-up of 1.5-5.9 years. Post-capsulectomy complications included short-term hypotony in 1 eye (5%) and macular edema in 1 eye (5%). Eleven of 22 eyes (50%) had at least one repeat placement of Ahmed glaucoma device, with median time to repeat surgery of 80 months.</div></div><div><h3>Conclusions</h3><div>In pediatric glaucoma patients with glaucoma drainage device encapsulation, capsulectomy likely does not prevent additional surgery in most children over the long term, but may serve as a temporizing measure before other interventions.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 104002"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jaapos.2024.104010
Yulia Haraguchi BA , Zeina Salem MD , Noor Ghali MS , Arianne Zeng BS , Faruk H. Örge MD
Purpose
To examine the effect of age at time of congenital nasolacrimal duct obstruction (CNLDO) intervention on symptom resolution and reoperation rates in patients with Down syndrome (DS).
Methods
The medical records of patients with DS and CNLDO between 2012 and 2021 were reviewed retrospectively. Age at the time of first stent placement was utilized to categorize patients into age groups <3 and >3 years of age. Epiphora resolution at last office visit and restenting rate were used as outcome measures.
Results
A total of 49 patients with DS and CLNDO were identified between 2012 and 2021; of these, 17 had received surgical stent placement with appropriate follow-up. Epiphora resolution (X21= 0.78, P = 0.33), restenting rate (X21 = 2.84, P = 0.09), cumulative stent duration (P = 0.33) and number of stent placement operations (P = 0.98) were not significantly different between the age groups. There was no significant difference between stent duration <1 year or >1 year with regard to epiphora resolution (X21 = 0.91, P = 0.34).
Conclusions
Success of stent placement and reoperation rates among patients with DS and CNLDO were not associated with age and duration of stent intubation. Intervention at later ages may still be beneficial for symptom resolution in patients with DS.
{"title":"The effect of age on congenital nasolacrimal duct obstruction probing and stent intubation outcomes in pediatric Down syndrome patients","authors":"Yulia Haraguchi BA , Zeina Salem MD , Noor Ghali MS , Arianne Zeng BS , Faruk H. Örge MD","doi":"10.1016/j.jaapos.2024.104010","DOIUrl":"10.1016/j.jaapos.2024.104010","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the effect of age at time of congenital nasolacrimal duct obstruction (CNLDO) intervention on symptom resolution and reoperation rates in patients with Down syndrome (DS).</div></div><div><h3>Methods</h3><div>The medical records of patients with DS and CNLDO between 2012 and 2021 were reviewed retrospectively. Age at the time of first stent placement was utilized to categorize patients into age groups <3 and >3 years of age. Epiphora resolution at last office visit and restenting rate were used as outcome measures.</div></div><div><h3>Results</h3><div>A total of 49 patients with DS and CLNDO were identified between 2012 and 2021; of these, 17 had received surgical stent placement with appropriate follow-up. Epiphora resolution (<em>X</em><sup><em>2</em></sup><sub><em>1</em></sub> <em>=</em> 0.78, <em>P</em> = 0.33), restenting rate (<em>X</em><sup><em>2</em></sup><sub><em>1</em></sub> = 2.84, <em>P</em> = 0.09), cumulative stent duration (<em>P</em> = 0.33) and number of stent placement operations (<em>P</em> = 0.98) were not significantly different between the age groups. There was no significant difference between stent duration <1 year or >1 year with regard to epiphora resolution (<em>X</em><sup><em>2</em></sup><sub><em>1</em></sub> = 0.91, <em>P</em> = 0.34).</div></div><div><h3>Conclusions</h3><div>Success of stent placement and reoperation rates among patients with DS and CNLDO were not associated with age and duration of stent intubation. Intervention at later ages may still be beneficial for symptom resolution in patients with DS.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 104010"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Molluscum contagiosum (MC) is a benign cutaneous viral infection commonly affecting children, sexually active adults, immunocompromised individuals, and patients on immunosuppressive therapy. Giant periorbital MC lesions with preseptal cellulitis are rare. We present 2 such pediatric cases. Case 1 was a 9-month-old boy with an enlarging left upper eyelid mass and preseptal cellulitis. MC was confirmed on histopathology, and surgical excision was curative. Case 2 was an 18-month-old girl with a right lower eyelid ulcerating mass and preseptal cellulitis. She was managed with antibiotics and surgical excision.
