Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102226
Sabine den Roover, J. Aerts
{"title":"MRNACalc: An accurate RNA quantification tool in the era of modified nucleosides","authors":"Sabine den Roover, J. Aerts","doi":"10.1016/j.omtn.2024.102226","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102226","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"26 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102255
M. Bhattacharya, S. Pal, S. Chatterjee, Sang-Soo Lee, C. Chakraborty
{"title":"Large Language Model (LLM) to Multimodal Large Language Model (MLLM): A journey to shape the biological macromolecules to biological sciences and medicine","authors":"M. Bhattacharya, S. Pal, S. Chatterjee, Sang-Soo Lee, C. Chakraborty","doi":"10.1016/j.omtn.2024.102255","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102255","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102253
Asger Givskov Jørgensen, D. M. Dupont, Søren Fjelstrup, Claus Bus, C. Hansen, Thomas Benfield, Peter Garred, Peter M.H. Heegaard, Jørgen Kjems
{"title":"Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk-factors","authors":"Asger Givskov Jørgensen, D. M. Dupont, Søren Fjelstrup, Claus Bus, C. Hansen, Thomas Benfield, Peter Garred, Peter M.H. Heegaard, Jørgen Kjems","doi":"10.1016/j.omtn.2024.102253","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102253","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"4 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102237
S. Aguti, Shuzhi Cheng, Pierpaolo Ala, Sean Briggs, Francesco Muntoni, Haiyan Zhou
{"title":"Strategies to improve the design of gapmer antisense oligonucleotide on allele-specific silencing","authors":"S. Aguti, Shuzhi Cheng, Pierpaolo Ala, Sean Briggs, Francesco Muntoni, Haiyan Zhou","doi":"10.1016/j.omtn.2024.102237","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102237","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"130 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102246
Naoki Iwamoto, Yuanjing Liu, M. Frank-Kamenetsky, Abbie Maguire, Wei Chou Tseng, Kristin Taborn, Nayantara Kothari, Ali Akhtar, K. Bowman, J. Shelke, A. Lamattina, X. Hu, Hyun Gyung Jang, P. Kandasamy, Fangjun Liu, K. Longo, Richard Looby, Meena, Jake Metterville, Qianli Pan, E. Purcell-Estabrook, M. Shimizu, Priyanka Shiva Prakasha, S. Standley, Hansini Upadhyay, Hailin Yang, Yuan Yin, Anderson Zhao, Christopher Francis, M. Byrne, Elena Dale, G. Verdine, C. Vargeese
{"title":"Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT","authors":"Naoki Iwamoto, Yuanjing Liu, M. Frank-Kamenetsky, Abbie Maguire, Wei Chou Tseng, Kristin Taborn, Nayantara Kothari, Ali Akhtar, K. Bowman, J. Shelke, A. Lamattina, X. Hu, Hyun Gyung Jang, P. Kandasamy, Fangjun Liu, K. Longo, Richard Looby, Meena, Jake Metterville, Qianli Pan, E. Purcell-Estabrook, M. Shimizu, Priyanka Shiva Prakasha, S. Standley, Hansini Upadhyay, Hailin Yang, Yuan Yin, Anderson Zhao, Christopher Francis, M. Byrne, Elena Dale, G. Verdine, C. Vargeese","doi":"10.1016/j.omtn.2024.102246","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102246","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"56 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102248
Melissa M. Evans, Shirley Liu, Joshua S. Krautner, Caroline G. Seguin, Rajan Leung, John A. Ronald
{"title":"Evaluation of DNA Minicircles for Delivery of Adenine and Cytosine Base Editors using Activatable Gene On “GO” Reporter Imaging Systems","authors":"Melissa M. Evans, Shirley Liu, Joshua S. Krautner, Caroline G. Seguin, Rajan Leung, John A. Ronald","doi":"10.1016/j.omtn.2024.102248","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102248","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"498 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102234
Jasmin Morandell, A. Monziani, Martina Lazioli, Deborah Donzel, J. Döring, Claudio Oss Pegorar, Angela D’Anzi, M. Pellegrini, Andrea Mattiello, Dalia Bortolotti, G. Bergonzoni, T. Tripathi, Virginia B. Mattis, M. Kovalenko, Jessica Rosati, Christoph Dieterich, E. Dassi, V. Wheeler, Z. Ellederová, J. Wilusz, Gabriella Viero, M. Biagioli
{"title":"CircHTT(2,3,4,5,6) – co-evolving with the HTT CAG-repeat tract - modulates Huntington`s disease phenotypes","authors":"Jasmin Morandell, A. Monziani, Martina Lazioli, Deborah Donzel, J. Döring, Claudio Oss Pegorar, Angela D’Anzi, M. Pellegrini, Andrea Mattiello, Dalia Bortolotti, G. Bergonzoni, T. Tripathi, Virginia B. Mattis, M. Kovalenko, Jessica Rosati, Christoph Dieterich, E. Dassi, V. Wheeler, Z. Ellederová, J. Wilusz, Gabriella Viero, M. Biagioli","doi":"10.1016/j.omtn.2024.102234","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102234","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"125 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.omtn.2024.102251
E. McConnell, Dennis Chan, Katelyn Ventura, Joshua P. Callahan, Kathryn Harris, Vernon Hunt, Spencer Boisjoli, Daniel Knight, Evan T. Monk, Matthew R. Holahan, M. DeRosa
{"title":"Selection of DNA aptamers that prevent the fibrillization of α-synuclein protein in cellular and mouse models","authors":"E. McConnell, Dennis Chan, Katelyn Ventura, Joshua P. Callahan, Kathryn Harris, Vernon Hunt, Spencer Boisjoli, Daniel Knight, Evan T. Monk, Matthew R. Holahan, M. DeRosa","doi":"10.1016/j.omtn.2024.102251","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102251","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"11 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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