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Molecular Therapy - Nucleic Acids最新文献

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miR-200-mediated inactivation of cancer-associated fibroblasts via targeting of NRP2-VEGFR signaling attenuates lung cancer invasion and metastasis 通过靶向 NRP2-VEGFR 信号，miR-200 介导的癌症相关成纤维细胞失活可减轻肺癌的侵袭和转移
Molecular Therapy - Nucleic Acids
Pub Date : 2024-04-01 DOI: 10.1016/j.omtn.2024.102194
Inyoung Cheon, Sieun Lee, S. Oh, Y. Ahn
{"title":"miR-200-mediated inactivation of cancer-associated fibroblasts via targeting of NRP2-VEGFR signaling attenuates lung cancer invasion and metastasis","authors":"Inyoung Cheon, Sieun Lee, S. Oh, Y. Ahn","doi":"10.1016/j.omtn.2024.102194","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102194","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"70 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR-based editing strategies to rectify EYA1 complex genomic rearrangement linked to haploinsufficiency 基于 CRISPR 的编辑策略，纠正与单倍体缺陷有关的 EYA1 复杂基因组重排
Molecular Therapy - Nucleic Acids
Pub Date : 2024-04-01 DOI: 10.1016/j.omtn.2024.102199
Hwalin Yi, Y. Yun, Won Hoon Choi, Hye-Yeon Hwang, J. Cha, Heeyoung Seok, Jae-Jin Song, Jun Ho Lee, Sang-Yeon Lee, Daesik Kim
{"title":"CRISPR-based editing strategies to rectify EYA1 complex genomic rearrangement linked to haploinsufficiency","authors":"Hwalin Yi, Y. Yun, Won Hoon Choi, Hye-Yeon Hwang, J. Cha, Heeyoung Seok, Jae-Jin Song, Jun Ho Lee, Sang-Yeon Lee, Daesik Kim","doi":"10.1016/j.omtn.2024.102199","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102199","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"311 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal Restriction of Cas9 Expression Improves CRISPR-Mediated Deletion Efficacy and Fidelity Cas9表达的时间限制提高了CRISPR介导的缺失效力和保真度
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102172
Jesse A. Weber, Jonathan F. Lang, Ellie Carrell, M. Alameh, Beverly L. Davidson
{"title":"Temporal Restriction of Cas9 Expression Improves CRISPR-Mediated Deletion Efficacy and Fidelity","authors":"Jesse A. Weber, Jonathan F. Lang, Ellie Carrell, M. Alameh, Beverly L. Davidson","doi":"10.1016/j.omtn.2024.102172","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102172","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"252 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140275593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Context base editing for splice correction of IVSI-110 β-thalassemia 用于 IVSI-110 β 型地中海贫血症剪接校正的上下文碱基编辑
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102183
Basma Naiisseh, P. Papasavva, Nikoletta Y Papaioannou, Marios Tomazou, L. Koniali, X. Felekis, Constantina G. Constantinou, Maria Sitarou, S. Christou, M. Kleanthous, C. Lederer, Petros Patsali
{"title":"Context base editing for splice correction of IVSI-110 β-thalassemia","authors":"Basma Naiisseh, P. Papasavva, Nikoletta Y Papaioannou, Marios Tomazou, L. Koniali, X. Felekis, Constantina G. Constantinou, Maria Sitarou, S. Christou, M. Kleanthous, C. Lederer, Petros Patsali","doi":"10.1016/j.omtn.2024.102183","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102183","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"51 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimized allele-specific silencing of the dominant-negative COL6A1 G293R substitution causing collagen VI-related dystrophy 优化等位基因特异性沉默显性阴性 COL6A1 G293R 取代导致胶原 VI 相关营养不良症
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102178
Astrid Brull, A. Sarathy, Véronique Bolduc, Grace S. Chen, R. McCarty, Carsten G. Bönnemann
{"title":"Optimized allele-specific silencing of the dominant-negative COL6A1 G293R substitution causing collagen VI-related dystrophy","authors":"Astrid Brull, A. Sarathy, Véronique Bolduc, Grace S. Chen, R. McCarty, Carsten G. Bönnemann","doi":"10.1016/j.omtn.2024.102178","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102178","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"17 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140268105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration 血管内皮生长因子介导的感光细胞变性反映了抗血管内皮生长因子疗法的无效性
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102176
Xin Xu, Ni Han, Fangkun Zhao, Ruoyue Fan, Qingguo Guo, Xuefei Han, Ying Liu, Guangzuo Luo
{"title":"Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration","authors":"Xin Xu, Ni Han, Fangkun Zhao, Ruoyue Fan, Qingguo Guo, Xuefei Han, Ying Liu, Guangzuo Luo","doi":"10.1016/j.omtn.2024.102176","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102176","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"46 197","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oligonucleotide Therapies for Nonalcoholic Steatohepatitis 治疗非酒精性脂肪性肝炎的寡核苷酸疗法
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102184
Sixu Li, Feng Xiong, Songbo Zhang, Jinghua Liu, Guangping Gao, Jun Xie, Yi Wang
{"title":"Oligonucleotide Therapies for Nonalcoholic Steatohepatitis","authors":"Sixu Li, Feng Xiong, Songbo Zhang, Jinghua Liu, Guangping Gao, Jun Xie, Yi Wang","doi":"10.1016/j.omtn.2024.102184","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102184","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"21 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140399784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TGF-β1-triggered BMI1 and SMAD2 cooperatively regulate miR-191 to modulate bone formation TGF-β1 触发的 BMI1 和 SMAD2 协同调控 miR-191 以调节骨形成
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102164
Xiao-Fei Zhang, Zi-Xuan Wang, Bo-Wen Zhang, Kun-Peng Huang, Tian-Xing Ren, Ting Wang, Xing Cheng, Ping Hu, Wei-Hua Xu, Jin Li, Jin-Xiang Zhang, Hui Wang
{"title":"TGF-β1-triggered BMI1 and SMAD2 cooperatively regulate miR-191 to modulate bone formation","authors":"Xiao-Fei Zhang, Zi-Xuan Wang, Bo-Wen Zhang, Kun-Peng Huang, Tian-Xing Ren, Ting Wang, Xing Cheng, Ping Hu, Wei-Hua Xu, Jin Li, Jin-Xiang Zhang, Hui Wang","doi":"10.1016/j.omtn.2024.102164","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102164","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"06 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enigmatic Exosomal Connection in Lung Cancer Drug Resistance 肺癌耐药性中神秘的外泌体联系
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102177
S. Patra, R. K. Sahoo, Stuti Biswal, Shikshya S. Panda, B. Biswal
{"title":"Enigmatic Exosomal Connection in Lung Cancer Drug Resistance","authors":"S. Patra, R. K. Sahoo, Stuti Biswal, Shikshya S. Panda, B. Biswal","doi":"10.1016/j.omtn.2024.102177","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102177","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"71 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140276004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Film Based Formulations that Move mRNA Lipid Nanoparticles Out of the Freezer 鉴定可将 mRNA 脂质纳米粒子移出冷冻室的薄膜配方
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102179
Trang Nguyen Kieu Doan, Madison M. Davis, M. Croyle
{"title":"Identification of Film Based Formulations that Move mRNA Lipid Nanoparticles Out of the Freezer","authors":"Trang Nguyen Kieu Doan, Madison M. Davis, M. Croyle","doi":"10.1016/j.omtn.2024.102179","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102179","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"45 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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