{"title":"Giant molluscum contagiosum with preseptal cellulitis","authors":"Amitouj S. Sidhu BMed, MD , Josefina Herrera MD , Shereen Aiyub MD, MMed , Nicole S. Graf FRCPA , Trent Sandercoe PhD, FRANZCO , Krishna Tumuluri FRANZCO","doi":"10.1016/j.jaapos.2024.103989","DOIUrl":"10.1016/j.jaapos.2024.103989","url":null,"abstract":"<div><div>Molluscum contagiosum (MC) is a benign cutaneous viral infection commonly affecting children, sexually active adults, immunocompromised individuals, and patients on immunosuppressive therapy. Giant periorbital MC lesions with preseptal cellulitis are rare. We present 2 such pediatric cases. Case 1 was a 9-month-old boy with an enlarging left upper eyelid mass and preseptal cellulitis. MC was confirmed on histopathology, and surgical excision was curative. Case 2 was an 18-month-old girl with a right lower eyelid ulcerating mass and preseptal cellulitis. She was managed with antibiotics and surgical excision.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 103989"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jaapos.2024.104016
Omar Solyman MD, FRCS , Abdelrahman M. Elhusseiny MD, MSc , Richard C. Allen MD, PhD
We describe the use of trypan blue stain to enhance visualization of the tract of the fistula during congenital lacrimal fistulectomy in a 9-year-old boy. This video demonstrates the surgical technique and the intraoperative finding of deep branching of the fistula in this case. We discuss alternative methods of improving delineation of the fistula’s path during congenital lacrimal fistulectomy.
{"title":"The use of trypan blue to enhance intraoperative visualization during congenital lacrimal fistulectomy","authors":"Omar Solyman MD, FRCS , Abdelrahman M. Elhusseiny MD, MSc , Richard C. Allen MD, PhD","doi":"10.1016/j.jaapos.2024.104016","DOIUrl":"10.1016/j.jaapos.2024.104016","url":null,"abstract":"<div><div>We describe the use of trypan blue stain to enhance visualization of the tract of the fistula during congenital lacrimal fistulectomy in a 9-year-old boy. This video demonstrates the surgical technique and the intraoperative finding of deep branching of the fistula in this case. We discuss alternative methods of improving delineation of the fistula’s path during congenital lacrimal fistulectomy.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 104016"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jaapos.2024.104012
Ece Ozdemir Zeydanli MD, FRCS(Ed) , Ahmet Yucel Ucgul MD, FRCS(Ed) , H. Tuba Atalay MD, FEBO , M. Elizabeth Hartnett MD, FASRS , Ehab El Rayes MD, FASRS , Huban Atilla MD, FEBO , Sengul Ozdek MD, FASRS
Purpose
To investigate cases exhibiting overlapping features of persistent fetal vasculature (PFV) and combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) and to explore potential associations between these developmental ocular anomalies.
Methods
This retrospective, descriptive case series included 9 eyes of 8 patients aged 0-7 years with shared clinical features of PFV and CHRRPE. Diagnoses were established through clinical examination and intraoperative findings.
Results
All eyes exhibited elevated pigmented retinal thickening, increased vascular tortuosity, and preretinal fibrotic/gliotic changes or epiretinal membranes. Macular involvement was observed in 56% of cases; peripapillary involvement, in 44%. Four eyes showed hyaloid stalklike fibrotic remnants extending from the lesion to the posterior lens surface, suggestive of PFV component; the other 5 harbored isolated CHRRPE. One patient presented with PFV in one eye and CHRPPE in the other.
Conclusions
This study reveals significant clinical overlap between PFV and CHRRPE, with some cases displaying features typically associated with the other condition. The presence of both diagnoses in the same patient further suggests a potential association between these entities. Further research, including molecular studies, is needed to explore this potential connection and deepen our understanding of ocular development.
