Journal of Aapos最新文献

英文中文

Innovative nonsurgical treatment for central-peripheral rivalry-type diplopia. 创新的非手术治疗中央-外周竞争型复视。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-17 DOI: 10.1016/j.jaapos.2026.104757

Lindsay D Klaehn, Tia B Bodi, Andrea M Kramer, Raymond Iezzi, David O Hodge, Erick D Bothun

Purpose: To evaluate whether a multifocal contact lens improves central-peripheral rivalry-type (CPR-type) diplopia in patients with epiretinal membrane and other maculopathies.

Methods: Seventeen consecutive adult patients with epiretinal membrane or macular hole and CPR-type diplopia were enrolled. A multifocal, center-distance contact lens, with +2.50 bifocal power, was applied to the eye with macular disease. Measurements of diplopia (optotype-frame test), metamorphopsia (M-Charts, Amsler grid), and aniseikonia (Awaya test) were obtained prior to contact lens placement on the affected eye and repeated 30 minutes after contact lens placement.

Results: Median best-corrected visual acuity in the affected eye(s) was 20/20 Snellen before and after multifocal contact lens placement. Diplopia improved in 10 patients (59%), from describing double letters in a single frame or a single letter in a double frame (both indicating central-peripheral rivalry) to a single letter in a single frame. Sixteen patients (94%) reported subjective improvement in M-Chart metamorphopsia (mean of 0.46 before treatment to 0.19 with the multifocal contact lens [mean difference, 0.27; 95% CI, 0.15-0.33; P ≤ 0.001]). Thirteen (76%) showed improvement on the Amsler grid: perceived grid distortion changed from a mean of 111.8 boxes to 38.2 boxes (mean difference, 73.6; 95% CI, 16.67-30.5; P = 0.024). Additionally, 10 (59%) demonstrated improvement in Awaya test aniseikonia, with a mean change from 4.4% to 3.6% (mean difference, -0.82; 95% CI, -1.66 to 0.02; P = 0.53).

Conclusions: Multifocal contact lenses present a promising alternative for alleviating CPR-type diplopia and reducing metamorphopsia associated with epiretinal membrane and macular hole by functionally masking the periphery while maintaining clear central vision.

目的：评价多焦点隐形眼镜是否能改善视网膜前膜及其他黄斑病变患者的中央-外周竞争型（cpr型）复视。方法：连续17例成人视网膜前膜或黄斑裂孔伴复视患者。使用双焦倍率+2.50的多焦点中心距隐形眼镜治疗黄斑病变。在配戴隐形眼镜前测量复视（视型镜架测试）、变形视（M-Charts, Amsler grid）和斜视（Awaya测试），并在配戴隐形眼镜后30分钟重复测量。结果：多焦点隐形眼镜置入术前后患眼最佳矫正视力中位数为20/20 Snellen。复视在10例（59%）患者中得到改善，从单框双字母或双框单字母（两者都表明中央-外周竞争）到单框单字母。16名患者（94%）报告M-Chart变形的主观改善（治疗前平均为0.46，多焦点隐形眼镜治疗后平均为0.19[平均差异为0.27;95% CI, 0.15-0.33; P≤0.001]）。13个（76%）在Amsler网格上表现出改善：感知到的网格畸变从平均111.8个盒子改变到38.2个盒子（平均差为73.6;95% CI, 16.67-30.5; P = 0.024）。此外，10例（59%）在Awaya测试中表现出改善，平均变化从4.4%到3.6%（平均差异，-0.82;95% CI, -1.66至0.02;P = 0.53）。结论：多焦点隐形眼镜是一种很有前景的替代方案，可以在保持清晰的中心视力的同时，在功能上掩盖外周，减轻cpr型复视和减少视网膜前膜和黄斑孔相关的变形。

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引用次数: 0

Recessing a muscle and roasting a chicken: teaching strabismus surgery in the spirit of a chef 切除肌肉和烤鸡：以厨师的精神教授斜视手术。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.jaapos.2026.104735