{"title":"Overlapping clinical features of persistent fetal vasculature and combined hamartoma of the retina and retinal pigment epithelium","authors":"Ece Ozdemir Zeydanli MD, FRCS(Ed) , Ahmet Yucel Ucgul MD, FRCS(Ed) , H. Tuba Atalay MD, FEBO , M. Elizabeth Hartnett MD, FASRS , Ehab El Rayes MD, FASRS , Huban Atilla MD, FEBO , Sengul Ozdek MD, FASRS","doi":"10.1016/j.jaapos.2024.104012","DOIUrl":"10.1016/j.jaapos.2024.104012","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate cases exhibiting overlapping features of persistent fetal vasculature (PFV) and combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) and to explore potential associations between these developmental ocular anomalies.</div></div><div><h3>Methods</h3><div>This retrospective, descriptive case series included 9 eyes of 8 patients aged 0-7 years with shared clinical features of PFV and CHRRPE. Diagnoses were established through clinical examination and intraoperative findings.</div></div><div><h3>Results</h3><div>All eyes exhibited elevated pigmented retinal thickening, increased vascular tortuosity, and preretinal fibrotic/gliotic changes or epiretinal membranes. Macular involvement was observed in 56% of cases; peripapillary involvement, in 44%. Four eyes showed hyaloid stalklike fibrotic remnants extending from the lesion to the posterior lens surface, suggestive of PFV component; the other 5 harbored isolated CHRRPE. One patient presented with PFV in one eye and CHRPPE in the other.</div></div><div><h3>Conclusions</h3><div>This study reveals significant clinical overlap between PFV and CHRRPE, with some cases displaying features typically associated with the other condition. The presence of both diagnoses in the same patient further suggests a potential association between these entities. Further research, including molecular studies, is needed to explore this potential connection and deepen our understanding of ocular development.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 104012"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jaapos.2024.103998
Anas Yasin MD , Steve Mathew , Joseph Maes , Terri Love MD , Angela Beavers MD , Sandra Allbery MD , Andria M. Powers MD , Paul Rychwalski MD , Samiksha Fouzdar Jain MD
In 2021, rapid magnetic resonance imaging (rMRI) became a primary imaging tool for suspected pediatric orbital cellulitis at our institution. We retrospectively reviewed the medical records of patients who underwent rMRI to evaluate the effectiveness of the protocol. A total of 31 patients were included (median age, 5.07 years). Of the 30 diagnostic scans, 11 (37%) showed preseptal cellulitis, and 19 (63%) showed orbital cellulitis. In 5 cases, orbital contrast-enhanced computed tomography (CT) was additionally ordered; rMRI and CT scan findings were similar in all 5 cases. Overall, we observed 93% (28/30) concordance of rMRI with the final clinical diagnosis.
{"title":"Performance of orbital rapid magnetic resonance imaging (rMRI) as a primary tool for evaluation of suspected pediatric orbital cellulitis","authors":"Anas Yasin MD , Steve Mathew , Joseph Maes , Terri Love MD , Angela Beavers MD , Sandra Allbery MD , Andria M. Powers MD , Paul Rychwalski MD , Samiksha Fouzdar Jain MD","doi":"10.1016/j.jaapos.2024.103998","DOIUrl":"10.1016/j.jaapos.2024.103998","url":null,"abstract":"<div><div>In 2021, rapid magnetic resonance imaging (rMRI) became a primary imaging tool for suspected pediatric orbital cellulitis at our institution. We retrospectively reviewed the medical records of patients who underwent rMRI to evaluate the effectiveness of the protocol. A total of 31 patients were included (median age, 5.07 years). Of the 30 diagnostic scans, 11 (37%) showed preseptal cellulitis, and 19 (63%) showed orbital cellulitis. In 5 cases, orbital contrast-enhanced computed tomography (CT) was additionally ordered; rMRI and CT scan findings were similar in all 5 cases. Overall, we observed 93% (28/30) concordance of rMRI with the final clinical diagnosis.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 103998"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Posterior lenticonus is a rare congenital anomaly of the crystalline lens characterized by the conical herniation of the posterior lenticular surface with or without cortex herniation into the anterior vitreous. It is usually unilateral and axial; bilateral cases are usually familial and have syndromic associations. The irregular lenticular surface produces high myopia and irregular astigmatism producing optical distortion and hence deprivation amblyopia. We report a case of a 13-year-old girl with a unilateral pigmented posterior lenticonus associated with a retinochoridal coloboma with deprivation amblyopia.
{"title":"Unilateral pigmented posterior lenticonus with retinochoroidal coloboma: a case report","authors":"Hennaav Kaur Dhillon MS, Abinaya Valliappan MS, FICO, Sumita Agarkar MS, DNB","doi":"10.1016/j.jaapos.2024.103995","DOIUrl":"10.1016/j.jaapos.2024.103995","url":null,"abstract":"<div><div>Posterior lenticonus is a rare congenital anomaly of the crystalline lens characterized by the conical herniation of the posterior lenticular surface with or without cortex herniation into the anterior vitreous. It is usually unilateral and axial; bilateral cases are usually familial and have syndromic associations. The irregular lenticular surface produces high myopia and irregular astigmatism producing optical distortion and hence deprivation amblyopia. We report a case of a 13-year-old girl with a unilateral pigmented posterior lenticonus associated with a retinochoridal coloboma with deprivation amblyopia.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 103995"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To assess the validity of the GoCheck Kids photoscreening application (Gobiquity Mobile Health, Scottdale, AZ) on iPhone, which was used (2018-2022) as standard of care by Child and Family (Kind en Gezin) to detect amblyopia risk factors in children 12-30 months of age.