Mark Silverberg MD , Federico Velez MD , Stacy Pineles MD

引用次数: 0

Self-reported physical activity in school age children with amblyopia 弱视学龄儿童自我报告的体育活动。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jaapos.2026.104739

Brooke A. Koritala BS, BA , Reed M. Jost MS , Christina Cheng-Patel CCRC , Cynthia Beauchamp MD , Prashanthi Giridhar MD , Becky Luu OD , Eileen E. Birch PhD

Background

Residual amblyopia is associated with difficulties with eye-hand coordination, aiming and catching, balance, and gait. Whether these motor skill difficulties have an impact on physical activity and health is poorly understood.

Methods

In this cross-sectional study, 132 children 8-13 years of age completed the self-report Physical Activity Questionnaire for Children: 59 amblyopic children, 29 children with strabismus or anisometropia who were never amblyopic or were no longer amblyopic after treatment (nonamblyopic), and 44 control children. Subsets of children in each group also completed BMI measurement, a self-perception of athletic competence questionnaire, motor skills assessment, and the PedEyeQ Functional Vision domain questionnaire. A subset of parents rated their child’s physical activity as sedentary, light, moderate, or very active.

Results

Overall, 63% were non-Hispanic White and 54% were female, with a mean age of 9.9 ± 1.7 years. Of the 59 amblyopic children, 46% had anisometropia, 31% had been treated for strabismus, and 24% had both. Neither a significant difference in overall physical activity nor BMI was identified among children with amblyopia, nonamblyopic children, and controls (F_2,129 = 1.12, P = 0.33; F_2,68 = 0.43, P = 0.65, resp.). Responses from both children and their parents were consistent with light to moderate levels of physical activity in all three groups. Children with amblyopia had deficits in motor skills, self-perception of athletic competence, and functional vision relative to controls (F_2,98 = 11.51, P < 0.0001; F_2,95 = 3.47, P = 0.04; F_2,129 = 20.20, P < 0.0001, resp.).

Conclusions

Despite significant impairments in motor skills, and differences in athletic self-perception and functional vision, children with amblyopia maintain overall physical activity levels and BMI comparable to their control peers.

背景：残余性弱视与手眼协调、瞄准和抓球、平衡和步态困难有关。这些运动技能障碍是否对身体活动和健康有影响尚不清楚。方法：在这项横断面研究中，132名8-13岁的儿童完成了儿童自我报告体力活动问卷：59名弱视儿童，29名患有斜视或屈光参差的儿童，从未弱视或治疗后不再弱视（非弱视），44名对照组。各组儿童还完成了BMI测量、运动能力自我感知问卷、运动技能评估和peteyeq功能视觉领域问卷。一部分家长将孩子的体育活动分为久坐、轻度、中度或非常活跃。结果：总体而言，63%为非西班牙裔白人，54%为女性，平均年龄9.9±1.7岁。在59名弱视儿童中，46%患有屈光参差，31%接受过斜视治疗，24%两者皆有。弱视儿童、非弱视儿童和对照组在总体体力活动和BMI方面均未发现显著差异（f2129 = 1.12, P = 0.33; F2,68 = 0.43, P = 0.65，均有差异）。在所有三组中，儿童及其父母的反应都与轻度到中度的体育锻炼水平一致。弱视患儿在运动技能、运动能力自我知觉和功能视力方面均较对照组存在缺陷（F2,98 = 11.51, P < 0.0001; F2,95 = 3.47, P = 0.04; f2129 = 20.20, P < 0.0001，均有差异）。结论：尽管弱视儿童在运动技能、运动自我感知和功能性视力方面存在显著缺陷，但他们的整体身体活动水平和BMI与对照组相当。

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引用次数: 0

Hispanic ethnicity associated with worse pediatric blepharokeratoconjunctivitis at a tertiary children’s hospital in the United States 在美国一家三级儿童医院，西班牙裔与儿童睑角结膜炎的恶化有关。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-01-31 DOI: 10.1016/j.jaapos.2026.104741

Jennifer M. Lai BS, Jennifer L. Patnaik PhD, MHS, Ronald Wise MD, Emily A. McCourt MD, Rebecca G. Edwards Mayhew MD, PhD

Purpose

To compare the severity of corneal disease and complications associated with pediatric blepharokeratoconjunctivitis (PBKC) as well as barriers to care in Hispanic and non-Hispanic children.

Methods

The medical records of all children <18 years of age who met broadened PBKC spectrum criteria at Children’s Hospital Colorado between 2019 and 2024 were reviewed retrospectively. Patients self-reported as Hispanic or non-Hispanic ethnicity. Data were collected on patient demographics, corneal disease severity, and adverse outcomes associated with PBKC at the time of diagnosis and worst stage during their care.

Results

A total of 405 records were reviewed. Of these, 175 children with PBKC were included, with 116 (66.3%) identifying as Hispanic, 52 (29.7%) as non-Hispanic, and 7 (4.0%) with unknown or unreported ethnicity. Hispanic children were more likely to have moderate and severe corneal disease at their worst stage than non-Hispanic children (P < 0.001). A higher proportion of Hispanic children required interpreter services (P < 0.001), lacked private insurance (P < 0.001), and resided in areas with lower median incomes (P = 0.004) and overall childhood opportunity indices (P < 0.001). Multivariable analysis showed moderate and severe corneal disease at the worst stage was associated only with Hispanic ethnicity (OR = 3.31; 95% CI, 1.53-7.14; P = 0.002).

Conclusions

In our patient cohort, Hispanic children are more frequently affected by PBKC, with worse corneal disease, in addition to, and independent of, experiencing differing social determinants of health compared with non-Hispanic children.

目的：比较西班牙裔和非西班牙裔儿童眼角膜结膜炎（PBKC）相关角膜疾病和并发症的严重程度以及护理障碍。方法：对所有患儿的病历资料进行回顾性分析。其中，175名PBKC患儿被纳入研究，其中116名（66.3%）为西班牙裔，52名（29.7%）为非西班牙裔，7名（4.0%）为未知或未报告的种族。与非西班牙裔儿童相比，西班牙裔儿童在最严重阶段更有可能患有中度和重度角膜疾病（P = 0.0002）。西班牙裔儿童需要口译服务的比例较高（P = 0.0002），缺乏私人保险（P = 0.0008），居住在收入中位数较低（P = 0.004）和整体儿童机会指数（P < 0.0001）的地区。多变量分析显示，最严重阶段的中度和重度角膜疾病仅与西班牙裔有关（OR = 3.31; 95% CI, 1.53-7.14; P = 0.002）。结论：在我们的患者队列中，与非西班牙裔儿童相比，西班牙裔儿童更容易受到PBKC的影响，除了经历不同的健康社会决定因素外，还有更严重的角膜疾病。