Methods
Between August 2021 and May 2022, 453 children 11-16 months of age underwent a confirmatory ophthalmic examination within 2 months of GoCheck Kids photoscreening at Child and Family, Flanders, Belgium. Additionally, manual review was performed by specialists of GoCheck Kids. Diagnostic metrics were assessed using the 2013 criteria of the American Association for Pediatric Ophthalmology and Strabismus as reference.
Results
Specificity was similar for automatic screening with or without manual review: 90.0% (95% CI, 87.6%-92.3%) and 90.3% (95% CI, 88.0%-92.7%), respectively. Sensitivity was estimated at 52.0% (95% CI, 35.6%-68.4%) for automatic grading and 56.0% (95% CI, 39.7%-72.3%) after manual review. Positive predictive values for automatic screening and manual review were, respectively, 23.2% (95% CI, 13.9-32.5) and 25.5% (95% CI, 15.8-35.1). Negative predictive values for automatic screening and manual review were, respectively, 97.0% (95% CI, 95.6-98.4) and 97.2 (95% CI, 95.8-98.6).
Conclusions
In our study cohort of children around 12 months of age, the GoCheck Kids application had a specificity of 90% for the targeted amblyopia risk factors, with sensitivity just over 50%.
{"title":"Validation of the eye screening tool GoCheck Kids for the detection of amblyopia risk factors in toddlers in Flanders","authors":"Hanne Otto MSc , Maaike Deschoemaeker MD , Bart Van Overmeire PhD, MD , Ingele Casteels PhD, MD , Catherine Cassiman PhD, MD","doi":"10.1016/j.jaapos.2024.104008","DOIUrl":"10.1016/j.jaapos.2024.104008","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the validity of the GoCheck Kids photoscreening application (Gobiquity Mobile Health, Scottdale, AZ) on iPhone, which was used (2018-2022) as standard of care by Child and Family (Kind en Gezin) to detect amblyopia risk factors in children 12-30 months of age.</div></div><div><h3>Methods</h3><div>Between August 2021 and May 2022, 453 children 11-16 months of age underwent a confirmatory ophthalmic examination within 2 months of GoCheck Kids photoscreening at Child and Family, Flanders, Belgium. Additionally, manual review was performed by specialists of GoCheck Kids. Diagnostic metrics were assessed using the 2013 criteria of the American Association for Pediatric Ophthalmology and Strabismus as reference.</div></div><div><h3>Results</h3><div>Specificity was similar for automatic screening with or without manual review: 90.0% (95% CI, 87.6%-92.3%) and 90.3% (95% CI, 88.0%-92.7%), respectively. Sensitivity was estimated at 52.0% (95% CI, 35.6%-68.4%) for automatic grading and 56.0% (95% CI, 39.7%-72.3%) after manual review. Positive predictive values for automatic screening and manual review were, respectively, 23.2% (95% CI, 13.9-32.5) and 25.5% (95% CI, 15.8-35.1). Negative predictive values for automatic screening and manual review were, respectively, 97.0% (95% CI, 95.6-98.4) and 97.2 (95% CI, 95.8-98.6).</div></div><div><h3>Conclusions</h3><div>In our study cohort of children around 12 months of age, the GoCheck Kids application had a specificity of 90% for the targeted amblyopia risk factors, with sensitivity just over 50%.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 5","pages":"Article 104008"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jaapos.2024.103993
Adam Jacobson MD , Brenda L. Bohnsack MD, PhD
Purpose
To evaluate frequency of surgery and post-treatment outcomes in glaucoma following cataract surgery (GFCS).
Methods
The medical records of patients with GFCS were reviewed retrospectively. Lensectomy and glaucoma surgery details and final examination findings were collected. Inclusion criteria included history of lensectomy at <1 year of age, diagnosis of glaucoma, and at least 1 year of follow-up.
Results
Of 169 eyes of 127 GFCS patients (66 male, 58 bilateral cases), 88 eyes (52%) of 73 (57%) patients underwent glaucoma surgery (median, 3.5 years of age at first glaucoma surgery; median of two glaucoma surgeries). At final follow-up (mean, 13.6 ± 7.0 years), eyes requiring glaucoma surgery had worse visual acuity (P = 0.01) and greater cup:disk ratio (P < 0.01). GFCS patients with history of bilateral congenital cataracts had better visual acuity in affected eyes than those with history of unilateral congenital cataract (P < 0.01). Angle surgery (n = 56), Baerveldt devices (n = 38), Ahmed valves (n = 19), and cycloablation (n = 21) showed 1-year survival rates between 64% and 75%. Baerveldt implants showed the highest 5- and 10-year survival rates, at 65% and 43%, respectively.
Conclusions
More than 50% of eyes with GFCS in our study cohort required at least one glaucoma surgery. Glaucoma surgery and history of unilateral cataract were associated with worse visual acuity outcomes.
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