{"title":"Hispanic ethnicity associated with worse pediatric blepharokeratoconjunctivitis at a tertiary children’s hospital in the United States","authors":"Jennifer M. Lai BS, Jennifer L. Patnaik PhD, MHS, Ronald Wise MD, Emily A. McCourt MD, Rebecca G. Edwards Mayhew MD, PhD","doi":"10.1016/j.jaapos.2026.104741","DOIUrl":"10.1016/j.jaapos.2026.104741","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the severity of corneal disease and complications associated with pediatric blepharokeratoconjunctivitis (PBKC) as well as barriers to care in Hispanic and non-Hispanic children.</div></div><div><h3>Methods</h3><div>The medical records of all children <18 years of age who met broadened PBKC spectrum criteria at Children’s Hospital Colorado between 2019 and 2024 were reviewed retrospectively. Patients self-reported as Hispanic or non-Hispanic ethnicity. Data were collected on patient demographics, corneal disease severity, and adverse outcomes associated with PBKC at the time of diagnosis and worst stage during their care.</div></div><div><h3>Results</h3><div>A total of 405 records were reviewed. Of these, 175 children with PBKC were included, with 116 (66.3%) identifying as Hispanic, 52 (29.7%) as non-Hispanic, and 7 (4.0%) with unknown or unreported ethnicity. Hispanic children were more likely to have moderate and severe corneal disease at their worst stage than non-Hispanic children (<em>P</em> < 0.001). A higher proportion of Hispanic children required interpreter services (<em>P</em> < 0.001), lacked private insurance (<em>P</em> < 0.001), and resided in areas with lower median incomes (<em>P</em> = 0.004) and overall childhood opportunity indices (<em>P</em> < 0.001). Multivariable analysis showed moderate and severe corneal disease at the worst stage was associated only with Hispanic ethnicity (OR = 3.31; 95% CI, 1.53-7.14; <em>P</em> = 0.002).</div></div><div><h3>Conclusions</h3><div>In our patient cohort, Hispanic children are more frequently affected by PBKC, with worse corneal disease, in addition to, and independent of, experiencing differing social determinants of health compared with non-Hispanic children.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"30 1","pages":"Article 104741"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterior megalophthalmos associated with CPAMD8 mutation: a case report 前眼大症伴camd8突变1例

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-02-05 DOI: 10.1016/j.jaapos.2026.104754

Laura Ninet MD, Mathilde Minot MD, Victor Morel MD, Florence Dupessey MD, Isabelle Rendu MD, Daniele Denis PhD, Thierry David PhD, Aurore Aziz MD

A 5-year-old girl was referred for bilateral iridodonesis. Clinical evaluation revealed an enlarged horizontal corneal diameter, a markedly deep anterior chamber, diffuse iris transillumination, and bilateral posterior subcapsular cataracts. Gonioscopic examination demonstrated angle dysgenesis with posterior embryotoxon. Ultrasound biomicroscopy confirmed the bilateral anterior segment clinical abnormalities. Axial length was within normal limits. Intraocular pressure remained within normal limits, and there was no evidence of juvenile glaucoma. A diagnosis of anterior megalophthalmos was established. Genetic analysis revealed a pathogenic mutation in the CPAMD8 gene, which is known to be associated with anterior segment dysgenesis. This case supports the mutation of CPAMD8 as a genetic contributor to this rare developmental anomaly.

一名5岁女孩因双侧虹膜缺损而就诊。临床表现为水平角膜直径增大，前房明显深，弥漫性虹膜透光，双侧后囊膜下白内障。宫腔镜检查显示角发育不良伴后胎毒瘤。超声生物显微镜检查证实双侧前段临床异常。轴长在正常范围内。眼压在正常范围内，无青光眼。诊断为前眼大症。遗传分析揭示了camd8基因的致病突变，已知该基因与前段发育不良有关。该病例支持camd8突变是这种罕见发育异常的遗传因素。

引用次数: 0

Risk factors for capsular phimosis following congenital cataract extraction 先天性白内障摘出后囊包下垂的危险因素。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.jaapos.2025.104726

Mohit Sharma MBBS, MS Ophthalmology, Soveeta Rath MBBS, DNB Ophthalmology, FICO, Shailja Tibrewal MBBS, MS Ophthalmology, Suma Ganesh MBBS, MS, DNB Ophthalmology

引用次数: 0

Spontaneous closure of a congenital lacrimal fistula 先天性泪道瘘的自然闭合。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.jaapos.2026.104728

Merry Z. Ruan MD, PhD , Jonathan C. Horton MD, PhD

A congenital external lacrimal fistula appears as a small aperture inferonasal to the inner canthus, exuding clear fluid. It is thought to arise from an accessory duct connected to the lacrimal sac. Various operations have been described for ablation of congenital lacrimal fistula, but no prior study has documented spontaneous closure. We describe a child whose congenital lacrimal fistula resolved after 5 years of observation, obviating the need for a surgical procedure.

先天性泪外瘘表现为鼻内眦的小开口，流出清澈的液体。它被认为起源于与泪囊相连的副导管。各种手术已经被描述为先天性泪瘘的消融，但没有先前的研究证明自然关闭。我们描述了一个孩子的先天性泪瘘解决后5年的观察，避免了手术的需要。

引用次数: 0

Strabismus surgery charges at ambulatory facilities across the United States 斜视手术收费在美国各地的流动设施。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-01-31 DOI: 10.1016/j.jaapos.2026.104745

Zoe (Zhiyu) Wu MS , Julius T. Oatts MD, MHS , David G. Hunter MD, PhD , Isdin Oke MD, MPH

Purpose

To identify factors associated with variation in strabismus surgery charges at hospital-owned facilities across the United States.

Methods

This cross-sectional study included all strabismus-related patient encounters in the National Ambulatory Surgery Sample over a 5-year period (January 2016 to December 2020). The primary outcome was total charge per encounter. Multivariable linear regression was used to estimate the association of charge per encounter with patient, hospital, and regional characteristics, adjusting for procedure complexity and inflation. Sampling weights were used to generate nationally representative estimates and appropriate standard errors.

Results

We included 154,005 patient encounters. Most surgeries were performed on pediatric patients (70%) and at teaching facilities (92%). The median charge per encounter was $12,889 (IQR, $8,840 to $17,573). Compared with the Midwest, charges were higher in the Northeast by 20.0% (95% CI, 8.4%, 32.9%; P = 0.0004) and South by 15.9% (95% CI, 4.8%-28.1%; P = 0.004). Nonteaching hospitals had 35.0% (95% CI, 17.6%-55.0%; P < 0.0001) higher charges compared with teaching hospitals. Rural hospitals had 26.6% (95% CI, 19.4%-33.1%; P < 0.0001) lower charges compared to urban hospitals. Patients residing in ZIP codes within the lowest income quartile had on average 6.8% (95% CI, 1.8%-12.2%; P = 0.0079) higher charges than those in the highest income quartile.

Conclusions

Our findings highlight substantial variation nationwide in charges for strabismus surgeries, raising important questions about how these differences may influence subspecialty geographic distribution of care and affect treatment access for patients with strabismus.

目的：确定与美国医院所有设施斜视手术费用变化相关的因素。方法：本横断面研究包括5年（2016年1月至2020年12月）期间全国门诊手术样本中所有与斜视相关的患者。主要结果是每次接触的总电荷。使用多变量线性回归来估计每次就诊费用与患者、医院和地区特征的关联，并对程序复杂性和通货膨胀进行调整。抽样权重用于产生具有全国代表性的估计值和适当的标准误差。结果：我们纳入了154,005例患者。大多数手术是在儿科患者（69.9%）和教学设施（91.8%）进行的。每次就诊的中位数费用为12,889美元（四分位数范围为8,840美元至17,573美元）。与中西部地区相比，东北地区的收费高20.0% (95% CI, 8.4%, 32.9%; P = 0.0004)，南部地区高15.9% （95% CI, 4.8%-28.1%; P = 0.004）。非教学医院的收费比教学医院高35.0% （95% CI, 17.6% ~ 55.0%; P < 0.0001）。农村医院的收费比城市医院低26.6% （95% CI, 19.4% ~ 33.1%; P < 0.0001）。居住在邮政编码最低收入四分位数内的患者的收费平均比最高收入四分位数高6.8% （95% CI, 1.8%-12.2%; P = 0.008）。结论：我们的研究结果突出了全国范围内斜视手术收费的巨大差异，提出了这些差异如何影响亚专科护理的地理分布和影响斜视患者治疗可及性的重要问题。

{"title":"Strabismus surgery charges at ambulatory facilities across the United States","authors":"Zoe (Zhiyu) Wu MS , Julius T. Oatts MD, MHS , David G. Hunter MD, PhD , Isdin Oke MD, MPH","doi":"10.1016/j.jaapos.2026.104745","DOIUrl":"10.1016/j.jaapos.2026.104745","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify factors associated with variation in strabismus surgery charges at hospital-owned facilities across the United States.</div></div><div><h3>Methods</h3><div>This cross-sectional study included all strabismus-related patient encounters in the National Ambulatory Surgery Sample over a 5-year period (January 2016 to December 2020). The primary outcome was total charge per encounter. Multivariable linear regression was used to estimate the association of charge per encounter with patient, hospital, and regional characteristics, adjusting for procedure complexity and inflation. Sampling weights were used to generate nationally representative estimates and appropriate standard errors.</div></div><div><h3>Results</h3><div>We included 154,005 patient encounters. Most surgeries were performed on pediatric patients (70%) and at teaching facilities (92%). The median charge per encounter was $12,889 (IQR, $8,840 to $17,573). Compared with the Midwest, charges were higher in the Northeast by 20.0% (95% CI, 8.4%, 32.9%; <em>P</em> = 0.0004) and South by 15.9% (95% CI, 4.8%-28.1%; <em>P</em> = 0.004). Nonteaching hospitals had 35.0% (95% CI, 17.6%-55.0%; <em>P</em> < 0.0001) higher charges compared with teaching hospitals. Rural hospitals had 26.6% (95% CI, 19.4%-33.1%; <em>P</em> < 0.0001) lower charges compared to urban hospitals. Patients residing in ZIP codes within the lowest income quartile had on average 6.8% (95% CI, 1.8%-12.2%; <em>P</em> = 0.0079) higher charges than those in the highest income quartile.</div></div><div><h3>Conclusions</h3><div>Our findings highlight substantial variation nationwide in charges for strabismus surgeries, raising important questions about how these differences may influence subspecialty geographic distribution of care and affect treatment access for patients with strabismus.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"30 1","pages":"Article 104745"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between maternal cannabis use disorder diagnosis and the development of retinopathy of prematurity 母亲大麻使用诊断与早产儿视网膜病变发展的关系。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-02-02 DOI: 10.1016/j.jaapos.2026.104748

Melanie D. Tran BS , Rebecca J. Baer MPH , Gretchen Bandoli PhD , Shira L. Robbins MD , David Granet MD, MHCM , Christina D. Chambers PhD, MPH , Jolene C. Rudell MD, PhD

Purpose

To compare the incidence of retinopathy of prematurity (ROP) among preterm infants born to mothers with and without a cannabis use disorder (CUD) diagnosis.

Methods

This retrospective cohort study used the UC San Diego Study of Outcomes in Mothers and Infants (SOMI) population-based database and restricted the sample to infants born between 22 and <31 weeks’ gestation, and/or having birth weight of <1500 g, who survived to the appropriate age for ROP screening. Infant ROP and maternal CUD during pregnancy were identified from International Classification of Diseases diagnostic codes from hospital discharge records. Adjusted relative risk (aRR) of ROP was calculated using log-linear regression, comparing mothers with and without CUD while controlling for demographic and clinical factors.

Results

Of the 997 infants born between 22 and <31 weeks to mothers with CUD, 32.1% developed ROP, compared with 33.3% of the 30,1113 infants born to mothers without CUD. Adjusting for maternal covariates, preterm infants born to mothers with CUD were not found to be at higher or lower risk of developing ROP than preterm infants born to mothers without CUD (aRR = 1.0; 95% CI, 0.9-1.1).

Conclusions

In our study cohort, preterm infants born to mothers with CUD did not have an increased or decreased risk of developing ROP compared with those born to mothers without CUD.

目的：比较有和没有大麻使用障碍（CUD）诊断的母亲所生的早产儿视网膜病变（ROP）的发生率。方法：这项回顾性队列研究使用了加州大学圣地亚哥分校母婴结局研究（SOMI）基于人群的数据库，并将样本限制在22岁至22岁之间出生的婴儿

{"title":"The relationship between maternal cannabis use disorder diagnosis and the development of retinopathy of prematurity","authors":"Melanie D. Tran BS , Rebecca J. Baer MPH , Gretchen Bandoli PhD , Shira L. Robbins MD , David Granet MD, MHCM , Christina D. Chambers PhD, MPH , Jolene C. Rudell MD, PhD","doi":"10.1016/j.jaapos.2026.104748","DOIUrl":"10.1016/j.jaapos.2026.104748","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the incidence of retinopathy of prematurity (ROP) among preterm infants born to mothers with and without a cannabis use disorder (CUD) diagnosis.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used the UC San Diego Study of Outcomes in Mothers and Infants (SOMI) population-based database and restricted the sample to infants born between 22 and <31 weeks’ gestation, and/or having birth weight of <1500 g, who survived to the appropriate age for ROP screening. Infant ROP and maternal CUD during pregnancy were identified from International Classification of Diseases diagnostic codes from hospital discharge records. Adjusted relative risk (aRR) of ROP was calculated using log-linear regression, comparing mothers with and without CUD while controlling for demographic and clinical factors.</div></div><div><h3>Results</h3><div>Of the 997 infants born between 22 and <31 weeks to mothers with CUD, 32.1% developed ROP, compared with 33.3% of the 30,1113 infants born to mothers without CUD. Adjusting for maternal covariates, preterm infants born to mothers with CUD were not found to be at higher or lower risk of developing ROP than preterm infants born to mothers without CUD (aRR = 1.0; 95% CI, 0.9-1.1).</div></div><div><h3>Conclusions</h3><div>In our study cohort, preterm infants born to mothers with CUD did not have an increased or decreased risk of developing ROP compared with those born to mothers without CUD.</div></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"30 1","pages":"Article 104748"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Offline AI-assisted fundus imaging for preliminary screening of childhood glaucoma 线下人工智能辅助眼底成像对儿童青光眼的初步筛查。

IF 1.3 4区医学 Q3 OPHTHALMOLOGY

Journal of Aapos

Pub Date : 2026-02-01 Epub Date: 2026-02-05 DOI: 10.1016/j.jaapos.2026.104755

Sirisha Senthil MS , Divya Parthasarathy Rao MS , Shreya Bhandary M Optom , Rashmi Krishnamurthy MD , Kalpa Negiloni PhD

Purpose

To evaluate the feasibility and performance of AI-assisted portable fundus photography in children with glaucoma.

Methods

This case series describes the use of smartphone-based fundus imaging with integrated offline glaucoma artificial intelligence (AI) in children (≤18 years) with various types of glaucoma who were evaluated at a tertiary eye care center, and comparing AI-derived referral recommendations with presence or absence of structural optic nerve changes determined on clinical evaluation.

Results

AI-assisted fundus photography and clinical evaluation were completed for 21 children. For vertical cup:disk ratio, the 95% limits of agreement between AI image analysis and clinical assessment on Bland-Altman analysis were –0.15 to +0.23. The AI output recommended referral for 7 of 8 children who had structural optic nerve changes on clinical examination and did not recommend referral for any of the children without such optic nerve changes.

Conclusions

AI-assisted smartphone-based fundus imaging may help identify cases of pediatric glaucoma exhibiting structural optic nerve changes.

目的：评价人工智能辅助便携式眼底摄影治疗儿童青光眼的可行性和效果。方法：本病例系列描述了在三级眼科保健中心评估的不同类型青光眼的儿童（≤18岁）中，基于智能手机的眼底成像与综合脱机青光眼人工智能（AI）的使用，并将AI衍生的转诊建议与临床评估确定的视神经结构改变的存在或不存在进行比较。结果：21例患儿完成人工智能辅助眼底摄影及临床评价。对于垂直杯盘比，人工智能图像分析与Bland-Altman分析临床评估的95%一致性限为-0.15 ~ +0.23。AI输出推荐8例临床检查中有视神经结构性改变的患儿中有7例转诊，没有视神经结构性改变的患儿不推荐转诊。结论：人工智能辅助的基于智能手机的眼底成像可能有助于识别表现出视神经结构改变的儿童青光眼病例。

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引用次数: 0

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